{"id":"https://openalex.org/W7221546522","doi":"https://doi.org/10.1038/s41598-026-75063-5","title":"LIPT1 is associated with rheumatoid arthritis fibroblast phenotypes and Wnt-related signaling","display_name":"LIPT1 is associated with rheumatoid arthritis fibroblast phenotypes and Wnt-related signaling","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221546522","doi":"https://doi.org/10.1038/s41598-026-75063-5"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-75063-5","doi":"https://doi.org/10.1038/s41598-026-75063-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75063-5","pdf_url":"https://www.nature.com/articles/s41598-026-75063-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-75063-5_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158528977","display_name":"Shu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Li","raw_affiliation_strings":["The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158441981","display_name":"Lei Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Wan","raw_affiliation_strings":["The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158529383","display_name":"Xiaojun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Zhang","raw_affiliation_strings":["Anhui University of Chinese Medicine, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui University of Chinese Medicine, Hefei, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158442894","display_name":"Nan Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Cheng","raw_affiliation_strings":["The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China","institution_ids":["https://openalex.org/I253932293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5158441981"],"corresponding_institution_ids":["https://openalex.org/I253932293"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78118609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipt1","display_name":"LIPT1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9509999752044678},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/skl2001","display_name":"SKL2001","score":0.9240000247955322},{"id":"https://openalex.org/keywords/synovial-transcriptome","display_name":"synovial transcriptome","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6299999952316284},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7730000019073486},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.8169999718666077},{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7716000080108643},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7537999749183655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6172000169754028},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5364999771118164},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5145000219345093},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35589998960494995},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3407000005245209},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.3294999897480011},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3075999915599823},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-75063-5","doi":"https://doi.org/10.1038/s41598-026-75063-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75063-5","pdf_url":"https://www.nature.com/articles/s41598-026-75063-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-75063-5","doi":"https://doi.org/10.1038/s41598-026-75063-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75063-5","pdf_url":"https://www.nature.com/articles/s41598-026-75063-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6705366635","display_name":null,"funder_award_id":"82274501","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7945398758","display_name":null,"funder_award_id":"2308085MH291","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221546522.pdf","grobid_xml":"https://content.openalex.org/works/W7221546522.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2000468514","https://openalex.org/W2036615406","https://openalex.org/W2057488198","https://openalex.org/W2080877817","https://openalex.org/W2092855542","https://openalex.org/W2943304682","https://openalex.org/W2986710644","https://openalex.org/W3092864602","https://openalex.org/W3191538707","https://openalex.org/W4221115671","https://openalex.org/W4289731102","https://openalex.org/W4312190224","https://openalex.org/W4386438843","https://openalex.org/W4392236301","https://openalex.org/W4398241781","https://openalex.org/W4404865910","https://openalex.org/W4405852264","https://openalex.org/W4411324603","https://openalex.org/W4411413766","https://openalex.org/W4412049292","https://openalex.org/W4412349026"],"related_works":["https://openalex.org/W4379521340","https://openalex.org/W3092864602","https://openalex.org/W4323305066","https://openalex.org/W2772620381","https://openalex.org/W4205651909","https://openalex.org/W4367183375","https://openalex.org/W2051249644","https://openalex.org/W2995889771","https://openalex.org/W7140215744","https://openalex.org/W2584441577"],"abstract_inverted_index":{"Lipoyltransferase":[0],"1":[1],"(LIPT1)":[2],"supports":[3],"mitochondrial":[4],"protein":[5,117],"lipoylation,":[6],"but":[7,79],"its":[8],"role":[9],"in":[10,30,86],"rheumatoid":[11],"arthritis":[12],"(RA)":[13],"fibroblasts":[14],"remains":[15,174],"unclear.":[16],"We":[17],"integrated":[18],"synovial":[19,40,74],"transcriptomes":[20],"from":[21,48],"39":[22],"RA":[23,36,50,59],"and":[24,37,42,52,66,92,102,108,111,119,137,139,149,160],"27":[25],"control":[26],"samples,":[27,41],"evaluated":[28],"expression":[29,85,122,141],"an":[31],"independent":[32],"cohort":[33],"of":[34,166],"152":[35],"28":[38],"healthy":[39,54],"examined":[43],"peripheral":[44],"blood":[45],"mononuclear":[46],"cells":[47],"six":[49,53],"participants":[51],"controls.":[55],"Commercially":[56],"obtained":[57],"primary":[58],"fibroblast-like":[60],"synoviocytes":[61],"(RA-FLS)":[62],"underwent":[63],"LIPT1":[64,88,138,156,167],"silencing":[65],"treatment":[67],"with":[68,126,157],"the":[69,164,170],"Wnt/\u03b2-catenin":[70],"agonist":[71],"SKL2001.":[72],"Independent":[73],"validation":[75],"showed":[76],"higher":[77],"LIPT1,":[78],"not":[80],"metal-regulatory":[81],"transcription":[82],"factor":[83],"1,":[84],"RA.":[87],"depletion":[89],"reduced":[90],"migration":[91],"Cell":[93,132],"Counting":[94,133],"Kit-8":[95,134],"signals,":[96,118,135],"increased":[97,105,130],"apoptosis-associated":[98],"Annexin":[99,144],"V":[100,145],"positivity":[101],"intracellular":[103],"copper,":[104],"superoxide":[106],"dismutase":[107],"peroxidase":[109],"activities,":[110],"decreased":[112],"malondialdehyde.":[113],"WNT5A":[114],"transcripts,":[115],"WNT5A/B-reactive":[116],"total":[120],"\u03b2-catenin":[121],"also":[123],"decreased.":[124],"Compared":[125],"knockdown":[127],"alone,":[128],"SKL2001":[129,162],"migration,":[131],"malondialdehyde,":[136],"Wnt-related":[140],"while":[142],"reducing":[143],"positivity,":[146],"copper":[147],"content,":[148],"antioxidant":[150],"enzyme":[151],"activities.":[152],"These":[153],"findings":[154],"associate":[155],"RA-FLS":[158],"survival":[159],"migration.":[161],"counteracts":[163],"effects":[165],"depletion,":[168],"although":[169],"underlying":[171],"signaling":[172],"mechanism":[173],"unresolved.":[175]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-13T00:00:00"}