{"id":"https://openalex.org/W7221632050","doi":"https://doi.org/10.64898/2026.10.12.26365358","title":"Cardiomyocyte-Derived Cell-Free DNA in Hypertrophic Cardiomyopathy","display_name":"Cardiomyocyte-Derived Cell-Free DNA in Hypertrophic Cardiomyopathy","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221632050","doi":"https://doi.org/10.64898/2026.10.12.26365358"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.12.26365358","doi":"https://doi.org/10.64898/2026.10.12.26365358","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.12.26365358","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/13/2026.10.12.26365358.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/13/2026.10.12.26365358.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048402895","display_name":"Daniel Kamna","orcid":"https://orcid.org/0009-0005-3680-7329","observed_orcids":["https://orcid.org/0009-0005-3680-7329"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kamna","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":"https://orcid.org/0009-0005-3680-7329","affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011837091","display_name":"Brett A. Davis","orcid":"https://orcid.org/0000-0001-7985-1921","observed_orcids":["https://orcid.org/0000-0001-7985-1921"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Davis","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158666791","display_name":"Cora Layman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cora E. Layman","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158550072","display_name":"Jack Wiedrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Wiedrick","raw_affiliation_strings":["Biostatistics and Design Program, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Design Program, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042389125","display_name":"Sammantha Avaylon","orcid":"https://orcid.org/0000-0001-9921-0347","observed_orcids":["https://orcid.org/0000-0001-9921-0347"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sammantha Avaylon","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158654333","display_name":"Kandace Wheeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kandace Wheeler","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158578786","display_name":"Israt Jahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Israt Jahan","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055501002","display_name":"Lucia Carbone","orcid":"https://orcid.org/0000-0002-2118-107X","observed_orcids":["https://orcid.org/0000-0002-2118-107X"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lucia Carbone","raw_affiliation_strings":["Department of Molecular and Medical Genetics, Oregon Health and Science University","Division of Genetics, Oregon National Primate Research Center","Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Genetics, Oregon National Primate Research Center","institution_ids":["https://openalex.org/I102507086"]},{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065594480","display_name":"Ahmad Masri","orcid":"https://orcid.org/0000-0002-6390-6526","observed_orcids":["https://orcid.org/0000-0002-6390-6526"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmad Masri","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health and Science University"],"raw_orcid":"https://orcid.org/0000-0002-6390-6526","affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health and Science University","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055501002","https://openalex.org/A5065594480"],"corresponding_institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6779999732971191},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9909999966621399},{"id":"https://openalex.org/keywords/left-ventricular-outflow-tract-obstruction","display_name":"left ventricular outflow tract obstruction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.7760000228881836},{"id":"https://openalex.org/keywords/troponin","display_name":"troponin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.7300000190734863},{"id":"https://openalex.org/keywords/wall-stress","display_name":"wall stress","score":0.5419999957084656},{"id":"https://openalex.org/keywords/cardiometabolic-comorbidities","display_name":"cardiometabolic comorbidities","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8234000205993652},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.7044000029563904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6502000093460083},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5950000286102295},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5356000065803528},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.49320000410079956},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45100000500679016},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.41359999775886536},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.40880000591278076},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.39399999380111694},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.36809998750686646},{"id":"https://openalex.org/C2777361368","wikidata":"https://www.wikidata.org/wiki/Q7920318","display_name":"Ventricular outflow tract","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.28940001130104065},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26429998874664307},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.257999986410141},{"id":"https://openalex.org/C2779192065","wikidata":"https://www.wikidata.org/wiki/Q19707","display_name":"Donkey","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.2535000145435333},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.12.26365358","doi":"https://doi.org/10.64898/2026.10.12.26365358","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.12.26365358","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/13/2026.10.12.26365358.