{"id":"https://openalex.org/W7221567413","doi":"https://doi.org/10.1038/s41588-026-02782-w","title":"Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival","display_name":"Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221567413","doi":"https://doi.org/10.1038/s41588-026-02782-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/40321211","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12047879"},"language":"en","primary_location":{"id":"doi:10.1038/s41588-026-02782-w","doi":"https://doi.org/10.1038/s41588-026-02782-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41588-026-02782-w","pdf_url":"https://www.nature.com/articles/s41588-026-02782-w.pdf","source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41588-026-02782-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043339503","display_name":"Lotte Br\u00fcckner","orcid":"https://orcid.org/0000-0002-6155-2277","observed_orcids":["https://orcid.org/0000-0002-6155-2277"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lotte Br\u00fcckner","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6155-2277","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032710952","display_name":"Robin Xu","orcid":"https://orcid.org/0000-0002-5618-246X","observed_orcids":["https://orcid.org/0000-0002-5618-246X"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robin Xu","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5618-246X","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102924878","display_name":"Jun Tang","orcid":"https://orcid.org/0009-0004-4606-2458","observed_orcids":["https://orcid.org/0009-0004-4606-2458"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Tang","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0009-0004-4606-2458","affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034718917","display_name":"Aditi Gnanasekar","orcid":"https://orcid.org/0000-0002-8303-8674","observed_orcids":["https://orcid.org/0000-0002-8303-8674"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi Gnanasekar","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061462202","display_name":"Alexander Herrmann","orcid":"https://orcid.org/0000-0002-2749-9003","observed_orcids":["https://orcid.org/0000-0002-2749-9003","https://orcid.org/0009-0002-7700-6788"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Herrmann","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0002-7700-6788","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045756697","display_name":"Ivy Tsz-Lo Wong","orcid":"https://orcid.org/0000-0002-9761-3422","observed_orcids":["https://orcid.org/0000-0002-9761-3422"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivy Tsz-Lo Wong","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9761-3422","affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452868","display_name":"Shu Zhang","orcid":"https://orcid.org/0000-0003-2543-5943","observed_orcids":["https://orcid.org/0000-0003-2543-5943"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Zhang","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2543-5943","affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003138149","display_name":"Fengyu Tu","orcid":"https://orcid.org/0000-0001-8748-7250","observed_orcids":["https://orcid.org/0000-0001-8748-7250"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyu Tu","raw_affiliation_strings":["Group of Theoretical Biology, The State Key Laboratory of Bio-control, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-8748-7250","affiliations":[{"raw_affiliation_string":"Group of Theoretical Biology, The State Key Laboratory of Bio-control, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117231256","display_name":"Madison Pilon","orcid":"https://orcid.org/0000-0001-9060-4817","observed_orcids":["https://orcid.org/0000-0001-9060-4817"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Madison Pilon","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9060-4817","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050428608","display_name":"Alexander Kukalev","orcid":"https://orcid.org/0000-0001-5847-3773","observed_orcids":["https://orcid.org/0000-0001-5847-3773"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Kukalev","raw_affiliation_strings":["Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5847-3773","affiliations":[{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060228598","display_name":"Katharina Pardon","orcid":"https://orcid.org/0009-0001-5048-3261","observed_orcids":["https://orcid.org/0009-0001-5048-3261"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Pardon","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085814062","display_name":"Olga Alexandra Sidorova","orcid":"https://orcid.org/0009-0004-1459-1662","observed_orcids":["https://orcid.org/0009-0004-1459-1662"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olga Sidorova","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0004-1459-1662","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061967640","display_name":"Joshua Atta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joshua Atta","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005551760","display_name":"Qinghao Yu","orcid":"https://orcid.org/0000-0002-2151-9624","observed_orcids":["https://orcid.org/0000-0002-2151-9624"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qinghao Yu","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029028029","display_name":"Giulia