{"id":"https://openalex.org/W7221520141","doi":"https://doi.org/10.1007/s00128-026-04322-y","title":"Biochemical, Genotoxic and Somatic responses of Oreochromis Niloticus Exposed to Enalapril Maleate in Water","display_name":"Biochemical, Genotoxic and Somatic responses of Oreochromis Niloticus Exposed to Enalapril Maleate in Water","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7221520141","doi":"https://doi.org/10.1007/s00128-026-04322-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42862340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13658400"},"language":"en","primary_location":{"id":"doi:10.1007/s00128-026-04322-y","doi":"https://doi.org/10.1007/s00128-026-04322-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00128-026-04322-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00128-026-04322-y.pdf","source":{"id":"https://openalex.org/S106502101","display_name":"Bulletin of Environmental Contamination and Toxicology","issn_l":"0007-4861","issn":["0007-4861","1432-0800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Environmental Contamination and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00128-026-04322-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005896799","display_name":"Allana Kiara Peretti da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283613182","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79","country_code":"BR","type":"education","lineage":["https://openalex.org/I1283613182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Allana Kiara Peretti da Silva","raw_affiliation_strings":["Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil","institution_ids":["https://openalex.org/I1283613182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158468999","display_name":"Ot\u00e1vio Augusto Wolff Cola\u00e7o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283613182","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79","country_code":"BR","type":"education","lineage":["https://openalex.org/I1283613182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ot\u00e1vio Augusto Wolff Cola\u00e7o","raw_affiliation_strings":["Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil","institution_ids":["https://openalex.org/I1283613182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020291547","display_name":"Yorrannys Mannes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283613182","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79","country_code":"BR","type":"education","lineage":["https://openalex.org/I1283613182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Yorrannys Mannes","raw_affiliation_strings":["Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil","institution_ids":["https://openalex.org/I1283613182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088643302","display_name":"Wanessa Algarte Ramsdorf","orcid":"https://orcid.org/0000-0002-8341-1408","observed_orcids":["https://orcid.org/0000-0002-8341-1408"]},"institutions":[{"id":"https://openalex.org/I1283613182","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79","country_code":"BR","type":"education","lineage":["https://openalex.org/I1283613182"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Wanessa Algarte Ramsdorf","raw_affiliation_strings":["Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil. wanessar@utfpr.edu.br"],"raw_orcid":"https://orcid.org/0000-0002-8341-1408","affiliations":[{"raw_affiliation_string":"Laboratory of Ecotoxicology -Academic Department of Chemistry and Biology, Federal Technological University of Paran\u00e1, Curitiba, PR, Brasil. wanessar@utfpr.edu.br","institution_ids":["https://openalex.org/I1283613182"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088643302"],"corresponding_institution_ids":["https://openalex.org/I1283613182"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64605613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"117","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.302700012922287,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enalapril-maleate","display_name":"enalapril maleate","score":0.996999979019165},{"id":"https://openalex.org/keywords/oreochromis-niloticus","display_name":"Oreochromis niloticus","score":0.902999997138977},{"id":"https://openalex.org/keywords/pharmaceutical-pollutants","display_name":"pharmaceutical pollutants","score":0.6629999876022339},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9070000052452087},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":1.0},{"id":"https://openalex.org/keywords/somatic-status","display_name":"somatic status","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fish-ecotoxicology","display_name":"fish ecotoxicology","score":0.7480000257492065},{"id":"https://openalex.org/keywords/subchronic-exposure","display_name":"subchronic exposure","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.8769999742507935},{"id":"https://openalex.org/C2778658382","wikidata":"https://www.wikidata.org/wiki/Q4621959","display_name":"Oreochromis","level":3,"score":0.7602999806404114},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.7447999715805054},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.6916000247001648},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.640500009059906},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6328999996185303},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6067000031471252},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.5863000154495239},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5582000017166138},{"id":"https://openalex.org/C115346097","wikidata":"https://www.wikidata.org/wiki/Q1412144","display_name":"Ecotoxicology","level":2,"score":0.550599992275238},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4611999988555908},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4449999928474426},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.44130000472068787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4260999858379364},{"id":"https://openalex.org/C41157215","wikidata":"https://www.wikidata.org/wiki/Q3995923","display_name":"Environmental toxicology","level":3,"score":0.4138999879360199},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.40209999680519104},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.3700000047683716},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.3675999939441681},{"id":"https://openalex.org/C8381438","wikidata":"https://www.wikidata.org/wiki/Q4117900","display_name":"Aquatic toxicology","level":3,"score":0.3578000068664551},{"id":"https://openalex.org/C141710004","wikidata":"https://www.wikidata.org/wiki/Q744364","display_name":"Clastogen","level":4,"score":0.3549000024795532},{"id":"https://openalex.org/C175327387","wikidata":"https://www.wikidata.org/wiki/Q3289906","display_name":"Aquatic