{"id":"https://openalex.org/W7221687299","doi":"https://doi.org/10.64898/2026.10.08.757707","title":"A mitotic restriction point for extrachromosomal DNA hubs in cancer cells","display_name":"A mitotic restriction point for extrachromosomal DNA hubs in cancer cells","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221687299","doi":"https://doi.org/10.64898/2026.10.08.757707"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.08.757707","doi":"https://doi.org/10.64898/2026.10.08.757707","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.08.757707","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757707.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757707.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090702324","display_name":"Xiaowei Yan","orcid":"https://orcid.org/0000-0002-4846-8812","observed_orcids":["https://orcid.org/0000-0002-4846-8812"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Yan","raw_affiliation_strings":["Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA","Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4846-8812","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069030089","display_name":"Ivy Tsz Lo Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivy Tsz-Lo Wong","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086079580","display_name":"Muhammad Murtaza Hassan","orcid":"https://orcid.org/0000-0001-7752-4011","observed_orcids":["https://orcid.org/0000-0001-7752-4011","https://orcid.org/0000-0002-7532-2261"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Murtaza Hassan","raw_affiliation_strings":["Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA","SPARK Translational Research Program, Stanford University School of Medicine, Stanford, CA, USA","Stanford Cancer Institute, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"SPARK Translational Research Program, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cancer Institute, Stanford, CA, USA","institution_ids":["https://openalex.org/I4390039303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158595371","display_name":"Rui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Li","raw_affiliation_strings":["Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064429377","display_name":"Katerina Kraft","orcid":"https://orcid.org/0000-0002-2011-6946","observed_orcids":["https://orcid.org/0000-0002-2011-6946"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katerina Kraft","raw_affiliation_strings":["Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA","Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034718917","display_name":"Aditi Gnanasekar","orcid":"https://orcid.org/0000-0002-8303-8674","observed_orcids":["https://orcid.org/0000-0002-8303-8674"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi Gnanasekar","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042065032","display_name":"Paul S. Mischel","orcid":"https://orcid.org/0000-0002-4560-2211","observed_orcids":["https://orcid.org/0000-0002-4560-2211"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul S. Mischel","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158634737","display_name":"Howard Y. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard Y. Chang","raw_affiliation_strings":["Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA","Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA","Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042065032","https://openalex.org/A5158634737"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extrachromosomal-dna","display_name":"extrachromosomal DNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":1.0},{"id":"https://openalex.org/keywords/oncogene-expression","display_name":"oncogene expression","score":0.734000027179718},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.5080000162124634},{"id":"https://openalex.org/keywords/interphase","display_name":"interphase","score":0.5590000152587891},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.5230000019073486},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.4880000054836273},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.36800000071525574},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7813000082969666},{"id":"https://openalex.org/C89684784","wikidata":"https://www.wikidata.org/wiki/Q5422184","display_name":"Extrachromosomal DNA","level":4,"score":0.6668999791145325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6406999826431274},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.5604000091552734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5250999927520752},{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.5138000249862671},{"id":"https://openalex.org/C6391034","wikidata":"https://www.wikidata.org/wiki/Q6881916","display_name":"Mitotic exit","level":5,"score":0.48429998755455017},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.47130000591278076},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4636000096797943},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4343000054359436},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41429999470710754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4099999964237213},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.35600000619888306},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3319999873638153},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.3287000060081482},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2904999852180481},{"id":"https://openalex.org/C6902291","wikidata":"https://www.wikidata.org/wiki/Q417889","display_name":"Maturation promoting factor","level":5,"score":0.27959999442100525},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.08.757707","doi":"https://doi.org/10.64898/2026.10.08.757707","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.08.757707","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757707.