{"id":"https://openalex.org/W7221925759","doi":"https://doi.org/10.1002/iju5.70282","title":"Primary Pure Yolk Sac Tumor of the Urinary Bladder: A Case Report","display_name":"Primary Pure Yolk Sac Tumor of the Urinary Bladder: A Case Report","publication_year":2026,"publication_date":"2026-10-15","ids":{"openalex":"https://openalex.org/W7221925759","doi":"https://doi.org/10.1002/iju5.70282","pmid":"https://pubmed.ncbi.nlm.nih.gov/42890642"},"language":"en","primary_location":{"id":"doi:10.1002/iju5.70282","doi":"https://doi.org/10.1002/iju5.70282","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iju5.70282","pdf_url":null,"source":{"id":"https://openalex.org/S4210179180","display_name":"IJU Case Reports","issn_l":"2577-171X","issn":["2577-171X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJU Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/iju5.70282","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130973799","display_name":"Yuki Hashimoto","orcid":"https://orcid.org/0009-0004-2151-6126","observed_orcids":["https://orcid.org/0009-0004-2151-6126"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yuki Hashimoto","raw_affiliation_strings":["Department of Urology Shiga General Hospital  Moriyama Shiga Japan"],"raw_orcid":"https://orcid.org/0009-0004-2151-6126","affiliations":[{"raw_affiliation_string":"Department of Urology Shiga General Hospital  Moriyama Shiga Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054494940","display_name":"Kosuke Shimizu","orcid":"https://orcid.org/0000-0002-2892-3750","observed_orcids":["https://orcid.org/0000-0002-2892-3750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Shimizu","raw_affiliation_strings":["Department of Urology Shiga General Hospital  Moriyama Shiga Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology Shiga General Hospital  Moriyama Shiga Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113665953","display_name":"Masayuki Uegaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayuki Uegaki","raw_affiliation_strings":["Department of Urology Shiga General Hospital  Moriyama Shiga Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology Shiga General Hospital  Moriyama Shiga Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034196874","display_name":"Fumihiko Kono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumihiko Kono","raw_affiliation_strings":["Department of Pathology Shiga General Hospital  Moriyama Shiga Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Shiga General Hospital  Moriyama Shiga Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158780131","display_name":"Toru Yoshida","orcid":"https://orcid.org/0000-0002-9397-2698","observed_orcids":["https://orcid.org/0000-0002-9397-2698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toru Yoshida","raw_affiliation_strings":["Department of Urology Shiga General Hospital  Moriyama Shiga Japan"],"raw_orcid":"https://orcid.org/0000-0002-9397-2698","affiliations":[{"raw_affiliation_string":"Department of Urology Shiga General Hospital  Moriyama Shiga Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5130973799"],"corresponding_institution_ids":[],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":{"value":4960,"currency":"USD","value_usd":4960},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89406062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"6","first_page":"e70282","last_page":"e70282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.40799999237060547,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yolk-sac-tumor","display_name":"yolk sac tumor","score":0.949999988079071},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.753000020980835},{"id":"https://openalex.org/keywords/extragonadal-germ-cell-tumor","display_name":"extragonadal germ cell tumor","score":0.9459999799728394},{"id":"https://openalex.org/keywords/gross-hematuria","display_name":"gross hematuria","score":0.796999990940094},{"id":"https://openalex.org/keywords/transurethral-resection","display_name":"transurethral resection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glypican-3","display_name":"glypican-3","score":0.984000027179718},{"id":"https://openalex.org/keywords/cisplatin-etoposide-chemotherapy","display_name":"etoposide and cisplatin chemotherapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/bladder-mass","display_name":"bladder mass","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.9437999725341797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.83160001039505},{"id":"https://openalex.org/C2778769751","wikidata":"https://www.wikidata.org/wiki/Q246090","display_name":"Cystoscopy","level":3,"score":0.6353999972343445},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6244999766349792},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.6068000197410583},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5713000297546387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5256999731063843},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5019000172615051},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.44429999589920044},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4228000044822693},{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.38019999861717224},{"id":"https://openalex.org/C2910508445","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder