{"id":"https://openalex.org/W7222009582","doi":"https://doi.org/10.1016/j.clinme.2026.100656","title":"Pathophysiology, workup and treatment of cancer-related ischaemic stroke","display_name":"Pathophysiology, workup and treatment of cancer-related ischaemic stroke","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7222009582","doi":"https://doi.org/10.1016/j.clinme.2026.100656","pmid":"https://pubmed.ncbi.nlm.nih.gov/42880717","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13730225"},"language":"en","primary_location":{"id":"doi:10.1016/j.clinme.2026.100656","doi":"https://doi.org/10.1016/j.clinme.2026.100656","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100656","pdf_url":null,"source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.clinme.2026.100656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130163528","display_name":"Shivam Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivam Patel","raw_affiliation_strings":["Department of Neurology, Tufts Medicine, Boston, MA, 02111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tufts Medicine, Boston, MA, 02111, United States","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003718738","display_name":"Soma Sengupta","orcid":"https://orcid.org/0000-0003-4577-1397","observed_orcids":["https://orcid.org/0000-0003-4577-1397"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soma Sengupta","raw_affiliation_strings":["Department of Neurology, Tufts Medicine, Boston, MA, 02111, United States"],"raw_orcid":"https://orcid.org/0000-0003-4577-1397","affiliations":[{"raw_affiliation_string":"Department of Neurology, Tufts Medicine, Boston, MA, 02111, United States","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152632762","display_name":"Wuwei Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wuwei Feng","raw_affiliation_strings":["Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087154090","display_name":"Dylan Ryan","orcid":"https://orcid.org/0000-0001-7254-0020","observed_orcids":["https://orcid.org/0000-0001-7254-0020"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dylan Ryan","raw_affiliation_strings":["Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, United States. Electronic address: Dylan.ryan@duke.edu"],"raw_orcid":"https://orcid.org/0000-0001-7254-0020","affiliations":[{"raw_affiliation_string":"Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, United States. Electronic address: Dylan.ryan@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087154090"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77872931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"5","first_page":"100656","last_page":"100656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.7419999837875366},{"id":"https://openalex.org/keywords/diagnostic-assessment","display_name":"diagnostic assessment","score":0.7549999952316284},{"id":"https://openalex.org/keywords/stroke-management","display_name":"stroke management","score":0.8880000114440918},{"id":"https://openalex.org/keywords/stroke-subtypes","display_name":"stroke subtypes","score":0.5429999828338623},{"id":"https://openalex.org/keywords/multidisciplinary-care","display_name":"multidisciplinary care","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9819999933242798},{"id":"https://openalex.org/C3018755981","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischaemic stroke","level":3,"score":0.7504000067710876},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6439999938011169},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5274999737739563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5239999890327454},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.4927000105381012},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4837000072002411},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.43689998984336853},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3968000113964081},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37529999017715454},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.3682999908924103},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C192328126","wikidata":"https://www.wikidata.org/wiki/Q4514647","display_name":"Schematic","level":2,"score":0.2842000126838684}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.clinme.2026.100656","doi":"https://doi.org/10.1016/j.clinme.2026.100656","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100656","pdf_url":null,"source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13730225","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730225/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730225/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Med (Lond)","raw_type":"Text"},{"id":"pmid:42880717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42880717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical medicine (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bc204a6ad53d4c0ab0f9e688ce6a1af8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bc204a6ad53d4c0ab0f9e688ce6a1af8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Medicine, Vol 26, Iss 5, Pp 100656- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.clinme.2026.100656","doi":"https://doi.org/10.1016/j.clinme.2026.100656","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100656","pdf_url":null,"source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222009582.pdf","grobid_xml":"https://content.openalex.org/works/W7222009582.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1977078716","https://openalex.org/W2109694775","https://openalex.org/W2395791699","https://openalex.org/W2564801162","https://openalex.org/W3108101514","https://openalex.org/W4283317026","https://openalex.org/W4296344698","https://openalex.org/W4385332540","https://openalex.org/W4387431658","https://openalex.org/W4399247153","https://openalex.org/W4399676188","https://openalex.org/W4401512775","https://openalex.org/W4404932463","https://openalex.org/W4408389846","https://openalex.org/W4409833563","https://openalex.org/W4410334145","https://openalex.org/W4412492200","https://openalex.org/W4415092555","https://openalex.org/W4417361860","https://openalex.org/W7127157088","https://openalex.org/W7155173990"],"related_works":["https://openalex.org/W4404932463","https://openalex.org/W4296180562","https://openalex.org/W3004912828","https://openalex.org/W2096649856","https://openalex.org/W7127157088","https://openalex.org/W4396977901","https://openalex.org/W4295540522","https://openalex.org/W4403489407","https://openalex.org/W4381462559","https://openalex.org/W3102033173"],"abstract_inverted_index":{"Cancer":[0],"and":[1,22,69,81,88],"acute":[2],"ischaemic":[3,36,56,89],"stroke":[4,37,57],"are":[5],"two":[6,16],"leading":[7],"causes":[8],"of":[9,42,53,62],"mortality":[10],"worldwide.":[11],"The":[12],"association":[13],"between":[14],"these":[15],"diseases":[17],"is":[18,30,38],"being":[19],"increasingly":[20],"recognised,":[21],"with":[23,86],"improvements":[24],"in":[25,84],"cancer":[26,87],"mortality,":[27],"the":[28,78],"co-prevalence":[29],"increasing.":[31],"Evidence":[32],"suggested":[33],"that":[34,64],"cancer-related":[35],"a":[39,45,59],"unique":[40],"subtype":[41],"stroke,":[43],"including":[44],"newly":[46],"proposed":[47],"schematic":[48],"to":[49],"define":[50],"this":[51,73],"subgroup":[52],"patients.":[54],"Cancer-related":[55],"encompasses":[58],"heterogeneous":[60],"group":[61],"mechanisms":[63],"requires":[65],"individualised":[66],"diagnostic":[67],"evaluation":[68],"multidisciplinary":[70],"collaboration.":[71],"In":[72],"narrative":[74],"review,":[75],"we":[76],"describe":[77],"pathophysiology,":[79],"workup,":[80],"management":[82],"considerations":[83],"patients":[85],"stroke.":[90]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-16T00:00:00"}