{"id":"https://openalex.org/W7221569149","doi":"https://doi.org/10.3389/fimmu.2026.1938077","title":"Tumor-educated macrophages promote ferroptosis inhibition in pancreatic cancer via activating the p62-KEAP1-NRF2 pathway","display_name":"Tumor-educated macrophages promote ferroptosis inhibition in pancreatic cancer via activating the p62-KEAP1-NRF2 pathway","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221569149","doi":"https://doi.org/10.3389/fimmu.2026.1938077","pmid":"https://pubmed.ncbi.nlm.nih.gov/42935962","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13696518"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1938077","doi":"https://doi.org/10.3389/fimmu.2026.1938077","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1938077","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938077/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938077/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158443887","display_name":"Shouying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouying Li","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158462517","display_name":"Dongxue Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongxue Qi","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140398117","display_name":"Hanyang Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanyang Yi","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158425421","display_name":"Lina Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Yang","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158423950","display_name":"Tonglei Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tonglei Xu","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","Zhongda Hospital, Southeast University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]},{"raw_affiliation_string":"Zhongda Hospital, Southeast University","institution_ids":["https://openalex.org/I4210105806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119605241","display_name":"Zhou wenkai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenkai Zhou","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158511228","display_name":"Weidong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Xu","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123211881","display_name":"XU Ziheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziheng Xu","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119605242","display_name":"Tang haodong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haodong Tang","raw_affiliation_strings":["The Affiliated Hospital of Xuzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Xuzhou Medical University","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894496","display_name":"Fangliang Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fangliang Xie","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158420772","display_name":"Chunfang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunfang Zhang","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087843128","display_name":"Xuyang Liang","orcid":"https://orcid.org/0009-0002-1946-553X","observed_orcids":["https://orcid.org/0009-0002-1946-553X"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuyang Liang","raw_affiliation_strings":["The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021894496","https://openalex.org/A5087843128","https://openalex.org/A5119605242","https://openalex.org/A5158420772"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70333504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1938077","last_page":"1938077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis-resistance","display_name":"ferroptosis resistance","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.777999997138977},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.8309999704360962},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nrf2-ubiquitination","display_name":"Nrf2 ubiquitination","score":0.7599999904632568},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9649999737739563},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.5350000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7310000061988831},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8511000275611877},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7652000188827515},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6410999894142151},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5302000045776367},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.5059000253677368},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4675999879837036},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4643999934196472},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.446399986743927