{"id":"https://openalex.org/W7221636767","doi":"https://doi.org/10.1016/j.nbd.2026.107648","title":"D2 dopamine and CB2 cannabinoid receptor cooperation restores striatal LTP in an epilepsy model","display_name":"D2 dopamine and CB2 cannabinoid receptor cooperation restores striatal LTP in an epilepsy model","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221636767","doi":"https://doi.org/10.1016/j.nbd.2026.107648","pmid":"https://pubmed.ncbi.nlm.nih.gov/42869231"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbd.2026.107648","doi":"https://doi.org/10.1016/j.nbd.2026.107648","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107648","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.nbd.2026.107648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004070239","display_name":"Miriam Sciaccaluga","orcid":"https://orcid.org/0000-0001-7951-8045","observed_orcids":["https://orcid.org/0000-0001-7951-8045"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Miriam Sciaccaluga","raw_affiliation_strings":["Department of Life Science, Health, and Health Professions, Link University, Rome, Italy; Fondazione Malattie Rare Mauro Baschirotto BIRD Onlus, Longare, VI, Italy; Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy. Electronic address: m.sciaccaluga@unilink.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Health, and Health Professions, Link University, Rome, Italy; Fondazione Malattie Rare Mauro Baschirotto BIRD Onlus, Longare, VI, Italy; Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy. Electronic address: m.sciaccaluga@unilink.it","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042943034","display_name":"Laura Bellingacci","orcid":"https://orcid.org/0000-0001-7514-2079","observed_orcids":["https://orcid.org/0000-0001-7514-2079"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Bellingacci","raw_affiliation_strings":["Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050161226","display_name":"Valentina Imperatore","orcid":"https://orcid.org/0000-0002-3608-6999","observed_orcids":["https://orcid.org/0000-0002-3608-6999"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Imperatore","raw_affiliation_strings":["Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158646350","display_name":"Anna Aurora Taddei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Aurora Taddei","raw_affiliation_strings":["Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015556586","display_name":"Alessandro Tozzi","orcid":"https://orcid.org/0000-0003-3153-2424","observed_orcids":["https://orcid.org/0000-0003-3153-2424"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Tozzi","raw_affiliation_strings":["Section of Physiology and Biochemistry, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Physiology and Biochemistry, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050850872","display_name":"Massimiliano Di Filippo","orcid":"https://orcid.org/0000-0002-2645-7477","observed_orcids":["https://orcid.org/0000-0002-2645-7477"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimiliano Di Filippo","raw_affiliation_strings":["Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034505614","display_name":"Marta Barzasi","orcid":"https://orcid.org/0009-0008-5282-1747","observed_orcids":["https://orcid.org/0009-0008-5282-1747"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Barzasi","raw_affiliation_strings":["Department of Pharmacological and Biomolecular Sciences, University of Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Biomolecular Sciences, University of Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001945408","display_name":"Fabrizio Gardoni","orcid":"https://orcid.org/0000-0003-4598-5563","observed_orcids":["https://orcid.org/0000-0003-4598-5563"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Gardoni","raw_affiliation_strings":["Department of Pharmacological and Biomolecular Sciences, University of Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Biomolecular Sciences, University of Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103269780","display_name":"Marina P. S\u00e1nchez","orcid":"https://orcid.org/0000-0001-6785-7680","observed_orcids":["https://orcid.org/0000-0001-6785-7680"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]},{"id":"https://openalex.org/I4405264755","display_name":"Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/02whsjy88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210129357","https://openalex.org/I4405264755"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marina P. S\u00e1nchez","raw_affiliation_strings":["Laboratory of Neurology, Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurology, Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain","institution_ids":["https://openalex.org/I4210129357","https://openalex.org/I4405264755","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112002907","display_name":"Jos\u00e9 M. Serratosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]},{"id":"https://openalex.org/I4405264755","display_name":"Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/02whsjy88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210129357","https://openalex.org/I4405264755"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Serratosa","raw_affiliation_strings":["Laboratory of Neurology, Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurology, Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain","institution_ids":["https://openalex.org/I4210129357","https://openalex.org/I4405264755","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019846852","display_name":"Lucilla Parnetti","orcid":"https://orcid.org/0000-0001-5722-3967","observed_orcids":["https://orcid.org/0000-0001-5722-3967"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucilla Parnetti","raw_affiliation_strings":["Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158654550","display_name":"Andrea Mancini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Mancini","raw_affiliation_strings":["Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035870058","display_name":"Cinzia Costa","orcid":"https://orcid.org/0000-0002-4862-4221","observed_orcids":["https://orcid.org/0000-0002-4862-4221"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cinzia Costa","raw_affiliation_strings":["Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy. Electronic address: cinzia.costa@unipg.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy; Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy. Electronic address: cinzia.costa@unipg.it","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004070239","https://openalex.org/A5035870058"],"corresponding_institution_ids":["https://openalex.org/I27483092"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":{"value":4180,"currency":"USD","value_usd":4180},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67539267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"231","issue":null,"first_page":"107648","last_page":"107648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.3944999873638153,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lafora-disease","display_name":"Lafora disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/striatal-medium-spiny-neurons","display_name":"striatal medium spiny neurons","score":0.9369999766349792},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nmda-receptor-subunits","display_name":"NMDA receptor subunits","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":1.0},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.7739999890327454},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5817999839782715},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5684000253677368},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.5604000091552734},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5446000099182129},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.5404999852180481},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.5367000102996826},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.45570001006126404},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.44760000705718994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43470001220703125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3684000074863434},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.35830000042915344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3531000018119812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3528999984264374},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.33070001006126404},{"id":"https://openalex.org/C120750228","wikidata":"https://www.wikidata.org/wiki/Q2035393","display_name":"Dopamine receptor D1","level":4,"score":0.3296000063419342},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.28110000491142273},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.27799999713897705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2513999938964844}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.nbd.2026.107648","doi":"https://doi.org/10.1016/j.nbd.2026.107648","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107648","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"pmid:42869231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42869231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1276542","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1276542","pdf_url":"https://air.unimi.it/bitstream/2434/1276542/4/1-s2.0-S0969996126003943-main.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:660171e661264fc1974c91f93ef64016","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/660171e661264fc1974c91f93ef64016","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 231, Iss , Pp 107648- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.nbd.2026.107648","doi":"https://doi.org/10.1016/j.nbd.2026.107648","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107648","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309725","display_name":"Fondazione Italiana Sclerosi Multipla","ror":"https://ror.org/006z1y950"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320324979","display_name":"Universit\u00e0 degli Studi di Udine","ror":null},{"id":"https://openalex.org/F4320326523","display_name":"Universit\u00e0 degli Studi di Perugia","ror":"https://ror.org/00x27da85"},{"id":"https://openalex.org/F7311471023","display_name":"NextGenerationEU","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221636767.pdf","grobid_xml":"https://content.openalex.org/works/W7221636767.