{"id":"https://openalex.org/W7221782976","doi":"https://doi.org/10.3389/fphar.2026.1945339","title":"Effective doses of propofol and oliceridine fumarate for painless hysteroscopy: a two-phase dose-finding study using Dixon\u2019s up-and-down method","display_name":"Effective doses of propofol and oliceridine fumarate for painless hysteroscopy: a two-phase dose-finding study using Dixon\u2019s up-and-down method","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221782976","doi":"https://doi.org/10.3389/fphar.2026.1945339","pmid":"https://pubmed.ncbi.nlm.nih.gov/42952714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713384"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1945339","doi":"https://doi.org/10.3389/fphar.2026.1945339","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1945339","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1945339/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1945339/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158709744","display_name":"Jinming Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738306","display_name":"The Affiliated Shunde Hospital of Jinan University","ror":"https://ror.org/04x2nq985","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I159948400","https://openalex.org/I4392738306"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinming Chen","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University","institution_ids":["https://openalex.org/I4392738306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158691519","display_name":"Yunhao Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738306","display_name":"The Affiliated Shunde Hospital of Jinan University","ror":"https://ror.org/04x2nq985","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I159948400","https://openalex.org/I4392738306"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunhao Shao","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University","institution_ids":["https://openalex.org/I4392738306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158732406","display_name":"Hao Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738306","display_name":"The Affiliated Shunde Hospital of Jinan University","ror":"https://ror.org/04x2nq985","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I159948400","https://openalex.org/I4392738306"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University","institution_ids":["https://openalex.org/I4392738306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052923849","display_name":"Zhongqi Zhang","orcid":"https://orcid.org/0000-0003-3204-6372","observed_orcids":["https://orcid.org/0000-0003-3204-6372"]},"institutions":[{"id":"https://openalex.org/I4392738306","display_name":"The Affiliated Shunde Hospital of Jinan University","ror":"https://ror.org/04x2nq985","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I159948400","https://openalex.org/I4392738306"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongqi Zhang","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University","institution_ids":["https://openalex.org/I4392738306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052923849"],"corresponding_institution_ids":["https://openalex.org/I4392738306"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81912862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1945339","last_page":"1945339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dose-finding","display_name":"dose-finding","score":0.6340000033378601},{"id":"https://openalex.org/keywords/effective-dose","display_name":"effective dose","score":0.7260000109672546},{"id":"https://openalex.org/keywords/dixon-up-and-down-method","display_name":"Dixon up-and-down method","score":0.7009999752044678},{"id":"https://openalex.org/keywords/probit-analysis","display_name":"probit model","score":0.8180000185966492},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/procedural-pain","display_name":"procedural pain","score":0.44699999690055847},{"id":"https://openalex.org/keywords/nociception-level-index","display_name":"Nociception Level Index","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cerebral-state-index","display_name":"cerebral state index","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hemodynamic-parameters","display_name":"hemodynamic