{"id":"https://openalex.org/W7221752151","doi":"https://doi.org/10.64898/2026.10.13.758926","title":"Functional Performance of Electrospun Tissue-Engineered Heart Valve Scaffolds Across Geometries Under Aortic Conditions","display_name":"Functional Performance of Electrospun Tissue-Engineered Heart Valve Scaffolds Across Geometries Under Aortic Conditions","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7221752151","doi":"https://doi.org/10.64898/2026.10.13.758926"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.13.758926","doi":"https://doi.org/10.64898/2026.10.13.758926","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.758926","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.758926.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.758926.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084232120","display_name":"Hannes Dillinger","orcid":"https://orcid.org/0000-0002-5597-5273","observed_orcids":["https://orcid.org/0000-0002-5597-5273"]},"institutions":[{"id":"https://openalex.org/I1285933455","display_name":"Physikalisch-Technische Bundesanstalt","ror":"https://ror.org/05r3f7h03","country_code":"DE","type":"government","lineage":["https://openalex.org/I1285933455","https://openalex.org/I4210136623"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Hannes Dillinger","raw_affiliation_strings":["Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands","Physikalisch-Technische Bundesanstalt (PTB), Abbestrasse 2-12, Berlin, 10587, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5597-5273","affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]},{"raw_affiliation_string":"Physikalisch-Technische Bundesanstalt (PTB), Abbestrasse 2-12, Berlin, 10587, Berlin, Germany","institution_ids":["https://openalex.org/I1285933455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043377439","display_name":"Aref Saberi","orcid":"https://orcid.org/0000-0002-2021-8491","observed_orcids":["https://orcid.org/0000-0002-2021-8491"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aref Saberi","raw_affiliation_strings":["Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2021-8491","affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062893568","display_name":"Mattia Manenti","orcid":"https://orcid.org/0009-0001-7274-205X","observed_orcids":["https://orcid.org/0009-0001-7274-205X"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mattia Manenti","raw_affiliation_strings":["Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158700926","display_name":"Iva van der Burgh-Vrees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Iva van der Burgh-Vrees","raw_affiliation_strings":["Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044939299","display_name":"Carlijn V. C. Bouten","orcid":"https://orcid.org/0000-0003-1035-5094","observed_orcids":["https://orcid.org/0000-0003-1035-5094"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Carlijn Bouten","raw_affiliation_strings":["Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1035-5094","affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology, Vector, Dominee Theodor Fliednerstraat 2, Eindhoven, 5600 MP, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084232120"],"corresponding_institution_ids":["https://openalex.org/I1285933455","https://openalex.org/I83019370"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.38499999046325684,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-engineered-heart-valves","display_name":"tissue-engineered heart valves","score":0.9599999785423279},{"id":"https://openalex.org/keywords/electrospun-scaffolds","display_name":"electrospun scaffolds","score":0.9860000014305115},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/leaflet-geometry","display_name":"leaflet geometry","score":0.8050000071525574},{"id":"https://openalex.org/keywords/aortic-hemodynamics","display_name":"aortic hemodynamics","score":0.6819999814033508},{"id":"https://openalex.org/keywords/scaffold-porosity","display_name":"scaffold porosity","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6841999888420105},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.6355999708175659},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6026999950408936},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.5623000264167786},{"id":"https://openalex.org/C2779868350","wikidata":"https://www.wikidata.org/wiki/Q109674","display_name":"Polycaprolactone","level":3,"score":0.5138000249862671},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5077000260353088},{"id":"https://openalex.org/C144796933","wikidata":"https://www.wikidata.org/wiki/Q1533542","display_name":"Electrospinning","level":3,"score":0.48559999465942383},{"id":"https://openalex.org/C2993866533","wikidata":"https://www.wikidata.org/wiki/Q26868","display_name":"Collagen fiber","level":2,"score":0.39259999990463257},{"id":"https://openalex.org/C2780168065","wikidata":"https://www.wikidata.org/wiki/Q1930043","display_name":"Regurgitation (circulation)","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C2779769944","wikidata":"https://www.wikidata.org/wiki/Q146439","display_name":"Silicone","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2824999988079071},{"id":"https://openalex.org/C139302045","wikidata":"https://www.wikidata.org/wiki/Q2845593","display_name":"Globe valve","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.25850000977516174},{"id":"https://openalex.org/C2779751349","wikidata":"https://www.wikidata.org/wiki/Q1474480","display_name":"Scanner","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.13.758926","doi":"https://doi.org/10.64898/2026.10.13.758926","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.758926","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.758926.