{"id":"https://openalex.org/W7221532684","doi":"https://doi.org/10.26434/chemrxiv.15010275/v1","title":"Chromoselective Control for Aminoalkylation of CF3\u2011Alkenes through Low-Energy Photoredox Catalysis","display_name":"Chromoselective Control for Aminoalkylation of CF3\u2011Alkenes through Low-Energy Photoredox Catalysis","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7221532684","doi":"https://doi.org/10.26434/chemrxiv.15010275/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15010275/v1","doi":"https://doi.org/10.26434/chemrxiv.15010275/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15010275/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010275/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010275/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116681874","display_name":"Marine Le Stum","orcid":"https://orcid.org/0009-0001-0095-2138","observed_orcids":["https://orcid.org/0009-0001-0095-2138"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marine Le Stum","raw_affiliation_strings":["SCBM","Universit\u00e9 Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SCBM","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003636193","display_name":"Maria Eduarda C. Thedy","orcid":"https://orcid.org/0000-0003-3914-9681","observed_orcids":["https://orcid.org/0000-0003-3914-9681"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria Eduarda Candido Thedy","raw_affiliation_strings":["SCBM","Universit\u00e9 Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SCBM","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076929846","display_name":"Taline Kerackian","orcid":"https://orcid.org/0000-0001-6011-7858","observed_orcids":["https://orcid.org/0000-0001-6011-7858"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Taline Kerackian","raw_affiliation_strings":["SCBM","Universit\u00e9 Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SCBM","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023788451","display_name":"Jean\u2010Christophe Cintrat","orcid":"https://orcid.org/0000-0001-5758-8077","observed_orcids":["https://orcid.org/0000-0001-5758-8077"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Christophe Cintrat","raw_affiliation_strings":["SCBM","Universit\u00e9 Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SCBM","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074198285","display_name":"Emmanuel Nicolas","orcid":"https://orcid.org/0000-0002-0017-5500","observed_orcids":["https://orcid.org/0000-0002-0017-5500"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Nicolas","raw_affiliation_strings":["CEA, CNRS, NIMBE, Universit\u00e9 Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, CNRS, NIMBE, Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039745519","display_name":"Laurence Grimaud","orcid":"https://orcid.org/0000-0003-3904-1822","observed_orcids":["https://orcid.org/0000-0003-3904-1822"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Grimaud","raw_affiliation_strings":["D\u00e9partement de Chimie","E\u0301cole Normale Sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Chimie","institution_ids":[]},{"raw_affiliation_string":"E\u0301cole Normale Sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241","https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071675290","display_name":"Eug\u00e9nie Romero","orcid":"https://orcid.org/0000-0003-0484-1221","observed_orcids":["https://orcid.org/0000-0003-0484-1221"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eug\u00e9nie Romero","raw_affiliation_strings":["SCBM","Universit\u00e9 Paris-Saclay"],"raw_orcid":"https://orcid.org/0000-0003-0484-1221","affiliations":[{"raw_affiliation_string":"SCBM","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13253","display_name":"Photolysis and Reactive Intermediates","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoalkylation","display_name":"aminoalkylation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/trifluoromethyl-alkenes","display_name":"trifluoromethyl alkenes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/blue-light","display_name":"blue light","score":0.3709999918937683},{"id":"https://openalex.org/keywords/red-light","display_name":"red light","score":0.996999979019165},{"id":"https://openalex.org/keywords/spin-forbidden-transitions","display_name":"spin-forbidden transitions","score":0.7639999985694885},{"id":"https://openalex.org/keywords/photoexcitation","display_name":"photoexcitation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/photoelectrochemistry","display_name":"photoelectrochemistry","score":0.7580000162124634},{"id":"https://openalex.org/keywords/td-dft","display_name":"TD-DFT","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C45849291","wikidata":"https://www.wikidata.org/wiki/Q17166058","display_name":"Photoredox