{"id":"https://openalex.org/W7221682016","doi":"https://doi.org/10.3389/fimmu.2026.1963346","title":"Effects of stress on thymic B cells in C57BL/6J mice: phenotypic characterization and mechanistic insights","display_name":"Effects of stress on thymic B cells in C57BL/6J mice: phenotypic characterization and mechanistic insights","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221682016","doi":"https://doi.org/10.3389/fimmu.2026.1963346","pmid":"https://pubmed.ncbi.nlm.nih.gov/42947705","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710050"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1963346","doi":"https://doi.org/10.3389/fimmu.2026.1963346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1963346","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1963346/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1963346/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134550233","display_name":"Longda Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longda Ma","raw_affiliation_strings":["Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University","Postdoctoral Research Station in Basic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"Postdoctoral Research Station in Basic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158586028","display_name":"Weibo Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weibo Shi","raw_affiliation_strings":["Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067682818","display_name":"Songjun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songjun Wang","raw_affiliation_strings":["Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158544320","display_name":"Bin Cong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Cong","raw_affiliation_strings":["Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5158544320"],"corresponding_institution_ids":["https://openalex.org/I111381250"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70335036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1963346","last_page":"1963346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-b-cells","display_name":"thymic B cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/psychological-stress","display_name":"psychological stress","score":0.7350000143051147},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glucocorticoid-responsiveness","display_name":"glucocorticoid responsiveness","score":0.9729999899864197},{"id":"https://openalex.org/keywords/central-tolerance","display_name":"central tolerance","score":0.6610000133514404},{"id":"https://openalex.org/keywords/self-antigen-presentation","display_name":"autoantigen presentation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/autoimmune-regulator","display_name":"AIRE","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cd80-cd86","display_name":"CD80/CD86","score":0.7250000238418579},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.7160000205039978},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6592000126838684},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.628600001335144},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5730000138282776},{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.5185999870300293},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4900999963283539},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.4844000041484833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4602999985218048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4593000113964081},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4296000003814697},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.41179999709129333},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3910999894142151},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.38760000467300415},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3873000144958496},{"id":"https://openalex.org/C2778830056","wikidata":"https://www.wikidata.org/wiki/Q606766","display_name":"Central tolerance","level":4,"score":0.37709999084472656},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3682999908924103},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34610000252723694},{"id":"https://openalex.org/C200180986","wikidata":"https://www.wikidata.org/wiki/Q3269473","display_name":"Naive B cell","level":5,"score":0.3433000147342682},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.32409998774528503},{"id":"https://openalex.org/C145558887","wikidata":"https://www.wikidata.org/wiki/Q3832893","display_name":"B-1 cell","level":5,"score":0.29670000076293945},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.2930000126361847},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C2777314012","wikidata":"https://www.wikidata.org/wiki/Q7799617","display_name":"Thymic involution","level":4,"score":0.2847999930381775},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.28139999508857727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2775982045","wikidata":"https://www.wikidata.org/wiki/Q6959842","display_name":"Naive T cell","level":5,"score":0.2558000087738037},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.25220000743865967}],"mesh":[{"descriptor_ui":"D000096927","descriptor_name":"AIRE Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012149","descriptor_name":"Restraint, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016175","descriptor_name":"B-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1963346","doi":"https://doi.org/10.3389/fimmu.2026.1963346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1963346","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1963346/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710050","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710050/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710050/pdf/fimmu-17-1963346.