parameters","score":0.6230000257492065},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.593999981880188},{"id":"https://openalex.org/keywords/opioid-sparing-anesthesia","display_name":"opioid-sparing anesthesia","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9470000267028809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8682000041007996},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7710000276565552},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.6072999835014343},{"id":"https://openalex.org/C42533223","wikidata":"https://www.wikidata.org/wiki/Q1378064","display_name":"ED50","level":3,"score":0.604200005531311},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5153999924659729},{"id":"https://openalex.org/C2776622691","wikidata":"https://www.wikidata.org/wiki/Q5065331","display_name":"Cervical dilation","level":4,"score":0.47380000352859497},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.47369998693466187},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.4675999879837036},{"id":"https://openalex.org/C149857219","wikidata":"https://www.wikidata.org/wiki/Q5239054","display_name":"Effective dose (radiation)","level":2,"score":0.4221999943256378},{"id":"https://openalex.org/C2781097354","wikidata":"https://www.wikidata.org/wiki/Q4918396","display_name":"Bispectral index","level":3,"score":0.3903000056743622},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.35040000081062317},{"id":"https://openalex.org/C2775963564","wikidata":"https://www.wikidata.org/wiki/Q597058","display_name":"Hysteroscopy","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C2778475344","wikidata":"https://www.wikidata.org/wiki/Q284321","display_name":"Mefenamic acid","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1945339","doi":"https://doi.org/10.3389/fphar.2026.1945339","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1945339","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1945339/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713384","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713384/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713384/pdf/fphar-17-1945339.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42952714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42952714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Clinical Trial"},{"id":"pmh:oai:doaj.org/article:dcf3c9a06c7a4b1192e6d6eeceb661ab","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dcf3c9a06c7a4b1192e6d6eeceb661ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1945339","doi":"https://doi.org/10.3389/fphar.2026.1945339","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1945339","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1945339/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221782976.pdf","grobid_xml":"https://content.openalex.org/works/W7221782976.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1048351776","https://openalex.org/W1973472997","https://openalex.org/W1984841713","https://openalex.org/W1992937713","https://openalex.org/W2013118810","https://openalex.org/W2025961690","https://openalex.org/W2067025729","https://openalex.org/W2070004758","https://openalex.org/W2076470170","https://openalex.org/W2134939120","https://openalex.org/W2136643530","https://openalex.org/W2141816194","https://openalex.org/W2160349094","https://openalex.org/W2589026107","https://openalex.org/W2807872214","https://openalex.org/W2910538915","https://openalex.org/W2922473809","https://openalex.org/W2942516102","https://openalex.org/W2948334509","https://openalex.org/W2954051793","https://openalex.org/W2984174412","https://openalex.org/W2986989127","https://openalex.org/W3093488015","https://openalex.org/W3166843588","https://openalex.org/W3169338912","https://openalex.org/W4205525493","https://openalex.org/W4220802531","https://openalex.org/W4285076890","https://openalex.org/W4376225631","https://openalex.org/W4386356819","https://openalex.org/W4395031567","https://openalex.org/W4395682799","https://openalex.org/W4400241892","https://openalex.org/W4404726371","https://openalex.org/W4406075511","https://openalex.org/W4407709832","https://openalex.org/W4409566651","https://openalex.org/W4411344692","https://openalex.org/W4415210849"],"related_works":["https://openalex.org/W7000064326","https://openalex.org/W7115704531","https://openalex.org/W4415