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.08.757707","doi":"https://doi.org/10.64898/2026.10.08.757707","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.08.757707","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757707.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G245757704","display_name":null,"funder_award_id":"CGCATF- 2021/100012","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3270689697","display_name":"eDyNAmiC - UCSD","funder_award_id":"OT2CA278635","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4004495550","display_name":"eDyNAmiC - STANFORD","funder_award_id":"OT2CA278688","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4268089617","display_name":null,"funder_award_id":"100012","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5594779030","display_name":null,"funder_award_id":"CGCATF-2021/100012","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8393059803","display_name":null,"funder_award_id":"OT2CA278688","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8631332399","display_name":null,"funder_award_id":"DRG-2474-22","funder_id":"https://openalex.org/F4320306271","funder_display_name":"Damon Runyon Cancer Research Foundation"},{"id":"https://openalex.org/G8687509801","display_name":null,"funder_award_id":"CGCATF-2021/100025","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221687299.pdf","grobid_xml":"https://content.openalex.org/works/W7221687299.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1974391793","https://openalex.org/W1987681742","https://openalex.org/W2008744347","https://openalex.org/W2024368545","https://openalex.org/W2048109276","https://openalex.org/W2064670731","https://openalex.org/W2073031672","https://openalex.org/W2096293110","https://openalex.org/W2105590267","https://openalex.org/W2130410032","https://openalex.org/W2138207763","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2180260229","https://openalex.org/W2185693210","https://openalex.org/W2214074259","https://openalex.org/W2523285811","https://openalex.org/W2587686129","https://openalex.org/W2810246680","https://openalex.org/W2966882472","https://openalex.org/W2975634117","https://openalex.org/W2983144541","https://openalex.org/W2991552764","https://openalex.org/W3036176033","https://openalex.org/W3049406491","https://openalex.org/W3087121815","https://openalex.org/W3111521801","https://openalex.org/W3217498804","https://openalex.org/W4211071958","https://openalex.org/W4283816752","https://openalex.org/W4286480178","https://openalex.org/W4296293070","https://openalex.org/W4309908782","https://openalex.org/W4309944312","https://openalex.org/W4365143649","https://openalex.org/W4382601896","https://openalex.org/W4392166794","https://openalex.org/W4401091925","https://openalex.org/W4402734089","https://openalex.org/W4404105359","https://openalex.org/W4404105412","https://openalex.org/W4407520407","https://openalex.org/W4409189334","https://openalex.org/W4412002219","https://openalex.org/W4413495365","https://openalex.org/W4414200922","https://openalex.org/W4416386003"],"related_works":["https://openalex.org/W3216681490","https://openalex.org/W4392166794","https://openalex.org/W7128376195","https://openalex.org/W4223625419","https://openalex.org/W3217498804","https://openalex.org/W4210879650","https://openalex.org/W4414379921","https://openalex.org/W7008313852","https://openalex.org/W4407609574","https://openalex.org/W7165745167"],"abstract_inverted_index":{"Abstract":[0],"Extrachromosomal":[1],"DNA":[2],"(ecDNA)":[3],"is":[4,119,136],"widespread":[5],"in":[6,113,174],"human":[7],"cancers":[8],"and":[9,15,42,80,90,124,133,142,160],"promotes":[10],"tumour":[11],"evolution,":[12],"intratumour":[13],"heterogeneity":[14],"poor":[16],"clinical":[17],"outcomes":[18],"1\u20135":[19],".":[20,35],"ecDNA":[21,56,103,116,155,161],"molecules":[22],"tend":[23],"to":[24,94,105],"cluster":[25],"into":[26,98],"micron-scale":[27],"nuclear":[28],"hubs":[29],"that":[30,67,88,153],"enhance":[31],"oncogene":[32,81,158],"transcription":[33],"6":[34],"However,":[36],"how":[37],"these":[38,146],"higher-order":[39],"assemblies":[40],"form":[41],"persist":[43],"remains":[44],"largely":[45],"unknown.":[46],"Here":[47],"we":[48],"discover":[49],"mitosis":[50,123],"as":[51,73],"the":[52,69],"critical":[53],"window":[54,170],"for":[55,171],"hub":[57,78,117,156],"organisation":[58,135],"across":[59,138],"cell":[60,165],"generations.":[61],"We":[62],"develop":[63],"an":[64,74],"optical":[65],"screen":[66],"identifies":[68],"mitotic-entry":[70],"regulator":[71,76],"WEE1":[72,85],"important":[75],"of":[77,84,102],"integrity":[79],"expression.":[82],"Analysis":[83],"perturbation":[86],"reveals":[87],"CDK1-":[89],"CDK2-regulated":[91],"programmes":[92],"cooperate":[93],"carry":[95],"unresolved":[96],"damage":[97],"mitosis,":[99],"promoting":[100],"reorganisation":[101],"tethered":[104],"mitotic":[106,132,150],"chromosomes.":[107],"Long-term":[108],"live-cell":[109],"imaging":[110],"shows":[111],"that,":[112],"unperturbed":[114],"cells,":[115],"architecture":[118],"remodelled":[120],"primarily":[121],"during":[122],"subsequently":[125],"maintained":[126],"throughout":[127],"interphase.":[128],"This":[129],"coupling":[130],"between":[131],"interphase":[134],"conserved":[137],"diverse":[139],"cancer":[140],"types":[141],"ecDNA-associated":[143],"oncogenes.":[144],"Together,":[145],"findings":[147],"define":[148],"a":[149,168],"restriction":[151],"point":[152],"governs":[154],"organisation,":[157],"expression":[159],"inheritance":[162],"through":[163],"successive":[164],"generations,":[166],"revealing":[167],"potential":[169],"therapeutic":[172],"intervention":[173],"ecDNA-driven":[175],"cancers.":[176]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-14T00:00:00"}