{"id":"https://openalex.org/W7221558409","doi":"https://doi.org/10.3390/nu18203334","title":"Nicotinamide Mononucleotide Does Not Prevent Cardiac Hypertrophy but Attenuates Cardiac Stress and Remodeling Markers in Mice Exposed to Intermittent Normobaric Hypoxia","display_name":"Nicotinamide Mononucleotide Does Not Prevent Cardiac Hypertrophy but Attenuates Cardiac Stress and Remodeling Markers in Mice Exposed to Intermittent Normobaric Hypoxia","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221558409","doi":"https://doi.org/10.3390/nu18203334","pmid":"https://pubmed.ncbi.nlm.nih.gov/42942905","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13708252"},"language":"en","primary_location":{"id":"doi:10.3390/nu18203334","doi":"https://doi.org/10.3390/nu18203334","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18203334","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nu18203334","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158511848","display_name":"Zhen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]},{"id":"https://openalex.org/I4210105514","display_name":"Capital Institute of Pediatrics","ror":"https://ror.org/00zw6et16","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Wang","raw_affiliation_strings":["Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China","Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China","State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210105514"]},{"raw_affiliation_string":"Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China","institution_ids":["https://openalex.org/I4210105514"]},{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127569956","display_name":"Mingxuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]},{"id":"https://openalex.org/I4210105514","display_name":"Capital Institute of Pediatrics","ror":"https://ror.org/00zw6et16","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxuan Wang","raw_affiliation_strings":["College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050091, China","Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050091, China","institution_ids":["https://openalex.org/I34155123"]},{"raw_affiliation_string":"Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China","institution_ids":["https://openalex.org/I4210105514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001025449","display_name":"Jingling Guo","orcid":"https://orcid.org/0000-0002-2427-1636","observed_orcids":["https://orcid.org/0000-0002-2427-1636"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingling Guo","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158419848","display_name":"Yajing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajing Wang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072904123","display_name":"\u738b\u4e16\u6770","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Wang","raw_affiliation_strings":["College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050091, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050091, China","institution_ids":["https://openalex.org/I34155123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101276534","display_name":"Jing Yuan","orcid":"https://orcid.org/0009-0006-2723-3834","observed_orcids":["https://orcid.org/0009-0006-2723-3834"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210105514","display_name":"Capital Institute of Pediatrics","ror":"https://ror.org/00zw6et16","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yuan","raw_affiliation_strings":["Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China","Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210105514"]},{"raw_affiliation_string":"Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China","institution_ids":["https://openalex.org/I4210105514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158437158","display_name":"Ruifu Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruifu Yang","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022560831","display_name":"Yujing Bi","orcid":"https://orcid.org/0000-0002-8309-2259","observed_orcids":["https://orcid.org/0000-0002-8309-2259"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yujing Bi","raw_affiliation_strings":["State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101777974","display_name":"Yuehua Ke","orcid":"https://orcid.org/0000-0001-6054-880X","observed_orcids":["https://orcid.org/0000-0001-6054-880X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]},{"id":"https://openalex.org/I4210105514","display_name":"Capital Institute of Pediatrics","ror":"https://ror.org/00zw6et16","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105514"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuehua Ke","raw_affiliation_strings":["Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China","College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050091, China","Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China"],"raw_orcid":"https://orcid.org/0000-0001-6054-880X","affiliations":[{"raw_affiliation_string":"Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210105514"]},{"raw_affiliation_string":"College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050091, China","institution_ids":["https://openalex.org/I34155123"]},{"raw_affiliation_string":"Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China","institution_ids":["https://openalex.org/I4210105514"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022560831","https://openalex.org/A5101777974"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2802541053","https://openalex.org/I34155123","https://openalex.org/I4210105514"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77052976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"20","first_page":"3334","last_page":"3334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2874000072479248,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2874000072479248,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.2615000009536743,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.1428000032901764,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinamide-mononucleotide","display_name":"nicotinamide mononucleotide","score":1.0},{"id":"https://openalex.org/keywords/intermittent-normobaric-hypoxia","display_name":"intermittent normobaric hypoxia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.828000009059906},{"id":"https://openalex.org/keywords/nad-precursors","display_name":"NAD+ precursors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6589999794960022},{"id":"https://openalex.org/keywords/beta-diversity","display_name":"beta diversity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.621999979019165},{"id":"https://openalex.org/keywords/myh7","display_name":"MYH7","score":0.9580000042915344},{"id":"https://openalex.org/keywords/right-ventricle","display_name":"right ventricle","score":0.8270000219345093},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cardiac-stress-response","display_name":"cardiac stress