{"id":"https://openalex.org/W7221677941","doi":"https://doi.org/10.3892/etm.2026.13335","title":"Associations of reticulocyte hemoglobin equivalent with erythrocyte indices and serum ferritin in anemic patients with hepatocellular carcinoma: A retrospective study","display_name":"Associations of reticulocyte hemoglobin equivalent with erythrocyte indices and serum ferritin in anemic patients with hepatocellular carcinoma: A retrospective study","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221677941","doi":"https://doi.org/10.3892/etm.2026.13335","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13711145"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2026.13335","doi":"https://doi.org/10.3892/etm.2026.13335","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2026.13335","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13335/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13335/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104181709","display_name":"Zixuan Liu","orcid":"https://orcid.org/0009-0000-8503-1508","observed_orcids":["https://orcid.org/0009-0000-8503-1508"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixuan Liu","raw_affiliation_strings":["Graduate School, School of Clinical Medicine, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, School of Clinical Medicine, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158569571","display_name":"Dengxiang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115020","display_name":"Xingtai People's Hospital","ror":"https://ror.org/0284jzx23","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115020"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dengxiang Liu","raw_affiliation_strings":["Department of Medical Oncology, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China","institution_ids":["https://openalex.org/I4210115020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5158569571"],"corresponding_institution_ids":["https://openalex.org/I4210115020"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75084938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"6","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reticulocyte-hemoglobin-equivalent","display_name":"reticulocyte hemoglobin equivalent","score":0.968999981880188},{"id":"https://openalex.org/keywords/cancer-related-anemia","display_name":"cancer-related anemia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/serum-ferritin","display_name":"serum ferritin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/red-blood-cell-indices","display_name":"red blood cell indices","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microcytic-hypochromic-anemia","display_name":"microcytic hypochromic anemia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anemia-severity","display_name":"anemia severity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hypersplenism","display_name":"hypersplenism","score":0.6629999876022339},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mean-corpuscular-volume","display_name":"mean corpuscular volume","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mean-corpuscular-hemoglobin","display_name":"mean corpuscular hemoglobin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mean-corpuscular-hemoglobin-concentration","display_name":"mean corpuscular hemoglobin concentration","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7384999990463257},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6854000091552734},{"id":"https://openalex.org/C2778403015","wikidata":"https://www.wikidata.org/wiki/Q1404923","display_name":"Reticulocyte","level":4,"score":0.66839998960495},{"id":"https://openalex.org/C3019184707","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Serum ferritin","level":3,"score":0.5967000126838684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5867000222206116},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5246000289916992},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.448199987411499},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4392000138759613},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4307999908924103},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4194999933242798},{"id":"https://openalex.org/C3020314195","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Hemoglobin s","level":4,"score":0.3781999945640564},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.34940001368522644},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34929999709129333},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.33959999680519104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C2779875672","wikidata":"https://www.wikidata.org/wiki/Q2537479","display_name":"Serum iron","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.2567000091075897},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/etm.2026.13335","doi":"https://doi.org/10.3892/etm.2026.13335","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2026.13335","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13335/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13711145","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711145/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711145/pdf/etm-32-06-13335.