catalysis","level":4,"score":0.916100025177002},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.6762999892234802},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6754000186920166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6528000235557556},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.6198999881744385},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.5774999856948853},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.5514000058174133},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5159000158309937},{"id":"https://openalex.org/C104663316","wikidata":"https://www.wikidata.org/wiki/Q76299","display_name":"Visible spectrum","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3723999857902527},{"id":"https://openalex.org/C197865113","wikidata":"https://www.wikidata.org/wiki/Q2566866","display_name":"Divergent synthesis","level":3,"score":0.36500000953674316},{"id":"https://openalex.org/C3017965124","wikidata":"https://www.wikidata.org/wiki/Q4929359","display_name":"Blue light","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33079999685287476},{"id":"https://openalex.org/C2777959998","wikidata":"https://www.wikidata.org/wiki/Q357222","display_name":"Photoelectrochemistry","level":4,"score":0.26190000772476196}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15010275/v1","doi":"https://doi.org/10.26434/chemrxiv.15010275/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15010275/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010275/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15010275/v1","doi":"https://doi.org/10.26434/chemrxiv.15010275/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15010275/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010275/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221532684.pdf","grobid_xml":"https://content.openalex.org/works/W7221532684.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400413473","https://openalex.org/W4364353234","https://openalex.org/W4294286850","https://openalex.org/W2911232171","https://openalex.org/W6887386907","https://openalex.org/W4311284750","https://openalex.org/W3197771458","https://openalex.org/W2913204808","https://openalex.org/W7123723601","https://openalex.org/W2148135460"],"abstract_inverted_index":{"Recent":[0],"advances":[1,31],"in":[2,32,141],"chromoselective":[3],"photoredox":[4,139],"catalysis":[5,140],"have":[6,151],"demonstrated":[7],"that":[8],"light":[9,79,95],"wavelength":[10,172],"can":[11],"serve":[12],"as":[13,74],"a":[14,24,42,111,120,154],"powerful":[15,121],"and":[16,61,122,149],"orthogonal":[17],"reaction":[18],"parameter,":[19],"enabling":[20],"divergent":[21,69,142],"reactivity":[22,118],"from":[23],"single":[25],"catalytic":[26],"system.":[27],"Building":[28],"on":[29,169],"recent":[30],"the":[33,47,66,91,100,126,134,160,170],"sequential":[34],"decarboxylative/defluorinative":[35],"aminoalkylation":[36],"of":[37,50,83,130,137,156],"trifluoromethyl-substituted":[38],"alkenes,":[39],"we":[40],"report":[41],"divergent,":[43],"wavelength-dependent":[44],"strategy":[45],"for":[46,125,159],"site-selective":[48],"functionalization":[49,162],"N-arylglycines.":[51],"High-throughput":[52],"experimentation":[53],"(HTE)":[54],"was":[55],"used":[56],"to":[57,64,93,163],"systematically":[58],"screen":[59],"photocatalysts":[60],"irradiation":[62,76,92,171],"wavelengths":[63],"identify":[65],"most":[67],"suitable":[68],"conditions.":[70],"Interestingly,":[71],"using":[72,147],"[Ru(bpy)3]2+":[73],"photocatalyst,":[75],"with":[77,85],"blue":[78],"promotes":[80],"efficient":[81],"difunctionalization":[82],"CF3-alkenes":[84],"N-arylglycines,":[86],"affording":[87],"monofluoroalkenyl-1,5-diamines,":[88],"while":[89],"switching":[90],"red":[94],"enables":[96],"selective":[97],"monofunctionalization,":[98],"delivering":[99],"corresponding":[101],"gem-difluoroalkenyl":[102],"amine":[103,143],"intermediates":[104],"exclusively":[105],"under":[106],"otherwise":[107],"identical":[108],"conditions,":[109],"via":[110],"spin-forbidden":[112],"transition":[113],"pathway.":[114],"This":[115],"wavelength-governed":[116],"switchable":[117],"provides":[119],"tunable":[123],"platform":[124],"controlled":[127],"radical":[128],"modification":[129],"amino":[131],"acids,":[132],"expanding":[133],"synthetic":[135],"utility":[136],"visible-light":[138],"synthesis.":[144],"Mechanistic":[145],"investigations":[146],"photoelectrochemistry":[148],"TD-DFT":[150],"revealed":[152],"notably":[153],"photo-excitation":[155],"intermediates,":[157],"allowing":[158],"second":[161],"whether":[164],"happens":[165],"or":[166],"not,":[167],"based":[168],"used.":[173]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-13T00:00:00"}