{"id":"https://openalex.org/W7221832230","doi":"https://doi.org/10.3389/fonc.2026.1772206","title":"Intratumoral habitat combined with peritumoral radiomics to improve the predictive performance of initial TACE efficacy: a multicenter retrospective study","display_name":"Intratumoral habitat combined with peritumoral radiomics to improve the predictive performance of initial TACE efficacy: a multicenter retrospective study","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221832230","doi":"https://doi.org/10.3389/fonc.2026.1772206","pmid":"https://pubmed.ncbi.nlm.nih.gov/42984998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13732582"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1772206","doi":"https://doi.org/10.3389/fonc.2026.1772206","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1772206","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1772206/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1772206/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146949865","display_name":"Zhefeng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhefeng Wang","raw_affiliation_strings":["Radiology Imaging Center, The First Affiliated Hospital of Wenzhou Medical University","The First Clinical Medical College of Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology Imaging Center, The First Affiliated Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"The First Clinical Medical College of Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113257543","display_name":"Ningbo Yin","orcid":"https://orcid.org/0009-0002-9320-8435","observed_orcids":["https://orcid.org/0009-0002-9320-8435"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningbo Yin","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","The First Clinical Medical College of Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First Clinical Medical College of Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111358974","display_name":"Ruisi Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruisi Su","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","The First Clinical Medical College of Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First Clinical Medical College of Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014742353","display_name":"Minhui Zhou","orcid":"https://orcid.org/0000-0001-5557-9441","observed_orcids":["https://orcid.org/0000-0001-5557-9441"]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minhui Zhou","raw_affiliation_strings":["Department of Radiology, The Central Affiliated Hospital of Shaoxing University (Shaoxing Central Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Central Affiliated Hospital of Shaoxing University (Shaoxing Central Hospital)","institution_ids":["https://openalex.org/I192209268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020184979","display_name":"Zhichao Sun","orcid":"https://orcid.org/0000-0003-2845-1519","observed_orcids":["https://orcid.org/0000-0003-2845-1519"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhichao Sun","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","The First Clinical Medical College of Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First Clinical Medical College of Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141158976","display_name":"Li Jiaying","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiaying Li","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","The First Clinical Medical College of Zhejiang Chinese Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First Clinical Medical College of Zhejiang Chinese Medical University","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034238695","display_name":"\u9648\u7acb\u5929","orcid":"https://orcid.org/0009-0006-3274-9771","observed_orcids":["https://orcid.org/0009-0006-3274-9771"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Litian Chen","raw_affiliation_strings":["Radiology Imaging Center, The First Affiliated Hospital of Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology Imaging Center, The First Affiliated Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020184979","https://openalex.org/A5034238695","https://openalex.org/A5141158976"],"corresponding_institution_ids":["https://openalex.org/I114539943","https://openalex.org/I2801769982"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75262969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1772206","last_page":"1772206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/peritumoral-radiomics","display_name":"peritumoral radiomics","score":0.9470000267028809},{"id":"https://openalex.org/keywords/contrast-enhanced-mri","display_name":"contrast-enhanced MRI","score":0.902999997138977},{"id":"https://openalex.org/keywords/k-means-clustering","display_name":"K-means clustering","score":0.7559999823570251},{"id":"https://openalex.org/keywords/texture-analysis","display_name":"texture analysis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/wavelet-features","display_name":"wavelet