{"id":"https://openalex.org/W7221820104","doi":"https://doi.org/10.3389/fphys.2026.1957980","title":"Coxiella burnetii effector CelF reprograms host proteostasis via competitive disruption of the UBQLN1-PSMD4 axis to stabilize autophagic SNARE SNAP29 and modulate lysosomal metabolic maturation","display_name":"Coxiella burnetii effector CelF reprograms host proteostasis via competitive disruption of the UBQLN1-PSMD4 axis to stabilize autophagic SNARE SNAP29 and modulate lysosomal metabolic maturation","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221820104","doi":"https://doi.org/10.3389/fphys.2026.1957980","pmid":"https://pubmed.ncbi.nlm.nih.gov/42952505","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713298"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2026.1957980","doi":"https://doi.org/10.3389/fphys.2026.1957980","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1957980","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1957980/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1957980/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100325414","display_name":"Shan Zhang","orcid":"https://orcid.org/0000-0002-1530-7561","observed_orcids":["https://orcid.org/0000-0002-1530-7561"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Zhang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129056923","display_name":"Yufei Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufei Jiang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014091835","display_name":"Yinhui Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinhui Lin","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694725","display_name":"Xiaoxiao Chen","orcid":"https://orcid.org/0000-0003-2493-6922","observed_orcids":["https://orcid.org/0000-0003-2493-6922"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxiao Chen","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158730877","display_name":"Yuchen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchen Zhang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102402072","display_name":"Yonghui Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghui Yu","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102001608","display_name":"Xuan Ouyang","orcid":"https://orcid.org/0000-0002-9414-5256","observed_orcids":["https://orcid.org/0000-0002-9414-5256"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan OuYang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125207254","display_name":"Dongsheng Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongsheng Zhou","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158748255","display_name":"Yajun Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yajun Song","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101851509","display_name":"Jun Jiao","orcid":"https://orcid.org/0000-0002-4041-1782","observed_orcids":["https://orcid.org/0000-0002-4041-1782"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Jiao","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences","institution_ids":["https://openalex.org/I2802541053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101851509","https://openalex.org/A5158748255"],"corresponding_institution_ids":["https://openalex.org/I2802541053"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68957484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1957980","last_page":"1957980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coxiella-burnetii","display_name":"Coxiella burnetii","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ubiquilin-1","display_name":"UBQLN1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/psmd4","display_name":"PSMD4","score":0.9850000143051147},{"id":"https://openalex.org/keywords/snap29","display_name":"SNAP29","score":0.8930000066757202},{"id":"https://openalex.org/keywords/autophagy-lysosome-pathway","display_name":"autophagy-lysosome pathway","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9679999947547913},{"id":"https://openalex.org/keywords/autophagosome-lysosome-fusion","display_name":"autophagosome-lysosome fusion","score":0.781000018119812},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6660000085830688},{"id":"https://openalex.org/keywords/bacterial-survival-in-host","display_name":"bacterial survival in