Montuori","orcid":"https://orcid.org/0009-0007-9072-7156","observed_orcids":["https://orcid.org/0009-0007-9072-7156","https://orcid.org/0000-0003-1595-8601"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Giulia Montuori","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071838619","display_name":"Davide Pradella","orcid":"https://orcid.org/0000-0002-8649-7817","observed_orcids":["https://orcid.org/0000-0002-8649-7817"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Pradella","raw_affiliation_strings":["Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-8649-7817","affiliations":[{"raw_affiliation_string":"Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087986477","display_name":"Mila Ili\u0107","orcid":"https://orcid.org/0000-0003-4664-9393","observed_orcids":["https://orcid.org/0000-0003-4664-9393"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mila Ili\u0107","raw_affiliation_strings":["Oncode Institute and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4664-9393","affiliations":[{"raw_affiliation_string":"Oncode Institute and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210111138","https://openalex.org/I4210127118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086320145","display_name":"Kentaro Suina","orcid":"https://orcid.org/0000-0001-7805-5480","observed_orcids":["https://orcid.org/0000-0001-7805-5480"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kentaro Suina","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040568994","display_name":"Marco Novais-Cruz","orcid":"https://orcid.org/0000-0002-0361-4855","observed_orcids":["https://orcid.org/0000-0002-0361-4855"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marco Novais-Cruz","raw_affiliation_strings":["Oncode Institute and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncode Institute and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210111138","https://openalex.org/I4210127118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058700468","display_name":"Sarah Kaltenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Kaltenbach","raw_affiliation_strings":["Institute of Molecular Biology, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002077225","display_name":"Denise Treue","orcid":"https://orcid.org/0000-0002-0657-5505","observed_orcids":["https://orcid.org/0000-0002-0657-5505"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denise Treue","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089065337","display_name":"M\u0103d\u0103lina Giurgiu","orcid":"https://orcid.org/0000-0001-5007-7442","observed_orcids":["https://orcid.org/0000-0001-5007-7442"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M\u0103d\u0103lina Giurgiu-Kralji\u010d","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5007-7442","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027338613","display_name":"Sergej Herzog","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sergej Herzog","raw_affiliation_strings":["Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117231252","display_name":"Ann-Sophie Hollinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ann-Sophie Hollinger","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004212449","display_name":"Nadine Wittstruck","orcid":"https://orcid.org/0009-0000-4378-3226","observed_orcids":["https://orcid.org/0009-0000-4378-3226"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine Wittstruck","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0000-4378-3226","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158447033","display_name":"Martina Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Fernandez","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158495097","display_name":"Nicole Wolozyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Wolozyn","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041701504","display_name":"Finnja Becker","orcid":"https://orcid.org/0009-0003-7014-7307","observed_orcids":["https://orcid.org/0009-0003-7014-7307"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Finnja Becker","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0003-7014-7307","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117231253","display_name":"Varvara-Rigina Louma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Varvara-Rigina Louma","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133435636","display_name":"Xiaowei Yan","orcid":"https://orcid.org/0000-0002-4846-8812","observed_orcids":["https://orcid.org/0000-0002-4846-8812"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Yan","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","Sarafan ChEM-H, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4846-8812","affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092500314","display_name":"Rachel Schmargon","orcid":"https://orcid.org/0009-0009-3535-7185","observed_orcids":["https://orcid.org/0009-0009-3535-7185"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rachel Schmargon","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0009-3535-7185","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085482577","display_name":"Jan R. D\u00f6rr","orcid":"https://orcid.org/0000-0002-4927-6548","observed_orcids":["https://orcid.org/0000-0002-4927-6548"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan R. D\u00f6rr","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117231254","display_name":"David Gamlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Gamlin","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158432678","display_name":"Annika Lehmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annika Lehmann","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062790616","display_name":"Dennis G\u00fcrgen","orcid":"https://orcid.org/0000-0001-9241-6537","observed_orcids":["https://orcid.org/0000-0001-9241-6537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis G\u00fcrgen","raw_affiliation_strings":["Experimental Pharmacology and Oncology (EPO), Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pharmacology and Oncology (EPO), Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056185430","display_name":"Matthias Richter","orcid":"https://orcid.org/0000-0002-5339-0781","observed_orcids":["https://orcid.org/0000-0002-5339-0781"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Richter","raw_affiliation_strings":["Advanced Light Microscopy, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Robert-R\u00f6ssle-Stra\u00dfe 10, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5339-0781","affiliations":[{"raw_affiliation_string":"Advanced Light Microscopy, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Robert-R\u00f6ssle-Stra\u00dfe 10, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066074546","display_name":"Frank P. B. Dubois","orcid":"https://orcid.org/0000-0002-7654-6208","observed_orcids":["https://orcid.org/0000-0002-7654-6208"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Dubois","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7654-6208","affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074530517","display_name":"Fabrizio Simeoni","orcid":"https://orcid.org/0000-0002-5543-6413","observed_orcids":["https://orcid.org/0000-0002-5543-6413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabrizio Simeoni","raw_affiliation_strings":["Econic Biosciences, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-5543-6413","affiliations":[{"raw_affiliation_string":"Econic Biosciences, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046451491","display_name":"Betheney R. Pennycook","orcid":"https://orcid.org/0000-0001-5721-6994","observed_orcids":["https://orcid.org/0000-0001-5721-6994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Betheney R. Pennycook","raw_affiliation_strings":["Econic Biosciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Econic Biosciences, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051727957","display_name":"Alastair Hamilton","orcid":"https://orcid.org/0000-0001-7242-0221","observed_orcids":["https://orcid.org/0000-0001-7242-0221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alastair Hamilton","raw_affiliation_strings":["Econic Biosciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Econic Biosciences, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070625577","display_name":"Ralph K. Lindemann","orcid":"https://orcid.org/0000-0003-2399-3992","observed_orcids":["https://orcid.org/0000-0003-2399-3992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph K. Lindemann","raw_affiliation_strings":["Econic Biosciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Econic Biosciences, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000501161","display_name":"Courtney Dawes","orcid":"https://orcid.org/0009-0006-3047-5762","observed_orcids":["https://orcid.org/0009-0006-3047-5762"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Dawes","raw_affiliation_strings":["Department of Biochemistry, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006103615","display_name":"Gabriel Balmus","orcid":"https://orcid.org/0000-0003-2872-4468","observed_orcids":["https://orcid.org/0000-0003-2872-4468"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]},{"id":"https://openalex.org/I4405276525","display_name":"Transylvanian Institute of Neuroscience","ror":"https://ror.org/05mkatf28","country_code":"RO","type":"nonprofit","lineage":["https://openalex.org/I4405276525"]}],"countries":["GB","RO"],"is_corresponding":false,"raw_author_name":"Gabriel Balmus","raw_affiliation_strings":["Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK","Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania","UK Dementia Research Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0003-2872-4468","affiliations":[{"raw_affiliation_string":"Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I4405276525"]},{"raw_affiliation_string":"UK Dementia Research Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210126463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072225157","display_name":"Barbara Hero","orcid":"https://orcid.org/0000-0003-4129-890X","observed_orcids":["https://orcid.org/0000-0003-4129-890X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Hero","raw_affiliation_strings":["Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4129-890X","affiliations":[{"raw_affiliation_string":"Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061831442","display_name":"Matthias Fischer","orcid":"https://orcid.org/0000-0003-1363-1242","observed_orcids":["https://orcid.org/0000-0003-1363-1242"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Fischer","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, Cologne, Germany","Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1363-1242","affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028801735","display_name":"Vineet Bafna","orcid":"https://orcid.org/0000-0002-5810-6241","observed_orcids":["https://orcid.org/0000-0002-5810-6241"]},"institutions":[{"id":"https://openalex.org/I160856358","display_name":"University