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.13.758926","doi":"https://doi.org/10.64898/2026.10.13.758926","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.758926","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.13.758926.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1164323722","display_name":"Materials-driven regeneration: Regenerating tissue and organ function with intelligent, life-like materials","funder_award_id":"024.003.013","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G420050720","display_name":null,"funder_award_id":"024.003","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5752817118","display_name":"HOLLAND HYBRID HEART, combining tissue engineering and soft robotics to build a biocompatible artificial heart that offers a future to heart failure patients","funder_award_id":"NWA.1518.22.049","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221752151.pdf","grobid_xml":"https://content.openalex.org/works/W7221752151.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W213050918","https://openalex.org/W1707040081","https://openalex.org/W2001105457","https://openalex.org/W2060556605","https://openalex.org/W2135236109","https://openalex.org/W2140276456","https://openalex.org/W2162378558","https://openalex.org/W2524386178","https://openalex.org/W2566087653","https://openalex.org/W2586644389","https://openalex.org/W2598026864","https://openalex.org/W2606627786","https://openalex.org/W2744815436","https://openalex.org/W2775859079","https://openalex.org/W2895025365","https://openalex.org/W2912652602","https://openalex.org/W2940989947","https://openalex.org/W3084190054","https://openalex.org/W3084196559","https://openalex.org/W3087149928","https://openalex.org/W4205838134","https://openalex.org/W4214951840","https://openalex.org/W4379743496","https://openalex.org/W4409182613","https://openalex.org/W4412450039","https://openalex.org/W7139951213"],"related_works":["https://openalex.org/W59767379","https://openalex.org/W7018437841","https://openalex.org/W1603468180","https://openalex.org/W2621108022","https://openalex.org/W2499445916","https://openalex.org/W7027942524","https://openalex.org/W2056320965","https://openalex.org/W4408009570","https://openalex.org/W4393341839","https://openalex.org/W6982268856"],"abstract_inverted_index":{"Electrospun,":[0],"bioresorbable":[1],"polymer":[2],"scaffolds":[3,68,109,139,146],"represent":[4],"a":[5,150,161,198],"compelling":[6],"platform":[7],"for":[8],"tissue-engineered":[9],"heart":[10,36,212],"valves":[11,44],"(TEHVs)":[12],"owing":[13],"to":[14,23,48,52,135,205],"their":[15,208],"fibrous":[16],"microstructure,":[17],"tunable":[18],"mechanics":[19],"and":[20,27,45,55,74,124,133,140,156,173,177,196,202],"inherent":[21],"capacity":[22],"support":[24,207],"host-cell":[25],"infiltration":[26],"remodeling.":[28],"While":[29],"recent":[30],"in-vitro":[31],"parametric":[32],"studies":[33],"of":[34,60,64,117,144,166,168],"bioprosthetic":[35],"valve":[37,171,213],"(BHV)":[38],"geometry":[39,104],"have":[40],"used":[41],"silicone":[42],"cast":[43],"Doppler":[46],"echocardiography":[47],"link":[49],"design":[50],"parameters":[51],"hemodynamic":[53],"performance":[54],"leaflet":[56,77,103],"strain,":[57],"the":[58,61,169],"characterization":[59],"functional":[62],"behavior":[63,179],"electrospun":[65,92,184],"whole-valve":[66,108,185],"TEHV":[67],"across":[69,75,110,138],"clinically":[70,192],"relevant":[71,193],"aortic":[72,158,194],"conditions":[73,195],"distinct":[76],"geometries":[78,112],"remains":[79],"limited.":[80],"Here,":[81],"we":[82],"present":[83],"an":[84],"end-to-end":[85],"workflow":[86],"in":[87,149],"which":[88],"polycaprolactone":[89],"(PCL)":[90],"is":[91],"directly":[93],"onto":[94],"parametrized,":[95],"3D-printed":[96],"mandrels":[97],"derived":[98],"from":[99],"two":[100],"established":[101],"analytical":[102],"models,":[105],"yielding":[106],"21":[107],"five":[111],"without":[113],"cutting":[114],"or":[115],"suturing":[116],"flat":[118],"fiber":[119],"sheets.":[120],"Fiber":[121],"diameter,":[122],"orientation":[123],"scaffold":[125],"porosity":[126],"were":[127,147],"assessed":[128],"by":[129],"scanning":[130],"electron":[131],"microscopy":[132],"confirmed":[134],"be":[136],"consistent":[137],"geometries.":[141],"A":[142],"subset":[143],"8":[145],"tested":[148],"pulse":[151],"duplicator":[152],"under":[153],"hypotensive,":[154],"normotensive":[155],"hypertensive":[157],"conditions,":[159],"achieving":[160],"mean":[162],"geometric":[163],"orifice":[164],"area":[165,172],"44.51%":[167],"total":[170],"demonstrating":[174],"physiological":[175],"opening":[176],"closing":[178],"throughout.":[180],"These":[181],"results":[182],"emphasize":[183],"TEHVs":[186],"as":[187],"hemodynamically":[188],"competent":[189],"constructs":[190],"at":[191],"provide":[197],"reproducible,":[199],"geometry-driven":[200],"fabrication":[201],"evaluation":[203],"framework":[204],"further":[206],"translation":[209],"toward":[210],"regenerative":[211],"replacement.":[214]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-15T00:00:00"}