host","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.7717000246047974},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7328000068664551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7311000227928162},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7307000160217285},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5710999965667725},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.4433000087738037},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4230000078678131},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.413100004196167},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4129999876022339},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3831000030040741},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.36329999566078186},{"id":"https://openalex.org/C187092789","wikidata":"https://www.wikidata.org/wiki/Q4654662","display_name":"ATG16L1","level":4,"score":0.35429999232292175},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.35040000081062317},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3377000093460083},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3199999928474426},{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.31310001015663147},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.3077999949455261},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.287200003862381},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.28690001368522644},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.27070000767707825},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C132647116","wikidata":"https://www.wikidata.org/wiki/Q18032677","display_name":"TFEB","level":4,"score":0.2662000060081482},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2515000104904175},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.25119999051094055},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphys.2026.1957980","doi":"https://doi.org/10.3389/fphys.2026.1957980","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1957980","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1957980/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmid:42952505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42952505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713298","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713298/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d98f4c9f13804c33840a5b6c9464c87e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d98f4c9f13804c33840a5b6c9464c87e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2026.1957980","doi":"https://doi.org/10.3389/fphys.2026.1957980","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1957980","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1957980/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6323849681","display_name":null,"funder_award_id":"2024YFC2607504","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320329258","display_name":"State Key Laboratory of Pathogen and Biosecurity","ror":"https://ror.org/02kdgk225"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221820104.pdf","grobid_xml":"https://content.openalex.org/works/W7221820104.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W986403962","https://openalex.org/W1142727778","https://openalex.org/W1520187505","https://openalex.org/W1715451660","https://openalex.org/W1972038271","https://openalex.org/W1980084094","https://openalex.org/W2008744347","https://openalex.org/W2021662620","https://openalex.org/W2025220240","https://openalex.org/W2047841570","https://openalex.org/W2055654995","https://openalex.org/W2061953258","https://openalex.org/W2062418171","https://openalex.org/W2063761428","https://openalex.org/W2070367241","https://openalex.org/W2074900534","https://openalex.org/W2075597028","https://openalex.org/W2096646435","https://openalex.org/W2099902372","https://openalex.org/W2110909388","https://openalex.org/W2140241830","https://openalex.org/W2149251909","https://openalex.org/W2150373302","https://openalex.org/W2165466367","https://openalex.org/W2176629742","https://openalex.org/W2460472689","https://openalex.org/W2467425087","https://openalex.org/W2579676443","https://openalex.org/W2583784108","https://openalex.org/W2592067246","https://openalex.org/W2761436821","https://openalex.org/W2790173623","https://openalex.org/W2802134813","https://openalex.org/W2886931860","https://openalex.org/W2939962770","https://openalex.org/W2950189828","https://openalex.org/W2972536774","https://openalex.org/W2988906435","https://openalex.org/W3009609838","https://openalex.org/W3027961446","https://openalex.org/W3084777754","https://openalex.org/W3088746333","https://openalex.org/W3094750175","https://openalex.org/W4200493036","https://openalex.org/W4220934261","https://openalex.org/W4285031268","https://openalex.org/W4294970362","https://openalex.org/W4362521882","https://openalex.org/W4386961358","https://openalex.org/W4389180521","https://openalex.org/W4390614857","https://