{"id":"https://openalex.org/W7221672964","doi":"https://doi.org/10.3389/fcell.2026.1929282","title":"Dynamic remodeling of microglial responses in Alzheimer\u2019s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulation","display_name":"Dynamic remodeling of microglial responses in Alzheimer\u2019s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulation","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221672964","doi":"https://doi.org/10.3389/fcell.2026.1929282","pmid":"https://pubmed.ncbi.nlm.nih.gov/42947965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710975"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1929282","doi":"https://doi.org/10.3389/fcell.2026.1929282","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1929282","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1929282/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1929282/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158646135","display_name":"Simin Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116868","display_name":"Shandong Sport University","ror":"https://ror.org/026b4k258","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210116868"]},{"id":"https://openalex.org/I4405279728","display_name":"Qilu Medical University","ror":"https://ror.org/01xbh9923","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405279728"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Simin Han","raw_affiliation_strings":["College of Sport and Health, Shandong Sport University","School of Management, Qilu Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Sport and Health, Shandong Sport University","institution_ids":["https://openalex.org/I4210116868"]},{"raw_affiliation_string":"School of Management, Qilu Medical University","institution_ids":["https://openalex.org/I4405279728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158661089","display_name":"Shanshan Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanshan Wang","raw_affiliation_strings":["Department of Neurology, Zibo 148 Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Zibo 148 Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151203180","display_name":"Jingjing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116868","display_name":"Shandong Sport University","ror":"https://ror.org/026b4k258","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210116868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Liu","raw_affiliation_strings":["College of Sport and Health, Shandong Sport University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Sport and Health, Shandong Sport University","institution_ids":["https://openalex.org/I4210116868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158615260","display_name":"Xulin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116868","display_name":"Shandong Sport University","ror":"https://ror.org/026b4k258","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210116868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xulin Liu","raw_affiliation_strings":["College of Sport and Health, Shandong Sport University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Sport and Health, Shandong Sport University","institution_ids":["https://openalex.org/I4210116868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140661570","display_name":"Qinglu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116868","display_name":"Shandong Sport University","ror":"https://ror.org/026b4k258","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210116868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinglu Wang","raw_affiliation_strings":["College of Sport and Health, Shandong Sport University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Sport and Health, Shandong Sport University","institution_ids":["https://openalex.org/I4210116868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136259321","display_name":"Chang Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279728","display_name":"Qilu Medical University","ror":"https://ror.org/01xbh9923","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405279728"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Meng","raw_affiliation_strings":["School of Management, Qilu Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Management, Qilu Medical University","institution_ids":["https://openalex.org/I4405279728"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49356725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"1929282","last_page":"1929282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/disease-associated-microglia","display_name":"disease-associated microglia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/microglial-heterogeneity","display_name":"microglial heterogeneity","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.925000011920929},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.8040000200271606},{"id":"https://openalex.org/keywords/trem2","display_name":"TREM2","score":0.7350000143051147},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microglial-plasticity","display_name":"microglial plasticity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lipid-dysregulation","display_name":"lipid dysregulation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.7009999752044678},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8878999948501587},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8076000213623047},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6377000212669373},{"id":"https://openalex.org/C2779685842","wikidata":"https://www.wikidata.org/wiki/Q18040973","display_name":"TREM2","level":4,"score":0.6032000184059143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5748999714851379},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5454000234603882},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5374000072479248},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5070000290870667},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.36059999465942383},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3474000096321106},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34049999713897705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3393000066280365},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3190000057220459},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3061999976634979},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.272599995136261},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C2992125399","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Lipid accumulation","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2605000138282776}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2026.1929282","doi":"https://doi.org/10.3389/fcell.2026.1929282","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1929282","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1929282/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710975","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710975/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710975/pdf/fcell-14-1929282.