{"id":"https://openalex.org/W7221801039","doi":"https://doi.org/10.1039/d6md00649c","title":"C11-conjugated soft glucocorticoid antibody\u2013drug conjugates for precision immunomodulation","display_name":"C11-conjugated soft glucocorticoid antibody\u2013drug conjugates for precision immunomodulation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7221801039","doi":"https://doi.org/10.1039/d6md00649c","pmid":"https://pubmed.ncbi.nlm.nih.gov/42979242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13728932"},"language":"en","primary_location":{"id":"doi:10.1039/d6md00649c","doi":"https://doi.org/10.1039/d6md00649c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00649c","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1039/d6md00649c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094126939","display_name":"Aiman A. Yaseen","orcid":"https://orcid.org/0009-0001-2379-3002","observed_orcids":["https://orcid.org/0009-0001-2379-3002"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aiman A. Yaseen","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158730847","display_name":"Daniel J Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Cohen","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158745151","display_name":"Anqi Zhang","orcid":"https://orcid.org/0000-0002-7158-4256","observed_orcids":["https://orcid.org/0000-0002-7158-4256"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anqi Zhang","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA"],"raw_orcid":"https://orcid.org/0000-0002-7158-4256","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158721029","display_name":"L. Nathan Tumey","orcid":"https://orcid.org/0000-0001-8890-7018","observed_orcids":["https://orcid.org/0000-0001-8890-7018"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. Nathan Tumey","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA"],"raw_orcid":"https://orcid.org/0000-0001-8890-7018","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902-6000, USA","institution_ids":["https://openalex.org/I123946342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5158721029"],"corresponding_institution_ids":["https://openalex.org/I123946342"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71033654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fluticasone-furoate","display_name":"fluticasone furoate","score":0.9829999804496765},{"id":"https://openalex.org/keywords/self-immolative-linker","display_name":"self-immolative linker","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd11a","display_name":"CD11a","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7699999809265137},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7020000219345093},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.7860000133514404},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.64410001039505},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5425000190734863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4147999882698059},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4059000015258789},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3562999963760376},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3224000036716461},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6md00649c","doi":"https://doi.org/10.1039/d6md00649c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00649c","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13728932","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13728932/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13728932/pdf/MD-OLF-D6MD00649C.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Med Chem","raw_type":"Text"},{"id":"pmid:42979242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42979242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6md00649c","doi":"https://doi.org/10.1039/d6md00649c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00649c","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221801039.pdf","grobid_xml":"https://content.openalex.org/works/W7221801039.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1971830675","https://openalex.org/W2035579869","https://openalex.org/W2037462205","https://openalex.org/W2052644591","https://openalex.org/W2060886231","https://openalex.org/W2091207705","https://openalex.org/W2120798598","https://openalex.org/W2167176353","https://openalex.org/W2225535431","https://openalex.org/W2600926306","https://openalex.org/W2621936089","https://openalex.org/W2769161407","https://openalex.org/W3089882877","https://openalex.org/W4210909255","https://openalex.org/W4220917570","https://openalex.org/W4294000653","https://openalex.org/W4309245499","https://openalex.org/W4316814847","https://openalex.org/W4386356953","https://openalex.org/W4386864025","https://openalex.org/W4386902600","https://openalex.org/W4396861063","https://openalex.org/W4398236110","https://openalex.org/W4409074308","https://openalex.org/W4409801124","https://openalex.org/W4416461284","https://openalex.org/W4416575167","https://openalex.org/W7117699761"],"related_works":["https://openalex.org/W3187451718","https://openalex.org/W4220917570","https://openalex.org/W4409074308","https://openalex.org/W2809207776","https://openalex.org/W4210909255","https://openalex.org/W4241050779","https://openalex.org/W4364309602","https://openalex.org/W4411411265","https://openalex.org/W4386902600","https://openalex.org/W7165016857"],"abstract_inverted_index":{"Glucocorticoids":[0],"(GCs)":[1],"are":[2,163],"highly":[3,164,174],"effective":[4],"therapies":[5],"for":[6,31,68,180,195],"inflammatory":[7,196],"diseases,":[8],"but":[9],"their":[10],"clinical":[11],"use":[12],"is":[13],"severely":[14],"limited":[15],"by":[16,102],"systemic":[17,41],"toxicities.":[18],"To":[19],"address":[20],"this":[21],"liability,":[22],"we":[23],"developed":[24],"a":[25,57,63,172],"modular":[26],"antibody-drug":[27],"conjugate":[28],"(ADC)":[29],"platform":[30,47,179],"targeted":[32,181],"delivery":[33],"of":[34,141,192],"GC":[35],"to":[36,43,77,80,166,186],"immune":[37],"cells,":[38],"thereby":[39],"minimizing":[40],"exposure":[42],"free":[44],"GC.":[45],"The":[46],"integrates":[48],"three":[49,108],"key":[50],"design":[51],"features:":[52],"(i)":[53],"fluticasone":[54],"furoate":[55],"(FF),":[56],"potent":[58,139],"metabolically":[59],"soft":[60,176],"glucocorticoid;":[61],"(ii)":[62],"legumain-cleavable":[64],"AsnAsnGlyPro":[65],"self-immolative":[66],"linker":[67],"lysosome-selective":[69],"payload":[70],"release;":[71],"and":[72,88,97,135,144,155,190],"(iii)":[73],"C11":[74,104],"hydroxyl":[75],"conjugation":[76],"enhance":[78],"resistance":[79],"serum":[81,99,157],"esterase-mediated":[82],"hydrolysis.":[83],"ADCs":[84,111],"targeting":[85],"TNF\u03b1,":[86],"CD38,":[87],"CD11a":[89],"exhibited":[90],"nanomolar":[91,113],"potency":[92,114],"in":[93,115,129,153],"glucocorticoid-responsive":[94,116],"reporter":[95,117],"assays":[96,128,152],"excellent":[98],"stability":[100,151],"enabled":[101],"the":[103,110,160,184,188],"conjugation.":[105],"Across":[106],"all":[107],"targets,":[109],"displayed":[112],"assays,":[118],"achieving":[119],"over":[120,123],"50-fold":[121],"selectivity":[122],"non-targeting":[124],"isotype":[125],"controls.":[126],"Functional":[127],"primary":[130],"bone":[131],"marrow-derived":[132],"macrophages":[133],"(BMDMs)":[134],"THP-1":[136],"cells":[137],"confirmed":[138],"inhibition":[140],"NF-\u03baB":[142],"signaling":[143],"pro-inflammatory":[145],"cytokine":[146],"secretion":[147],"(IL-6,":[148],"IL-8).":[149],"Extensive":[150],"human":[154],"mouse":[156],"revealed":[158],"that":[159],"C11-conjugated":[161],"constructs":[162],"resistant":[165],"premature":[167],"cleavage.":[168],"These":[169],"findings":[170],"establish":[171],"robust,":[173],"stable":[175],"glucocorticoid":[177,193],"ADC":[178],"immunosuppression":[182],"with":[183],"potential":[185],"improve":[187],"safety":[189],"efficacy":[191],"therapy":[194],"diseases.":[197]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-15T00:00:00"}
