{"id":"https://openalex.org/W7221548816","doi":"https://doi.org/10.1021/acsomega.6c07276","title":"Toward Chemoselective Modification of Selenocysteine-Containing Biomolecules Via Doubly Activated Cyclopropanes","display_name":"Toward Chemoselective Modification of Selenocysteine-Containing Biomolecules Via Doubly Activated Cyclopropanes","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221548816","doi":"https://doi.org/10.1021/acsomega.6c07276","pmid":"https://pubmed.ncbi.nlm.nih.gov/42959919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13717745"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c07276","doi":"https://doi.org/10.1021/acsomega.6c07276","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c07276","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07276/68818412/acsomega.6c07276.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07276/68818412/acsomega.6c07276.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019230935","display_name":"Hiroyuki Yamakoshi","orcid":"https://orcid.org/0000-0002-9263-577X","observed_orcids":["https://orcid.org/0000-0002-9263-577X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroyuki Yamakoshi","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":"https://orcid.org/0000-0002-9263-577X","affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158458313","display_name":"Hiro Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiro Ikeda","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158446158","display_name":"Wang Yinuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wang Yinuo","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031023047","display_name":"Takashi Toyama","orcid":"https://orcid.org/0000-0001-8322-3733","observed_orcids":["https://orcid.org/0000-0001-8322-3733"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Toyama","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123786151","display_name":"Hayato Takashima","orcid":"https://orcid.org/0009-0000-9906-4204","observed_orcids":["https://orcid.org/0009-0000-9906-4204"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayato Takashima","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158477126","display_name":"Hideyuki Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Nagai","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080741475","display_name":"Ryo Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Watanabe","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102728579","display_name":"Yoshiro Saito","orcid":"https://orcid.org/0000-0002-0559-5889","observed_orcids":["https://orcid.org/0000-0002-0559-5889"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiro Saito","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":"https://orcid.org/0000-0002-0559-5889","affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062220638","display_name":"Yoshiharu Iwabuchi","orcid":"https://orcid.org/0000-0002-0679-939X","observed_orcids":["https://orcid.org/0000-0002-0679-939X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiharu Iwabuchi","raw_affiliation_strings":["Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,"],"raw_orcid":"https://orcid.org/0000-0002-0679-939X","affiliations":[{"raw_affiliation_string":"Tohoku University , , 6-3 Aoba, Aramaki, Aoba-ku , ,","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019230935","https://openalex.org/A5062220638"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64889361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"42","first_page":"65125","last_page":"65132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenocysteine","display_name":"selenocysteine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chemoselective-modification","display_name":"chemoselective modification","score":0.8799999952316284},{"id":"https://openalex.org/keywords/thiol-reactivity","display_name":"thiol reactivity","score":0.7459999918937683},{"id":"https://openalex.org/keywords/selenoproteins","display_name":"selenoproteins","score":0.7670000195503235},{"id":"https://openalex.org/keywords/selenoprotein-p","display_name":"selenoprotein P","score":0.9589999914169312},{"id":"https://openalex.org/keywords/peroxiredoxin-6","display_name":"peroxiredoxin 6","score":0.9829999804496765},{"id":"https://openalex.org/keywords/biotinylated-probes","display_name":"biotinylated probes","score":0.906000018119812},{"id":"https://openalex.org/keywords/chemical-probes","display_name":"chemical probes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/electrophilic-warheads","display_name":"electrophilic warheads","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8235999941825867},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.7922000288963318},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.7505000233650208},{"id":"https://openalex.org/C930959","wikidata":"https://www.wikidata.org/wiki/Q4086920","display_name":"Bioorthogonal chemistry","level":3,"score":0.6808000206947327},{"id":"https://openalex.org/C2776087148","wikidata":"https://www.wikidata.org/wiki/Q408663","display_name":"Selenocysteine","level":4,"score":0.6747999787330627},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5899999737739563},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.539900004863739},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4896000027656555},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.429500013589859},{"id":"https://openalex.org/C23963754","wikidata":"https://www.wikidata.org/wiki/Q4914729","display_name":"Bioconjugation","level":2,"score":0.41029998660087585},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.3912999927997589},{"id":"https://openalex.org/C2775997276","wikidata":"https://www.wikidata.org/wiki/Q420241","display_name":"Carbodiimide","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.3474999964237213},{"id":"https://openalex.org/C2780815831","wikidata":"https://www.wikidata.org/wiki/Q5272198","display_name":"Diazirine","level":2,"score":0.3474000096321106},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.3206999897956848},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30660000443458557},{"id":"https://openalex.org/C184133267","wikidata":"https://www.wikidata.org/wiki/Q5090480","display_name":"Chemical