{"id":"https://openalex.org/W7221754045","doi":"https://doi.org/10.3389/fcimb.2026.1892233","title":"Paired biopsy-surface and tissue microbiome profiling reveals tissue-associated bacterial signatures in nasopharyngeal carcinoma","display_name":"Paired biopsy-surface and tissue microbiome profiling reveals tissue-associated bacterial signatures in nasopharyngeal carcinoma","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221754045","doi":"https://doi.org/10.3389/fcimb.2026.1892233","pmid":"https://pubmed.ncbi.nlm.nih.gov/42952527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713345"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1892233","doi":"https://doi.org/10.3389/fcimb.2026.1892233","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1892233","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1892233/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1892233/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101936386","display_name":"Nan Shi","orcid":"https://orcid.org/0009-0001-0462-4027","observed_orcids":["https://orcid.org/0009-0001-0462-4027"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Shi","raw_affiliation_strings":["Department of Head and Neck Tumor Surgery, Guangxi Medical University Cancer Hospital","Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Tumor Surgery, Guangxi Medical University Cancer Hospital","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123187401","display_name":"Zongjian Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongjian Huang","raw_affiliation_strings":["Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143601418","display_name":"Xuesong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuesong Wang","raw_affiliation_strings":["Department of Otorhinolaryngology Head and Neck Surgery, Binzhou Central Hospital","Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, Binzhou Central Hospital","institution_ids":[]},{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158755599","display_name":"Ying Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Xie","raw_affiliation_strings":["Department of Head and Neck Tumor Surgery, Guangxi Medical University Cancer Hospital","Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","School of International Education, Guangxi Medical University","School of Life Sciences Institute, Guangxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Tumor Surgery, Guangxi Medical University Cancer Hospital","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of International Education, Guangxi Medical University","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Life Sciences Institute, Guangxi Medical University","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015950630","display_name":"\u5510\u5b89\u6d32","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Anzhou Tang","raw_affiliation_strings":["Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129829549","display_name":"Wei Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Xia","raw_affiliation_strings":["Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumours (Guangxi Medical University), Ministry of Education","institution_ids":["https://openalex.org/I160354086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015950630","https://openalex.org/A5129829549","https://openalex.org/A5158755599"],"corresponding_institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210126060","https://openalex.org/I4210155683"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82186967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1892233","last_page":"1892233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.10779999941587448,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-microbiota","display_name":"tumor microbiome","score":0.8669999837875366},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.765999972820282},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.550000011920929},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7039999961853027},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.8992999792098999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7371000051498413},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6136000156402588},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.46149998903274536},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.415800005197525},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3707999885082245},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.35409998893737793},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3537999987602234},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.3515999913215637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32429999113082886},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.2953999936580658},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2815000116825104},{"id":"https://openalex.org/C2910796902","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelial tissue","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26170000433921814}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2026.1892233","doi":"https://doi.org/10.3389/fcimb.2026.1892233","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1892233","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1892233/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713345","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713345/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713345/pdf/fcimb-16-1892233.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:42952527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42952527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ed9e235feaa748d09c921a4018a31d25","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ed9e235feaa748d09c921a4018a31d25","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1892233","doi":"https://doi.org/10.3389/fcimb.2026.1892233","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1892233","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1892233/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4494036525","display_name":null,"funder_award_id":"AD25069077","funder_id":"https://openalex.org/F4320322768","funder_display_name":"Natural Science Foundation of Guangxi Province"},{"id":"https://openalex.org/G921002950","display_name":null,"funder_award_id":"AD25069077","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322768","display_name":"Natural Science Foundation of Guangxi Province","ror":null},{"id":"https://openalex.org/F4320327301","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221754045.pdf","grobid_xml":"https://content.openalex.org/works/W7221754045.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2612772400","https://openalex.org/W2753803220","https://openalex.org/W2942610007","https://openalex.org/W2952463830","https://openalex.org/W2952837153","https://openalex.org/W3007498160","https://openalex.org/W3030942202","https://openalex.org/W3043438918","https://openalex.org/W3080162954","https://openalex.org/W3116739534","https://openalex.org/W3138215020","https://openalex.org/W4205125026","https://openalex.org/W4223431213","https://openalex.org/W4281289455","https://openalex.org/W4282552290","https://openalex.org/W4285390672","https://openalex.org/W4310992305","https://openalex.org/W4316466692","https://openalex.org/W4382987324","https://openalex.org/W4390730449","https://openalex.org/W4392032873","https://openalex.org/W4392094956","https://openalex.org/W4403029887","https://openalex.org/W4407722763"],"related_works":["https://openalex.org/W4410462674","https://openalex.org/W7148653838","https://openalex.org/W4281289455","https://openalex.org/W7129698437","https://openalex.org/W7158078702","https://openalex.org/W3198907765","https://openalex.org/W4401831461","https://openalex.org/W4409690731","https://openalex.org/W4285390672","https://openalex.org/W4392032873"],"abstract_inverted_index":{"Introduction:":[0],"Tumor-associated":[1],"microbiota":[2],"have":[3],"been":[4],"implicated":[5],"in":[6,96],"cancer":[7],"biology,":[8],"but":[9],"the":[10,16],"relationship":[11],"between":[12,68,89],"bacteria":[13],"detected":[14,21],"on":[15],"biopsy":[17],"surface":[18],"and":[19,37,46,78,91,113,117,122,141],"those":[20],"within":[22],"tumor":[23],"tissue":[24,38,132],"remains":[25],"poorly":[26],"defined.":[27],"Methods:":[28],"In":[29],"this":[30,97],"study,":[31],"we":[32],"profiled":[33],"paired":[34],"biopsy-surface":[35,94,139],"swabs":[36],"biopsies":[39],"from":[40,138],"patients":[41],"with":[42,107],"nasopharyngeal":[43,48],"carcinoma":[44],"(NPC)":[45],"benign":[47],"lymphoid":[49],"hyperplasia":[50],"(NLH)":[51],"controls":[52],"using":[53],"five-region":[54],"16S":[55],"rRNA":[56],"gene":[57],"sequencing.":[58],"Matched":[59],"bulk":[60],"RNA-seq":[61],"data":[62],"were":[63,105],"analyzed":[64],"to":[65],"explore":[66],"associations":[67],"microbial":[69,84,134],"features,":[70],"Epstein-Barr":[71],"virus":[72],"(EBV)":[73],"transcription,":[74],"host":[75],"pathway":[76,115],"activity,":[77,116],"inferred":[79,119],"immune-cell":[80],"composition.":[81],"Results:":[82],"Tissue-associated":[83],"profiles":[85,95],"showed":[86],"stronger":[87],"separation":[88],"NPC":[90,131],"NLH":[92],"than":[93],"discovery":[98],"cohort.":[99],"Several":[100],"NPC-enriched":[101],"species-level":[102],"taxonomic":[103],"assignments":[104],"associated":[106],"higher":[108],"EBV":[109],"transcript":[110],"levels,":[111],"proliferative":[112],"cell-cycle":[114],"lower":[118],"CD8":[120],"T-cell":[121],"plasmacytoid":[123],"dendritic-cell":[124],"signatures.":[125],"Discussion:":[126],"These":[127],"findings":[128],"indicate":[129],"that":[130,136],"contains":[133],"signatures":[135],"differ":[137],"communities":[140],"support":[142],"further":[143],"validation":[144],"of":[145],"tissue-associated":[146],"microbe-EBV-host":[147],"relationships.":[148]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-15T00:00:00"}