{"id":"https://openalex.org/W7221582314","doi":null,"title":"Molecular Characterization of the G9a/GLP Complex and Its Application in Targeted Epigenetic Regulation","display_name":"Molecular Characterization of the G9a/GLP Complex and Its Application in Targeted Epigenetic Regulation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7221582314"},"language":"cs","primary_location":{"id":"pmh:oai:invenio.nusl.cz:784231","doi":null,"is_oa":false,"landing_page_url":"http://www.nusl.cz/ntk/nusl-784231","pdf_url":null,"source":{"id":"https://openalex.org/S4306402266","display_name":"Digital Repository (National Repository of Grey Literature)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79620101","host_organization_name":"University of Arkansas for Medical Sciences","host_organization_lineage":["https://openalex.org/I79620101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001839371","display_name":"Prokop \u010cern\u1ef3","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u010cern\u00fd, Prokop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001839371"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09279999881982803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ehmt2","display_name":"G9a","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ehmt1","display_name":"EHMT1","score":1.0},{"id":"https://openalex.org/keywords/histone-lysine-methyltransferase","display_name":"histone lysine methyltransferase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/h3k9-methylation","display_name":"H3K9 methylation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/h3k9","display_name":"H3K9","score":0.7020000219345093},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7760000228881836},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/coactivator-function","display_name":"coactivator function","score":0.7269999980926514},{"id":"https://openalex.org/keywords/turboid","display_name":"TurboID","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.6748999953269958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6642000079154968},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6377999782562256},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.621399998664856},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6078000068664551},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.5769000053405762},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.5540000200271606},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.5156000256538391},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4982999861240387},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.4925999939441681},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46470001339912415},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4535999894142151},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.446399986743927},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43070000410079956},{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.423799991607666},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4230000078678131},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.41670000553131104},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.3862000107765198},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.35690000653266907},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.35109999775886536},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.35089999437332153},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.33239999413490295},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C137338518","wikidata":"https://www.wikidata.org/wiki/Q4919210","display_name":"Bivalent chromatin","level":5,"score":0.31470000743865967},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.3118000030517578},{"id":"https://openalex.org/C92477616","wikidata":"https://www.wikidata.org/wiki/Q7119217","display_name":"PHD finger","level":5,"score":0.3102000057697296},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.30709999799728394},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.28780001401901245},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.2728999853134155},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2703999876976013},{"id":"https://openalex.org/C2910921701","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone Acetyltransferases","level":4,"score":0.2694999873638153},{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.2648000121116638},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.26159998774528503},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.25600001215934753},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:invenio.nusl.cz:784231","doi":null,"is_oa":false,"landing_page_url":"http://www.nusl.cz/ntk/nusl-784231","pdf_url":null,"source":{"id":"https://openalex.org/S4306402266","display_name":"Digital Repository (National Repository of Grey Literature)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79620101","host_organization_name":"University of Arkansas for Medical Sciences","host_organization_lineage":["https://openalex.org/I79620101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163771097","https://openalex.org/W2080018207","https://openalex.org/W2591846151","https://openalex.org/W2786420595","https://openalex.org/W2095626300","https://openalex.org/W2040064405","https://openalex.org/W2122781654","https://openalex.org/W2970501227","https://openalex.org/W2625047796","https://openalex.org/W1986003631"],"abstract_inverted_index":{"Histone":[0],"lysine":[1,24],"methyltransferases":[2],"G9a":[3,60],"(EHMT2)":[4],"and":[5,21,53,61,67,83,97,117,173],"GLP":[6,62],"(EHMT1)":[7],"form":[8],"an":[9],"evolutionarily":[10],"conserved":[11],"heterodimeric":[12],"complex":[13,42,89,134,165],"responsible,":[14],"among":[15],"other":[16],"functions,":[17],"for":[18],"the":[19,31,40,45,54,87,102,106,113,122,133,153,158,163,167],"mono-":[20],"dimethylation":[22],"of":[23,33,47,56,86,105,115,127,132,162],"9":[25],"on":[26,76],"histone":[27],"H3":[28],"(H3K9me1/2)":[29],"in":[30,92,139],"euchromatin":[32],"mammalian":[34],"cells.":[35],"Through":[36],"this":[37,93,146],"epigenetic":[38],"modification,":[39],"G9a/GLP":[41,88,164],"contributes":[43],"to":[44,70,101,177],"regulation":[46,114],"gene":[48],"expression,":[49],"chromatin":[50,116],"organization,":[51],"differentiation":[52],"maintenance":[55],"cellular":[57],"identity.":[58],"However,":[59],"themselves":[63],"lack":[64],"DNA-binding":[65],"domains,":[66],"their":[68],"targeting":[69],"specific":[71],"genomic":[72],"loci":[73],"therefore":[74],"depends":[75],"additional":[77],"interacting":[78],"partners.":[79],"The":[80],"molecular":[81],"composition":[82],"protein":[84],"interactome":[85],"were":[90,119],"characterized":[91],"study":[94],"using":[95],"co-immunoprecipitation":[96],"TurboID.":[98],"In":[99],"addition":[100],"core":[103],"components":[104],"complex,":[107],"further":[108],"candidate":[109],"proteins":[110,171],"associated":[111],"with":[112,135],"transcription":[118],"identified.":[120],"Given":[121],"previously":[123],"described":[124],"coactivator":[125],"function":[126],"G9a,":[128],"a":[129],"potential":[130],"interaction":[131,147],"estrogen":[136],"receptor":[137],"alpha":[138],"MCF7":[140],"cells":[141],"was":[142],"also":[143],"investigated;":[144],"however,":[145],"could":[148],"not":[149],"be":[150],"confirmed":[151],"under":[152],"experimental":[154],"conditions":[155],"tested.":[156],"Among":[157],"important":[159],"regulatory":[160],"subunits":[161],"are":[166],"C2H2":[168],"zinc":[169],"finger-containing":[170],"ZNF644":[172],"WIZ,":[174],"which":[175],"contribute":[176],"its...":[178]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-10-13T00:00:00"}