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:42947965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42947965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6e7bef22202447309f954c6051c60b39","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6e7bef22202447309f954c6051c60b39","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1929282","doi":"https://doi.org/10.3389/fcell.2026.1929282","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1929282","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1929282/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221672964.pdf","grobid_xml":"https://content.openalex.org/works/W7221672964.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W1980789245","https://openalex.org/W2011041653","https://openalex.org/W2032920422","https://openalex.org/W2033617297","https://openalex.org/W2046847750","https://openalex.org/W2054717478","https://openalex.org/W2060458492","https://openalex.org/W2094660330","https://openalex.org/W2096500024","https://openalex.org/W2122828560","https://openalex.org/W2131686384","https://openalex.org/W2139976280","https://openalex.org/W2190404250","https://openalex.org/W2314634699","https://openalex.org/W2482717739","https://openalex.org/W2619332462","https://openalex.org/W2622807556","https://openalex.org/W2725377723","https://openalex.org/W2743727231","https://openalex.org/W2769071992","https://openalex.org/W2889172944","https://openalex.org/W2894203109","https://openalex.org/W2909504736","https://openalex.org/W2941510527","https://openalex.org/W2942678593","https://openalex.org/W2951541013","https://openalex.org/W2976163884","https://openalex.org/W2980270906","https://openalex.org/W2981166078","https://openalex.org/W2992894594","https://openalex.org/W2996386659","https://openalex.org/W2998795963","https://openalex.org/W2999300346","https://openalex.org/W3000061011","https://openalex.org/W3012111315","https://openalex.org/W3109942090","https://openalex.org/W3173194636","https://openalex.org/W3184188306","https://openalex.org/W3194048913","https://openalex.org/W3198479934","https://openalex.org/W3206683634","https://openalex.org/W4224216596","https://openalex.org/W4244315768","https://openalex.org/W4295903538","https://openalex.org/W4307695821","https://openalex.org/W4308150510","https://openalex.org/W4310461604","https://openalex.org/W4313311888","https://openalex.org/W4315707278","https://openalex.org/W4318984787","https://openalex.org/W4366749218","https://openalex.org/W4378212353","https://openalex.org/W4381189833","https://openalex.org/W4384522480","https://openalex.org/W4385873204","https://openalex.org/W4386162250","https://openalex.org/W4387142551","https://openalex.org/W4387142556","https://openalex.org/W4388207473","https://openalex.org/W4388977617","https://openalex.org/W4392762752","https://openalex.org/W4392807721","https://openalex.org/W4393225316","https://openalex.org/W4396560090","https://openalex.org/W4400091359","https://openalex.org/W4400948944","https://openalex.org/W4401947164","https://openalex.org/W4402143990","https://openalex.org/W4403478971","https://openalex.org/W4404613107","https://openalex.org/W4404870407","https://openalex.org/W4405763994","https://openalex.org/W4405931805","https://openalex.org/W4407045297","https://openalex.org/W4407842359","https://openalex.org/W4408893878","https://openalex.org/W4409086229","https://openalex.org/W4409210053","https://openalex.org/W4409380420","https://openalex.org/W4410494821","https://openalex.org/W4412387828","https://openalex.org/W4412552493","https://openalex.org/W4412929235","https://openalex.org/W4414347863","https://openalex.org/W4415655497","https://openalex.org/W4416663360","https://openalex.org/W4416898742","https://openalex.org/W7119065993","https://openalex.org/W7119138571","https://openalex.org/W7125608282","https://openalex.org/W7163507268"],"related_works":["https://openalex.org/W7169715563","https://openalex.org/W7221096771","https://openalex.org/W4281564272","https://openalex.org/W7167628425","https://openalex.org/W7161121117","https://openalex.org/W3006325627","https://openalex.org/W4281717678","https://openalex.org/W4387142551","https://openalex.org/W7139978124","https://openalex.org/W4366772456"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,86],"(AD)":[2],"is":[3],"characterized":[4],"by":[5],"progressive":[6],"neuroinflammation":[7],"involving":[8],"microglia":[9,31],"whose":[10],"functional":[11,67,178],"responses":[12],"extend":[13],"far":[14],"beyond":[15],"the":[16,63,150,164],"classical":[17],"M1/M2":[18],"framework":[19,155],"and":[20,34,43,66,76,85,93,102,114,135,158,162,170,177],"form":[21],"a":[22,145],"dynamically":[23],"heterogeneous":[24],"continuum.":[25],"Here,":[26],"we":[27],"review":[28],"recurrent":[29],"disease-associated":[30],"(DAM)":[32],"states":[33,179],"transcriptional":[35],"programs,":[36],"including":[37,133],"DAM-associated,":[38],"interferon-responsive,":[39],"cytokine-responsive,":[40],"proliferative,":[41],"antigen-presentation-associated,":[42],"lipid-associated":[44],"features,":[45],"emphasizing":[46],"that":[47],"these":[48,70],"labels":[49],"do":[50],"not":[51],"necessarily":[52],"represent":[53],"fixed":[54],"or":[55],"mutually":[56],"exclusive":[57],"cellular":[58],"subtypes.":[59],"Across":[60],"AD":[61,130],"progression,":[62],"relative":[64],"engagement":[65],"consequences":[68],"of":[69,119,152],"programs":[71,89],"vary":[72],"according":[73],"to":[74,166,173],"A\u03b2":[75],"tau":[77,127],"burden,":[78],"local":[79],"microenvironment,":[80],"genetic":[81],"background,":[82],"metabolic":[83,103],"status,":[84],"stage.":[87],"DAM-associated":[88],"may":[90],"support":[91],"phagocytosis":[92],"plaque":[94],"containment":[95],"in":[96,117,144,180],"some":[97],"contexts,":[98],"whereas":[99],"persistent":[100],"inflammatory":[101,115],"stress":[104],"can":[105],"increase":[106],"lipid":[107],"dysregulation,":[108],"mitochondrial":[109],"dysfunction,":[110],"impaired":[111],"phagocytic":[112],"competence,":[113],"signaling":[116],"subsets":[118],"microglia.":[120],"Microglia":[121],"also":[122],"exert":[123],"bidirectional":[124],"effects":[125],"on":[126],"pathology.":[128],"Core":[129],"risk":[131],"pathways,":[132],"TREM2":[134],"APOE,":[136],"together":[137],"with":[138],"immunometabolic":[139],"remodeling,":[140],"shape":[141],"microglial":[142,175],"plasticity":[143],"context-dependent":[146],"manner.":[147],"We":[148],"discuss":[149],"implications":[151],"this":[153],"dynamic":[154],"for":[156],"stage-":[157],"state-aware":[159],"therapeutic":[160],"strategies":[161],"highlight":[163],"need":[165],"integrate":[167],"single-cell,":[168],"spatial,":[169],"multi-omic":[171],"approaches":[172],"resolve":[174],"trajectories":[176],"human":[181],"AD.":[182]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-14T00:00:00"}
