{"id":"https://openalex.org/W7221535587","doi":"https://doi.org/10.1371/journal.pgen.1012334","title":"An NKX2-3/5/6 homolog is required downstream of BMP signaling to pattern the sensory-adhesive organ of a tunicate larva","display_name":"An NKX2-3/5/6 homolog is required downstream of BMP signaling to pattern the sensory-adhesive organ of a tunicate larva","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221535587","doi":"https://doi.org/10.1371/journal.pgen.1012334","pmid":"https://pubmed.ncbi.nlm.nih.gov/41509299","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12776149"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1012334","doi":"https://doi.org/10.1371/journal.pgen.1012334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1012334","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1012334&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1012334&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103570116","display_name":"Christopher Jay Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher J. Johnson","raw_affiliation_strings":["School of Biological Sciences, Georgia Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079733480","display_name":"Joshua Kavaler","orcid":"https://orcid.org/0000-0002-4603-5781","observed_orcids":["https://orcid.org/0000-0002-4603-5781"]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Kavaler","raw_affiliation_strings":["Colby College"],"raw_orcid":"https://orcid.org/0000-0002-4603-5781","affiliations":[{"raw_affiliation_string":"Colby College","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158455095","display_name":"Timethea Slade","orcid":"https://orcid.org/0009-0000-2450-0593","observed_orcids":["https://orcid.org/0009-0000-2450-0593"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timethea Slade","raw_affiliation_strings":["School of Biological Sciences, Georgia Institute of Technology"],"raw_orcid":"https://orcid.org/0009-0000-2450-0593","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031648969","display_name":"Kayla Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayla Wilson","raw_affiliation_strings":["School of Biological Sciences, Georgia Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023298088","display_name":"Christina D. Cota","orcid":"https://orcid.org/0000-0003-1307-903X","observed_orcids":["https://orcid.org/0000-0003-1307-903X"]},"institutions":[{"id":"https://openalex.org/I27504731","display_name":"Colby College","ror":"https://ror.org/00fvyjk73","country_code":"US","type":"education","lineage":["https://openalex.org/I27504731"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina D. Cota","raw_affiliation_strings":["Colby College"],"raw_orcid":"https://orcid.org/0000-0003-1307-903X","affiliations":[{"raw_affiliation_string":"Colby College","institution_ids":["https://openalex.org/I27504731"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014613784","display_name":"Alberto Stolfi","orcid":"https://orcid.org/0000-0001-7179-9700","observed_orcids":["https://orcid.org/0000-0001-7179-9700"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alberto Stolfi","raw_affiliation_strings":["School of Biological Sciences, Georgia Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0001-7179-9700","affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014613784","https://openalex.org/A5103570116"],"corresponding_institution_ids":["https://openalex.org/I130701444"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6479714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"10","first_page":"e1012334","last_page":"e1012334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ciona-intestinalis","display_name":"Ciona intestinalis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chordin","display_name":"chordin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/msx","display_name":"MSX","score":0.984000027179718},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8610000014305115},{"id":"https://openalex.org/keywords/neural-plate-border","display_name":"neural plate border","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9229999780654907},{"id":"https://openalex.org/C2778712684","wikidata":"https://www.wikidata.org/wiki/Q10915","display_name":"Chordate","level":4,"score":0.8815000057220459},{"id":"https://openalex.org/C2779528156","wikidata":"https://www.wikidata.org/wiki/Q2567701","display_name":"Ciona intestinalis","level":3,"score":0.7889000177383423},{"id":"https://openalex.org/C2780930470","wikidata":"https://www.wikidata.org/wiki/Q165118","display_name":"Tunicate","level":2,"score":0.7717000246047974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7315999865531921},{"id":"https://openalex.org/C2780205128","wikidata":"https://www.wikidata.org/wiki/Q3677397","display_name":"Ciona","level":4,"score":0.72079998254776},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6428999900817871},{"id":"https://openalex.org/C2776133846","wikidata":"https://www.wikidata.org/wiki/Q243469","display_name":"Notochord","level":4,"score":0.6273000240325928},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.54339998960495},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.5138999819755554},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.4921000003814697},{"id":"https://openalex.org/C197849852","wikidata":"https://www.wikidata.org/wiki/Q2314823","display_name":"Neural