{"id":"https://openalex.org/W7221508773","doi":"https://doi.org/10.1016/j.clinme.2026.100655","title":"The current landscape of neuro-oncology clinical trials","display_name":"The current landscape of neuro-oncology clinical trials","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7221508773","doi":"https://doi.org/10.1016/j.clinme.2026.100655","pmid":"https://pubmed.ncbi.nlm.nih.gov/42863764","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13730228"},"language":"en","primary_location":{"id":"doi:10.1016/j.clinme.2026.100655","doi":"https://doi.org/10.1016/j.clinme.2026.100655","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100655","pdf_url":null,"source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.clinme.2026.100655","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117597308","display_name":"Neelia Abadi","orcid":"https://orcid.org/0009-0002-5638-6048","observed_orcids":["https://orcid.org/0009-0002-5638-6048"]},"institutions":[{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelia E. Abadi","raw_affiliation_strings":["University of Vermont Medical Center, United States of America"],"raw_orcid":"https://orcid.org/0009-0002-5638-6048","affiliations":[{"raw_affiliation_string":"University of Vermont Medical Center, United States of America","institution_ids":["https://openalex.org/I2801980284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103120116","display_name":"Alissa A. Thomas","orcid":"https://orcid.org/0000-0003-2397-736X","observed_orcids":["https://orcid.org/0000-0003-2397-736X"]},"institutions":[{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alissa A. Thomas","raw_affiliation_strings":["University of Vermont Medical Center, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont Medical Center, United States of America","institution_ids":["https://openalex.org/I2801980284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049623146","display_name":"Oluwatosin O. Akintola","orcid":"https://orcid.org/0009-0008-8634-0925","observed_orcids":["https://orcid.org/0009-0008-8634-0925"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oluwatosin O. Akintola","raw_affiliation_strings":["University of Vermont Cancer Center, United States of America. Electronic address: oluwatosin.akintola@uvmhealth.org"],"raw_orcid":"https://orcid.org/0009-0008-8634-0925","affiliations":[{"raw_affiliation_string":"University of Vermont Cancer Center, United States of America. Electronic address: oluwatosin.akintola@uvmhealth.org","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049623146"],"corresponding_institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":2.7418,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.93579916,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"26","issue":"5","first_page":"100655","last_page":"100655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8019999861717224},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.8999999761581421},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8519999980926514},{"id":"https://openalex.org/keywords/glioma-heterogeneity","display_name":"glioma heterogeneity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/surgical-trials","display_name":"surgical trials","score":0.6899999976158142},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9520000219345093},{"id":"https://openalex.org/keywords/molecular-targeting","display_name":"molecular targeting","score":0.7720000147819519},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.47999998927116394},{"id":"https://openalex.org/keywords/trial-reproducibility","display_name":"trial reproducibility","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8716999888420105},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7821000218391418},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7080000042915344},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4625999927520752},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4187000095844269},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.39559999108314514},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.3285999894142151},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3248000144958496},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31869998574256897},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.267300009727478},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.clinme.2026.100655","doi":"https://doi.org/10.1016/j.clinme.2026.100655","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100655","pdf_url":null,"source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13730228","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730228/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730228/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Med (Lond)","raw_type":"Text"},{"id":"pmid:42863764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42863764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical medicine (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9abc1b7342c44e4cabaa6876a2c773ff","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9abc1b7342c44e4cabaa6876a2c773ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Medicine, Vol 26, Iss 5, Pp 100655- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.clinme.2026.100655","doi":"https://doi.org/10.1016/j.clinme.2026.100655","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clinme.2026.100655","pdf_url":null,"source":{"id":"https://openalex.org/S186589310","display_name":"Clinical Medicine","issn_l":"1470-2118","issn":["1470-2118","1473-4893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310311682","host_organization_name":"Royal College of Physicians","host_organization_lineage":["https://openalex.org/P4310311682"],"host_organization_lineage_names":["Royal College of Physicians"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312462","display_name":"University of Vermont","ror":"https://ror.org/0155zta11"},{"id":"https://openalex.org/F4320334300","display_name":"Larner College of Medicine, University of Vermont","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221508773.pdf","grobid_xml":"https://content.openalex.org/works/W7221508773.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1987668448","https://openalex.org/W2096287682","https://openalex.org/W2778283729","https://openalex.org/W3094328244","https://openalex.org/W3144291249","https://openalex.org/W3199632320","https://openalex.org/W4205374244","https://openalex.org/W4282971088","https://openalex.org/W4297513234","https://openalex.org/W4321445965","https://openalex.org/W4402467096","https://openalex.org/W4403229121","https://openalex.org/W4405327807","https://openalex.org/W4408063824","https://openalex.org/W4413304637","https://openalex.org/W4414574112","https://openalex.org/W4415169863","https://openalex.org/W4417168765","https://openalex.org/W7140225918"],"related_works":["https://openalex.org/W3005468192","https://openalex.org/W4403989686","https://openalex.org/W2085072793","https://openalex.org/W2007139768","https://openalex.org/W2913784171","https://openalex.org/W4405870998","https://openalex.org/W3002319954","https://openalex.org/W4361282374","https://openalex.org/W3131578245","https://openalex.org/W2586810802"],"abstract_inverted_index":{"CNS":[0],"malignancies,":[1],"particularly":[2],"gliomas,":[3],"are":[4],"aggressive":[5],"and":[6,25,56,81,94,117,125],"often":[7],"terminal":[8],"brain":[9],"tumours":[10],"in":[11,18,72,103],"adults.":[12],"While":[13],"advances":[14],"have":[15],"been":[16],"made":[17],"the":[19,22,26,49,57,62,87,123],"understanding":[20],"of":[21,61,69,89,127],"glioma":[23,54,90,128],"microenvironment":[24],"molecular":[27,118],"genetic":[28],"pathways":[29],"that":[30],"drive":[31],"gliomagenesis,":[32],"translation":[33],"into":[34,120],"effective":[35],"clinical":[36,91,112],"therapies":[37,106],"remains":[38],"challenging.":[39],"Barriers":[40],"to":[41],"therapeutic":[42,70],"advancement":[43],"include":[44],"intrinsic":[45],"factors":[46],"such":[47,109],"as":[48,110],"poorly":[50],"understood":[51],"blood-brain":[52],"barrier,":[53],"heterogeneity,":[55],"immunologically":[58],"privileged":[59],"environment":[60],"brain.":[63],"This":[64],"review":[65],"provides":[66],"an":[67],"exploration":[68],"developments":[71],"neuro-oncology,":[73],"namely":[74],"-":[75],"immunotherapies,":[76],"targeted":[77],"therapies,":[78],"surgical":[79],"trials":[80,92],"radiation":[82],"therapy":[83],"trials.":[84,129],"We":[85,99],"address":[86],"difficulty":[88],"designs":[93],"lessons":[95],"from":[96],"ineffective":[97],"interventions.":[98],"discuss":[100],"future":[101],"strategies":[102],"improving":[104],"breakthrough":[105],"for":[107],"gliomas":[108],"streamlining":[111],"trial":[113],"design,":[114],"integrating":[115],"biomarkers":[116],"targeting":[119],"studies,":[121],"enhancing":[122],"validity":[124],"reproducibility":[126]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-13T00:00:00"}