{"id":"https://openalex.org/W7221811546","doi":"https://doi.org/10.3389/fonc.2026.1959152","title":"Epithelial-mesenchymal transition plasticity in breast cancer: regulatory mechanisms and therapeutic implications","display_name":"Epithelial-mesenchymal transition plasticity in breast cancer: regulatory mechanisms and therapeutic implications","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221811546","doi":"https://doi.org/10.3389/fonc.2026.1959152","pmid":"https://pubmed.ncbi.nlm.nih.gov/42953055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13714581"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1959152","doi":"https://doi.org/10.3389/fonc.2026.1959152","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1959152","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1959152/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1959152/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101940098","display_name":"Chunlei Wang","orcid":"https://orcid.org/0000-0002-8069-9792","observed_orcids":["https://orcid.org/0000-0002-8069-9792"]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210108140","display_name":"Shaoxing City Women and Children Hospital","ror":"https://ror.org/01hvjym56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108140"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunlei Wang","raw_affiliation_strings":["Maternity and Child Health Care Affiliated Hospital, Shaoxing University","Shaoxing Maternity and Child Health Care Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternity and Child Health Care Affiliated Hospital, Shaoxing University","institution_ids":["https://openalex.org/I192209268"]},{"raw_affiliation_string":"Shaoxing Maternity and Child Health Care Hospital","institution_ids":["https://openalex.org/I4210108140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121261280","display_name":"Jie Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210108140","display_name":"Shaoxing City Women and Children Hospital","ror":"https://ror.org/01hvjym56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108140"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Cao","raw_affiliation_strings":["Maternity and Child Health Care Affiliated Hospital, Shaoxing University","Shaoxing Maternity and Child Health Care Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternity and Child Health Care Affiliated Hospital, Shaoxing University","institution_ids":["https://openalex.org/I192209268"]},{"raw_affiliation_string":"Shaoxing Maternity and Child Health Care Hospital","institution_ids":["https://openalex.org/I4210108140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121283995","display_name":"Bo Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192209268","display_name":"Shaoxing University","ror":"https://ror.org/0435tej63","country_code":"CN","type":"education","lineage":["https://openalex.org/I192209268"]},{"id":"https://openalex.org/I4210108140","display_name":"Shaoxing City Women and Children Hospital","ror":"https://ror.org/01hvjym56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108140"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Qin","raw_affiliation_strings":["Maternity and Child Health Care Affiliated Hospital, Shaoxing University","Shaoxing Maternity and Child Health Care Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternity and Child Health Care Affiliated Hospital, Shaoxing University","institution_ids":["https://openalex.org/I192209268"]},{"raw_affiliation_string":"Shaoxing Maternity and Child Health Care Hospital","institution_ids":["https://openalex.org/I4210108140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5121283995"],"corresponding_institution_ids":["https://openalex.org/I192209268","https://openalex.org/I4210108140"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55542076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1959152","last_page":"1959152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.828000009059906},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/precision-therapy","display_name":"precision therapy","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6608999967575073},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5699999928474426},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5667999982833862},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5576000213623047},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.4844000041484833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46959999203681946},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4438999891281128},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.42730000615119934},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.36079999804496765},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.33719998598098755},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.323199987411499},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32280001044273376},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31209999322891235},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.262800008058548},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.25380000472068787},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1959152","doi":"https://doi.org/10.3389/fonc.2026.1959152","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1959152","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1959152/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13714581","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13714581/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13714581/pdf/fonc-16-1959152.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42953055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:55dcbfe5cb1243cd9df223f91e0f5864","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/55dcbfe5cb1243cd9df223f91e0f5864","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1959152","doi":"https://doi.org/10.3389/fonc.2026.1959152","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1959152","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1959152/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320332531","display_name":"Wu Jieping Medical Foundation","ror":"https://ror.org/05dgwj702"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221811546.pdf","grobid_xml":"https://content.openalex.org/works/W7221811546.