{"id":"https://openalex.org/W7221995657","doi":"https://doi.org/10.2147/ndt.s642828","title":"Peripheral GRM2 and GRM3 mRNA Alterations and Clinical Correlates in Insomnia Disorder: A Case\u2013Control Pilot Study","display_name":"Peripheral GRM2 and GRM3 mRNA Alterations and Clinical Correlates in Insomnia Disorder: A Case\u2013Control Pilot Study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7221995657","doi":"https://doi.org/10.2147/ndt.s642828","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682293"},"language":"en","primary_location":{"id":"doi:10.2147/ndt.s642828","doi":"https://doi.org/10.2147/ndt.s642828","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s642828","pdf_url":"https://www.dovepress.com/article/download/120970","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/120970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158808002","display_name":"Liqing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liqing Zhang","raw_affiliation_strings":["Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","Department of Psychiatry, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","institution_ids":["https://openalex.org/I4210162753"]},{"raw_affiliation_string":"Department of Psychiatry, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, People's Republic of China","institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104215465","display_name":"Fangyi Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142622","display_name":"Wuhan Children's Hospital","ror":"https://ror.org/047c53f83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142622"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangyi Deng","raw_affiliation_strings":["Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430010, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","institution_ids":["https://openalex.org/I4210162753"]},{"raw_affiliation_string":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430010, People's Republic of China","institution_ids":["https://openalex.org/I4210142622","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158829332","display_name":"Jiaheng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaheng Lin","raw_affiliation_strings":["Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, People's Republic of China","Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, People's Republic of China","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081181776","display_name":"Liao Jiwu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiwu Liao","raw_affiliation_strings":["Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158816626","display_name":"Jiyang Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiyang Pan","raw_affiliation_strings":["Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, People's Republic of China","institution_ids":["https://openalex.org/I4210162753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5158808002","https://openalex.org/A5158816626"],"corresponding_institution_ids":["https://openalex.org/I4210088873","https://openalex.org/I4210162753","https://openalex.org/I58200834"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80314428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 22","issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-insomnia","display_name":"chronic insomnia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mglur2","display_name":"mGluR2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/grm3","display_name":"GRM3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mglu2-receptor","display_name":"mGlu2 receptor","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mglu3-receptor","display_name":"mGlu3 receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5360000133514404},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5849999785423279},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.8889999985694885},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.949999988079071},{"id":"https://openalex.org/keywords/polysomnography","display_name":"polysomnography","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.7968999743461609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7340999841690063},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6456999778747559},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5791000127792358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5473999977111816},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38119998574256897},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.36559998989105225},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3650999963283539},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35659998655319214},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.3395000100135803},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.3228999972343445},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.31470000743865967},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3140999972820282},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2962000072002411},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.29580000042915344},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2732999920845032},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ndt.s642828","doi":"https://doi.org/10.2147/ndt.s642828","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s642828","pdf_url":"https://www.dovepress.com/article/download/120970","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682293","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682293/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682293/pdf/NDT-22-642828.