Neoplasm","level":4,"score":0.36899998784065247},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.3619000017642975},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.32420000433921814},{"id":"https://openalex.org/C2778065480","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Transitional cell carcinoma","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C2776938808","wikidata":"https://www.wikidata.org/wiki/Q1737977","display_name":"Germ cell tumors","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C2779342463","wikidata":"https://www.wikidata.org/wiki/Q3542021","display_name":"Endodermal sinus tumor","level":4,"score":0.28110000491142273},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2784999907016754},{"id":"https://openalex.org/C2778475373","wikidata":"https://www.wikidata.org/wiki/Q6066379","display_name":"Urinary bladder disease","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C2993461684","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Upper urinary tract","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C2780327976","wikidata":"https://www.wikidata.org/wiki/Q1451877","display_name":"Embryonal carcinoma","level":4,"score":0.2590999901294708},{"id":"https://openalex.org/C2776057878","wikidata":"https://www.wikidata.org/wiki/Q200741","display_name":"Teratoma","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C3019864225","wikidata":"https://www.wikidata.org/wiki/Q5867482","display_name":"Combination chemotherapy","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/iju5.70282","doi":"https://doi.org/10.1002/iju5.70282","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iju5.70282","pdf_url":null,"source":{"id":"https://openalex.org/S4210179180","display_name":"IJU Case Reports","issn_l":"2577-171X","issn":["2577-171X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJU Case Reports","raw_type":"journal-article"},{"id":"pmid:42890642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42890642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJU case reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cf9b972104af4d608d6107d84ed67941","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cf9b972104af4d608d6107d84ed67941","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IJU Case Reports, Vol 9, Iss 6, Pp n/a-n/a (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13672174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13672174/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IJU Case Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/iju5.70282","doi":"https://doi.org/10.1002/iju5.70282","is_oa":true,"landing_page_url":"https://doi.org/10.1002/iju5.70282","pdf_url":null,"source":{"id":"https://openalex.org/S4210179180","display_name":"IJU Case Reports","issn_l":"2577-171X","issn":["2577-171X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IJU Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2016412840","https://openalex.org/W2021279117","https://openalex.org/W2052365905","https://openalex.org/W2062478826","https://openalex.org/W2149953171","https://openalex.org/W2476901013","https://openalex.org/W3031923344","https://openalex.org/W3167620509","https://openalex.org/W4211162786","https://openalex.org/W4292547963","https://openalex.org/W4297023055","https://openalex.org/W4414520995"],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Yolk":[1],"sac":[2,73,96,121],"tumors":[3,8],"are":[4],"malignant":[5],"germ":[6],"cell":[7],"that":[9],"typically":[10],"arise":[11],"in":[12],"the":[13,24,52,89],"gonads.":[14],"Although":[15],"extragonadal":[16],"cases":[17],"have":[18],"been":[19],"reported,":[20],"primary":[21,84,93,118],"involvement":[22],"of":[23,51,91,103],"urinary":[25],"tract":[26],"is":[27],"extremely":[28],"rare.":[29],"Case":[30],"Presentation:":[31],"A":[32],"67-year-old":[33],"man":[34],"presented":[35],"with":[36,70,117,129],"gross":[37],"hematuria.":[38],"Cystoscopy":[39],"and":[40,58,63,105,108,133],"contrast-enhanced":[41],"computed":[42],"tomography":[43],"revealed":[44,82],"a":[45,71,76,92],"6-cm":[46],"bladder":[47,53,94,119],"mass.":[48],"Transurethral":[49],"resection":[50,132],"tumor":[54,74],"was":[55],"performed.":[56],"Histopathological":[57],"immunohistochemical":[59],"findings":[60],"(alpha-fetoprotein,":[61],"glypican-3,":[62],"Sal-like":[64],"protein":[65],"4":[66],"positivity)":[67],"were":[68],"consistent":[69],"yolk":[72,95,120],"without":[75],"urothelial":[77],"carcinoma":[78],"component.":[79],"Additional":[80],"examinations":[81],"no":[83],"lesions":[85],"elsewhere,":[86],"leading":[87],"to":[88],"diagnosis":[90],"tumor.":[97],"The":[98],"patient":[99],"received":[100],"four":[101],"cycles":[102],"etoposide":[104],"cisplatin":[106],"chemotherapy":[107],"has":[109],"remained":[110],"recurrence-free":[111],"for":[112],"2":[113],"years.":[114],"Conclusions:":[115],"Patients":[116],"tumors,":[122],"although":[123],"rare,":[124],"may":[125],"achieve":[126],"favorable":[127],"outcomes":[128],"combined":[130],"surgical":[131],"chemotherapy.":[134]},"counts_by_year":[],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2026-10-16T00:00:00"}