of San Diego","ror":"https://ror.org/03jbbze48","country_code":"US","type":"education","lineage":["https://openalex.org/I160856358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vineet Bafna","raw_affiliation_strings":["Department of Computer Science and Engineering, University of San Diego, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5810-6241","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I160856358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040971821","display_name":"Roel G.W. Verhaak","orcid":"https://orcid.org/0000-0003-2773-0436","observed_orcids":["https://orcid.org/0000-0003-2773-0436"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Roel Verhaak","raw_affiliation_strings":["Department of Neurosurgery, Amsterdam University Medical Centers/VUmc, Amsterdam, the Netherlands","Department of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0003-2773-0436","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Amsterdam University Medical Centers/VUmc, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038885111","display_name":"Geoffrey M. Wahl","orcid":"https://orcid.org/0000-0003-3658-2279","observed_orcids":["https://orcid.org/0000-0003-3658-2279"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Wahl","raw_affiliation_strings":["Salk Institute for Biological Studies, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3658-2279","affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies, San Diego, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001914104","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-3889-9707","observed_orcids":["https://orcid.org/0000-0002-3889-9707"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Biochemistry, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":"https://orcid.org/0000-0002-3889-9707","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069334303","display_name":"Richard P. Koche","orcid":"https://orcid.org/0000-0002-6820-5083","observed_orcids":["https://orcid.org/0000-0002-6820-5083"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard P. Koche","raw_affiliation_strings":["Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-6820-5083","affiliations":[{"raw_affiliation_string":"Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088872079","display_name":"Stamatis Papathanasiou","orcid":"https://orcid.org/0000-0001-6969-044X","observed_orcids":["https://orcid.org/0000-0001-6969-044X"]},"institutions":[{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stamatis Papathanasiou","raw_affiliation_strings":["Institute of Molecular Biology, Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6969-044X","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158464906","display_name":"Ren\u00e9 Medema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Medema","raw_affiliation_strings":["Oncode Institute and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncode Institute and Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210111138","https://openalex.org/I4210127118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045187327","display_name":"Bastiaan Spanjaard","orcid":"https://orcid.org/0000-0003-1309-8839","observed_orcids":["https://orcid.org/0000-0003-1309-8839"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bastiaan Spanjaard","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1309-8839","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033666678","display_name":"Andrea Ventura","orcid":"https://orcid.org/0000-0003-4320-9907","observed_orcids":["https://orcid.org/0000-0003-4320-9907"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Ventura","raw_affiliation_strings":["Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-4320-9907","affiliations":[{"raw_affiliation_string":"Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070136083","display_name":"Ana Pombo","orcid":"https://orcid.org/0000-0002-7493-6288","observed_orcids":["https://orcid.org/0000-0002-7493-6288"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ana Pombo","raw_affiliation_strings":["Institute of Biology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7493-6288","affiliations":[{"raw_affiliation_string":"Institute of Biology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082497527","display_name":"Weini Huang","orcid":"https://orcid.org/0000-0002-9016-2665","observed_orcids":["https://orcid.org/0000-0002-9016-2665"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Weini Huang","raw_affiliation_strings":["Department of Mathematics, Queen Mary University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-9016-2665","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002688480","display_name":"Monika Scheer","orcid":"https://orcid.org/0000-0002-0665-6268","observed_orcids":["https://orcid.org/0000-0002-0665-6268"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Scheer","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069836964","display_name":"Benjamin Werner","orcid":"https://orcid.org/0000-0002-6857-8699","observed_orcids":["https://orcid.org/0000-0002-6857-8699"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin Werner","raw_affiliation_strings":["Evolutionary Dynamics Group, Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-6857-8699","affiliations":[{"raw_affiliation_string":"Evolutionary Dynamics Group, Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040230088","display_name":"Howard