features","score":0.7950000166893005},{"id":"https://openalex.org/keywords/xgboost","display_name":"XGBoost","score":0.699999988079071},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.9539999961853027},{"id":"https://openalex.org/keywords/intermediate-stage-liver-cancer","display_name":"intermediate-stage liver cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/non-invasive-prediction-model","display_name":"non-invasive prediction model","score":0.7049999833106995},{"id":"https://openalex.org/keywords/shap","display_name":"SHAP","score":0.5849999785423279},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.8665000200271606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.815500020980835},{"id":"https://openalex.org/C2778455285","wikidata":"https://www.wikidata.org/wiki/Q221788","display_name":"Transcatheter arterial chemoembolization","level":3,"score":0.6478000283241272},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6297000050544739},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6248999834060669},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5936999917030334},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5810999870300293},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5184999704360962},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3824000060558319},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3799000084400177},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.25040000677108765},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1772206","doi":"https://doi.org/10.3389/fonc.2026.1772206","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1772206","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1772206/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13732582","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732582/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732582/pdf/fonc-16-1772206.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42984998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42984998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:eb0f6709102f40238f92524ae0a135e1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/eb0f6709102f40238f92524ae0a135e1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1772206","doi":"https://doi.org/10.3389/fonc.2026.1772206","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1772206","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1772206/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322929","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221832230.pdf","grobid_xml":"https://content.openalex.org/works/W7221832230.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1964070895","https://openalex.org/W1977547491","https://openalex.org/W2015801294","https://openalex.org/W2022138851","https://openalex.org/W2036193982","https://openalex.org/W2043343327","https://openalex.org/W2103004421","https://openalex.org/W2117823960","https://openalex.org/W2125816991","https://openalex.org/W2131456570","https://openalex.org/W2136512959","https://openalex.org/W2142266080","https://openalex.org/W2209944545","https://openalex.org/W2329141585","https://openalex.org/W2404030016","https://openalex.org/W2464076499","https://openalex.org/W2611242281","https://openalex.org/W2748996042","https://openalex.org/W2763355946","https://openalex.org/W2767281692","https://openalex.org/W2784178687","https://openalex.org/W2802241248","https://openalex.org/W2900668961","https://openalex.org/W2905242566","https://openalex.org/W2915597952","https://openalex.org/W2953559648","https://openalex.org/W2984620290","https://openalex.org/W2986820198","https://openalex.org/W3118377602","https://openalex.org/W3126648155","https://openalex.org/W3128646645","https://openalex.org/W3132467135","https://openalex.org/W3133697902","https://openalex.org/W3133852634","https://openalex.org/W3147893827","https://openalex.org/W3162270595","https://openalex.org/W3181214796","https://openalex.org/W3213277274","https://openalex.org/W3216815105","https://openalex.org/W4221071191","https://openalex.org/W4313468661","https://openalex.org/W4324046169","https://openalex.org/W4366429894","https://openalex.org/W4366742634","https://openalex.org/W4385422236","https://openalex.org/W4386000392","https://openalex.org/W4386415224","https://openalex.org/W4387906832","https://openalex.org/W4388199272","https://openalex.org/W4389615175","https://openalex.org/W4392902110","https://openalex.org/W4393132144","https://openalex.org/W4393192653","https://openalex.org/W4393222179","https://openalex.org/W4397001901","https://openalex.org/W4401084494","https://openalex.org/W4403263291","https://openalex.org/W4403905575","https://openalex.org/W4404051618","https://openalex.org/W4404216819","https://openalex.org/W4406063534","https://openalex.org/W4406073131"],"related_works":["https://openalex.org/W7154344921","https://openalex.org/W4387906832","https://openalex.org/W4383163964","https://