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4043999910354614},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.3903999924659729},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3880999982357025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3869999945163727},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.382099986076355},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.31119999289512634},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2865999937057495},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.2703000009059906},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.26159998774528503},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000071456","descriptor_name":"Sequestosome-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000084582","descriptor_name":"Tumor-Associated Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1938077","doi":"https://doi.org/10.3389/fimmu.2026.1938077","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1938077","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938077/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13696518","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13696518/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13696518/pdf/fimmu-17-1938077.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42935962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42935962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cc4372cc5aa941bebaea3ccd2857d9f4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cc4372cc5aa941bebaea3ccd2857d9f4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1938077","doi":"https://doi.org/10.3389/fimmu.2026.1938077","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1938077","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938077/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9001171917","display_name":null,"funder_award_id":"PYJH2025302","funder_id":"https://openalex.org/F4320327501","funder_display_name":"Xuzhou Medical University"},{"id":"https://openalex.org/G9001175457","display_name":null,"funder_award_id":"MS202301, LYG065212025069, 202309","funder_id":"https://openalex.org/F4320325638","funder_display_name":"Lianyungang Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320325638","display_name":"Lianyungang Science and Technology Bureau","ror":"https://ror.org/0390km291"},{"id":"https://openalex.org/F4320327501","display_name":"Xuzhou Medical University","ror":"https://ror.org/04fe7hy80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221569149.pdf","grobid_xml":"https://content.openalex.org/works/W7221569149.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1979783084","https://openalex.org/W2014918593","https://openalex.org/W2026878412","https://openalex.org/W2059266855","https://openalex.org/W2112474929","https://openalex.org/W2126934086","https://openalex.org/W2153716722","https://openalex.org/W2192943385","https://openalex.org/W2757812515","https://openalex.org/W2762087180","https://openalex.org/W2770003411","https://openalex.org/W2788640168","https://openalex.org/W2801988573","https://openalex.org/W2921575300","https://openalex.org/W2943793201","https://openalex.org/W2948024202","https://openalex.org/W2954917865","https://openalex.org/W2969554686","https://openalex.org/W2979937337","https://openalex.org/W2982091811","https://openalex.org/W2999670862","https://openalex.org/W3000233190","https://openalex.org/W3005828713","https://openalex.org/W3009534706","https://openalex.org/W3089193007","https://openalex.org/W3091185756","https://openalex.org/W3097655109","https://openalex.org/W3099729809","https://openalex.org/W3108493784","https://openalex.org/W3121485073","https://openalex.org/W3162305544","https://openalex.org/W3163920613","https://openalex.org/W3185445230","https://openalex.org/W3186406858","https://openalex.org/W3186649896","https://openalex.org/W3202100113","https://openalex.org/W3205204506","https://openalex.org/W3213184315","https://openalex.org/W4200436940","https://openalex.org/W4205167813","https://openalex.org/W4213455992","https://openalex.org/W4224272069","https://openalex.org/W4229719081","https://openalex.org/W4283016865","https://openalex.org/W4291476217","https://openalex.org/W4319063470","https://openalex.org/W4361222214","https://openalex.org/W4362040523","https://openalex.org/W4379384846","https://openalex.org/W4387297645","https://openalex.org/W4390946922","https://openalex.org/W4392095262","https://openalex.org/W4396561717"],"related_works":["https://openalex.org/W3213876682","https://openalex.org/W4225417779","https://openalex.org/W4412383212","https://openalex.org/W4296335122","https://openalex.org/W4416869096","https://openalex.org/W3118915634","