{"id":"https://openalex.org/W7221817951","doi":"https://doi.org/10.64898/2026.10.13.757294","title":"Preoperative thymic output and T-cell repertoire diversity are associated with recurrence after nephrectomy for localized renal cell carcinoma","display_name":"Preoperative thymic output and T-cell repertoire diversity are associated with recurrence after nephrectomy for localized renal cell carcinoma","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221817951","doi":"https://doi.org/10.64898/2026.10.13.757294"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.13.757294","doi":"https://doi.org/10.64898/2026.10.13.757294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.757294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.757294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.757294.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158678709","display_name":"Christina Espeseth Grand","orcid":"https://orcid.org/0009-0009-9601-2703","observed_orcids":["https://orcid.org/0009-0009-9601-2703"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christina Espeseth Grand","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0009-0009-9601-2703","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093116037","display_name":"Laura Iisager","orcid":"https://orcid.org/0000-0002-5704-0586","observed_orcids":["https://orcid.org/0000-0002-5704-0586"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Laura Iisager","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5704-0586","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007693112","display_name":"Asbj\u00f8rn Kj\u00e6r","orcid":"https://orcid.org/0009-0006-3307-0031","observed_orcids":["https://orcid.org/0009-0006-3307-0031"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Asbj\u00f8rn Kj\u00e6r Attermann","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0009-0006-3307-0031","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038793637","display_name":"Iver Nordentoft","orcid":"https://orcid.org/0000-0003-4856-4086","observed_orcids":["https://orcid.org/0000-0003-4856-4086"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Iver Nordentoft","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-4856-4086","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123596108","display_name":"Laura Zanini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Laura Zanini","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010194544","display_name":"Randi Istrup Juul","orcid":"https://orcid.org/0000-0001-7829-9071","observed_orcids":["https://orcid.org/0000-0001-7829-9071"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Randi Istrup Juul","raw_affiliation_strings":["Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-7829-9071","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008324975","display_name":"Anna Krarup Keller","orcid":"https://orcid.org/0000-0002-9109-5521","observed_orcids":["https://orcid.org/0000-0002-9109-5521"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anna Krarup Keller","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Urology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-9109-5521","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Urology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072658251","display_name":"Mie Gaedt Thorlund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mie Gaedt Thorlund","raw_affiliation_strings":["Department of Urology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067846731","display_name":"Anne\u2010Sofie Vib\u00e6k Eisum","orcid":"https://orcid.org/0000-0002-8072-9517","observed_orcids":["https://orcid.org/0000-0002-8072-9517"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anne-Sofie Vib\u00e6k Eisum","raw_affiliation_strings":["Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark","Department of Urology, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8072-9517","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of Urology, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078469940","display_name":"Tommy Kj\u00e6rgaard Nielsen","orcid":"https://orcid.org/0000-0002-4379-1979","observed_orcids":["https://orcid.org/0000-0002-4379-1979"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tommy Kj\u00e6rgaard Nielsen","raw_affiliation_strings":["Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark","Department of Urology, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-4379-1979","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of Urology, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104119954","display_name":"Jesper Huitfeld Jespersen","orcid":"https://orcid.org/0009-0001-7516-403X","observed_orcids":["https://orcid.org/0009-0001-7516-403X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper Jespersen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0009-0001-7516-403X","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020909384","display_name":"Niels Fristrup","orcid":"https://orcid.org/0009-0006-4442-0535","observed_orcids":["https://orcid.org/0009-0006-4442-0535"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Niels Fristrup","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Oncology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0009-0006-4442-0535","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Oncology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050758135","display_name":"Lars Dyrskj\u00f8t","orcid":"https://orcid.org/0000-0001-7061-9851","observed_orcids":["https://orcid.org/0000-0001-7061-9851"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Dyrskj\u00f8t","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-7061-9851","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080932242","display_name":"Nicolai J. Birkbak","orcid":"https://orcid.org/0000-0003-1613-9587","observed_orcids":["https://orcid.org/0000-0003-1613-9587"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nicolai Juul Birkbak","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-1613-9587","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000813076","display_name":"Iben