openalex.org/W4396811634","https://openalex.org/W4403276390","https://openalex.org/W4404496347","https://openalex.org/W4409732962"],"related_works":["https://openalex.org/W2051984298","https://openalex.org/W4280488534","https://openalex.org/W3006918128","https://openalex.org/W2099902372","https://openalex.org/W4390745526","https://openalex.org/W4285031268","https://openalex.org/W2047841570","https://openalex.org/W4409732962","https://openalex.org/W2166788282","https://openalex.org/W2491999327"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,94,232],"ubiquitin-proteasome":[2],"system":[3],"(UPS)":[4],"and":[5,20,64,75,89,106,120,132,148,150,155,174,224,242,299,312],"autophagy-lysosome":[6],"pathway":[7],"constitute":[8],"the":[9,139,164,189,194,201,228,301],"core":[10],"proteolytic":[11],"metabolic":[12,22,29,165,245,293,314],"networks":[13],"that":[14,186,257,286],"maintain":[15],"cellular":[16],"protein":[17,117,222],"homeostasis":[18],"(proteostasis)":[19],"organelle":[21,43,292],"identity.":[23],"Intracellular":[24],"pathogens":[25,288],"frequently":[26],"reprogram":[27],"host":[28,116,280,297],"pathways":[30],"to":[31,41,60,81,137,157,247],"establish":[32],"replicative":[33],"niches,":[34],"yet":[35],"how":[36],"they":[37],"manipulate":[38],"proteostatic":[39,281],"metabolism":[40],"remodel":[42],"maturation":[44,166],"remains":[45],"incompletely":[46],"understood.":[47],"Methods:":[48],"CelF":[49,62,97,142,154,160,180,264],"secretion":[50],"was":[51,58,101,111],"confirmed":[52],"by":[53,71,103,118,123,295],"TEM":[54],"translocation":[55],"assay.":[56],"CRISPR-dCas9":[57],"used":[59,80,136],"generate":[61],"knockdown":[63],"complementation":[65],"strains,":[66],"with":[67],"celF":[68],"transcription":[69],"verified":[70],"RT-qPCR.":[72],"Cell":[73],"infection":[74],"SCID":[76],"mouse":[77],"models":[78],"were":[79,135],"assess":[82],"intracellular":[83,287],"survival,":[84],"Coxiella-containing":[85],"vacuole":[86],"(CCV)":[87],"maturation,":[88],"virulence":[90,176],"of":[91,96,141,153,167,193,212,227,279],"Coxiella":[92],"burnetii.":[93],"effect":[95,140],"on":[98,143],"late":[99],"autophagy":[100],"examined":[102],"dual-fluorescence":[104],"LC3":[105],"Western":[107,130],"blotting.":[108],"Then,":[109],"UBQLN1":[110,128],"identified":[112],"as":[113,182,259,304],"a":[114,183,272,305],"CelF-interacting":[115],"co-IP":[119],"pull-down,":[121],"followed":[122],"truncation":[124],"mapping.":[125],"Finally,":[126],"co-IP,":[127],"knockdown,":[129],"blotting":[131],"MST":[133],"assays":[134],"analyze":[138],"SNARE":[144,234,310],"assembly,":[145],"SNAP29":[146,213,221],"degradation":[147],"ubiquitination,":[149],"competitive":[151,206,268],"binding":[152],"PSMD4":[156],"UBQLN1.":[158],"Results:":[159],"depletion":[161],"severely":[162],"impaired":[163],"CCV,":[168],"suppressed":[169],"bacterial":[170],"proliferation":[171],"in":[172,177],"macrophages,":[173],"attenuated":[175],"vivo.":[178],"Mechanistically,":[179],"acted":[181],"molecular":[184],"decoy":[185],"directly":[187],"bound":[188],"ubiquitin-like":[190],"(UBL)":[191],"domain":[192],"proteasomal":[195,210],"shuttle":[196],"factor":[197],"UBQLN1,":[198],"competitively":[199],"displacing":[200],"proteasome":[202],"subunit":[203],"PSMD4.":[204],"This":[205],"interference":[207],"blocked":[208],"UBQLN1-mediated":[209],"delivery":[211],"without":[214],"altering":[215],"its":[216],"ubiquitination":[217],"status,":[218],"thereby":[219],"enhancing":[220],"stability":[223],"promoting":[225],"assembly":[226],"STX17-SNAP29-VAMP8":[229],"fusogenic":[230],"complex.":[231],"augmented":[233],"activity":[235],"drove":[236],"autophagosome-lysosome":[237],"fusion,":[238],"sustained":[239],"autophagic":[240],"flux,":[241],"facilitated":[243],"lysosomal":[244,313],"remodeling":[246],"support":[248],"CCV":[249],"biogenesis.":[250],"Discussion:":[251],"Unlike":[252],"canonical":[253],"pathogen-encoded":[254],"UPS":[255],"modulators":[256],"function":[258],"E3":[260],"ligases":[261],"or":[262],"deubiquitinases,":[263],"operates":[265],"purely":[266],"through":[267],"protein-protein":[269],"interaction,":[270],"representing":[271],"previously":[273],"unrecognized":[274],"paradigm":[275],"for":[276,309],"microbial":[277],"manipulation":[278],"metabolism.":[282],"Our":[283],"findings":[284],"reveal":[285],"can":[289],"actively":[290],"orchestrate":[291],"identity":[294],"rewiring":[296],"proteostasis,":[298],"identify":[300],"UBQLN1-PSMD4-SNAP29":[302],"axis":[303],"novel":[306],"regulatory":[307],"checkpoint":[308],"proteostasis":[311],"maturation.":[315]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-15T00:00:00"}