response","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2777088662","wikidata":"https://www.wikidata.org/wiki/Q21547155","display_name":"Nicotinamide mononucleotide","level":5,"score":0.7515000104904175},{"id":"https://openalex.org/C2780796939","wikidata":"https://www.wikidata.org/wiki/Q25326656","display_name":"Intermittent hypoxia","level":3,"score":0.6464999914169312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6446999907493591},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6340000033378601},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5770999789237976},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5303000211715698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4860999882221222},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.4424000084400177},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4246000051498413},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.36559998989105225},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.3617999851703644},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C2779376020","wikidata":"https://www.wikidata.org/wiki/Q2014808","display_name":"Right ventricular hypertrophy","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C2777152744","wikidata":"https://www.wikidata.org/wiki/Q366935","display_name":"Adrenomedullin","level":3,"score":0.3264999985694885},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.2892000079154968},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009537","descriptor_name":"Nicotinamide Mononucleotide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu18203334","doi":"https://doi.org/10.3390/nu18203334","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18203334","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13708252","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13708252/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13708252/pdf/nutrients-18-03334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:42942905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42942905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/nu18203334","doi":"https://doi.org/10.3390/nu18203334","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18203334","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221558409.pdf","grobid_xml":"https://content.openalex.org/works/W7221558409.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W933342441","https://openalex.org/W1938218641","https://openalex.org/W1998093961","https://openalex.org/W2018787086","https://openalex.org/W2067400934","https://openalex.org/W2072970694","https://openalex.org/W2077883552","https://openalex.org/W2087377825","https://openalex.org/W2088833470","https://openalex.org/W2096960190","https://openalex.org/W2126971215","https://openalex.org/W2128557475","https://openalex.org/W2133856765","https://openalex.org/W2135965113","https://openalex.org/W2153819921","https://openalex.org/W2163282809","https://openalex.org/W2513506562","https://openalex.org/W2546015443","https://openalex.org/W2592857683","https://openalex.org/W2759810236","https://openalex.org/W2839378034","https://openalex.org/W2890037650","https://openalex.org/W2954807358","https://openalex.org/W2959442417","https://openalex.org/W3096261089","https://openalex.org/W3167707845","https://openalex.org/W3174072953","https://openalex.org/W3185141200","https://openalex.org/W3192098310","https://openalex.org/W4214897555","https://openalex.org/W4220894725","https://openalex.org/W4282943275","https://openalex.org/W4283332819","https://openalex.org/W4378175764","https://openalex.org/W4389888819","https://openalex.org/W4391281022","https://openalex.org/W4401794417","https://openalex.org/W4413335045","https://openalex.org/W4414404462","https://openalex.org/W7165536709"],"related_works":["https://openalex.org/W2030459820","https://openalex.org/W2188833094","https://openalex.org/W2339724940","https://openalex.org/W2294484957","https://openalex.org/W3024719993","https://openalex.org/W2340881901","https://openalex.org/W2741045810","https://openalex.org/W2065234547","https://openalex.org/W7099492265","https://openalex.org/W2075736159"],"abstract_inverted_index":{"Background:":[0],"Nicotinamide":[1],"mononucleotide":[2],"(NMN)":[3],"is":[4,25],"a":[5,14,120,152],"naturally":[6],"occurring,":[7],"biologically":[8],"active":[9],"nucleotide":[10],"that":[11,191,222],"serves":[12],"as":[13],"crucial":[15],"NAD+":[16],"precursor":[17],"in":[18,155,169],"various":[19,30],"physiological":[20],"conditions.":[21],"Although":[22,138],"intermittent":[23,40,57,196],"hypoxia":[24,42,61,87],"known":[26],"to":[27,53],"substantially":[28],"induce":[29],"health":[31],"problems,":[32],"whether":[33],"NMN":[34,63,69,139,192,223],"protects":[35],"against":[36],"injury":[37],"induced":[38],"by":[39,72],"normobaric":[41,58,86,197],"remains":[43],"unclear.":[44],"Methods:":[45],"In":[46],"this":[47],"study,":[48],"mice":[49],"were":[50,70],"randomly":[51],"assigned":[52],"groups":[54],"under":[55,230],"normoxia,":[56],"hypoxia,":[59],"and":[60,65,78,97,105,111,117,134,167,177,179,213,227,239],"with":[62],"intervention,":[64],"the":[66,106,127,131,162,170,174,181,184,202,215],"effects":[67,229],"of":[68,109,119,130,165,183],"evaluated":[71],"examining":[73],"organ":[74,146,203],"indices,":[75,149],"hematology,":[76],"histopathology,":[77],"16S":[79],"rRNA":[80],"gene":[81],"amplicon":[82],"sequencing.":[83],"Results:":[84],"Intermittent":[85],"significantly":[88,143,160],"increased":[89],"heart":[90],"weight,":[91],"cardiac":[92,107,115,199,207],"index,":[93,98,100,178],"right":[94,171],"ventricular":[95,121],"weight":[96,176],"spleen":[99,175],"serum":[101,156],"lactate":[102],"dehydrogenase":[103],"activity,":[104,158],"expression":[108,164],"BNP":[110,166],"Myh7,":[112],"indicating":[113],"pathological":[114],"hypertrophy":[116,200],"activation":[118],"stress":[122,208],"response.":[123],"It":[124],"also":[125],"reduced":[126],"beta":[128],"diversity":[129],"gut":[132,185,216],"microbiota":[133],"altered":[135],"its":[136],"composition.":[137],"intervention":[140],"did":[141],"not":[142,194],"affect":[144],"most":[145],"or":[147],"hematological":[148],"except":[150],"for":[151],"further":[153,241],"increase":[154],"LDH":[157],"it":[159],"attenuated":[161],"hypoxia-induced":[163,198],"Myh7":[168],"ventricle,":[172],"restored":[173],"changed":[180],"composition":[182],"microbiota.":[186,217],"These":[187,219],"exploratory":[188],"results":[189],"indicate":[190],"does":[193],"prevent":[195],"at":[201],"level":[204],"but":[205],"mitigates":[206],"markers,":[209],"ameliorates":[210],"splenic":[211],"changes,":[212],"modulates":[214],"Conclusions:":[218],"findings":[220],"suggest":[221],"produced":[224],"selective":[225],"molecular":[226],"systemic":[228],"hypoxic":[231],"exposure":[232],"rather":[233],"than":[234],"an":[235],"overall":[236],"protective":[237],"phenotype":[238],"warrant":[240],"investigation.":[242]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-13T00:00:00"}