ecosystem","level":2,"score":0.34709998965263367},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.3197000026702881},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C46797941","wikidata":"https://www.wikidata.org/wiki/Q5333900","display_name":"Ecotoxicity","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C158278297","wikidata":"https://www.wikidata.org/wiki/Q1756633","display_name":"Aquatic animal","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.26669999957084656},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C109051061","wikidata":"https://www.wikidata.org/wiki/Q864610","display_name":"Biomonitoring","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.2522999942302704}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015162","descriptor_name":"Micronucleus Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023681","descriptor_name":"Cichlids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00128-026-04322-y","doi":"https://doi.org/10.1007/s00128-026-04322-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00128-026-04322-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00128-026-04322-y.pdf","source":{"id":"https://openalex.org/S106502101","display_name":"Bulletin of Environmental Contamination and Toxicology","issn_l":"0007-4861","issn":["0007-4861","1432-0800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Environmental Contamination and Toxicology","raw_type":"journal-article"},{"id":"pmid:42862340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42862340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of environmental contamination and toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13658400","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13658400/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull Environ Contam Toxicol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00128-026-04322-y","doi":"https://doi.org/10.1007/s00128-026-04322-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00128-026-04322-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00128-026-04322-y.pdf","source":{"id":"https://openalex.org/S106502101","display_name":"Bulletin of Environmental Contamination and Toxicology","issn_l":"0007-4861","issn":["0007-4861","1432-0800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Environmental Contamination and Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Clean water and sanitation","score":0.6618000268936157,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320326516","display_name":"Universidade Federal do Pampa","ror":"https://ror.org/003qt4p19"},{"id":"https://openalex.org/F4320331167","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221520141.pdf","grobid_xml":"https://content.openalex.org/works/W7221520141.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W1971048984","https://openalex.org/W2002798549","https://openalex.org/W2006865540","https://openalex.org/W2012385474","https://openalex.org/W2017274489","https://openalex.org/W2035002706","https://openalex.org/W2052178794","https://openalex.org/W2092629964","https://openalex.org/W2104105182","https://openalex.org/W2145937475","https://openalex.org/W2310321965","https://openalex.org/W2727925832","https://openalex.org/W2735371974","https://openalex.org/W2760521814","https://openalex.org/W2971622312","https://openalex.org/W2974120510","https://openalex.org/W3020041111","https://openalex.org/W3022235137","https://openalex.org/W3108186171","https://openalex.org/W3194641090","https://openalex.org/W4254124489","https://openalex.org/W4387303269","https://openalex.org/W4400065327","https://openalex.org/W4401438596"],"related_works":["https://openalex.org/W7120815809","https://openalex.org/W7120396501","https://openalex.org/W2595397284","https://openalex.org/W2511133664","https://openalex.org/W4400065327","https://openalex.org/W4389638826","https://openalex.org/W4413468903","https://openalex.org/W4417211228","https://openalex.org/W7204656905","https://openalex.org/W2966449341"],"abstract_inverted_index":{"Pharmaceutical":[0],"residues":[1],"are":[2],"increasingly":[3],"detected":[4],"in":[5,24,44,194],"aquatic":[6,181,195],"environments;":[7],"however,":[8],"information":[9],"regarding":[10],"the":[11,31,82,153,187,224],"ecotoxicological":[12,190],"effects":[13,32,78,217],"of":[14,33,66,118,189,192,227],"antihypertensive":[15,229],"drugs":[16],"such":[17],"as":[18,115],"enalapril":[19],"maleate":[20],"remains":[21],"limited,":[22],"particularly":[23],"fish.":[25],"This":[26],"study":[27,185],"aimed":[28],"to":[29,36,60,103,166,221],"evaluate":[30,215],"aqueous":[34],"exposure":[35,165],"EM":[37,167,193],"on":[38],"somatic,":[39],"biochemical,":[40],"and":[41,70,85,97,107,139,168,206,214,218],"genotoxic":[42,125],"biomarkers":[43,90],"Oreochromis":[45],"niloticus":[46],"under":[47],"controlled":[48],"laboratory":[49],"conditions.":[50],"A":[51],"21-day":[52],"subchronic":[53],"bioassay":[54],"was":[55,112],"conducted":[56],"using":[57,81],"fish":[58],"exposed":[59],"EM-contaminated":[61],"water":[62],"at":[63],"nominal":[64],"concentrations":[65],"100,":[67],"500,":[68],"1000,":[69],"2000":[71],"\u00b5g/L,":[72],"alongside":[73],"a":[74],"control":[75],"group.":[76],"Genotoxic":[77],"were":[79,101,157],"evaluated":[80],"comet":[83],"assay":[84],"micronucleus":[86],"test,":[87],"while":[88,143],"biochemical":[89],"-":[91,100],"including":[92],"acetylcholinesterase,":[93],"catalase,":[94],"glutathione":[95],"S-transferase,":[96],"lipid":[98],"peroxidation":[99],"assessed":[102],"investigate":[104],"oxidative":[105,137],"stress":[106,138],"potential":[108,140,177,203],"neurotoxicity.":[109],"Somatic":[110],"condition":[111],"also":[113],"analyzed":[114],"an":[116],"indicator":[117],"overall":[119],"organism":[120],"health.":[121],"The":[122,197],"results":[123],"demonstrated":[124],"effects,":[126],"evidenced":[127],"by":[128],"DNA":[129],"damage.":[130],"Biochemical":[131],"analyses":[132],"revealed":[133],"alterations":[134],"consistent":[135],"with":[136,176],"neurotoxic":[141],"responses,":[142],"somatic":[144],"indices":[145],"showed":[146],"minor":[147],"but":[148],"detectable":[149],"health":[150],"changes.":[151],"Although":[152],"observed":[154,198],"damage":[155],"levels":[156],"relatively":[158],"low,":[159],"these":[160],"findings":[161],"indicate":[162],"that":[163],"continuous":[164],"its":[169,202],"byproducts":[170],"can":[171],"induce":[172],"sublethal":[173],"physiological":[174],"disturbances":[175],"long-term":[178,216],"consequences":[179],"for":[180],"organisms.":[182],"Overall,":[183],"this":[184,228],"highlights":[186],"relevance":[188],"monitoring":[191],"systems.":[196],"biological":[199],"responses":[200],"underscore":[201],"ecological":[204],"risk,":[205],"future":[207],"studies":[208],"should":[209],"incorporate":[210],"preliminary":[211],"stability":[212],"assessments":[213],"degradation":[219],"products":[220],"better":[222],"understand":[223],"environmental":[225],"impact":[226],"drug.":[230]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-13T00:00:00"}
