{"id":"https://openalex.org/W7221556952","doi":"https://doi.org/10.64898/2026.10.09.757964","title":"Intrinsically disordered regions influence protein motif usage in Drosophila Ubx and AbdA Hox proteins","display_name":"Intrinsically disordered regions influence protein motif usage in Drosophila Ubx and AbdA Hox proteins","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221556952","doi":"https://doi.org/10.64898/2026.10.09.757964"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.09.757964","doi":"https://doi.org/10.64898/2026.10.09.757964","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.757964","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757964.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757964.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035990355","display_name":"Corinne Maurel-Zaffran","orcid":"https://orcid.org/0000-0002-7943-6995","observed_orcids":["https://orcid.org/0000-0002-7943-6995"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Maurel-Zaffran","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108936670","display_name":"Ilan Edelstein","orcid":"https://orcid.org/0009-0004-2488-4020","observed_orcids":["https://orcid.org/0009-0004-2488-4020"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ilan Edelstein","raw_affiliation_strings":["Dept. of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel;","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158448285","display_name":"Laurianne Michel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurianne Michel","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111400804","display_name":"Meiggie Macchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Meiggie Macchi","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010746377","display_name":"Nathalie Caruso","orcid":"https://orcid.org/0000-0001-6535-9178","observed_orcids":["https://orcid.org/0000-0001-6535-9178"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Caruso","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047066970","display_name":"Andrew J. Saurin","orcid":"https://orcid.org/0000-0001-5162-003X","observed_orcids":["https://orcid.org/0000-0001-5162-003X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andrew J Saurin","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054904960","display_name":"Yaakov Levy","orcid":"https://orcid.org/0000-0002-9929-973X","observed_orcids":["https://orcid.org/0000-0002-9929-973X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yaakov Levy","raw_affiliation_strings":["Dept. of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053823327","display_name":"Yacine Graba","orcid":"https://orcid.org/0000-0003-1324-1308","observed_orcids":["https://orcid.org/0000-0003-1324-1308"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Yacine Graba","raw_affiliation_strings":["Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), IBDM-UMR 7288, Case 907, Parc Scientifique de Luminy, Marseille Cedex 09 13288, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053823327"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hox-proteins","display_name":"Hox proteins","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ultrabithorax","display_name":"Ultrabithorax","score":0.9800000190734863},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8569999933242798},{"id":"https://openalex.org/keywords/homeodomain","display_name":"homeodomain","score":0.9850000143051147},{"id":"https://openalex.org/keywords/protein-motifs","display_name":"protein motifs","score":0.7179999947547913},{"id":"https://openalex.org/keywords/intramolecular-interactions","display_name":"intramolecular interactions","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.4410000145435333},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C197564579","wikidata":"https://www.wikidata.org/wiki/Q2019281","display_name":"Ultrabithorax","level":5,"score":0.900600016117096},{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.8154000043869019},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.6736000180244446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6621000170707703},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.661300003528595},{"id":"https://openalex.org/C64632358","wikidata":"https://www.wikidata.org/wiki/Q95351881","display_name":"engrailed","level":5,"score":0.6225000023841858},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5468999743461609},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.4903999865055084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4787999987602234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4302000105381012},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4226999878883362},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.3781999945640564},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.36399999260902405},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.36329999566078186},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3450999855995178},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.34290000796318054},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.3310999870300293},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.301800012588501},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.2946000099182129},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.26510000228881836},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.10.09.757964","doi":"https://doi.org/10.64898/2026.10.09.757964","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.757964","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757964.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:HAL:hal-05845160v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05845160","pdf_url":null,"source":{"id":"https://openalex.org/S4406922393","display_name":"HAL AMU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioRxiv, 2026, &#x27E8;10.64898/2026.10.09.757964&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.64898/2026.10.09.757964","doi":"https://doi.org/10.64898/2026.10.09.757964","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.757964","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757964.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309911","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221556952.pdf","grobid_xml":"https://content.openalex.org/works/W7221556952.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009151439","https://openalex.org/W7009885337","https://openalex.org/W2056034569","https://openalex.org/W2048109549","https://openalex.org/W2020817293","https://openalex.org/W22957624","https://openalex.org/W2911762785","https://openalex.org/W2138254300","https://openalex.org/W7029301155","https://openalex.org/W2412457665"],"abstract_inverted_index":{"Hox":[0,47,56],"proteins":[1],"are":[2,31,85],"evolutionary":[3],"conserved":[4,33,41,78,106],"transcription":[5],"factors":[6],"guiding":[7],"morphogenesis":[8],"in":[9,64,88,117,128,150],"all":[10],"bilaterian":[11],"animals.":[12],"Conservation":[13],"mainly":[14],"concerns":[15],"the":[16,83,112],"homeodomain":[17],"(HD),":[18],"a":[19,52,60,97,151],"helix-turn-helix":[20],"DNA":[21],"binding":[22],"motif":[23,126,148],"and":[24,34,58,71,90,110,119,124,140],"flanking":[25],"sequences":[26,30],"close":[27,81],"by.":[28],"Besides,":[29],"poorly":[32,40,105],"disordered.":[35],"Here":[36],"we":[37,75],"investigate":[38],"how":[39],"Intrinsically":[42],"Disordered":[43],"Regions":[44],"(IDRs)":[45],"influence":[46,146],"protein":[48,79,122,147],"activity,":[49],"focusing":[50],"on":[51],"closely":[53],"related":[54],"Drosophila":[55,68],"pair":[57],"using":[59],"wide":[61],"range":[62],"of":[63,100,143],"vivo":[65],"function.":[66],"Studying":[67],"Ultrabithorax":[69],"(Ubx)":[70],"AbdominalA":[72],"(AbdA)":[73],"proteins,":[74],"find":[76],"that":[77,134],"motifs":[80],"to":[82,137],"HD":[84],"differently":[86],"used":[87],"Ubx":[89,118],"AbdA.":[91],"Coarse-grained":[92],"molecular":[93],"dynamics":[94],"simulations":[95],"identify":[96],"large":[98,139],"set":[99],"intra-molecular":[101],"interactions,":[102,145],"notably":[103],"involving":[104],"disordered":[107],"regions":[108,116],"upstream":[109],"downstream":[111],"HD.":[113],"Swapping":[114],"these":[115],"AbdA":[120],"alters":[121],"functions":[123],"switches":[125],"dependency":[127],"some":[129],"biological":[130],"situations.":[131],"This":[132],"suggests":[133],"IDRs,":[135],"predicted":[136],"mediate":[138],"dynamic":[141],"sets":[142],"intramolecular":[144],"usage":[149],"context":[152],"dependent":[153],"manner.":[154]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-13T00:00:00"}