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},{"id":"pmid:42903742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric disease and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7c90d23febf94ce0be2fb6361521153d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7c90d23febf94ce0be2fb6361521153d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropsychiatric Disease and Treatment, Vol Volume 22, Iss Issue 1, Pp 1-11 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/120970","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/peripheral-grm2-and-grm3-mrna-alterations-and-clinical-correlates-in-i-peer-reviewed-fulltext-article-NDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ndt.s642828","doi":"https://doi.org/10.2147/ndt.s642828","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s642828","pdf_url":"https://www.dovepress.com/article/download/120970","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1979245691","display_name":null,"funder_award_id":"2022YFC2503902","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221995657.pdf","grobid_xml":"https://content.openalex.org/works/W7221995657.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W21555973","https://openalex.org/W229788128","https://openalex.org/W1965092386","https://openalex.org/W1974900636","https://openalex.org/W1976597312","https://openalex.org/W1977383381","https://openalex.org/W1977465442","https://openalex.org/W1979055237","https://openalex.org/W1997113206","https://openalex.org/W2030214963","https://openalex.org/W2043705607","https://openalex.org/W2045861729","https://openalex.org/W2049025142","https://openalex.org/W2065351044","https://openalex.org/W2079300654","https://openalex.org/W2100497492","https://openalex.org/W2114613490","https://openalex.org/W2158282570","https://openalex.org/W2160070901","https://openalex.org/W2163898426","https://openalex.org/W2168420558","https://openalex.org/W2191445273","https://openalex.org/W2824076077","https://openalex.org/W2905176374","https://openalex.org/W2934055545","https://openalex.org/W2946224829","https://openalex.org/W2960267696","https://openalex.org/W3081624198","https://openalex.org/W3175119777","https://openalex.org/W3213511760","https://openalex.org/W4220823022","https://openalex.org/W4225313395","https://openalex.org/W4306973295","https://openalex.org/W4323348552","https://openalex.org/W4389687658","https://openalex.org/W4404991357","https://openalex.org/W4409736934","https://openalex.org/W4413184849"],"related_works":["https://openalex.org/W4403170808","https://openalex.org/W4319750139","https://openalex.org/W3200299707","https://openalex.org/W4379163538","https://openalex.org/W4281619441","https://openalex.org/W4401713370","https://openalex.org/W2082417771","https://openalex.org/W3099282261","https://openalex.org/W3127295156","https://openalex.org/W4404843723"],"abstract_inverted_index":{"Objectives:":[0],"This":[1],"pilot":[2],"study":[3],"examined":[4],"whether":[5],"peripheral":[6,59,222,244],"GRM2/GRM3":[7,60,245],"mRNA":[8,61,118],"expression":[9,119,226],"differed":[10],"between":[11],"chronic":[12,35,230],"insomnia":[13,268],"disorder":[14,269],"(ID)":[15],"and":[16,20,24,40,46,53,58,72,87,103,110,116,134,151,158,170,174,180,224,238],"healthy":[17],"controls":[18],"(HCs)":[19],"correlated":[21],"with":[22,34,43,77,96,125,178,229,232,235],"emotional":[23,179,237],"polysomnographic":[25],"(PSG)":[26],"features.":[27],"Methods:":[28],"After":[29],"PSG":[30,54],"screening,":[31],"43":[32],"patients":[33,99],"ID":[36,98,123],"meeting":[37],"DSM-5-TR":[38],"criteria":[39],"34":[41],"HCs":[42],"comparable":[44],"age":[45,133],"sex":[47,135],"distributions":[48],"were":[49,56,148,167,212],"included.":[50],"Mood,":[51],"sleep,":[52],"parameters":[55],"assessed,":[57],"was":[62,120,227],"quantified":[63],"by":[64],"RT-qPCR.":[65],"Statistical":[66],"analyses":[67],"comprised":[68],"group":[69],"comparisons,":[70],"age-":[71],"sex-adjusted":[73],"regression,":[74],"partial":[75],"correlations":[76],"false":[78],"discovery":[79],"rate":[80],"(FDR)":[81],"correction,":[82],"Bayesian":[83,205],"analyses,":[84,86],"sensitivity":[85],"exploratory":[88,233],"receiver":[89],"operating":[90],"characteristic":[91],"(ROC)":[92],"analyses.":[93],"Results:":[94],"Compared":[95],"HCs,":[97],"showed":[100,176,204],"greater":[101],"depressive":[102],"anxiety":[104],"symptoms,":[105],"poorer":[106],"subjective":[107],"sleep":[108,112,181,239],"quality,":[109],"altered":[111],"architecture.":[113],"Peripheral":[114],"GRM2":[115,154,173,201,223,262],"GRM3":[117,156,175,184,225,264],"lower":[121],"in":[122],"patients,":[124],"both":[126],"differences":[127],"remaining":[128],"significant":[129,188],"after":[130,189,214],"adjustment":[131,216],"for":[132,153,217],"(":[136,192,207],"P":[137,139,196],"=0.001;":[138],"=0.029).":[140],"The":[141],"apparent":[142],"area":[143],"under":[144],"the":[145,159,183,200],"curves":[146],"(AUCs)":[147],"0.744,":[149],"0.666,":[150],"0.769":[152],",":[155,157,263,265],"combined":[160],"model,":[161],"respectively;":[162],"corresponding":[163],"cross-validated":[164],"mean":[165],"AUCs":[166],"0.745,":[168],"0.645,":[169],"0.732.":[171],"Both":[172],"associations":[177,211,234],"measures;":[182],"\u2013PHQ-9":[185],"association":[186,203],"remained":[187],"FDR":[190],"correction":[191],"r":[193],"=\u2212":[194],"0.373,":[195],"adj":[197],"=0.020),":[198],"while":[199],"\u2013REM":[202],"support":[206],"BF":[208],"=4.473).":[209],"These":[210,241],"attenuated":[213],"further":[215],"diagnostic":[218,259],"group.":[219],"Conclusions:":[220],"Lower":[221],"associated":[228],"ID,":[231],"selected":[236],"measures.":[240],"findings":[242],"identify":[243],"as":[246],"candidate":[247],"molecular":[248],"correlates":[249],"of":[250],"ID.":[251],"Independent":[252],"external":[253],"validation":[254],"is":[255],"required":[256],"before":[257],"clinical":[258],"application.":[260],"Keywords:":[261],"RT-qPCR,":[266],"polysomnography,":[267]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-16T00:00:00"}