plate","level":4,"score":0.46299999952316284},{"id":"https://openalex.org/C102225024","wikidata":"https://www.wikidata.org/wiki/Q1388375","display_name":"Neurulation","level":5,"score":0.4424000084400177},{"id":"https://openalex.org/C2781316418","wikidata":"https://www.wikidata.org/wiki/Q14903397","display_name":"Bone morphogenetic protein 4","level":4,"score":0.4334000051021576},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.42170000076293945},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4156000018119812},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.41429999470710754},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.3962000012397766},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3878999948501587},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.3716999888420105},{"id":"https://openalex.org/C83484664","wikidata":"https://www.wikidata.org/wiki/Q24727001","display_name":"Chordin","level":5,"score":0.3693999946117401},{"id":"https://openalex.org/C170286479","wikidata":"https://www.wikidata.org/wiki/Q24787399","display_name":"Ephrin","level":3,"score":0.36239999532699585},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.35100001096725464},{"id":"https://openalex.org/C78577261","wikidata":"https://www.wikidata.org/wiki/Q3391691","display_name":"Floor plate","level":2,"score":0.34950000047683716},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.34290000796318054},{"id":"https://openalex.org/C160351604","wikidata":"https://www.wikidata.org/wiki/Q6033113","display_name":"Ingression","level":5,"score":0.3400999903678894},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.32420000433921814},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.31520000100135803},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.31150001287460327},{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.3109999895095825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3046000003814697},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.29980000853538513},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C2780597806","wikidata":"https://www.wikidata.org/wiki/Q4133185","display_name":"Ganglionic eminence","level":4,"score":0.28189998865127563},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.2768999934196472}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.1012334","doi":"https://doi.org/10.1371/journal.pgen.1012334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1012334","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1012334&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},{"id":"doi:10.64898/2025.12.18.695272","doi":"https://doi.org/10.64898/2025.12.18.695272","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2025.12.18.695272","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13671656","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13671656/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13671656/pdf/pgen.1012334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:41509299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41509299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42862850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42862850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12776149","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12776149/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:31740f842baa48b5b152c4c0cf86408d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/31740f842baa48b5b152c4c0cf86408d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 22, Iss 10, p e1012334 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1012334","doi":"https://doi.org/10.1371/journal.pgen.1012334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1012334","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1012334&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1302685996","display_name":null,"funder_award_id":"2052493","funder_id":"https://openalex.org/F4320337399","funder_display_name":"Division of Integrative Organismal Systems"},{"id":"https://openalex.org/G7279946640","display_name":"Collaborative Research: RUI: Comparative analysis of endocytic trafficking during cell division","funder_award_id":"2052493","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000899911","display_name":"Regulation of neurodevelopmental cell behaviors in Ciona","funder_award_id":"R01HD104825","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000917731","display_name":"Leveraging the biphasic life cycle of a non-vertebrate chordate to investigate developmental transitions and phenotypic plasticity","funder_award_id":"R35GM158421","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337399","display_name":"Division of Integrative Organismal Systems","ror":"https://ror.org/01rvays47"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221535587.pdf","grobid_xml":"https://content.openalex.org/works/W7221535587.