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.12.26365358","doi":"https://doi.org/10.64898/2026.10.12.26365358","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.12.26365358","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/13/2026.10.12.26365358.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221632050.pdf","grobid_xml":"https://content.openalex.org/works/W7221632050.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W17701363","https://openalex.org/W29770056","https://openalex.org/W2016985382","https://openalex.org/W2018512046","https://openalex.org/W2029449642","https://openalex.org/W2043091217","https://openalex.org/W2051521078","https://openalex.org/W2064991058","https://openalex.org/W2125352971","https://openalex.org/W2131374955","https://openalex.org/W2140575188","https://openalex.org/W2156496744","https://openalex.org/W2336198476","https://openalex.org/W2338764889","https://openalex.org/W2520011570","https://openalex.org/W2744905922","https://openalex.org/W2756203218","https://openalex.org/W2767152003","https://openalex.org/W2800567352","https://openalex.org/W2800646946","https://openalex.org/W2911333943","https://openalex.org/W2914945422","https://openalex.org/W2961404751","https://openalex.org/W2978515721","https://openalex.org/W2988737500","https://openalex.org/W2999988704","https://openalex.org/W3001596261","https://openalex.org/W3098430919","https://openalex.org/W3118471169","https://openalex.org/W3193452811","https://openalex.org/W4292511196","https://openalex.org/W4293102283","https://openalex.org/W4309151333","https://openalex.org/W4313544615","https://openalex.org/W4387781857","https://openalex.org/W4390747504","https://openalex.org/W4399504522","https://openalex.org/W4399717985","https://openalex.org/W4403275986","https://openalex.org/W4413018811","https://openalex.org/W6912636611","https://openalex.org/W7162802190"],"related_works":["https://openalex.org/W3160770149","https://openalex.org/W2980526132","https://openalex.org/W1530452309","https://openalex.org/W4283689811","https://openalex.org/W7110098566","https://openalex.org/W1985511703","https://openalex.org/W2095657948","https://openalex.org/W2800646946","https://openalex.org/W3038909356","https://openalex.org/W4282028722"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"In":[2],"hypertrophic":[3],"cardiomyopathy":[4],"(HCM),":[5],"wall":[6,229],"stress":[7,230],"and":[8,38,47,65,91,104,115,182,200,218,232,242,247,273,297],"subclinical":[9],"myocardial":[10,73,233,294],"injury":[11,37,234],"related":[12],"in":[13,19,123,151,196,257],"part":[14],"to":[15,50,157],"pathological":[16],"hypercontractility,":[17],"which":[18],"turn":[20],"are":[21,263],"associated":[22,166,208,269],"with":[23,63,71,93,167,209,261,270,281],"worse":[24],"outcomes.":[25],"Cell-free":[26],"DNA":[27],"(cfDNA)":[28],"is":[29],"released":[30],"from":[31,60,69,80,155],"cardiomyocytes":[32],"(cfDNA-CM)":[33],"through":[34],"irreversible":[35],"cellular":[36],"death.":[39],"We":[40,55],"investigated":[41],"the":[42,129,132,135,138],"feasibility":[43],"of":[44,110,131,159,177,186,228,249,255,279,293],"quantifying":[45],"cfDNA-CM":[46,116,149,163,204,256,266,287],"its":[48],"relationship":[49],"HCM":[51,64,136,262],"patient":[52],"characteristics.":[53,202],"Methods":[54],"analyzed":[56],"57":[57],"plasma":[58,67],"samples":[59,68],"stable":[61,259],"patients":[62,70,260],"10":[66],"acute":[72],"infarction":[74],"(AMI).":[75],"Plasma":[76],"cfDNA":[77,106,111,140,250],"was":[78,142,206,268],"isolated":[79],"both":[81],"groups.":[82],"Whole":[83],"genome":[84],"bisulfite":[85],"sequencing":[86],"(WGBS)":[87],"libraries":[88],"were":[89,98,121,165,194],"generated":[90],"sequenced":[92],"short-read":[94],"sequencing.":[95],"Methylation":[96],"patterns":[97],"used":[99],"for":[100],"tissue":[101],"deconvolution":[102],"analysis":[103],"cell-specific":[105],"quantification.":[107],"Results":[108],"Yields":[109],"(p":[112,117],"=":[113,118],"0.003)":[114],"0.002)":[119],"fractions":[120],"higher":[122,168,184,210],"AMI":[124],"controls":[125],"than":[126],"HCM,":[127],"supporting":[128],"validity":[130],"assay.":[133],"Within":[134],"cohort,":[137],"median":[139],"yield":[141],"12.22":[143],"ng":[144],"[IQR:":[145],"7.77,":[146],"18.94].":[147],"The":[148,277],"fraction":[150,267],"this":[152],"cohort":[153],"ranged":[154],"0%":[156],"6.4%":[158],"total":[160],"cfDNA.":[161],"Higher":[162,203,265],"tertiles":[164,240],"body":[169],"mass":[170],"index":[171],"(BMI,":[172],"p=0.001),":[173],"a":[174,183,290],"greater":[175],"prevalence":[176,185],"BMI":[178,272],"\u226530":[179],"kg/m\u00b2":[180],"(p<0.001),":[181],"obstructive":[187],"sleep":[188],"apnea":[189],"(p=0.038).":[190],"No":[191],"significant":[192],"differences":[193],"observed":[195],"other":[197],"demographic,":[198],"genetic,":[199],"laboratory":[201],"tertile":[205],"numerically":[207],"New":[211],"York":[212],"Heart":[213],"Association":[214],"(NYHA)":[215],"functional":[216],"class":[217],"left":[219],"ventricular":[220],"outflow":[221],"tract":[222],"(LVOT)":[223],"obstruction,":[224],"while":[225],"circulating":[226,283],"biomarkers":[227,284],"(NT-proBNP)":[231],"(troponin)":[235],"did":[236],"not":[237],"differ":[238],"across":[239],"(p=0.83":[241],"p=0.29,":[243],"respectively).":[244],"Conclusion":[245],"Isolation":[246],"quantification":[248],"as":[251,253],"well":[252],"detection":[254],"chronic":[258],"feasible.":[264],"increasing":[271],"cardiometabolic":[274],"comorbidity":[275],"burden.":[276],"absence":[278],"association":[280],"traditional":[282],"suggests":[285],"that":[286],"may":[288],"reflect":[289],"distinct":[291],"domain":[292],"health,":[295],"injury,":[296],"adverse":[298],"remodeling.":[299]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-14T00:00:00"}