{"id":"https://openalex.org/W7221551804","doi":"https://doi.org/10.64898/2026.10.09.26365170","title":"Ascending Aortic Calcium Identifies Patients at Risk Despite Normal Myocardial Flow, Perfusion and Coronary Calcium: A 13-Site Cohort Study","display_name":"Ascending Aortic Calcium Identifies Patients at Risk Despite Normal Myocardial Flow, Perfusion and Coronary Calcium: A 13-Site Cohort Study","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221551804","doi":"https://doi.org/10.64898/2026.10.09.26365170"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.09.26365170","doi":"https://doi.org/10.64898/2026.10.09.26365170","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.26365170","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.10.09.26365170","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158477338","display_name":"Clemens Spielvogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Clemens P. Spielvogel","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014550289","display_name":"Aakash Dhananjay Shanbhag","orcid":"https://orcid.org/0000-0001-5199-3071","observed_orcids":["https://orcid.org/0000-0001-5199-3071"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aakash Shanbhag","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122864483","display_name":"Shaun Khanna","orcid":"https://orcid.org/0000-0002-6741-1096","observed_orcids":["https://orcid.org/0000-0002-6741-1096","https://orcid.org/0000-0001-6594-6655"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Shaun Khanna","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","Cardiovascular Program, The George Institute for Global Health, UNSW Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Cardiovascular Program, The George Institute for Global Health, UNSW Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092630063","display_name":"Tara Zuhair Kassem","orcid":"https://orcid.org/0000-0002-0224-4346","observed_orcids":["https://orcid.org/0000-0002-0224-4346"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tara Zuhair Kassem","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","Department of Cardiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Cardiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015699574","display_name":"Mark H. Lemley","orcid":"https://orcid.org/0000-0002-1531-880X","observed_orcids":["https://orcid.org/0000-0002-1531-880X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Lemley","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062719102","display_name":"Jirong Yi","orcid":"https://orcid.org/0000-0002-3106-4715","observed_orcids":["https://orcid.org/0000-0002-3106-4715"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jirong Yi","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108146824","display_name":"Giselle Ramirez","orcid":"https://orcid.org/0009-0004-3730-5075","observed_orcids":["https://orcid.org/0009-0004-3730-5075"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giselle Ramirez","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053608718","display_name":"Paul Kavanagh","orcid":"https://orcid.org/0000-0002-2242-1936","observed_orcids":["https://orcid.org/0000-0002-2242-1936"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Kavanagh","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113177952","display_name":"Assiata Kamagate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Assiata Kamagate","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013905794","display_name":"Leandro N. Slipczuk","orcid":"https://orcid.org/0000-0003-3091-3735","observed_orcids":["https://orcid.org/0000-0003-3091-3735"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leandro Slipczuk","raw_affiliation_strings":["Department of Radiology (Nuclear Medicine), Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology (Nuclear Medicine), Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071165428","display_name":"Mark I. Travin","orcid":"https://orcid.org/0000-0003-0968-2143","observed_orcids":["https://orcid.org/0000-0003-0968-2143"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210112371","display_name":"Montefiore Health System","ror":"https://ror.org/01x0e6k76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark I. Travin","raw_affiliation_strings":["Cardiology Division, Montefiore Health System/Albert Einstein College of Medicine, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Montefiore Health System/Albert Einstein College of Medicine, NY, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052938278","display_name":"Ronny R. Buechel","orcid":"https://orcid.org/0000-0001-8064-8904","observed_orcids":["https://orcid.org/0000-0001-8064-8904"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ronny R. Buechel","raw_affiliation_strings":["Department of Nuclear Medicine, Cardiac Imaging, University Hospital of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cardiac Imaging, University Hospital of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056264770","display_name":"Robert A. deKemp","orcid":"https://orcid.org/0000-0001-9136-5563","observed_orcids":["https://orcid.org/0000-0001-9136-5563"]},"institutions":[{"id":"https://openalex.org/I4401200298","display_name":"Ottawa Heart Institute","ror":"https://ror.org/00h533452","country_code":"CA","type":"facility","lineage":["https://openalex.org/I153718931","https://openalex.org/I4401200298"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert