{"id":"https://openalex.org/W7221831908","doi":"https://doi.org/10.26442/26586630.2026.3.203812","title":"Chronic constipation in children: current approaches to diagnosis and treatment with osmotic laxatives. A review","display_name":"Chronic constipation in children: current approaches to diagnosis and treatment with osmotic laxatives. A review","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221831908","doi":"https://doi.org/10.26442/26586630.2026.3.203812"},"language":"en","primary_location":{"id":"doi:10.26442/26586630.2026.3.203812","doi":"https://doi.org/10.26442/26586630.2026.3.203812","is_oa":true,"landing_page_url":"https://doi.org/10.26442/26586630.2026.3.203812","pdf_url":null,"source":{"id":"https://openalex.org/S4210198449","display_name":"Pediatrics Consilium Medicum","issn_l":"2658-6622","issn":["2658-6622","2658-6630"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics. Consilium Medicum","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7221831908"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.26442/26586630.2026.3.203812","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026940987","display_name":"Irina N. Zakharova","orcid":"https://orcid.org/0000-0003-4200-4598","observed_orcids":["https://orcid.org/0000-0003-4200-4598","https://orcid.org/0000-0002-6948-2904"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Irina N. Zakharova","raw_affiliation_strings":["Russian Medical Academy of Continuous Professional Education"],"raw_orcid":"https://orcid.org/0000-0003-4200-4598","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education","institution_ids":["https://openalex.org/I4210108300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019453548","display_name":"Rezeda A. Fayzullina","orcid":"https://orcid.org/0000-0002-7209-5737","observed_orcids":["https://orcid.org/0000-0002-7209-5737"]},"institutions":[{"id":"https://openalex.org/I186356647","display_name":"Kazan State Medical University","ror":"https://ror.org/013pk4y14","country_code":"RU","type":"education","lineage":["https://openalex.org/I186356647"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Rezeda A. Faizullina","raw_affiliation_strings":["Kazan State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-7209-5737","affiliations":[{"raw_affiliation_string":"Kazan State Medical University","institution_ids":["https://openalex.org/I186356647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036072823","display_name":"I. V. Berezhnaya","orcid":"https://orcid.org/0000-0002-2847-6268","observed_orcids":["https://orcid.org/0000-0002-2847-6268"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina V. Berezhnaya","raw_affiliation_strings":["Russian Medical Academy of Continuous Professional Education"],"raw_orcid":"https://orcid.org/0000-0002-2847-6268","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education","institution_ids":["https://openalex.org/I4210108300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030910220","display_name":"E. A. Medvedeva","orcid":"https://orcid.org/0000-0001-7786-3777","observed_orcids":["https://orcid.org/0000-0001-7786-3777"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210115129","display_name":"Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky","ror":"https://ror.org/0233m9s16","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210115129"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeniia A. Medvedeva","raw_affiliation_strings":["Russian Medical Academy of Continuous Professional Education","Vladimirsky Moscow Regional Research Clinical Institute"],"raw_orcid":"https://orcid.org/0000-0001-7786-3777","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education","institution_ids":["https://openalex.org/I4210108300"]},{"raw_affiliation_string":"Vladimirsky Moscow Regional Research Clinical Institute","institution_ids":["https://openalex.org/I4210115129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069760357","display_name":"Viktoria V. Pupykina","orcid":"https://orcid.org/0000-0003-2181-8138","observed_orcids":["https://orcid.org/0000-0003-2181-8138"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Viktoria V. Pupykina","raw_affiliation_strings":["Russian Medical Academy of Continuous Professional Education"],"raw_orcid":"https://orcid.org/0000-0003-2181-8138","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education","institution_ids":["https://openalex.org/I4210108300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057724854","display_name":"Yana V. Orobinskaya","orcid":"https://orcid.org/0009-0005-2121-4010","observed_orcids":["https://orcid.org/0009-0005-2121-4010"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yana V. Orobinskaya","raw_affiliation_strings":["Russian Medical Academy of Continuous Professional Education"],"raw_orcid":"https://orcid.org/0009-0005-2121-4010","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education","institution_ids":["https://openalex.org/I4210108300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026940987"],"corresponding_institution_ids":["https://openalex.org/I4210108300"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"3","first_page":"178","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-constipation","display_name":"chronic constipation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pediatric-constipation","display_name":"pediatric constipation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/functional-constipation","display_name":"functional constipation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/osmotic-laxatives","display_name":"osmotic laxatives","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lactulose","display_name":"lactulose","score":1.0},{"id":"https://openalex.org/keywords/intestinal-motility","display_name":"intestinal motility","score":0.875},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7839999794960022},{"id":"https://openalex.org/keywords/family-education","display_name":"family education","score":0.746999979019165},{"id":"https://openalex.org/keywords/dietary-change","display_name":"dietary change","score":0.7480000257492065},{"id":"https://openalex.org/keywords/treatment-algorithm","display_name":"treatment algorithm","score":0.6980000138282776},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8428999781608582},{"id":"https://openalex.org/C3017955636","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Chronic