{"id":"https://openalex.org/W7221668487","doi":"https://doi.org/10.64898/2026.10.06.757042","title":"Dual Roles of Interferon-\u03b3 Receptor in Somatostatin Interneurons at Baseline and During","display_name":"Dual Roles of Interferon-\u03b3 Receptor in Somatostatin Interneurons at Baseline and During","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221668487","doi":"https://doi.org/10.64898/2026.10.06.757042"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.06.757042","doi":"https://doi.org/10.64898/2026.10.06.757042","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757042","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.06.757042.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.06.757042.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005546144","display_name":"Sara Rezaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sara Rezaei","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024320075","display_name":"Toshifumi Tomoda","orcid":"https://orcid.org/0000-0003-3587-0914","observed_orcids":["https://orcid.org/0000-0003-3587-0914"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Toshifumi Tomoda","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","Department of Psychiatry, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158658825","display_name":"Michael Marcotte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Marcotte","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005081549","display_name":"Thomas D. Pr\u00e9vot","orcid":"https://orcid.org/0000-0002-6774-603X","observed_orcids":["https://orcid.org/0000-0002-6774-603X"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas D. Prevot","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","Department of Psychiatry, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004477208","display_name":"Mounira Banasr","orcid":"https://orcid.org/0000-0002-9347-7523","observed_orcids":["https://orcid.org/0000-0002-9347-7523","https://orcid.org/0000-0003-4619-4632"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mounira Banasr","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","Department of Psychiatry, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103067297","display_name":"Yashika Bansal","orcid":"https://orcid.org/0000-0002-3912-9579","observed_orcids":["https://orcid.org/0000-0002-3912-9579"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yashika Bansal","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158579153","display_name":"Ali Ezzeddine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ali Ezzeddine","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113049132","display_name":"Aaron Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aaron Guan","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121931096","display_name":"Erica Vieira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Erica Vieira","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","Department of Psychiatry, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158607993","display_name":"Etienne Sibille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Etienne Sibille","raw_affiliation_strings":["Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","Department of Psychiatry, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada,","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5158607993"],"corresponding_institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma-receptor","display_name":"interferon-gamma receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/somatostatin-interneurons","display_name":"somatostatin interneurons","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gabaergic-dysfunction","display_name":"GABAergic dysfunction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9700000286102295},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9909999966621399},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.8410000205039978},{"id":"https://openalex.org/keywords/synapsin-1","display_name":"synapsin-1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gephyrin","display_name":"gephyrin","score":0.7620000243186951},{"id":"https://openalex.org/keywords/allograft-inflammatory-factor-1","display_name":"allograft inflammatory factor-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5153999924659729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5094000101089478},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45350000262260437},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.43369999527931213},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4239000082015991},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3865000009536743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.376800000667572},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.3693999946117401},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3434999883174896},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.3336000144481659},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31279999017715454},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.27230000495910645},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26429998874664307},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25929999351501465},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.25760000944137573},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.25619998574256897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.06.757042","doi":"https://doi.org/10.64898/2026.10.06.757042","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757042","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.06.757042.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.06.757042","doi":"https://doi.org/10.64898/2026.10.06.757042","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.06.757042","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.06.757042.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G100551774","display_name":null,"funder_award_id":"165852","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221668487.pdf","grobid_xml":"https://content.openalex.org/works/W7221668487.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986916303","https://openalex.org/W2094913456","https://openalex.org/W2622461305","https://openalex.org/W4393070997","https://openalex.org/W4409280658","https://openalex.org/W2556544290","https://openalex.org/W1924066","https://openalex.org/W1988788559","https://openalex.org/W2741540769","https://openalex.org/W4414520423"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Neuropsychiatric":[2],"disorders":[3],"such":[4],"as":[5],"major":[6,238],"depressive":[7,239],"disorder":[8,240],"show":[9],"converging":[10],"evidence":[11],"of":[12,85,112],"gamma-aminobutyric":[13],"acid":[14],"(GABA)":[15],"dysfunction,":[16],"including":[17],"consistent":[18],"reductions":[19,174],"in":[20,44,58,65,130,178,182,209,237,245],"somatostatin":[21],"(SST)":[22],"interneuron":[23],"markers.":[24],"SST":[25,66,88,131,183,210,246],"interneurons":[26,67],"are":[27],"selectively":[28],"vulnerable":[29],"to":[30,232],"inflammation,":[31,127],"yet":[32],"the":[33,51,233],"underlying":[34],"mechanisms":[35],"remain":[36],"unclear.":[37],"Interferon-gamma":[38],"(IFN-\u03b3),":[39],"a":[40,213],"pro-inflammatory":[41],"cytokine":[42],"implicated":[43,236],"mood":[45],"and":[46,70,73,90,98,105,116,124,166,194,219,241,255],"anxiety":[47],"disorders,":[48],"signals":[49],"through":[50],"IFN-\u03b3":[52],"receptor":[53],"(IFNGR),":[54],"which":[55],"is":[56],"expressed":[57],"neurons.":[59],"We":[60,79],"tested":[61],"whether":[62],"IFNGR":[63,86,128,181,207,243],"signaling":[64,208,231,244],"regulates":[68],"anxiety-like":[69,92,134],"cognitive":[71],"behavior":[72,93,135,218],"prevents":[74],"inflammation-induced":[75],"molecular":[76,220,225],"deficits.":[77,226],"Methods":[78],"generated":[80],"mice":[81,179],"with":[82],"conditional":[83],"deletion":[84,129],"from":[87],"cells":[89,132,211,247],"assessed":[91],"using":[94,101],"elevated":[95],"plus":[96],"maze":[97],"working":[99,138],"memory":[100],"Y-maze":[102],"at":[103,253],"baseline":[104,123,189,254],"after":[106,125],"lipopolysaccharide":[107],"(LPS)":[108],"induced":[109],"inflammation.":[110],"Expression":[111],"SST-related,":[113],"neurotrophic,":[114],"synaptic,":[115],"glial":[117],"markers":[118],"was":[119],"quantified.":[120],"Results":[121],"At":[122],"LPS-induced":[126,224],"increased":[133],"without":[136],"affecting":[137],"memory.":[139],"In":[140],"control":[141],"mice,":[142],"LPS":[143],"reduced":[144],"Sst":[145],"(":[146,151,154,160,163,169,199],"p=":[147,155],"0.0006),":[148],"neuropeptide":[149],"Y":[150],"Npy":[152],")":[153,162,171],"0.0022),":[156],"brain-derived":[157],"neurotrophic":[158],"factor":[159,197],"Bdnf":[161],"p":[164],"<0.0001),":[165],"synapsin":[167],"1":[168,198],"Syn1":[170],"(p=0.0150);":[172],"these":[173],"were":[175],"not":[176],"significant":[177],"lacking":[180],"cells.":[184],"Knockouts":[185],"also":[186],"showed":[187],"lower":[188],"Bdnf,":[190],"Syn1,":[191],"Gephyrin":[192],"(Gphn),":[193],"allograft":[195],"inflammatory":[196,257],"Aif1":[200],",":[201],"encoding":[202],"Iba1)":[203],"than":[204],"controls.":[205],"Conclusions":[206],"plays":[212],"dual":[214],"role:":[215],"supporting":[216],"normal":[217],"homeostasis":[221],"while":[222],"mediating":[223],"These":[227],"findings":[228],"link":[229],"immune":[230],"GABAergic":[234],"dysfunction":[235],"suggest":[242],"may":[248],"regulate":[249],"cortical":[250],"microcircuit":[251],"integrity":[252],"during":[256],"challenge.":[258]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-14T00:00:00"}