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W78734763","https://openalex.org/W234956257","https://openalex.org/W929470254","https://openalex.org/W1520125945","https://openalex.org/W1561436437","https://openalex.org/W1962330728","https://openalex.org/W1964773110","https://openalex.org/W1995762311","https://openalex.org/W2011682316","https://openalex.org/W2014611846","https://openalex.org/W2022342905","https://openalex.org/W2031143033","https://openalex.org/W2037405524","https://openalex.org/W2040114529","https://openalex.org/W2040910893","https://openalex.org/W2052393548","https://openalex.org/W2054913890","https://openalex.org/W2059145903","https://openalex.org/W2063853502","https://openalex.org/W2064464259","https://openalex.org/W2065274926","https://openalex.org/W2068507812","https://openalex.org/W2087918426","https://openalex.org/W2088554257","https://openalex.org/W2089055277","https://openalex.org/W2089803149","https://openalex.org/W2102988868","https://openalex.org/W2104090970","https://openalex.org/W2112047378","https://openalex.org/W2115875155","https://openalex.org/W2126793493","https://openalex.org/W2129593538","https://openalex.org/W2133350356","https://openalex.org/W2141197414","https://openalex.org/W2154345596","https://openalex.org/W2155186791","https://openalex.org/W2167279371","https://openalex.org/W2233603983","https://openalex.org/W2324713557","https://openalex.org/W2461013690","https://openalex.org/W2803479625","https://openalex.org/W2901760767","https://openalex.org/W2930202750","https://openalex.org/W2951019515","https://openalex.org/W2956327509","https://openalex.org/W2971502600","https://openalex.org/W2980560327","https://openalex.org/W2982671496","https://openalex.org/W3047528415","https://openalex.org/W3082034430","https://openalex.org/W3085172158","https://openalex.org/W3093872977","https://openalex.org/W3111148713","https://openalex.org/W3129424759","https://openalex.org/W4220952537","https://openalex.org/W4288758414","https://openalex.org/W4366463239","https://openalex.org/W4375956004","https://openalex.org/W4385897567","https://openalex.org/W4391484505","https://openalex.org/W4391643727","https://openalex.org/W4392747201","https://openalex.org/W4392820366","https://openalex.org/W4400514574","https://openalex.org/W4402128705","https://openalex.org/W4407557941","https://openalex.org/W4408337980","https://openalex.org/W4408474462","https://openalex.org/W4409696474","https://openalex.org/W4416530303","https://openalex.org/W7124977993","https://openalex.org/W7162018997"],"related_works":["https://openalex.org/W7116659615","https://openalex.org/W7153396131","https://openalex.org/W4392747201","https://openalex.org/W4367673826","https://openalex.org/W4375956004","https://openalex.org/W4416230505","https://openalex.org/W4366463239","https://openalex.org/W2039015384","https://openalex.org/W2023003889","https://openalex.org/W2089055277"],"abstract_inverted_index":{"Tunicates":[0],"are":[1,34,46],"the":[2,8,35,101,107,126,143,146,169,172,185,194,209,215,223,228,235,243,248],"sister":[3],"group":[4,52],"to":[5,78,92,141,167,177,184],"vertebrates":[6],"within":[7],"chordate":[9,14],"phylum,":[10],"yet":[11],"unlike":[12],"other":[13],"groups,":[15],"they":[16],"evolved":[17],"a":[18,51,131,161,197],"biphasic":[19],"lifecycle":[20],"alternating":[21],"between":[22,68],"motile":[23],"larvae":[24,33],"and":[25,42,71,82,104,159],"sessile":[26],"adults.":[27],"The":[28,44],"papillae":[29,45,144],"of":[30,53,106,138,171,189,196,204,217,238,247],"most":[31],"tunicate":[32],"key":[36,132],"sensory-adhesive":[37],"organ":[38],"regulating":[39],"their":[40,79],"settlement":[41],"metamorphosis.":[43],"nearly":[47],"always":[48],"arranged":[49],"as":[50],"three":[54,178,186],"morphologically":[55],"identical":[56],"organs":[57],"that":[58,100,125,135,152,164,181,214],"arise":[59],"from":[60],"an":[61],"anterior":[62,86],"neural":[63,74],"plate":[64],"border":[65,87],"region":[66,110],"nested":[67],"ventral":[69],"epidermis":[70],"more":[72],"dorsal/posterior":[73],"tube":[75],"progenitors.":[76],"Due":[77],"embryonic":[80,108],"origin":[81],"molecular":[83],"signatures,":[84],"this":[85],"has":[88],"been":[89],"evolutionarily":[90],"linked":[91],"vertebrate":[93],"placode":[94],"regions.":[95],"It":[96],"was":[97],"previously":[98],"shown":[99],"specification,":[102],"patterning,":[103],"morphogenesis":[105],"papilla":[109,173],"all":[111],"depend":[112],"on":[113],"BMP":[114,139,157,224],"signaling,":[115],"though":[116],"downstream":[117,137],"mechanisms":[118],"remain":[119],"poorly":[120],"understood.":[121],"Here":[122],"we":[123],"show":[124,213],"NKX2-3/5/6":[127],"ortholog":[128],"NK4":[129,153,190,205,218],"is":[130,154,165,219],"transcription":[133,230],"factor":[134,231],"acts":[136],"signaling":[140,158],"pattern":[142],"in":[145,193],"Ciona":[147],"embryo.":[148],"We":[149,211],"present":[150],"evidence":[151],"activated":[155],"by":[156,222],"encodes":[160],"transcriptional":[162],"repressor":[163],"required":[166],"restrict":[168],"expression":[170,216],"regulatory":[174],"gene":[175],"Foxg":[176],"cell":[179],"clusters":[180],"give":[182],"rise":[183],"papillae.":[187,210,249],"Loss":[188],"function":[191],"results":[192],"formation":[195],"single":[198],"large":[199],"papilla.":[200],"In":[201],"contrast,":[202],"overexpression":[203],"represses":[206],"Foxg,":[207],"eliminating":[208],"also":[212],"restricted":[220],"dorsally":[221],"antagonist":[225],"Chordin,":[226],"while":[227],"ventrally-expressed":[229],"Msx":[232],"can":[233],"alleviate":[234],"repressive":[236],"effect":[237],"NK4,":[239],"potentially":[240],"allowing":[241],"for":[242],"characteristic":[244],"tripartite":[245],"patterning":[246]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-13T00:00:00"}