{"id":"https://openalex.org/W7221649280","doi":"https://doi.org/10.5281/zenodo.23345739","title":"DEVELOPMENT AND VALIDATION OF HPLC METHODS FOR QUANTITATIVE ANALYSIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) IN COMPLEX FORMULATIONS","display_name":"DEVELOPMENT AND VALIDATION OF HPLC METHODS FOR QUANTITATIVE ANALYSIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) IN COMPLEX FORMULATIONS","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221649280","doi":"https://doi.org/10.5281/zenodo.23345739"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23345739","doi":"https://doi.org/10.5281/zenodo.23345739","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23345739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23345739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158639438","display_name":"Waghamare Suresh Aashutosh Yeole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aashutosh Yeole, Waghamare Suresh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5158639438"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hplc-method-development","display_name":"HPLC method development","score":0.9679999947547913},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.9890000224113464},{"id":"https://openalex.org/keywords/quantitative-analysis","display_name":"quantitative analysis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.9089999794960022},{"id":"https://openalex.org/keywords/robustness","display_name":"robustness","score":0.8320000171661377},{"id":"https://openalex.org/keywords/limit-of-detection-and-quantification","display_name":"detection and quantification limits","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.574999988079071},{"id":"https://openalex.org/keywords/dissolution-testing","display_name":"dissolution testing","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.7175999879837036},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7001000046730042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6363999843597412},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.5985000133514404},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5442000031471252},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5335000157356262},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.4828000068664551},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.448199987411499},{"id":"https://openalex.org/C45188465","wikidata":"https://www.wikidata.org/wiki/Q645497","display_name":"Reversed-phase chromatography","level":3,"score":0.4041000008583069},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.33149999380111694},{"id":"https://openalex.org/C2778870860","wikidata":"https://www.wikidata.org/wiki/Q4751155","display_name":"Analytical procedures","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.30160000920295715},{"id":"https://openalex.org/C2779535233","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Pharmaceutical drug","level":3,"score":0.30079999566078186},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C2983406500","wikidata":"https://www.wikidata.org/wiki/Q7604347","display_name":"Stationary phase","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C170814935","wikidata":"https://www.wikidata.org/wiki/Q4751159","display_name":"Analytical technique","level":2,"score":0.2777999937534332},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23345739","doi":"https://doi.org/10.5281/zenodo.23345739","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23345739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.23345740","doi":"https://doi.org/10.5281/zenodo.23345740","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23345740","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23345739","doi":"https://doi.org/10.5281/zenodo.23345739","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23345739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7128962159","https://openalex.org/W7167582290","https://openalex.org/W7106151296","https://openalex.org/W7128922755","https://openalex.org/W6892970518","https://openalex.org/W4406847819","https://openalex.org/W4415588184","https://openalex.org/W4416693721","https://openalex.org/W4391284741","https://openalex.org/W995219566"],"abstract_inverted_index":{"High-Performance":[0],"Liquid":[1],"Chromatography":[2],"(HPLC)":[3],"is":[4,44,96,125],"a":[5,88],"powerful":[6],"and":[7,17,40,43,75,91,102,118,122,134,144,160],"widely":[8],"used":[9],"analytical":[10],"technique":[11,29,148],"for":[12,47],"the":[13,37,71,79,100,105,155],"separation,":[14],"identification,":[15],"purification,":[16],"quantitative":[18,92],"determination":[19],"of":[20,58,70,78,83,87,104,120,162],"active":[21],"pharmaceutical":[22,48,129,163],"ingredients":[23],"(APIs)":[24],"in":[25,128,153],"complex":[26],"formulations.":[27],"The":[28,56,147],"separates":[30],"components":[31],"based":[32],"on":[33],"their":[34],"interactions":[35],"with":[36],"stationary":[38],"phase":[39,42],"mobile":[41,80],"particularly":[45],"useful":[46],"compounds":[49],"that":[50],"are":[51],"non-volatile":[52],"or":[53],"thermally":[54],"unstable.":[55],"development":[57,77],"an":[59,150],"HPLC":[60,124],"method":[61,107],"involves":[62],"several":[63],"important":[64,151],"steps,":[65],"including":[66],"sample":[67],"preparation,":[68],"selection":[69,86],"appropriate":[72],"chromatographic":[73,84],"mode":[74],"column,":[76],"phase,":[81],"optimization":[82],"conditions,":[85],"suitable":[89],"detector,":[90],"analysis.":[93,146],"Method":[94],"validation":[95],"performed":[97],"to":[98],"establish":[99],"reliability":[101],"suitability":[103],"developed":[106],"by":[108],"evaluating":[109],"parameters":[110],"such":[111],"as":[112,137,139],"accuracy,":[113],"precision,":[114],"linearity,":[115],"specificity,":[116],"robustness,":[117],"limits":[119],"detection":[121],"quantification.":[123],"extensively":[126],"applied":[127],"quality":[130],"control,":[131],"drug":[132],"stability":[133],"dissolution":[135],"studies,":[136],"well":[138],"clinical,":[140],"forensic,":[141],"environmental,":[142],"food,":[143],"flavor":[145],"plays":[149],"role":[152],"ensuring":[154],"quality,":[156],"purity,":[157],"safety,":[158],"efficacy,":[159],"consistency":[161],"products.":[164],"Keywords:":[165],"HPLC,":[166],"Chromatography,":[167],"Wavelength,":[168],"Robustness,":[169],"Manufacturing.":[170]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-14T00:00:00"}