Lyskj\u00e6r","orcid":"https://orcid.org/0000-0003-3446-1182","observed_orcids":["https://orcid.org/0000-0003-3446-1182"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Iben Lyskj\u00e6r","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-3446-1182","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/thymic-output","display_name":"thymic output","score":0.8709999918937683},{"id":"https://openalex.org/keywords/t-cell-receptor-excision-circles","display_name":"TREC","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6700000166893005},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.906000018119812},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8510000109672546},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.7910000085830688},{"id":"https://openalex.org/keywords/localized-renal-cell-carcinoma","display_name":"localized renal cell carcinoma","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.8047999739646912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7875999808311462},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.7689999938011169},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5256999731063843},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.5120999813079834},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.4952999949455261},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4424000084400177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44119998812675476},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.3953999876976013},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3889999985694885},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.3686999976634979},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36660000681877136},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3635999858379364},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.3440999984741211},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.27309998869895935},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2540999948978424}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.10.13.757294","doi":"https://doi.org/10.64898/2026.10.13.757294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.757294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.757294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pure.atira.dk:publications/e815954b-a64b-4d69-98aa-a3636ed05399","doi":null,"is_oa":false,"landing_page_url":"https://vbn.aau.dk/da/publications/e815954b-a64b-4d69-98aa-a3636ed05399","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Grand, C E, Iisager, L, Attermann, A K, Nordentoft, I, Zanini, L, Juul, R I, Keller, A K, Thorlund, M G, Eisum, A-S V, Nielsen, T K, Jespersen, J, Fristrup, N, Dyrskj\u00f8t, L, Birkbak, N J & Lyskj\u00e6r, I 2026, Preoperative thymic output and T-cell repertoire diversity are associated with recurrence after nephrectomy for localized renal cell carcinoma. https://doi.org/10.64898/2026.10.13.757294","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.64898/2026.10.13.757294","doi":"https://doi.org/10.64898/2026.10.13.757294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.757294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.757294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221817951.pdf","grobid_xml":"https://content.openalex.org/works/W7221817951.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3006739116","https://openalex.org/W4391303238","https://openalex.org/W2086144867","https://openalex.org/W4388037354","https://openalex.org/W3157161120","https://openalex.org/W3113919085","https://openalex.org/W4395464675","https://openalex.org/W2504780281","https://openalex.org/W4220826344","https://openalex.org/W2903514660"],"abstract_inverted_index":{"Abstract":[0],"Radiographic":[1],"thymic":[2,41],"health":[3],"and":[4,51,66,72,79,96,133,140,158,171],"peripheral":[5],"T-cell":[6,33,53],"repertoire":[7],"features":[8],"have":[9],"been":[10],"linked":[11],"to":[12],"outcomes":[13],"in":[14,43,58],"renal":[15],"cell":[16],"carcinoma":[17],"(RCC),":[18],"but":[19],"their":[20],"prognostic":[21,124,182],"value":[22],"after":[23,91],"curative-intent":[24],"surgery":[25],"is":[26],"unclear.":[27],"We":[28,61],"quantified":[29],"preoperative":[30],"blood":[31],"signal-joint":[32],"receptor":[34,54],"excision":[35],"circles":[36],"(sjTRECs),":[37],"a":[38,111],"marker":[39],"of":[40],"output,":[42],"218":[44],"patients":[45,136,161],"with":[46,88,110,148,162,187,192],"localized":[47],"RCC":[48],"undergoing":[49],"nephrectomy":[50],"characterized":[52],"\u03b2":[55],"(TCR\u03b2)":[56],"repertoires":[57],"201":[59],"patients.":[60],"assessed":[62],"overall":[63,132,151],"survival":[64,68],"(OS)":[65],"recurrence-free":[67],"(RFS)":[69],"using":[70],"Kaplan-Meier":[71],"Cox":[73],"models":[74],"adjusted":[75],"for":[76,93,130],"age,":[77,94],"sex,":[78,95],"Leibovich":[80,97,127],"risk":[81,98,128],"group.":[82],"High":[83],"sjTREC":[84,121,180],"levels":[85],"were":[86],"associated":[87,147,191],"longer":[89,149,163],"RFS":[90,150,164],"adjustment":[92],"group":[99],"(hazard":[100],"ratio":[101],"[HR]":[102],"0.50;":[103],"95%":[104,117,154,167,175],"confidence":[105],"interval":[106],"[CI],":[107],"0.29-0.87;":[108],"p=0.015),":[109],"concordant":[112],"OS":[113,172],"estimate":[114],"(HR":[115,152,165,173],"0.62;":[116],"CI,":[118,155,168,176],"0.38-1.02;":[119],"p=0.058).":[120],"provided":[122,181],"additional":[123],"information":[125,183],"beyond":[126,184],"stratification":[129],"recurrence":[131],"among":[134,159],"intermediate/high-risk":[135,160],"(likelihood-ratio":[137],"test,":[138],"p=0.024":[139],"p=0.034,":[141],"respectively).":[142],"Higher":[143],"TCR\u03b2":[144,189],"diversity":[145,190],"was":[146],"0.76;":[153],"0.60-0.96;":[156],"p=0.024)":[157],"0.71;":[166],"0.55-0.92;":[169],"p=0.009)":[170],"0.80;":[174],"0.65-0.98;":[177],"p=0.031).":[178],"Preoperative":[179],"clinicopathological":[185],"risk,":[186],"higher":[188],"favorable":[193],"outcomes.":[194]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-15T00:00:00"}