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42947705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42947705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5443f99812c443a59056673d9c97c1dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5443f99812c443a59056673d9c97c1dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1963346","doi":"https://doi.org/10.3389/fimmu.2026.1963346","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1963346","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1963346/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5732927309","display_name":null,"funder_award_id":"82293651","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7924934264","display_name":null,"funder_award_id":"82130055","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327628","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221682016.pdf","grobid_xml":"https://content.openalex.org/works/W7221682016.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1499972896","https://openalex.org/W1898640512","https://openalex.org/W1904414649","https://openalex.org/W1947866403","https://openalex.org/W1969483733","https://openalex.org/W2004554152","https://openalex.org/W2007346871","https://openalex.org/W2035618305","https://openalex.org/W2081765214","https://openalex.org/W2091203722","https://openalex.org/W2138207763","https://openalex.org/W2139358643","https://openalex.org/W2179438025","https://openalex.org/W2528538746","https://openalex.org/W2552935169","https://openalex.org/W2569777770","https://openalex.org/W2587941297","https://openalex.org/W2785469523","https://openalex.org/W2914650668","https://openalex.org/W2949177718","https://openalex.org/W2954122547","https://openalex.org/W2964849163","https://openalex.org/W2994003829","https://openalex.org/W3091971470","https://openalex.org/W3210616983","https://openalex.org/W4220956414","https://openalex.org/W4300962836","https://openalex.org/W4321440698","https://openalex.org/W4385476149","https://openalex.org/W4386154638","https://openalex.org/W4386759862","https://openalex.org/W4389390583","https://openalex.org/W4390818102","https://openalex.org/W4390929320","https://openalex.org/W4391994098","https://openalex.org/W4394996717","https://openalex.org/W4402598854","https://openalex.org/W4406104571","https://openalex.org/W4408949847","https://openalex.org/W4409293615","https://openalex.org/W7125639517"],"related_works":["https://openalex.org/W1538345593","https://openalex.org/W2980510234","https://openalex.org/W1536333507","https://openalex.org/W3094380072","https://openalex.org/W2366503377","https://openalex.org/W2037060893","https://openalex.org/W2154192115","https://openalex.org/W2043660567","https://openalex.org/W2594697594","https://openalex.org/W2079928944"],"abstract_inverted_index":{"Introduction":[0],"As":[1],"an":[2],"important":[3],"cause":[4],"of":[5,36,47,101,137,148,185,191,198,214],"immune":[6],"system":[7],"dysfunction,":[8],"stress":[9,48,73,127,163,215,221],"can":[10,26],"damage":[11],"thymic":[12,21,50,64,83,103,130,200,217,223,244],"stromal":[13],"cells,":[14,143],"leading":[15,239],"to":[16,62,78,240],"a":[17,30,111,241],"persistent":[18],"imbalance":[19],"in":[20,33,82,152,196,243],"function.":[22],"Thymic":[23,107],"B":[24,51,65,84,104,108,114,131,142,157,201,218,224,245],"cells":[25,52,109],"present":[27],"autoantigens,":[28],"playing":[29],"critical":[31,229],"role":[32],"the":[34,45,135,146,183,188,199,211,233],"establishment":[35],"central":[37],"T":[38],"cell":[39,66,85,115,132,165,202,225,246],"tolerance.":[40],"However,":[41],"current":[42],"research":[43],"on":[44,49,216],"effects":[46],"remains":[53],"limited.":[54],"Methods":[55],"Publicly":[56],"available":[57],"scRNA-seq":[58],"datasets":[59],"were":[60,204],"analyzed":[61],"characterize":[63],"phenotypes":[67],"and":[68,87,92,94,122,144,150,167,173,181,193,227,235,250],"glucocorticoid":[69,124],"responsiveness.":[70,125],"A":[71],"restraint":[72],"mouse":[74],"model":[75],"was":[76],"employed":[77],"assess":[79],"stress-induced":[80],"changes":[81],"abundance":[86],"phenotype":[88],"by":[89,97],"flow":[90],"cytometry":[91],"histopathology,":[93],"transcriptomic":[95],"alterations":[96],"bulk":[98],"RNA":[99],"sequencing":[100],"sorted":[102],"cells.":[105,158],"Results":[106],"exhibited":[110],"distinctive":[112],"memory":[113],"signature":[116],"with":[117],"constitutively":[118],"activated":[119],"immune-related":[120],"pathways,":[121],"robust":[123],"Restraint":[126],"significantly":[128],"reduced":[129],"numbers,":[133,247],"increased":[134],"proportion":[136],"IgD":[138,153],"+":[139,141,154,156],"IgM":[140,155],"downregulated":[145],"expression":[147,189],"CD80":[149],"CD86":[151],"Transcriptomic":[159],"profiling":[160],"revealed":[161],"that":[162],"suppressed":[164],"cycle":[166],"G2/M":[168],"checkpoint":[169],"pathway,":[170],"inhibited":[171],"CD40L-":[172],"IFN-\u03bb-responsive":[174],"gene":[175,179],"expression,":[176,180],"attenuated":[177],"Aire-dependent":[178],"diminished":[182],"presentation":[184],"autoantigens.":[186],"Furthermore,":[187],"levels":[190],"CD40":[192],"MHC":[194],"II":[195],"most":[197],"subsets":[203],"markedly":[205],"decreased.":[206],"Discussion":[207],"This":[208],"study":[209],"reveals":[210],"detrimental":[212],"impact":[213],"cell.":[219],"Collectively,":[220],"impairs":[222],"proliferation":[226],"attenuates":[228],"licensing":[230],"signals,":[231],"including":[232],"CD40L\u2013CD40":[234],"IFN-\u03bb":[236],"signaling,":[237],"thereby":[238],"reduction":[242],"compromised":[248],"activation,":[249],"impaired":[251],"antigen-presenting":[252],"capacity.":[253]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-14T00:00:00"}