modification","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C2776841403","wikidata":"https://www.wikidata.org/wiki/Q2745644","display_name":"Selenoprotein","level":5,"score":0.2743000090122223},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27140000462532043},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.2531000077724457}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.6c07276","doi":"https://doi.org/10.1021/acsomega.6c07276","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c07276","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07276/68818412/acsomega.6c07276.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13717745","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717745/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717745/pdf/ao6c07276.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:42959919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42959919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d2ec390715b7488ab543aa6463622f71","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d2ec390715b7488ab543aa6463622f71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 11, Iss 42, Pp 65125-65132 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c07276","doi":"https://doi.org/10.1021/acsomega.6c07276","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c07276","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07276/68818412/acsomega.6c07276.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7036881657","display_name":null,"funder_award_id":"JPMXS0440600022","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7446900812","display_name":null,"funder_award_id":"JP22ama121040j0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7932395812","display_name":null,"funder_award_id":"JP22ama121040j0001","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G9001173499","display_name":null,"funder_award_id":"26K23301","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221548816.pdf","grobid_xml":"https://content.openalex.org/works/W7221548816.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1991498432","https://openalex.org/W2011198909","https://openalex.org/W2011223343","https://openalex.org/W2013131201","https://openalex.org/W2017648151","https://openalex.org/W2025257694","https://openalex.org/W2039198912","https://openalex.org/W2064202483","https://openalex.org/W2102519512","https://openalex.org/W2125930202","https://openalex.org/W2130798915","https://openalex.org/W2202133293","https://openalex.org/W2255588859","https://openalex.org/W2294386056","https://openalex.org/W2322728052","https://openalex.org/W2436539256","https://openalex.org/W2487027960","https://openalex.org/W2513565515","https://openalex.org/W2519738989","https://openalex.org/W2593028600","https://openalex.org/W2615205682","https://openalex.org/W2618850006","https://openalex.org/W2748521911","https://openalex.org/W2752223608","https://openalex.org/W2765108072","https://openalex.org/W2769072076","https://openalex.org/W2793941161","https://openalex.org/W2793995742","https://openalex.org/W2806200562","https://openalex.org/W2898863862","https://openalex.org/W2951781521","https://openalex.org/W2967878513","https://openalex.org/W3010311908","https://openalex.org/W3012062716","https://openalex.org/W3161031031","https://openalex.org/W3162889006","https://openalex.org/W3188321281","https://openalex.org/W3203549277","https://openalex.org/W4282016460","https://openalex.org/W4298008754","https://openalex.org/W4366958744","https://openalex.org/W4366997945","https://openalex.org/W4382930014","https://openalex.org/W4388416753","https://openalex.org/W4400725135","https://openalex.org/W4402679579","https://openalex.org/W4406758788","https://openalex.org/W4407793132","https://openalex.org/W4410775365","https://openalex.org/W4413325312"],"related_works":["https://openalex.org/W2826128847","https://openalex.org/W4210602229","https://openalex.org/W2322728052","https://openalex.org/W7039435833","https://openalex.org/W2952430093","https://openalex.org/W3001846960","https://openalex.org/W3188321281","https://openalex.org/W4390696802","https://openalex.org/W4237804344","https://openalex.org/W3034694337"],"abstract_inverted_index":{"Selective":[0,44],"modification":[1],"of":[2,91],"selenocysteine":[3],"(Sec)":[4],"remains":[5],"challenging":[6],"due":[7],"to":[8,79],"competing":[9],"thiol":[10],"reactivity.":[11],"In":[12],"this":[13],"study,":[14],"we":[15],"demonstrate":[16],"that":[17],"doubly":[18,81],"activated":[19,82],"cyclopropanes":[20,83],"can":[21],"serve":[22],"as":[23,84],"effective":[24],"electrophilic":[25],"warheads":[26],"for":[27,88],"Sec-selective":[28],"modification.":[29],"The":[30],"electrophile":[31],"undergoes":[32],"efficient":[33],"ring-opening":[34],"reactions":[35],"with":[36],"selenols,":[37],"while":[38,64],"showing":[39],"limited":[40],"reactivity":[41],"toward":[42],"thiols.":[43],"labeling":[45,61],"using":[46],"Sec-containing":[47],"peptides":[48],"was":[49],"confirmed":[50],"by":[51],"mass":[52],"spectrometry.":[53],"A":[54],"biotinylated":[55],"probe":[56],"enabled":[57,77],"protein-level":[58],"validation,":[59],"selectively":[60],"selenoprotein":[62],"P":[63],"avoiding":[65],"the":[66,89],"cysteine-containing":[67],"protein":[68],"peroxiredoxin":[69],"6":[70],"under":[71],"mildly":[72],"acidic":[73],"conditions.":[74],"These":[75],"findings":[76],"us":[78],"identify":[80],"a":[85],"promising":[86],"scaffold":[87],"development":[90],"chemical":[92],"probes":[93],"targeting":[94],"selenoproteins.":[95]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-13T00:00:00"}