{"id":"https://openalex.org/W7221610705","doi":"https://doi.org/10.64898/2026.10.11.758319","title":"RTK signaling and epidermis remodeling instruct dendrite regrowth after pruning in the fly PNS","display_name":"RTK signaling and epidermis remodeling instruct dendrite regrowth after pruning in the fly PNS","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7221610705","doi":"https://doi.org/10.64898/2026.10.11.758319"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.11.758319","doi":"https://doi.org/10.64898/2026.10.11.758319","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.11.758319","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.11.758319.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.11.758319.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065994848","display_name":"Neeraja Sanal","orcid":"https://orcid.org/0009-0001-8703-5956","observed_orcids":["https://orcid.org/0009-0001-8703-5956"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Neeraja Sanal","raw_affiliation_strings":["Multiscale Imaging Center and Institute for Neurobiology, University of M\u00fcnster, R\u00f6ntgenstrasse 16, 48149 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiscale Imaging Center and Institute for Neurobiology, University of M\u00fcnster, R\u00f6ntgenstrasse 16, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001766393","display_name":"Ulrike Gigengack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike Gigengack","raw_affiliation_strings":["Multiscale Imaging Center and Institute for Neurobiology, University of M\u00fcnster, R\u00f6ntgenstrasse 16, 48149 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiscale Imaging Center and Institute for Neurobiology, University of M\u00fcnster, R\u00f6ntgenstrasse 16, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050462912","display_name":"Sebastian Rumpf","orcid":"https://orcid.org/0000-0002-7128-2645","observed_orcids":["https://orcid.org/0000-0002-7128-2645"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sebastian Rumpf","raw_affiliation_strings":["Multiscale Imaging Center and Institute for Neurobiology, University of M\u00fcnster, R\u00f6ntgenstrasse 16, 48149 M\u00fcnster, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7128-2645","affiliations":[{"raw_affiliation_string":"Multiscale Imaging Center and Institute for Neurobiology, University of M\u00fcnster, R\u00f6ntgenstrasse 16, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050462912"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.21310000121593475,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendrite-pruning","display_name":"dendrite pruning","score":0.9480000138282776},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/ret-receptor-tyrosine-kinase","display_name":"RET receptor tyrosine kinase","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ecdysone-signaling","display_name":"ecdysone signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/metamorphosis","display_name":"metamorphosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/histoblasts","display_name":"histoblasts","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.8328999876976013},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.7545999884605408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.742900013923645},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6521999835968018},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.569100022315979},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.41670000553131104},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.40869998931884766},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40139999985694885},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.36500000953674316},{"id":"https://openalex.org/C136397037","wikidata":"https://www.wikidata.org/wiki/Q33753","display_name":"Metamorphosis","level":3,"score":0.3513000011444092},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.325300008058548},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.3179999887943268},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2572999894618988},{"id":"https://openalex.org/C2780681696","wikidata":"https://www.wikidata.org/wiki/Q3705416","display_name":"Apical dendrite","level":3,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.11.758319","doi":"https://doi.org/10.64898/2026.10.11.758319","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.11.758319","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.11.758319.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.11.758319","doi":"https://doi.org/10.64898/2026.10.11.758319","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.11.758319","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/13/2026.10.11.758319.