{"id":"https://openalex.org/W7221643255","doi":"https://doi.org/10.3389/fcvm.2026.1790767","title":"Age-related cardiac dysfunction is not associated with shorter telomere length in laboratory rats","display_name":"Age-related cardiac dysfunction is not associated with shorter telomere length in laboratory rats","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221643255","doi":"https://doi.org/10.3389/fcvm.2026.1790767","pmid":"https://pubmed.ncbi.nlm.nih.gov/42947745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710237"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1790767","doi":"https://doi.org/10.3389/fcvm.2026.1790767","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1790767","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1790767/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1790767/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158562662","display_name":"Sindre T. Strandberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sindre T. Strandberg","raw_affiliation_strings":["Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085412635","display_name":"Trine Baur Opstad","orcid":"https://orcid.org/0000-0002-9229-3132","observed_orcids":["https://orcid.org/0000-0002-9229-3132"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Trine B. Opstad","raw_affiliation_strings":["Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045691838","display_name":"Andreas Romaine","orcid":"https://orcid.org/0000-0002-4952-7052","observed_orcids":["https://orcid.org/0000-0002-4952-7052"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Andreas Romaine","raw_affiliation_strings":["Institute for Surgical Research, Oslo University Hospital","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Surgical Research, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158575641","display_name":"Emil Espe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210122484","display_name":"Institutt for Eksperimentell Medisinsk Forskning","ror":"https://ror.org/027n77q19","country_code":"NO","type":"education","lineage":["https://openalex.org/I4210122484"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Emil Espe","raw_affiliation_strings":["Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183","https://openalex.org/I4210122484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158660628","display_name":"Mani Sadredini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184531372","display_name":"OsloMet \u2013 Oslo Metropolitan University","ror":"https://ror.org/04q12yn84","country_code":"NO","type":"education","lineage":["https://openalex.org/I184531372"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210122484","display_name":"Institutt for Eksperimentell Medisinsk Forskning","ror":"https://ror.org/027n77q19","country_code":"NO","type":"education","lineage":["https://openalex.org/I4210122484"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Mani Sadredini","raw_affiliation_strings":["Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University","Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University","institution_ids":["https://openalex.org/I184531372"]},{"raw_affiliation_string":"Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183","https://openalex.org/I4210122484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158564839","display_name":"Kari Gulbrandsen L\u00f8ken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210122484","display_name":"Institutt for Eksperimentell Medisinsk Forskning","ror":"https://ror.org/027n77q19","country_code":"NO","type":"education","lineage":["https://openalex.org/I4210122484"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kari Gulbrandsen L\u00f8ken","raw_affiliation_strings":["Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183","https://openalex.org/I4210122484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007651319","display_name":"Sheryl Palmero","orcid":"https://orcid.org/0000-0002-8130-107X","observed_orcids":["https://orcid.org/0000-0002-8130-107X"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sheryl Palmero","raw_affiliation_strings":["Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082700741","display_name":"J\u00f8rgen A. Gravning","orcid":"https://orcid.org/0000-0002-2035-627X","observed_orcids":["https://orcid.org/0000-0002-2035-627X"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"J\u00f8rgen A. Gravning","raw_affiliation_strings":["Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072502003","display_name":"Ivar Sjaastad","orcid":"https://orcid.org/0000-0002-0131-2036","observed_orcids":["https://orcid.org/0000-0002-0131-2036"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210122484","display_name":"Institutt for Eksperimentell Medisinsk Forskning","ror":"https://ror.org/027n77q19","country_code":"NO","type":"education","lineage":["https://openalex.org/I4210122484"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ivar