https://openalex.org/W3112599058","https://openalex.org/W4237525927","https://openalex.org/W4281700739","https://openalex.org/W3103900582"],"abstract_inverted_index":{"Background":[0],"Pancreatic":[1],"cancer":[2,37,56,75,90,177,319],"is":[3,364],"one":[4],"of":[5,24,50,127,175,188,211,223],"the":[6,25,47,60,73,186,220,255,281,322],"most":[7],"aggressive":[8],"and":[9,13,30,59,79,81,97,110,125,135,148,153,155,161,190,203,206,237,242,261,263,272,279,351,360],"lethal":[10],"gastrointestinal":[11],"malignancies,":[12],"ferroptosis":[14,34,58,315,335],"resistance":[15,316,336],"contributes":[16],"to":[17,45,87,118,193,246],"chemoresistance.":[18],"Tumor-educated":[19],"macrophages(TAMs)":[20],"are":[21,343],"key":[22,231],"components":[23],"tumor":[26],"microenvironment,":[27],"but":[28,213],"whether":[29],"how":[31],"they":[32],"regulate":[33],"in":[35,54,288,317,337,347,354,361],"pancreatic":[36,55,74,89,176,318,338],"cells":[38,71,141,192,320],"remains":[39],"largely":[40],"unknown.":[41],"This":[42,325],"study":[43],"aimed":[44],"investigate":[46],"regulatory":[48],"role":[49],"tumor-educated":[51],"macrophages":[52],"(TEMs)":[53],"cell":[57,76,349,356],"underlying":[61],"molecular":[62],"mechanism.":[63],"Methods":[64],"TEMs":[65],"were":[66,100,137,168,295],"generated":[67],"by":[68,95,102,139,198,284,297],"coculturing":[69],"THP-1":[70],"with":[72,142],"lines":[77],"PANC1":[78,189],"CFPAC,":[80],"TEM-conditioned":[82],"medium":[83],"(TEM-CM)":[84],"was":[85,93,116],"collected":[86],"treat":[88],"cells.":[91],"Ferroptosis":[92],"induced":[94],"erastin,":[96],"ferroptotic":[98],"events":[99],"assessed":[101],"lipid":[103,200],"ROS,":[104,201],"MDA,":[105,202],"iron":[106,204],"accumulation,":[107],"GSH":[108,208],"levels,":[109,239],"transmission":[111],"electron":[112],"microscopy.":[113],"RNA":[114,225],"sequencing":[115,226],"performed":[117],"identify":[119],"differentially":[120],"expressed":[121],"genes.":[122],"The":[123],"expression":[124],"activity":[126],"VEGFR2,":[128],"C-Raf,":[129],"ERK1/2,":[130],"mTOR,":[131,241],"LC3,":[132],"p62,":[133],"KEAP1,":[134,253],"NRF2":[136,259,265],"investigated":[138],"treating":[140],"pharmacological":[143],"inhibitors":[144],"(Ki8751,":[145],"LY3009120,":[146],"chloroquine,":[147],"ferrostatin-1),":[149],"performing":[150],"gene":[151],"knockdown":[152],"overexpression,":[154],"conducting":[156],"Western":[157],"blot":[158],"co-immunoprecipitation,":[159],"ubiquitination,":[160],"cycloheximide":[162],"chase":[163],"assays.":[164],"In":[165],"vivo":[166,362],"experiments":[167],"conducted":[169],"using":[170],"an":[171],"orthotopic":[172],"mouse":[173],"model":[174],"(n":[178],"=":[179],"5":[180],"per":[181],"group).":[182],"Results":[183],"TEM-CM":[184,233],"reduced":[185],"sensitivity":[187],"CFPAC":[191],"erastin-induced":[194],"ferroptosis,":[195],"as":[196,229],"evidenced":[197],"decreased":[199],"accumulation":[205],"increased":[207],"levels.":[209],"Neutralization":[210],"VEGF,":[212],"not":[214],"IL-10":[215],"or":[216,304],"TGF\u03b2,":[217],"significantly":[218],"reversed":[219,296],"ferroptosis-inhibiting":[221],"effect":[222],"TEM-CM.":[224],"identified":[227],"TM7SF2":[228,235,298],"a":[230,329],"mediator.":[232],"upregulated":[234],"mRNA":[236],"protein":[238],"activated":[240,280],"suppressed":[243],"autophagy,":[244],"leading":[245],"p62":[247,250],"accumulation.":[248],"Accumulated":[249],"competitively":[251],"bound":[252,277],"disrupted":[254],"KEAP1\u2013NRF2":[256],"interaction,":[257],"inhibited":[258],"ubiquitination":[260],"degradation,":[262],"promoted":[264,290],"nuclear":[266],"translocation,":[267],"thereby":[268],"upregulating":[269,285],"GPX4,":[270],"HMOX1,":[271],"GCLM.":[273],"Mechanistically,":[274],"TEM-derived":[275,312],"VEGF":[276,300,313],"VEGFR2":[278,302],"C-Raf/ERK1/2":[282],"pathway":[283],"TM7SF2,":[286],"which":[287],"turn":[289],"mTOR":[291],"phosphorylation.":[292],"These":[293,308],"effects":[294],"knockdown,":[299],"neutralization,":[301],"inhibition,":[303],"C-Raf":[305],"inhibition.":[306],"Conclusions":[307],"findings":[309],"suggest":[310],"that":[311],"promotes":[314],"through":[321],"VEGFR2\u2013TM7SF2\u2013C-Raf/ERK1/2\u2013mTOR\u2013autophagy\u2013p62\u2013NRF2":[323],"axis.":[324],"axis":[326],"may":[327],"represent":[328],"potential":[330],"therapeutic":[331],"target":[332],"for":[333],"overcoming":[334],"cancer.":[339],"However,":[340],"our":[341],"conclusions":[342],"mainly":[344],"based":[345],"on":[346],"vitro":[348],"models,":[350],"further":[352],"validation":[353],"additional":[355],"lines,":[357],"patient-derived":[358],"organoids,":[359],"models":[363],"warranted.":[365]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-13T00:00:00"}