210849","https://openalex.org/W4415618394","https://openalex.org/W7203648244","https://openalex.org/W4411841279","https://openalex.org/W3169338912","https://openalex.org/W4415567153","https://openalex.org/W7172520162","https://openalex.org/W4405456337"],"abstract_inverted_index":{"Background:":[0],"Painless":[1],"hysteroscopy":[2,73],"is":[3,311],"widely":[4],"performed":[5],"in":[6,63,76,111,160,319],"gynecological":[7],"practice,":[8],"yet":[9],"achieving":[10],"an":[11,102,302],"optimal":[12,54],"balance":[13],"between":[14],"anesthetic":[15],"safety":[16,304],"and":[17,30,59,124,153,166,181,190,206,212,222,240,266,315],"patient":[18],"comfort":[19],"remains":[20],"challenging.":[21],"Combining":[22],"propofol":[23,58,97,122,145,215],"with":[24,34,126,164,283,301],"oliceridine":[25,60,94,154],"may":[26],"mitigate":[27],"respiratory":[28],"depression":[29],"injection":[31],"pain":[32],"associated":[33],"conventional":[35],"regimens,":[36],"though":[37],"the":[38,53,133,149,231],"effective":[39,171],"doses":[40],"for":[41,61,70,255,298,326],"this":[42,77,320],"combination":[43,56],"have":[44],"not":[45],"been":[46],"established.":[47],"This":[48],"study":[49,321],"sought":[50],"to":[51,120,293],"identify":[52],"dose":[55,92],"of":[57,93,214,274],"use":[62],"painless":[64,72,299],"hysteroscopy.":[65],"Methods:":[66],"Fifty-one":[67],"women":[68],"scheduled":[69],"elective":[71],"were":[74,216],"enrolled":[75],"prospective,":[78],"two-phase":[79],"dose-finding":[80],"study.":[81],"In":[82,142],"Phase":[83,143,150],"I,":[84],"all":[85],"patients":[86],"received":[87],"a":[88,182,295],"fixed":[89,147],"1":[90,158],"mg":[91,159,162,236,244],"at":[95,148],"induction;":[96],"was":[98,118,146,155,173,234,242],"subsequently":[99],"titrated":[100,156],"from":[101,157],"initial":[103],"2":[104],"mg/kg":[105,113,218,224],"using":[106],"Dixon's":[107],"up-and-down":[108],"sequential":[109],"method":[110],"0.1":[112,161],"intervals.":[114],"Probit":[115],"regression":[116,137,268],"modeling":[117],"used":[119],"derive":[121],"ED50":[123,165,211,233,270,314],"ED95,":[125],"95%":[127],"confidence":[128],"intervals":[129],"(CIs)":[130],"obtained":[131],"via":[132],"delta":[134],"method;":[135],"isotonic":[136,267],"served":[138],"as":[139,175],"sensitivity":[140],"analysis.":[141],"II,":[144],"I":[151],"ED50,":[152],"increments,":[163],"ED95":[167,213,241,316],"determined":[168],"identically.":[169],"An":[170],"response":[172],"defined":[174],"no":[176,179,284],"body":[177],"movement,":[178],"frowning,":[180],"Ramsay":[183],"Sedation":[184],"Score":[185],"\u22655":[186],"during":[187],"cervical":[188],"dilation":[189],"hysteroscope":[191],"insertion.":[192],"Secondary":[193],"outcomes":[194],"included":[195],"Nociception":[196],"Level":[197],"Index":[198,202],"(NOX),":[199],"Cerebral":[200],"State":[201],"(CSI),":[203],"hemodynamic":[204],"parameters,":[205],"adverse":[207,286],"events.":[208],"Results:":[209],"The":[210,290,313],"1.818":[217],"(95%":[219,225,237,245],"CI:":[220,226,238,246],"1.696-1.940)":[221],"2.223":[223],"1.840-2.605),":[227],"respectively.":[228],"For":[229],"oliceridine,":[230],"corresponding":[232],"0.663":[235],"0.605-0.720)":[239],"0.813":[243],"0.692-0.934).":[247],"Pearson":[248],"goodness-of-fit":[249],"tests":[250],"confirmed":[251],"adequate":[252],"model":[253],"fit":[254],"both":[256],"phases":[257],"(propofol:":[258],"P":[259,263],"=":[260,264],"0.755;":[261],"oliceridine:":[262],"0.899),":[265],"yielded":[269],"estimates":[271],"within":[272],"3%":[273],"probit-derived":[275],"values.":[276],"Hemodynamic":[277],"parameters":[278],"remained":[279],"stable":[280],"throughout":[281],"sedation,":[282],"serious":[285],"events":[287],"observed.":[288],"Conclusion:":[289],"propofol-oliceridine":[291],"appears":[292],"be":[294],"feasible":[296],"option":[297],"hysteroscopy,":[300],"acceptable":[303],"profile":[305],"provided":[306],"that":[307],"continuous":[308],"airway":[309],"monitoring":[310],"maintained.":[312],"values":[317],"observed":[318],"offer":[322],"preliminary":[323],"dosing":[324],"guidance":[325],"outpatient":[327],"practice.":[328],"Clinical":[329],"Trial":[330],"Registration:":[331],"www.chictr.org.cn/showproj.html?proj=241260,":[332],"identifier":[333],"ChiCTR2500102118.":[334]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-15T00:00:00"}