Y. Chang","orcid":"https://orcid.org/0000-0002-9459-4393","observed_orcids":["https://orcid.org/0000-0002-9459-4393"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Y. Chang","raw_affiliation_strings":["Departments of Dermatology, Genetics, and Pathology, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9459-4393","affiliations":[{"raw_affiliation_string":"Departments of Dermatology, Genetics, and Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042065032","display_name":"Paul S. Mischel","orcid":"https://orcid.org/0000-0002-4560-2211","observed_orcids":["https://orcid.org/0000-0002-4560-2211"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul S. Mischel","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. pmischel@stanford.edu","Sarafan ChEM-H, Stanford University, Stanford, CA, USA. pmischel@stanford.edu"],"raw_orcid":"https://orcid.org/0000-0002-4560-2211","affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. pmischel@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarafan ChEM-H, Stanford University, Stanford, CA, USA. pmischel@stanford.edu","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002107117","display_name":"Anton George Henssen","orcid":"https://orcid.org/0000-0003-1534-778X","observed_orcids":["https://orcid.org/0000-0003-1534-778X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anton G. Henssen","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany. henssenlab@gmail.com","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany. henssenlab@gmail.com","German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany. henssenlab@gmail.com","Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany. henssenlab@gmail.com"],"raw_orcid":"https://orcid.org/0000-0003-1534-778X","affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany. henssenlab@gmail.com","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany. henssenlab@gmail.com","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany. henssenlab@gmail.com","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany. henssenlab@gmail.com","institution_ids":["https://openalex.org/I205582932"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":26,"corresponding_author_ids":["https://openalex.org/A5002107117","https://openalex.org/A5042065032"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I205582932","https://openalex.org/I4210137306","https://openalex.org/I4391767962","https://openalex.org/I7877124","https://openalex.org/I97018004"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":{"value":12690,"currency":"USD","value_usd":12690},"fwci":11.2669,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.98884913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extrachromosomal-dna","display_name":"extrachromosomal DNA","score":0.996999979019165},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oncogene-amplification","display_name":"oncogene amplification","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/mycn-amplification","display_name":"MYCN amplification","score":0.968999981880188},{"id":"https://openalex.org/keywords/asymmetric-inheritance","display_name":"asymmetric inheritance","score":0.6389999985694885},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7501999735832214},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4293000102043152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4271000027656555},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4043000042438507},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.38609999418258667},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.38589999079704285},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35530000925064087},{"id":"https://openalex.org/C2780558122","wikidata":"https://www.wikidata.org/wiki/Q7310803","display_name":"Relative survival","level":4,"score":0.35440000891685486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2578999996185303}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41588-026-02782-w","doi":"https://doi.org/10.1038/s41588-026-02782-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41588-026-02782-w","pdf_url":"https://www.nature.com/articles/s41588-026-02782-w.pdf","source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/2025.04.15.648906","doi":"https://doi.org/10.1101/2025.04.15.648906","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.15.648906","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/18/2025.04.15.648906.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40321211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40321211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42864499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42864499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature genetics","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:27038","doi":null,"is_oa":true,"landing_page_url":"https://edoc.mdc-berlin.de/id/eprint/27038/2/27038suppl.zip","pdf_url":"https://edoc.mdc-berlin.de/id/eprint/27038/1/27038oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:25301","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-6155-2277","pdf_url":"https://edoc.mdc-berlin.de/id/eprint/25301/1/25301oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:12047879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12047879","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41588-026-02782-w","doi":"https://doi.org/10.1038/s41588-026-02782-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41588-026-02782-w","pdf_url":"https://www.nature.com/articles/s41588-026-02782-w.pdf","source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1238530441","display_name":"Smart