constipation","level":3,"score":0.8201000094413757},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6244999766349792},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.6229000091552734},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5403000116348267},{"id":"https://openalex.org/C2779642851","wikidata":"https://www.wikidata.org/wiki/Q5508805","display_name":"Functional constipation","level":3,"score":0.5358999967575073},{"id":"https://openalex.org/C108797546","wikidata":"https://www.wikidata.org/wiki/Q204015","display_name":"Defecation","level":2,"score":0.45669999718666077},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.4300000071525574},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.4058000147342682},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33980000019073486},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2985445135","wikidata":"https://www.wikidata.org/wiki/Q13100823","display_name":"Life quality","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26442/26586630.2026.3.203812","doi":"https://doi.org/10.26442/26586630.2026.3.203812","is_oa":true,"landing_page_url":"https://doi.org/10.26442/26586630.2026.3.203812","pdf_url":null,"source":{"id":"https://openalex.org/S4210198449","display_name":"Pediatrics Consilium Medicum","issn_l":"2658-6622","issn":["2658-6622","2658-6630"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics. Consilium Medicum","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.26442/26586630.2026.3.203812","doi":"https://doi.org/10.26442/26586630.2026.3.203812","is_oa":true,"landing_page_url":"https://doi.org/10.26442/26586630.2026.3.203812","pdf_url":null,"source":{"id":"https://openalex.org/S4210198449","display_name":"Pediatrics Consilium Medicum","issn_l":"2658-6622","issn":["2658-6622","2658-6630"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics. Consilium Medicum","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1572140070","https://openalex.org/W1614882725","https://openalex.org/W2030029622","https://openalex.org/W2096219534","https://openalex.org/W2466141895","https://openalex.org/W2615801135","https://openalex.org/W2797285236","https://openalex.org/W2907801549","https://openalex.org/W2912695317","https://openalex.org/W2950219345","https://openalex.org/W2966494958","https://openalex.org/W3112611263","https://openalex.org/W3113335726","https://openalex.org/W3124244002","https://openalex.org/W3137164839","https://openalex.org/W3162369280","https://openalex.org/W3178789657","https://openalex.org/W3184167136","https://openalex.org/W3199635008","https://openalex.org/W3206705613","https://openalex.org/W3212612759","https://openalex.org/W4205663465","https://openalex.org/W4220918710","https://openalex.org/W4221072420","https://openalex.org/W4229022235","https://openalex.org/W4295924044","https://openalex.org/W4296117667","https://openalex.org/W4297645812","https://openalex.org/W4312018700","https://openalex.org/W4321609996","https://openalex.org/W4366413212","https://openalex.org/W4367846208","https://openalex.org/W4377090569","https://openalex.org/W4385751730","https://openalex.org/W4385981972","https://openalex.org/W4386251644","https://openalex.org/W4388013819","https://openalex.org/W4389393171","https://openalex.org/W4390666287","https://openalex.org/W4394610242","https://openalex.org/W4395013562","https://openalex.org/W4407132632","https://openalex.org/W4409436682","https://openalex.org/W4410248134","https://openalex.org/W4410966813","https://openalex.org/W4411431673","https://openalex.org/W4413227930","https://openalex.org/W4415312372","https://openalex.org/W4416598945","https://openalex.org/W4416694761","https://openalex.org/W7121270282","https://openalex.org/W7129696134","https://openalex.org/W7136748996","https://openalex.org/W7147640702","https://openalex.org/W7147693941","https://openalex.org/W7154481540","https://openalex.org/W7155070768"],"related_works":["https://openalex.org/W2964246553","https://openalex.org/W61131956","https://openalex.org/W4321609996","https://openalex.org/W7213261229","https://openalex.org/W4280561932","https://openalex.org/W4395013562","https://openalex.org/W2220670212","https://openalex.org/W7025229188","https://openalex.org/W4294694113"],"abstract_inverted_index":{"Chronic":[0],"constipation":[1,80],"in":[2,33],"children":[3,76],"is":[4],"a":[5,94],"multifactorial":[6],"condition":[7,63],"characterized":[8],"by":[9],"the":[10,13,16,27,34,44,58,62,66,129],"interplay":[11],"between":[12],"intestine":[14],"and":[15,31,51,64,70,91,100,121,133,144],"brain.":[17],"Key":[18],"factors":[19],"include":[20],"abnormal":[21],"intestinal":[22,35],"motility,":[23],"defecation":[24],"reflex":[25],"dysfunction,":[26],"child\u2019s":[28],"retention":[29],"behavior,":[30],"alterations":[32],"microbiota.":[36],"The":[37,72],"updated":[38],"Rome":[39,130],"V":[40,131],"criteria":[41,132],"(2026)":[42],"underscore":[43],"importance":[45],"of":[46,54,61,68,75,97,147],"clinical":[47,136],"diagnosis,":[48],"early":[49],"detection,":[50],"timely":[52],"initiation":[53],"therapy":[55],"to":[56,114],"prevent":[57],"chronic":[59,78],"progression":[60],"mitigate":[65],"risk":[67],"complications":[69],"relapses.":[71],"current":[73],"management":[74],"with":[77],"functional":[79],"should":[81],"employ":[82],"an":[83,125],"integrated":[84],"approach":[85],"that":[86],"encompasses":[87],"family":[88],"education,":[89],"dietary":[90],"lifestyle":[92],"modifications,":[93],"proper":[95],"duration":[96],"pharmacological":[98],"treatment,":[99],"ongoing":[101],"follow-up.":[102],"Osmotic":[103],"laxatives,":[104],"particularly":[105],"lactulose,":[106],"are":[107],"used":[108],"as":[109],"first-line":[110],"therapeutic":[111],"agents":[112],"due":[113],"their":[115],"proven":[116],"efficacy,":[117,140],"favorable":[118],"safety":[119],"profile,":[120],"prebiotic":[122],"properties.":[123],"Implementing":[124],"algorithm":[126],"based":[127],"on":[128],"contemporary":[134],"international":[135],"guidelines":[137],"enhances":[138],"treatment":[139],"reduces":[141],"relapse":[142],"rate,":[143],"improves":[145],"quality":[146],"life":[148],"for":[149],"affected":[150],"children.":[151]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-10-15T00:00:00"}