A. DeKemp","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4401200298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158459274","display_name":"Erick Alexanderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Erick Alexanderson","raw_affiliation_strings":["Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011059785","display_name":"Isabel Carvajal-Ju\u00e1rez","orcid":"https://orcid.org/0000-0001-8764-6012","observed_orcids":["https://orcid.org/0000-0001-8764-6012","https://orcid.org/0000-0003-0753-1739"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Isabel Carvajal-Juarez","raw_affiliation_strings":["Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017721355","display_name":"Ren\u00e9 R. Sevag Packard","orcid":"https://orcid.org/0000-0002-8520-5843","observed_orcids":["https://orcid.org/0000-0002-8520-5843"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I2801272649","display_name":"Ronald Reagan UCLA Medical Center","ror":"https://ror.org/04k3jt835","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I2801272649"]},{"id":"https://openalex.org/I4210108215","display_name":"VA West Los Angeles Medical Center","ror":"https://ror.org/01xfgtq85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210108215","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 R.S. Packard","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles; Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA","West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles; Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I2801272649"]},{"raw_affiliation_string":"West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210108215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023253601","display_name":"Mouaz Husayn Al-Mallah","orcid":"https://orcid.org/0000-0003-2348-0484","observed_orcids":["https://orcid.org/0000-0003-2348-0484"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mouaz Al-Mallah","raw_affiliation_strings":["Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Academic Institute, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Academic Institute, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042867497","display_name":"Andrew Jeffrey Einstein","orcid":"https://orcid.org/0000-0003-2583-9278","observed_orcids":["https://orcid.org/0000-0003-2583-9278"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Einstein","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, and Department of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, and Department of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072988371","display_name":"Wanda Acampa","orcid":"https://orcid.org/0000-0003-2187-4076","observed_orcids":["https://orcid.org/0000-0003-2187-4076"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Wanda Acampa","raw_affiliation_strings":["Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086525044","display_name":"Stacey Knight","orcid":"https://orcid.org/0000-0003-0092-7327","observed_orcids":["https://orcid.org/0000-0003-0092-7327"]},"institutions":[{"id":"https://openalex.org/I108785884","display_name":"Intermountain Healthcare","ror":"https://ror.org/04mvr1r74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2803061204","display_name":"Intermountain Medical Center","ror":"https://ror.org/009c06z12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I2803061204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Knight","raw_affiliation_strings":["Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA","Intermountain Medical Center Heart Institute, Intermountain Healthcare, Murray, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Intermountain Medical Center Heart Institute, Intermountain Healthcare, Murray, UT, USA","institution_ids":["https://openalex.org/I108785884","https://openalex.org/I2803061204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051547394","display_name":"Viet T. Le","orcid":"https://orcid.org/0000-0001-6659-5332","observed_orcids":["https://orcid.org/0000-0001-6659-5332"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viet T. Le","raw_affiliation_strings":["Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150941289","display_name":"Steve Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Mason","raw_affiliation_strings":["Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090422321","display_name":"Thomas L. Rosamond","orcid":"https://orcid.org/0009-0000-1417-8342","observed_orcids":["https://orcid.org/0009-0000-1417-8342"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. Rosamond","raw_affiliation_strings":["Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034002001","display_name":"Robert J.H. Miller","orcid":"https://orcid.org/0000-0003-4676-2433","observed_orcids":["https://orcid.org/0000-0003-4676-2433","https://orcid.org/0000-0002-7181-7080"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert J.H. Miller","raw_affiliation_strings":["Department of Cardiac Sciences, University of Calgary, Calgary Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Sciences, University of Calgary, Calgary Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024726160","display_name":"Panithaya Chareonthaitawee","orcid":"https://orcid.org/0000-0002-3811-8712","observed_orcids":["https://orcid.org/0000-0002-3811-8712"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panithaya Chareonthaitawee","raw_affiliation_strings":["Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034002001","display_name":"Robert