Objects For Intelligent Applications","funder_award_id":"100017","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1588214524","display_name":null,"funder_award_id":"CRC1588","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1796198730","display_name":null,"funder_award_id":"398299703","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1805875624","display_name":"eDyNAmiC - CHARITE","funder_award_id":"OT2CA278644","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2007345164","display_name":null,"funder_award_id":"949172","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2051006376","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G2162712764","display_name":null,"funder_award_id":"MGU045","funder_id":"https://openalex.org/F4320315143","funder_display_name":"Mark Foundation For Cancer Research"},{"id":"https://openalex.org/G2249785681","display_name":"GRK 2424: Computermethoden f\u00fcr personalisierte Therapien in der Onkologie","funder_award_id":"377984878","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G245757704","display_name":null,"funder_award_id":"CGCATF- 2021/100012","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G289723095","display_name":null,"funder_award_id":"P30\u00a0CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G3018451292","display_name":"eDyNAmiC-QMUL","funder_award_id":"OT2CA278670","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3270689697","display_name":"eDyNAmiC - UCSD","funder_award_id":"OT2CA278635","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G394081560","display_name":null,"funder_award_id":"398299703","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4004495550","display_name":"eDyNAmiC - STANFORD","funder_award_id":"OT2CA278688","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4177809754","display_name":"SFB 1588: Entschl\u00fcsselung evolution\u00e4rer Mechanismen beim Neuroblastom","funder_award_id":"493872418","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4201519118","display_name":"Quantifying the evolutionary dynamics of extra-chromosomal DNA in human cancers.","funder_award_id":"MR/V02342X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4238938849","display_name":null,"funder_award_id":"MR/V02342X/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G4268089617","display_name":null,"funder_award_id":"100012","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4830400555","display_name":null,"funder_award_id":"P30 CA008748","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5467192712","display_name":null,"funder_award_id":"100017","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5594779030","display_name":null,"funder_award_id":"CGCATF-2021/100012","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6393038893","display_name":null,"funder_award_id":"P30 CA008748","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6843509793","display_name":null,"funder_award_id":"70114107","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"},{"id":"https://openalex.org/G7745828677","display_name":null,"funder_award_id":"MGU045","funder_id":"https://openalex.org/F4320315977","funder_display_name":"Barts Charity"},{"id":"https://openalex.org/G7796364618","display_name":null,"funder_award_id":"P30 CA008748","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8353012754","display_name":"eDyNAmiC (extrachromosomal DNA in Cancer) - Understanding the biology of ecDNA generation and action, and developing new ways to target these mechanisms in cancer","funder_award_id":"OT2CA301085","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8393059803","display_name":null,"funder_award_id":"OT2CA278688","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8687509801","display_name":null,"funder_award_id":"CGCATF-2021/100025","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8990464473","display_name":"Sequenzspezifische DNA Rekombination als Ursache genomischer Mutationen im Neuroblastom","funder_award_id":"398299703","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000859426","display_name":"Investigating the roles of oncogenic extrachromosomal circular DNAs in cancer","funder_award_id":"R01CA282913","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308687","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320315143","display_name":"Mark Foundation For Cancer Research","ror":"https://ror.org/00v7th354"},{"id":"https://openalex.org/F4320315977","display_name":"Barts Charity","ror":"https://ror.org/0513pp416"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320328160","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60"},{"id":"https://openalex.org/F4320329666","display_name":"Berlin Institute of Health","ror":"https://ror.org/0493xsw21"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F7311471023","display_name":"NextGenerationEU","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221567413.pdf","grobid_xml":"https://content.openalex.org/works/W7221567413.