openalex.org/W4403263291","https://openalex.org/W7155072144","https://openalex.org/W7131134364","https://openalex.org/W4392929159","https://openalex.org/W4315574497","https://openalex.org/W3181214796","https://openalex.org/W4414851649"],"abstract_inverted_index":{"Background":[0],"and":[1,26,46,54,71,83,94,107,122,124,142,149,160,175,196,209,224,239,252,276,292,297,317,324,327,347],"purpose:":[2],"Transcatheter":[3],"arterial":[4],"chemoembolization":[5],"(TACE)":[6],"is":[7],"the":[8,38,86,206,214,237,332,367,391,395],"primary":[9],"treatment":[10,31,64,189,263],"for":[11,29,50,379],"intermediate-stage":[12],"hepatocellular":[13],"carcinoma":[14],"(HCC).":[15],"However,":[16],"significant":[17],"heterogeneity":[18],"in":[19,194,198,265,295,356],"patient":[20],"response":[21,264,355],"to":[22,36,236,389],"TACE":[23,51,63,188,262,354],"necessitates":[24],"non-invasive":[25,372],"precise":[27],"methods":[28],"evaluating":[30],"efficacy.":[32],"This":[33,371],"study":[34],"aims":[35],"explore":[37],"predictive":[39,281],"ability":[40],"of":[41,181,285,394],"combined":[42,161,269,338],"intratumoral":[43,113,203,274,344,368],"habitat":[44,117,207,275,345,369],"imaging":[45],"peritumoral":[47,125,215,277,348],"radiomics":[48,135,211,278,349],"features":[49,126,136,204,212,361],"response.":[52],"Materials":[53],"methods:":[55],"We":[56],"retrospectively":[57],"enrolled":[58],"HCC":[59,183,357],"patients":[60,75,184],"who":[61,185],"underwent":[62,76,186],"at":[65],"four":[66],"centers":[67,81,92],"between":[68,322],"January":[69],"2015":[70],"December":[72],"2023.":[73],"All":[74],"contrast-enhanced":[77],"MRI.":[78],"Patients":[79],"from":[80,91,205,213,221,231],"A":[82,179],"B":[84],"formed":[85],"training":[87,195,296],"cohort,":[88],"while":[89],"those":[90],"C":[93],"D":[95],"comprised":[96],"external":[97],"validation":[98,199,298],"cohorts.":[99,200],"Using":[100],"three-phase":[101],"enhanced":[102],"MRI":[103],"(arterial,":[104],"portal":[105],"venous,":[106],"delayed":[108],"phase),":[109],"K-Means":[110],"clustering":[111],"divided":[112],"regions":[114],"into":[115],"three":[116],"subregions":[118,208],"(Habitat":[119],"1,":[120],"2,":[121],"3),":[123],"were":[127,131,137,145,190,217],"extracted.":[128],"Clinical":[129],"variables":[130],"also":[132],"collected.":[133],"Key":[134],"selected":[138],"by":[139],"LASSO":[140],"regression,":[141],"clinical":[143,392],"indicators":[144],"identified":[146],"through":[147],"univariable":[148],"multivariable":[150,266],"logistic":[151],"regression.":[152],"The":[153,227,268,337],"XGBoost":[154],"algorithm":[155],"constructed":[156],"intratumoral,":[157],"peritumoral,":[158],"clinical,":[159,273],"models.":[162],"Performance":[163],"was":[164],"evaluated":[165,333],"using":[166],"ROC":[167],"curves,":[168,170],"calibration":[169],"decision":[171],"curve":[172],"analysis":[173],"(DCA),":[174],"DeLong":[176],"tests.":[177],"Results:":[178],"total":[180],"174":[182],"initial":[187,353],"enrolled,":[191],"including":[192],"104":[193],"70":[197],"Fifteen":[201],"key":[202],"24":[210],"region":[216],"identified,":[218],"primarily":[219],"derived":[220],"wavelet":[222],"transforms":[223],"texture":[225],"analysis.":[226,267],"wavelet-LLL_glszm_ZoneVariance_":[228],"PVP":[229],"feature":[230],"Cluster":[232,359],"2":[233],"contributed":[234],"significantly":[235,259],"model":[238,270,339],"had":[240],"a":[241],"positive":[242],"impact":[243],"(highest":[244],"SHAP":[245],"value).":[246],"Alpha-fetoprotein":[247],"(AFP)":[248],"(P":[249,255],"=":[250,256,305,309,313],"0.015)":[251],"Tumor":[253,342],"size":[254],"0.016)":[257],"remained":[258],"associated":[260],"with":[261,283],"based":[271],"on":[272],"showed":[279,362],"superior":[280],"performance,":[282],"AUCs":[284],"0.950":[286],"(95%":[287],"CI:":[288],"0.89-1.00),":[289],"0.850":[290],"(0.79-0.91)":[291],"0.830":[293],"(0.77-0.89)":[294],"cohorts,":[299],"outperforming":[300],"single":[301],"models":[302],"(Clinic:":[303],"AUC":[304,308,312],"0.700,":[306],"Tumor_Habitat:":[307],"0.880,":[310],"Peritumor_Radiomics:":[311],"0.870,":[314],"P<0.05).":[315],"Calibration":[316],"DCA":[318],"demonstrated":[319],"good":[320],"agreement":[321],"predicted":[323],"observed":[325],"outcomes":[326],"favorable":[328],"net":[329],"benefit":[330],"across":[331],"threshold":[334],"probabilities.":[335],"Conclusion:":[336],"integrating":[340],"AFP,":[341],"size,":[343],"imaging,":[346],"could":[350],"accurately":[351],"predict":[352],"patients.":[358],"2-derived":[360],"relatively":[363],"greater":[364],"contributions":[365],"among":[366],"subregions.":[370],"prediction":[373],"tool":[374],"may":[375],"provide":[376],"complementary":[377],"information":[378],"pretreatment":[380],"risk":[381],"stratification.":[382],"Future":[383],"prospective":[384],"multicenter":[385],"studies":[386],"are":[387],"needed":[388],"verify":[390],"applicability":[393],"model.":[396]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-15T00:00:00"}