J.H. Miller","orcid":"https://orcid.org/0000-0003-4676-2433","observed_orcids":["https://orcid.org/0000-0003-4676-2433","https://orcid.org/0000-0002-7181-7080"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damini Dey","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0003-4676-2433","affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727282","display_name":"Daniel S. Berman","orcid":"https://orcid.org/0000-0002-3793-9578","observed_orcids":["https://orcid.org/0000-0002-3793-9578"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Berman","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086342448","display_name":"Marcelo F. Di Carli","orcid":"https://orcid.org/0000-0003-3119-025X","observed_orcids":["https://orcid.org/0000-0003-3119-025X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelo F. Di Carli","raw_affiliation_strings":["Cardiovascular Imaging Program, Departments of Radiology and Medicine, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Imaging Program, Departments of Radiology and Medicine, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089319978","display_name":"Piotr J. Slomka","orcid":"https://orcid.org/0000-0002-6110-938X","observed_orcids":["https://orcid.org/0000-0002-6110-938X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr J. Slomka","raw_affiliation_strings":["Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0002-6110-938X","affiliations":[{"raw_affiliation_string":"Artificial Intelligence in Medicine Research Center, Department of Medicine, Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":26,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascending-aortic-calcification","display_name":"ascending aortic calcification","score":0.9769999980926514},{"id":"https://openalex.org/keywords/myocardial-perfusion-imaging","display_name":"myocardial perfusion imaging","score":0.824999988079071},{"id":"https://openalex.org/keywords/myocardial-flow-reserve","display_name":"myocardial flow reserve","score":0.9179999828338623},{"id":"https://openalex.org/keywords/coronary-artery-calcium","display_name":"coronary artery calcium","score":0.9509999752044678},{"id":"https://openalex.org/keywords/residual-cardiovascular-risk","display_name":"residual cardiovascular risk","score":0.8109999895095825},{"id":"https://openalex.org/keywords/heart-failure-admission","display_name":"heart failure admission","score":0.7860000133514404},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8050000071525574},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.7269999980926514},{"id":"https://openalex.org/keywords/agatston-score","display_name":"Agatston score","score":0.7509999871253967},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.621999979019165},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.44600000977516174},{"id":"https://openalex.org/keywords/pet-ct","display_name":"PET/CT","score":0.32600000500679016},{"id":"https://openalex.org/keywords/coronary-microvascular-dysfunction","display_name":"coronary microvascular dysfunction","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.930899977684021},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8040000200271606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7300999760627747},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7017999887466431},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6306999921798706},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5953999757766724},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5852000117301941},{"id":"https://openalex.org/C2994533308","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Coronary artery calcium","level":3,"score":0.4350999891757965},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2778405248","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial perfusion imaging","level":3,"score":0.3361999988555908},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C2780609585","wikidata":"https://www.wikidata.org/wiki/Q5629407","display_name":"Agatston score","level":4,"score":0.31299999356269836},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.28130000829696655},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C123688308","wikidata":"https://www.wikidata.org/wiki/Q7309537","display_name":"Correction for attenuation","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.09.26365170","doi":"https://doi.org/10.64898/2026.10.09.26365170","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.26365170","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.09.26365170","doi":"https://doi.org/10.64898/2026.10.09.26365170","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.26365170","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W198055846","https://openalex.org/W1612218396","https://openalex.org/W2010839989","https://openalex.org/W2028748749","https://openalex.org/W2081684149","https://openalex.org/W2121514893","https://openalex.org/W2134440176","https://openalex.org/W2137792032","https://openalex.org/W2149755434","https://openalex.org/W2153785016","https://openalex.org/W2157995113","https://openalex.org/W2177562330","https://openalex.org/W2546645584","https://openalex.org/W2623065852","https://openalex.org/W2792588444","https://openalex.org/W2811113278","https://openalex.org/W2861366762","https://openalex.org/W2900705378","https://openalex.org/W2919789849","https://openalex.org/W2955405259","https://openalex.org/W2971164718","https://openalex.org/W3001966161","https://openalex.org/W3139099279","https://openalex.org/W3140705365","https://openalex.org/W4220946720","https://openalex.org/W4223502931","https://openalex.org/W4294300422","https://openalex.org/W4295774775","https://openalex.org/W4376631124","https://openalex.org/W4383218413","https://openalex.org/W4383871935","https://openalex.org/W4388211952","https://openalex.org/W4405983352","https://openalex.org/W4407739326","https://openalex.org/W4409020924","https://openalex.org/W4410375495","https://openalex.org/W4413031530","https://openalex.org/W4413782235","https://openalex.org/W4416733145","https://openalex.org/W4416809145","https://openalex.org/W7133225813","https://openalex.org/W7161275739","https://openalex.org/W7164907824","https://openalex.org/W7165765657"],"related_works":["https://openalex.org/W7171500993","https://openalex.org/W4386596786","https://openalex.org/W4407313158","https://openalex.org/W4285728627","https://openalex.org/W7154692123","https://openalex.org/W4384945184","https://openalex.org/W2122765691","https://openalex.org/W4409744712","https://openalex.org/W4403409081","https://openalex.org/W7167025780"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Patients":[2,390],"with":[3,108,143,175,217,227,236,259,293,313,326,345,375],"normal":[4,6,228,260,262,342,346],"perfusion,":[5,261],"myocardial":[7,18,102,263,296],"flow":[8,264,347],"reserve":[9,265],"(MFR)":[10],"and":[11,30,78,93,196,214,249,266,348],"no":[12,31,267,349],"coronary":[13,268,350],"artery":[14,269],"calcium":[15,270,351],"(CAC)":[16],"on":[17,271,282],"perfusion":[19,87,248,343,377],"imaging":[20,34],"are":[21],"considered":[22],"low":[23,356,392],"risk.":[24,38],"Yet,":[25],"adverse":[26,237],"events":[27,166],"still":[28],"occur":[29],"routinely":[32,383],"reported":[33,382],"marker":[35],"stratifies":[36,56],"residual":[37],"This":[39],"study":[40],"aims":[41],"to":[42,149,328,332],"determine":[43],"whether":[44],"fully":[45,319],"automated":[46,231,320],"ascending":[47,279,323,360,365,396],"aortic":[48,76,280,288,324,366,397],"calcification":[49,281,289,325,367,398],"(AAC)":[50],"from":[51,70,371],"the":[52,63,176,283,338,359,372],"attenuation":[53,284],"correction":[54,285],"CT":[55,72,373],"risk":[57,246,357,393],"in":[58,220,276],"these":[59],"patients.":[60],"Methods":[61],"In":[62,225,256],"multicenter":[64],"REFINE-PET":[65],"registry,":[66],"AAC":[67,136,171,206,232],"was":[68,82,99,147,172,233,290],"quantified":[69],"non-contrast":[71],"using":[73],"deep":[74],"learning":[75],"segmentation":[77],"Agatston":[79,138],"scoring.":[80],"Triple-normal":[81],"defined":[83],"as":[84,112,405],"stress":[85],"total":[86],"deficit":[88],"(TPD)":[89],"<5%,":[90],"MFR":[91,213],">2":[92],"CAC":[94],"0.":[95],"The":[96],"primary":[97,165,177],"endpoint":[98,178],"cardiovascular":[100,294],"death,":[101,295],"infarction":[103,297],"or":[104,298,388],"heart":[105,109,186,241,299,314,401],"failure":[106,110,187,242,300,315],"admission,":[107,243],"admission":[111,188,301],"key":[113],"secondary":[114],"endpoint.":[115],"Cox":[116],"models":[117],"were":[118,129],"adjusted":[119],"for":[120],"clinical":[121,211,245],"confounders.":[122],"Results":[123],"Of":[124],"21,923":[125],"patients,":[126],"3,580":[127,257],"(16.3%)":[128],"triple-normal,":[130],"of":[131,159],"whom":[132],"1,322":[133],"(36.9%)":[134],"had":[135,278],"(median":[137],"65,":[139],"IQR":[140],"22-212).":[141],"Agreement":[142],"three":[144,277],"blinded":[145],"readers":[146,330],"good":[148],"excellent":[150],"(Intraclass":[151],"correlation":[152],"coefficient":[153],"0.87-0.90).":[154],"Over":[155],"a":[156],"median":[157],"follow-up":[158],"52":[160],"months":[161],"(IQR":[162],"26-69),":[163],"194":[164],"occurred.":[167],"Per":[168],"standard":[169],"deviation,":[170],"independently":[173,234,291],"associated":[174,235,292],"(adjusted":[179,189,199,302],"HR":[180,190,200],"1.24,":[181,307],"95%":[182,192,202,308],"CI":[183,193,203,309],"1.09-1.40;":[184],"p<0.001),":[185],"1.30,":[191],"1.10-1.55;":[194],"p=0.003)":[195],"all-cause":[197],"mortality":[198],"1.17,":[201],"1.04-1.32;":[204],"p=0.009).":[205],"improved":[207],"model":[208],"fit":[209],"beyond":[210,244],"factors,":[212,247],"TPD":[215],"(p\u22640.009),":[216],"modest":[218],"gains":[219],"discrimination":[221],"(\u0394C":[222],"0.007-0.009).":[223],"Conclusions":[224],"patients":[226,258],"PET":[229,344],"readouts,":[230],"outcomes,":[238],"most":[239,311],"strongly":[240,312],"flow.":[250],"Clinical":[251,339],"Perspective":[252],"What":[253,336],"Is":[254],"New?":[255],"PET,":[272,378],"more":[273],"than":[274],"one":[275],"CT.":[286],"Ascending":[287],"hazard":[303],"ratio":[304],"per":[305],"SD":[306],"1.09-1.40),":[310],"admission.":[316],"A":[317,341],"fast,":[318],"method":[321],"scored":[322,369],"agreement":[327,333],"expert":[329],"similar":[331],"between":[334],"readers.":[335],"Are":[337],"Implications?":[340],"does":[352],"not":[353],"mean":[354],"uniformly":[355],"when":[358],"aorta":[361],"is":[362,368],"calcified.":[363],"Because":[364],"automatically":[370],"acquired":[374],"every":[376],"it":[379],"could":[380],"be":[381],"without":[384],"additional":[385],"scanning,":[386],"cost":[387],"radiation.":[389],"presumed":[391],"who":[394],"have":[395],"may":[399],"warrant":[400],"failure-oriented":[402],"prevention,":[403],"such":[404],"natriuretic":[406],"peptide":[407],"screening,":[408],"pending":[409],"prospective":[410],"validation.":[411]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-13T00:00:00"}