Sjaastad","raw_affiliation_strings":["Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183","https://openalex.org/I4210122484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042601092","display_name":"Ida Gjervold Lunde","orcid":"https://orcid.org/0000-0001-9502-6841","observed_orcids":["https://orcid.org/0000-0001-9502-6841"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ida G. Lunde","raw_affiliation_strings":["KG Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, University of Oslo","Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KG Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, University of Oslo","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018037750","display_name":"Mathis K. Stokke","orcid":"https://orcid.org/0000-0002-8869-8153","observed_orcids":["https://orcid.org/0000-0002-8869-8153"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210122484","display_name":"Institutt for Eksperimentell Medisinsk Forskning","ror":"https://ror.org/027n77q19","country_code":"NO","type":"education","lineage":["https://openalex.org/I4210122484"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Mathis K. Stokke","raw_affiliation_strings":["Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Medical Research (IEMR), University of Oslo and Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183","https://openalex.org/I4210122484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158617483","display_name":"Ragnhild Helseth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Ragnhild Helseth","raw_affiliation_strings":["Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo Center for Clinical Heart Research (Oslo-CCHR), Department of Cardiology Ullevaal, Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5158617483"],"corresponding_institution_ids":["https://openalex.org/I1281400175"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78011667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1790767","last_page":"1790767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.8420000076293945},{"id":"https://openalex.org/keywords/age-related-cardiac-dysfunction","display_name":"age-related cardiac dysfunction","score":0.847000002861023},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/leukocyte-telomere-length","display_name":"leukocyte telomere length","score":0.9610000252723694},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.671999990940094},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.578000009059906},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8403000235557556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7307999730110168},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.6743999719619751},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.5436999797821045},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.5360000133514404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5336999893188477},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5218999981880188},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5101000070571899},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.5048999786376953},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.45350000262260437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4185999929904938},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.40560001134872437},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.3840999901294708},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3544999957084656},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3467999994754791},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33709999918937683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33239999413490295},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C2993469949","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Cardiac dysfunction","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.25600001215934753},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2026.1790767","doi":"https://doi.org/10.3389/fcvm.2026.1790767","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1790767","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1790767/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710237","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710237/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710237/pdf/fcvm-13-1790767.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:42947745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42947745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e3914299e1b2461e82e8b2ec708aecdd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e3914299e1b2461e82e8b2ec708aecdd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1790767","doi":"https://doi.org/10.3389/fcvm.2026.1790767","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1790767","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1790767/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323260","display_name":"Universitetet i Oslo","ror":"https://ror.org/01xtthb56"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221643255.pdf","grobid_xml":"https://content.openalex.org/works/W7221643255.