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1511444437","https://openalex.org/W1601755300","https://openalex.org/W1844981334","https://openalex.org/W1920718601","https://openalex.org/W1963740134","https://openalex.org/W1974549850","https://openalex.org/W1981138509","https://openalex.org/W1988073250","https://openalex.org/W2004691672","https://openalex.org/W2025555587","https://openalex.org/W2025696304","https://openalex.org/W2035618305","https://openalex.org/W2070026305","https://openalex.org/W2071905683","https://openalex.org/W2077145482","https://openalex.org/W2098147098","https://openalex.org/W2099610218","https://openalex.org/W2102619694","https://openalex.org/W2102904139","https://openalex.org/W2105190923","https://openalex.org/W2120321636","https://openalex.org/W2120943086","https://openalex.org/W2124181908","https://openalex.org/W2134526812","https://openalex.org/W2136574608","https://openalex.org/W2140099276","https://openalex.org/W2169456326","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2337209831","https://openalex.org/W2341539131","https://openalex.org/W2411397641","https://openalex.org/W2594764564","https://openalex.org/W2738563754","https://openalex.org/W2742514058","https://openalex.org/W2789843538","https://openalex.org/W2920347438","https://openalex.org/W2939841769","https://openalex.org/W2978510226","https://openalex.org/W2989609914","https://openalex.org/W2991552764","https://openalex.org/W2995298529","https://openalex.org/W3001932600","https://openalex.org/W3016718031","https://openalex.org/W3022783334","https://openalex.org/W3041047318","https://openalex.org/W3042292144","https://openalex.org/W3049406491","https://openalex.org/W3099143699","https://openalex.org/W3116548071","https://openalex.org/W3164934122","https://openalex.org/W3207537581","https://openalex.org/W3213694110","https://openalex.org/W3217498804","https://openalex.org/W4211214153","https://openalex.org/W4246301087","https://openalex.org/W4292790981","https://openalex.org/W4296293070","https://openalex.org/W4298856955","https://openalex.org/W4306412179","https://openalex.org/W4372337352","https://openalex.org/W4376133139","https://openalex.org/W4379768361","https://openalex.org/W4379768957","https://openalex.org/W4380625325","https://openalex.org/W4385704323","https://openalex.org/W4390703313","https://openalex.org/W4390703857","https://openalex.org/W4394666350","https://openalex.org/W4401390974","https://openalex.org/W4401804400","https://openalex.org/W4402356297","https://openalex.org/W4403401600","https://openalex.org/W4404105359","https://openalex.org/W4404105412","https://openalex.org/W4404105446","https://openalex.org/W4405515088","https://openalex.org/W4410124905","https://openalex.org/W4412002219","https://openalex.org/W4412783092","https://openalex.org/W4416386003","https://openalex.org/W7140248855","https://openalex.org/W7165745167","https://openalex.org/W7167415238"],"related_works":["https://openalex.org/W4409630129","https://openalex.org/W4400069425","https://openalex.org/W4413045433","https://openalex.org/W4410812931","https://openalex.org/W7128376195","https://openalex.org/W4414532411","https://openalex.org/W7212144966","https://openalex.org/W4400069096","https://openalex.org/W4412002219","https://openalex.org/W7008313852"],"abstract_inverted_index":{"Abstract":[0],"Extrachromosomal":[1],"DNA":[2],"(ecDNA)":[3],"contributes":[4],"to":[5,58,109,178],"cancer":[6,70],"genome":[7],"instability":[8],"by":[9,95],"enabling":[10],"high-copy":[11],"oncogene":[12],"amplification,":[13],"intratumoural":[14],"heterogeneity":[15],"and":[16,32,49,60,82,118,143,169,181],"rapid":[17],"genetic":[18],"change.":[19],"Micronuclei":[20],"(MN)":[21],"are":[22,105,164],"frequently":[23,56],"observed":[24],"in":[25,34,68,120],"chromosomally":[26],"unstable":[27],"cancers,":[28],"yet":[29],"their":[30],"origins":[31],"relevance":[33,200],"ecDNA-driven":[35],"tumours":[36],"remain":[37],"incompletely":[38],"understood.":[39],"Here,":[40],"we":[41,132],"investigate":[42],"the":[43],"relationship":[44],"between":[45],"ecDNA":[46,55,90,108,176,196],"segregation":[47],"errors":[48],"MN":[50,59,66,92,104,121,138,161,179,188],"formation.":[51],"We":[52],"find":[53],"that":[54,102,112,119,134,186],"localizes":[57],"represents":[61],"a":[62,110,191],"prominent":[63],"source":[64],"of":[65,74,87,147,159,193],"content":[67],"ecDNA-positive":[69,137,160,187],"cells.":[71],"Mitotic":[72],"clustering":[73],"oncogene-bearing":[75],"ecDNAs":[76,127],"is":[77,93],"associated":[78,165],"with":[79,153,166,198],"asymmetric":[80],"inheritance":[81],"mis-segregation":[83,117,177],"into":[84,91],"MN.":[85],"Transfer":[86],"oncogenes":[88,122],"from":[89,115,124],"accompanied":[94],"reduced":[96,182],"transcriptional":[97],"output.":[98],"Single-MN":[99],"sequencing":[100],"shows":[101],"individual":[103],"enriched":[106],"for":[107,201],"degree":[111],"exceeds":[113],"expectations":[114],"stochastic":[116],"originating":[123],"multiple":[125],"distinct":[126],"coalesce.":[128],"Using":[129],"live-cell":[130],"imaging,":[131],"observe":[133],"cells":[135],"inheriting":[136],"show":[139],"limited":[140],"proliferative":[141],"capacity":[142],"an":[144],"increased":[145],"likelihood":[146],"cell":[148],"death.":[149],"In":[150],"neuroblastoma":[151],"patients":[152],"MYCN":[154],"-amplified":[155],"ecDNA,":[156],"higher":[157],"frequencies":[158],"at":[162],"diagnosis":[163],"improved":[167],"event-free":[168],"overall":[170],"survival.":[171],"Together,":[172],"these":[173],"findings":[174],"link":[175],"formation":[180],"cellular":[183],"fitness,":[184],"suggesting":[185],"may":[189],"reflect":[190],"state":[192],"impaired":[194],"oncogenic":[195],"function":[197],"potential":[199],"clinical":[202],"outcome.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-13T00:00:00"}