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W1620051969","https://openalex.org/W1760215417","https://openalex.org/W1775309324","https://openalex.org/W1805581579","https://openalex.org/W1964299112","https://openalex.org/W1976324983","https://openalex.org/W1980097189","https://openalex.org/W1988373809","https://openalex.org/W1991025954","https://openalex.org/W1992968941","https://openalex.org/W1999321257","https://openalex.org/W2000296536","https://openalex.org/W2000315116","https://openalex.org/W2002597275","https://openalex.org/W2014691022","https://openalex.org/W2020943577","https://openalex.org/W2022956911","https://openalex.org/W2027944118","https://openalex.org/W2035131746","https://openalex.org/W2042965279","https://openalex.org/W2043236594","https://openalex.org/W2051718172","https://openalex.org/W2058443035","https://openalex.org/W2079318210","https://openalex.org/W2081777966","https://openalex.org/W2100433758","https://openalex.org/W2106292881","https://openalex.org/W2135164358","https://openalex.org/W2138736619","https://openalex.org/W2144677406","https://openalex.org/W2152965684","https://openalex.org/W2162647319","https://openalex.org/W2167664841","https://openalex.org/W2169281418","https://openalex.org/W2237148396","https://openalex.org/W2397766943","https://openalex.org/W2474317928","https://openalex.org/W2530608816","https://openalex.org/W2542081802","https://openalex.org/W2552459489","https://openalex.org/W2589006459","https://openalex.org/W2623485051","https://openalex.org/W2769004457","https://openalex.org/W2775509002","https://openalex.org/W2789720205","https://openalex.org/W2802308079","https://openalex.org/W2804508967","https://openalex.org/W2807104695","https://openalex.org/W2901741449","https://openalex.org/W2911799907","https://openalex.org/W2912606030","https://openalex.org/W2932722941","https://openalex.org/W2940712523","https://openalex.org/W2945068621","https://openalex.org/W2949633340","https://openalex.org/W2950996070","https://openalex.org/W2953057790","https://openalex.org/W2962072222","https://openalex.org/W2976687905","https://openalex.org/W2981396086","https://openalex.org/W2985567829","https://openalex.org/W3005904785","https://openalex.org/W3011308415","https://openalex.org/W3015420921","https://openalex.org/W3017305512","https://openalex.org/W3018126040","https://openalex.org/W3019907052","https://openalex.org/W3035967781","https://openalex.org/W3037749322","https://openalex.org/W3049761941","https://openalex.org/W3110881902","https://openalex.org/W3112974929","https://openalex.org/W3114924782","https://openalex.org/W3128646645","https://openalex.org/W3156231767","https://openalex.org/W3170403408","https://openalex.org/W3172823398","https://openalex.org/W3178669904","https://openalex.org/W3190939840","https://openalex.org/W3193437905","https://openalex.org/W3215092418","https://openalex.org/W4200129720","https://openalex.org/W4210621758","https://openalex.org/W4223456024","https://openalex.org/W4223608326","https://openalex.org/W4225152006","https://openalex.org/W4285136414","https://openalex.org/W4311870276","https://openalex.org/W4312067415","https://openalex.org/W4312095302","https://openalex.org/W4317734375","https://openalex.org/W4319756609","https://openalex.org/W4320040176","https://openalex.org/W4322486410","https://openalex.org/W4362696445","https://openalex.org/W4375955374","https://openalex.org/W4380085028","https://openalex.org/W4381547706","https://openalex.org/W4382983073","https://openalex.org/W4385840614","https://openalex.org/W4386396323","https://openalex.org/W4387517804","https://openalex.org/W4387905188","https://openalex.org/W4390535732","https://openalex.org/W4391388305","https://openalex.org/W4392166305","https://openalex.org/W4394567665","https://openalex.org/W4394968260","https://openalex.org/W4396979311","https://openalex.org/W4399447155","https://openalex.org/W4399548125","https://openalex.org/W4400233583","https://openalex.org/W4400646514","https://openalex.org/W4400765670","https://openalex.org/W4401412639","https://openalex.org/W4401713374","https://openalex.org/W4401844694","https://openalex.org/W4402124123","https://openalex.org/W4402832204","https://openalex.org/W4405822889","https://openalex.org/W4405828944","https://openalex.org/W4406016668","https://openalex.org/W4406628684","https://openalex.org/W4408695444","https://openalex.org/W4409236576","https://openalex.org/W4410635464","https://openalex.org/W4411063786","https://openalex.org/W4412030907","https://openalex.org/W4412745493","https://openalex.org/W4412943402","https://openalex.org/W4413735126","https://openalex.org/W4414661733","https://openalex.org/W4414810098","https://openalex.org/W4415131913","https://openalex.org/W4415293406","https://openalex.org/W4416328385","https://openalex.org/W4417507085","https://openalex.org/W7125778938","https://openalex.org/W7125802245","https://openalex.org/W7125936567","https://openalex.org/W7126252969","https://openalex.org/W7128537562","https://openalex.org/W7147566142","https://openalex.org/W7167336760"],"related_works":["https://openalex.org/W2079448911","https://openalex.org/W1977186103","https://openalex.org/W3017941532","https://openalex.org/W1986911605","https://openalex.org/W2189291274","https://openalex.org/W2188453892","https://openalex.org/W2039071997","https://openalex.org/W7169501084","https://openalex.org/W2176446849","https://openalex.org/W2601009186"],"abstract_inverted_index":{"Metastatic":[0],"dissemination":[1],"and":[2,19,49,73,77,90],"therapeutic":[3,81],"failure,":[4],"the":[5,27,37,61,75,107],"major":[6],"determinants":[7],"of":[8,30,79,109],"breast":[9,34,114],"cancer":[10,115],"mortality,":[11],"are":[12],"fundamentally":[13],"driven":[14],"by":[15,84],"epithelial-mesenchymal":[16],"transition":[17],"(EMT)":[18],"its":[20],"phenotypic":[21],"plasticity.":[22],"This":[23],"review":[24],"comprehensively":[25],"interrogates":[26],"regulatory":[28],"logic":[29],"EMT":[31,70],"plasticity":[32],"in":[33,67],"cancer,":[35],"decoding":[36],"intricate":[38],"interplay":[39],"among":[40],"transcription":[41],"factor":[42],"cascades,":[43],"epigenetic":[44],"landscapes,":[45],"non-coding":[46],"RNA":[47],"circuits,":[48],"microenvironmental":[50],"cues":[51],"that":[52],"collectively":[53],"sustain":[54],"tumor":[55],"cell":[56],"adaptability.":[57],"We":[58],"further":[59],"delineate":[60],"translational":[62,91],"frontier,":[63],"summarizing":[64],"recent":[65],"advances":[66],"pharmacologically":[68],"targeting":[69],"core":[71],"regulators":[72],"discussing":[74],"promise":[76],"pitfalls":[78],"plasticity-modulating":[80],"paradigms.":[82],"Ultimately,":[83],"integrating":[85],"evolving":[86],"knowledge":[87],"from":[88],"basic":[89],"research,":[92],"we":[93],"present":[94],"a":[95],"cohesive":[96],"framework":[97],"aimed":[98],"at":[99],"bridging":[100],"mechanistic":[101],"understanding":[102],"with":[103,106],"clinical":[104],"decision-making,":[105],"goal":[108],"refining":[110],"precision":[111],"therapy":[112],"for":[113],"patients.":[116]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-15T00:00:00"}