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1826750984","https://openalex.org/W1996380574","https://openalex.org/W2003035943","https://openalex.org/W2006389323","https://openalex.org/W2023591374","https://openalex.org/W2033855112","https://openalex.org/W2073244138","https://openalex.org/W2091267313","https://openalex.org/W2108244360","https://openalex.org/W2160621707","https://openalex.org/W2257383956","https://openalex.org/W2514354384","https://openalex.org/W2619173638","https://openalex.org/W2751811457","https://openalex.org/W2783839013","https://openalex.org/W2805577315","https://openalex.org/W2892804608","https://openalex.org/W3006313637","https://openalex.org/W3007560401","https://openalex.org/W3084920978","https://openalex.org/W3111207111","https://openalex.org/W3136265970","https://openalex.org/W3204811749","https://openalex.org/W4212937702","https://openalex.org/W4214601236","https://openalex.org/W4236357753","https://openalex.org/W4286588842","https://openalex.org/W4313531093","https://openalex.org/W4317733679","https://openalex.org/W4385265026","https://openalex.org/W4392077460","https://openalex.org/W4392468734","https://openalex.org/W4394578536","https://openalex.org/W4395699481","https://openalex.org/W4399731281","https://openalex.org/W4403645639","https://openalex.org/W4404738383"],"related_works":["https://openalex.org/W2327568272","https://openalex.org/W3134420150","https://openalex.org/W1807933617","https://openalex.org/W2045483603","https://openalex.org/W2169264885","https://openalex.org/W2280114093","https://openalex.org/W2820573084","https://openalex.org/W7095404932","https://openalex.org/W2745233491","https://openalex.org/W1963839660"],"abstract_inverted_index":{"Introduction":[0],"Ageing":[1],"is":[2,24,36,44],"an":[3],"independent":[4],"risk":[5],"factor":[6],"for":[7,247],"cardiovascular":[8],"disease":[9],"(CVD).":[10],"Preclinical":[11],"models":[12,55],"of":[13,109,173,254,271],"ageing":[14,30],"are":[15],"needed":[16],"to":[17,52,147],"better":[18],"understand":[19],"human":[20,263],"diseases.":[21],"Telomere":[22],"shortening":[23,40],"a":[25,282],"critical":[26],"process":[27],"in":[28,41,75,115,121,275],"cellular":[29],"and":[31,68,72,111,117,124,153,161,165,169,179,187,210,227,260],"senescence.":[32],"In":[33],"humans,":[34],"it":[35],"well-established":[37],"that":[38],"telomere":[39,61,65,105,273],"circulating":[42,122,276],"leukocytes":[43,123,277],"associated":[45],"with":[46,140,241],"CVD,":[47],"however,":[48],"whether":[49],"this":[50],"applies":[51],"common":[53],"preclinical":[54],"remains":[56],"disputable.":[57],"We":[58],"investigated":[59],"leukocyte":[60],"length":[62,66],"(LTL),":[63],"cardiac":[64,70,151,171,242,258,264,279],"(CTL),":[67],"age-related":[69],"remodeling":[71],"functional":[73],"decline":[74],"commonly":[76],"used":[77],"laboratory":[78],"rats.":[79],"Methods":[80],"Sprague-Dawley":[81],"rats":[82,253],"(":[83,176,181,232],"n":[84],"=":[85,208,224,234,237],"51)":[86],"were":[87,119],"euthanized":[88],"at":[89],"3,":[90],"9,":[91],"16,":[92],"or":[93,130,135],"24":[94,204,220],"months":[95,145,197,201,205,213,217,221],"(mo),":[96],"respectively.":[97],"Cardiac":[98],"function":[99],"was":[100,244],"assessed":[101],"by":[102,128,158],"echocardiography.":[103],"Relative":[104,185],"length,":[106],"mRNA":[107],"levels":[108],"telomerase":[110],"signature":[112],"genes":[113],"involved":[114],"inflammation":[116],"fibrosis":[118],"quantified":[120],"left":[125],"ventricular":[126],"tissue":[127],"quantitative":[129],"digital":[131],"droplet":[132],"PCR":[133],"(qPCR":[134],"ddPCR,":[136],"respectively).":[137],"Results":[138],"Rats":[139],"increasing":[141],"chronological":[142,192],"age":[143,193,256],"(16/24":[144],"compared":[146],"9":[148,196,212],"months)":[149],"exhibited":[150,257],"hypertrophy":[152,259],"diastolic":[154],"dysfunction,":[155,261],"as":[156],"evidenced":[157],"increased":[159,170],"septal":[160],"posterior":[162],"wall":[163],"thickness,":[164],"elevated":[166],"E/e\u2019":[167],"ratio,":[168],"expression":[172],"central":[174],"inflammatory":[175],"Il6":[177],")":[178,183],"fibrotic":[180],"Ctgf":[182],"genes.":[184],"LTL":[186,228,248],"CTL":[188,226],"remained":[189],"unchanged":[190],"across":[191],"groups":[194],"(LTL:":[195],"1.000":[198,214],"vs.":[199,203,215,219],"16":[200,216],"0.939":[202],"1.120,":[206],"p":[207,223,236],"0.37;":[209],"CTL:":[211],"1.021":[218],"0.897,":[222],"0.42).":[225],"did":[229],"not":[230],"correlate":[231],"r":[233],"\u22120.027,":[235],"0.89).":[238],"No":[239],"association":[240],"dysfunction":[243],"observed,":[245],"neither":[246],"nor":[249,278],"CTL.":[250],"Discussion":[251],"Laboratory":[252],"high":[255],"resembling":[262],"ageing,":[265],"however":[266],"we":[267],"found":[268],"no":[269],"evidence":[270],"shorter":[272],"lengths":[274],"cells,":[280],"suggesting":[281],"translational":[283],"gap.":[284]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-14T00:00:00"}