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6757550044","display_name":null,"funder_award_id":"RU1673/4-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G820177544","display_name":null,"funder_award_id":"SFB1348","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8667814210","display_name":null,"funder_award_id":"RU1673/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322957","display_name":"Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster","ror":"https://ror.org/00pd74e08"},{"id":"https://openalex.org/F4320327553","display_name":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering","ror":"https://ror.org/04hazks31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221610705.pdf","grobid_xml":"https://content.openalex.org/works/W7221610705.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1904307646","https://openalex.org/W1969997585","https://openalex.org/W1970684598","https://openalex.org/W1987578342","https://openalex.org/W1990943845","https://openalex.org/W1992720123","https://openalex.org/W2029478181","https://openalex.org/W2038557516","https://openalex.org/W2047448689","https://openalex.org/W2048516550","https://openalex.org/W2058888545","https://openalex.org/W2084246842","https://openalex.org/W2094676199","https://openalex.org/W2096059852","https://openalex.org/W2109110326","https://openalex.org/W2114786488","https://openalex.org/W2117905283","https://openalex.org/W2122657809","https://openalex.org/W2123858302","https://openalex.org/W2150972545","https://openalex.org/W2155844269","https://openalex.org/W2167279371","https://openalex.org/W2234412400","https://openalex.org/W2408774929","https://openalex.org/W2597440646","https://openalex.org/W2754297845","https://openalex.org/W2781224478","https://openalex.org/W2791010802","https://openalex.org/W2889120281","https://openalex.org/W2913405058","https://openalex.org/W3009060585","https://openalex.org/W3012087741","https://openalex.org/W3040942181","https://openalex.org/W3213808029","https://openalex.org/W4200216215","https://openalex.org/W4283312774","https://openalex.org/W4316814809","https://openalex.org/W4376224785","https://openalex.org/W4391402287","https://openalex.org/W4400953535","https://openalex.org/W4413414632","https://openalex.org/W7153127571","https://openalex.org/W7165942072"],"related_works":["https://openalex.org/W2095029509","https://openalex.org/W1542468145","https://openalex.org/W1987578342","https://openalex.org/W4376224785","https://openalex.org/W2547542276","https://openalex.org/W2286399536","https://openalex.org/W2084246842","https://openalex.org/W3048028439","https://openalex.org/W7099136260","https://openalex.org/W1992763886"],"abstract_inverted_index":{"Abstract":[0],"Morphology":[1],"and":[2,19,22,83,85,112,130,132,154],"function":[3],"of":[4,108,114,158,176],"many":[5],"neuron":[6],"types":[7],"must":[8],"be":[9,146],"adapted":[10],"to":[11,63,162,173],"the":[12,79,94,141,171],"current":[13],"developmental":[14,178],"stage":[15],"through":[16,105],"neurite":[17],"pruning":[18,64,129,153],"regrowth.":[20],"Pruning":[21],"regrowth":[23,72,155,167],"occur":[24],"during":[25,50,103,123],"defined":[26,33],"temporal":[27],"windows,":[28],"but":[29,57],"how":[30,58],"these":[31],"are":[32,91,156],"is":[34,61,65,100,169],"often":[35],"unclear.":[36],"Drosophila":[37,98],"peripheral":[38],"c4da":[39],"neurons":[40],"prune":[41],"their":[42],"larval":[43,109],"sensory":[44],"dendrites":[45],"in":[46],"an":[47],"ecdysone-induced":[48],"manner":[49],"metamorphosis.":[51],"They":[52],"subsequently":[53],"regrow":[54],"adult-specific":[55],"dendrites,":[56],"dendrite":[59,71,128,138,152],"regeneration":[60],"linked":[62],"not":[66],"known.":[67],"We":[68,118,149],"show":[69],"that":[70,88,120,133,151],"requires":[73],"two":[74,142],"receptor":[75,81],"tyrosine":[76],"kinases":[77],"(RTKs),":[78],"insulin":[80],"InR":[82],"Ret,":[84],"present":[86],"evidence":[87],"RTK":[89],"ligands":[90],"derived":[92],"from":[93],"adjacent":[95],"epidermis.":[96],"The":[97],"epidermis":[99,135,172],"extensively":[101],"remodeled":[102],"metamorphosis":[104],"ecdysone-dependent":[106],"apoptosis":[107],"epidermal":[110],"cells":[111],"expansion":[113],"adult":[115],"so-called":[116],"histoblasts.":[117],"find":[119],"this":[121],"occurs":[122],"a":[124,159,165],"time":[125],"window":[126],"between":[127],"regrowth,":[131],"preventing":[134],"remodeling":[136],"inhibits":[137],"remodeling.":[139],"Furthermore,":[140],"processes":[143],"might":[144],"also":[145],"evolutionarily":[147],"linked.":[148],"propose":[150],"part":[157],"biphasic":[160],"response":[161],"ecdysone,":[163],"where":[164],"delayed":[166],"signal":[168],"via":[170],"ensure":[174],"coordination":[175],"tissue":[177],"processes.":[179]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-14T00:00:00"}