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1542528083","https://openalex.org/W1550260758","https://openalex.org/W1634005937","https://openalex.org/W1821373092","https://openalex.org/W1958547196","https://openalex.org/W1966303381","https://openalex.org/W1966443363","https://openalex.org/W2003314029","https://openalex.org/W2014980565","https://openalex.org/W2025046694","https://openalex.org/W2034259033","https://openalex.org/W2050066016","https://openalex.org/W2058077554","https://openalex.org/W2059243765","https://openalex.org/W2081706868","https://openalex.org/W2083832493","https://openalex.org/W2092535327","https://openalex.org/W2094654753","https://openalex.org/W2104504339","https://openalex.org/W2109789978","https://openalex.org/W2118830830","https://openalex.org/W2122333521","https://openalex.org/W2131667348","https://openalex.org/W2135184362","https://openalex.org/W2147122909","https://openalex.org/W2154974608","https://openalex.org/W2155416349","https://openalex.org/W2159609705","https://openalex.org/W2161825563","https://openalex.org/W2167021628","https://openalex.org/W2213719612","https://openalex.org/W2258636851","https://openalex.org/W2437830582","https://openalex.org/W2608948341","https://openalex.org/W2619940596","https://openalex.org/W2740931961","https://openalex.org/W2767171461","https://openalex.org/W2792857412","https://openalex.org/W2793615518","https://openalex.org/W2889692592","https://openalex.org/W2907499793","https://openalex.org/W2941525855","https://openalex.org/W2976141814","https://openalex.org/W2981178372","https://openalex.org/W2989864966","https://openalex.org/W2989939721","https://openalex.org/W2996308318","https://openalex.org/W3007463076","https://openalex.org/W3009580564","https://openalex.org/W3137928800","https://openalex.org/W3193860031","https://openalex.org/W3197313500","https://openalex.org/W4205179746","https://openalex.org/W4253524409","https://openalex.org/W4301599748","https://openalex.org/W4310232735","https://openalex.org/W4311289066","https://openalex.org/W4313422396","https://openalex.org/W4365452575","https://openalex.org/W4382582744","https://openalex.org/W4392659245","https://openalex.org/W4396891507","https://openalex.org/W4406303350","https://openalex.org/W4406365921","https://openalex.org/W4406632638"],"related_works":["https://openalex.org/W2894991744","https://openalex.org/W1755374671","https://openalex.org/W1991492258","https://openalex.org/W3007593857","https://openalex.org/W2929292891","https://openalex.org/W4417497935","https://openalex.org/W2003314029","https://openalex.org/W2002851360","https://openalex.org/W1573319238","https://openalex.org/W7123605490"],"abstract_inverted_index":{"Increasing":[0],"evidence":[1],"suggests":[2],"that":[3],"subcortical":[4],"structures":[5],"contribute":[6],"to":[7,64,119,126],"seizure":[8],"susceptibility":[9],"and":[10,24,35,70,85,94,102,109,125,137,153],"cognitive":[11],"impairment":[12],"in":[13,27,82,112,131,150],"several":[14],"epileptic":[15],"syndromes.":[16],"However,":[17],"research":[18],"into":[19],"mechanisms":[20],"linking":[21],"neuronal":[22,66],"excitability":[23],"synaptic":[25,68,87],"dysfunction":[26,149],"epilepsy":[28,152],"has":[29],"mainly":[30],"focused":[31],"on":[32,141],"the":[33],"cortex":[34],"hippocampus,":[36],"leaving":[37],"basal":[38,147],"ganglia":[39,148],"contributions":[40],"largely":[41],"unexplored.":[42],"Using":[43],"a":[44,52,98,120,135],"genetic":[45],"murine":[46],"model":[47],"of":[48,55,72,105,115],"Lafora":[49],"disease":[50],"(LD),":[51],"drug-resistant":[53],"form":[54],"neurodegenerative":[56],"epilepsy,":[57],"we":[58],"performed":[59],"ex":[60],"vivo":[61],"patch-clamp":[62],"recordings":[63],"assess":[65],"excitability,":[67],"transmission,":[69],"plasticity":[71,130],"striatal":[73,113,142],"medium":[74],"spiny":[75],"neurons.":[76],"Our":[77,144],"results":[78],"reveal":[79],"progressive":[80],"alterations":[81],"corticostriatal":[83],"transmission":[84],"long-term":[86,90,129],"plasticity,":[88],"including":[89],"potentiation":[91],"(LTP).":[92],"Electrophysiological":[93],"biochemical":[95],"assessments":[96],"showed":[97],"reduced":[99,103],"NMDA/AMPA":[100],"ratio":[101],"expression":[104],"NMDA":[106],"receptor":[107,123],"subunits":[108],"dopamine":[110,121],"receptors":[111],"neurons":[114],"LD":[116,132],"mice.":[117],"Exposure":[118],"D2":[122],"agonist":[124],"cannabidiol":[127],"restored":[128],"mice,":[133],"suggesting":[134],"D2R-":[136],"CB2R-dependent":[138],"synergic":[139],"action":[140],"LTP.":[143],"findings":[145],"highlight":[146],"experimental":[151],"suggest":[154],"an":[155],"unconventional":[156],"dopaminergic-endocannabinoid":[157],"interplay.":[158]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-14T00:00:00"}