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:42948365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2026.13335","doi":"https://doi.org/10.3892/etm.2026.13335","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2026.13335","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13335/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221677941.pdf","grobid_xml":"https://content.openalex.org/works/W7221677941.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3084346404"],"related_works":["https://openalex.org/W4224225192","https://openalex.org/W2100744313","https://openalex.org/W2904980537","https://openalex.org/W2341906051","https://openalex.org/W2996649030","https://openalex.org/W1829982815","https://openalex.org/W2588500667","https://openalex.org/W4387812488","https://openalex.org/W2597311710","https://openalex.org/W4310756186"],"abstract_inverted_index":{"Cancer-related":[0],"anemia":[1,37,123,147,166,207,227,279,290],"is":[2,13],"common":[3],"in":[4,39,149,169,233,280,333,360],"patients":[5,42,185,281],"with":[6,43,61,68,81,203,210,239,262,274,282,293,300,312],"hepatocellular":[7],"carcinoma":[8],"(HCC),":[9],"and":[10,29,52,64,74,117,127,130,140,145,154,163,176,191,215,217,224,250,268,288,318,331,368],"its":[11,349],"pathogenesis":[12],"complex":[14],"due":[15],"to":[16,135,304],"the":[17,54,192,234,361],"coexistence":[18],"of":[19,47,56,79,183,220,328,363],"chronic":[20,364],"liver":[21,365],"disease,":[22,366],"portal":[23],"hypertension,":[24],"hypersplenism,":[25],"inflammation,":[26],"nutritional":[27],"disorders":[28],"tumor-related":[30,369],"factors.":[31,370],"The":[32,84,314],"present":[33],"retrospective":[34],"study":[35],"characterized":[36],"morphology":[38],"96":[40],"anemic":[41],"HCC":[44,283],"before":[45],"initiation":[46],"their":[48],"first":[49],"antitumor":[50],"therapy,":[51],"examined":[53],"associations":[55],"reticulocyte":[57,113],"hemoglobin":[58,98,107],"equivalent":[59],"(RET-He)":[60],"erythrocyte":[62,301],"indices":[63,302],"serum":[65],"ferritin":[66],"(SF),":[67],"a":[69],"focus":[70],"on":[71,340],"whether":[72],"RET-He":[73,116,128,139,188,221,230,240,258,295,297,317,335],"SF":[75,194,275,319,355],"displayed":[76],"distinct":[77],"patterns":[78],"association":[80,309],"hematological":[82],"parameters.":[83,142],"data":[85],"collected":[86],"included":[87],"sex,":[88],"age,":[89],"Barcelona":[90],"Clinic":[91],"Liver":[92],"Cancer":[93],"stage,":[94],"Child-Pugh":[95],"grade,":[96],"splenomegaly/hypersplenism,":[97],"(Hb)":[99],"concentration,":[100,246,264],"mean":[101,105],"corpuscular":[102,106],"volume":[103],"(MCV),":[104],"(MCH),":[108],"MCH":[109],"concentration":[110],"(MCHC),":[111],"absolute":[112],"count":[114],"(RET#),":[115],"SF.":[118,313],"Patients":[119,238],"were":[120,167],"compared":[121],"by":[122,346],"severity,":[124],"morphological":[125,286],"type":[126],"level,":[129],"Spearman'a":[131],"correlation":[132],"was":[133,195,208,231,259,291,298,310],"used":[134],"assess":[136],"relationships":[137],"between":[138,316],"other":[141],"Mild,":[143],"moderate":[144],"severe":[146],"occurred":[148],"41":[150],"(42.71%),":[151],"52":[152],"(54.17%)":[153],"3":[155],"(3.13%)":[156],"patients,":[157,179],"respectively.":[158,180],"Macrocytic,":[159],"normocytic,":[160],"simple":[161],"microcytic":[162,164,225,235,289],"hypochromic":[165,226],"found":[168],"29":[170],"(30.21%),":[171],"40":[172],"(41.67%),":[173],"5":[174],"(5.21%)":[175],"22":[177],"(22.92%)":[178],"A":[181],"total":[182],"26":[184],"(27.08%)":[186],"had":[187,243],"\u226429":[189,222,241],"pg,":[190],"median":[193],"248.5":[196],"ng/ml":[197],"(interquartile":[198],"range,":[199],"146.8-346.0":[200],"ng/ml).":[201],"Compared":[202],"mild":[204],"anemia,":[205],"moderate-to-severe":[206],"associated":[209,292,299],"lower":[211,244,294],"MCV,":[212,247,265],"MCH,":[213,248,266],"MCHC":[214,249,267],"RET-He,":[216],"higher":[218],"proportions":[219],"pg":[223,242],"(all":[228,252,270],"P<0.05).":[229,253],"lowest":[232],"group":[236],"(P<0.001).":[237],"Hb":[245,263],"RET#":[251,269],"Spearman's":[254],"analysis":[255],"indicated":[256],"that":[257,321],"positively":[260],"correlated":[261],"P<0.05),":[271],"but":[272,348],"not":[273,343],"(P=0.408).":[276],"In":[277],"conclusion,":[278],"demonstrated":[284],"heterogeneous":[285],"patterns,":[287],"levels.":[296],"related":[303],"hemoglobinization,":[305],"whereas":[306],"no":[307],"such":[308],"observed":[311],"dissociation":[315],"suggests":[320],"these":[322],"markers":[323],"may":[324,336],"reflect":[325],"different":[326],"aspects":[327],"iron":[329],"metabolism":[330],"erythropoiesis":[332],"HCC.":[334],"offer":[337],"complementary":[338],"information":[339],"erythroid":[341],"hemoglobinization":[342],"directly":[344],"captured":[345],"SF,":[347],"clinical":[350],"utility":[351],"requires":[352],"further":[353],"validation.":[354],"should":[356],"be":[357],"interpreted":[358],"cautiously":[359],"context":[362],"inflammation":[367]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-14T00:00:00"}