{"id":"https://openalex.org/W7221474568","doi":"https://doi.org/10.64898/2026.10.07.757032","title":"Mapping the Trade-Offs That Shape Mammalian Brain Network Architecture","display_name":"Mapping the Trade-Offs That Shape Mammalian Brain Network Architecture","publication_year":2026,"publication_date":"2026-10-11","ids":{"openalex":"https://openalex.org/W7221474568","doi":"https://doi.org/10.64898/2026.10.07.757032"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.07.757032","doi":"https://doi.org/10.64898/2026.10.07.757032","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.757032","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.10.07.757032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091979246","display_name":"Adrian Dendorfer","orcid":"https://orcid.org/0000-0003-0141-2800","observed_orcids":["https://orcid.org/0000-0003-0141-2800"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Adrian Dendorfer","raw_affiliation_strings":["Technical University of Munich;"],"raw_orcid":"https://orcid.org/0000-0003-0141-2800","affiliations":[{"raw_affiliation_string":"Technical University of Munich;","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054486177","display_name":"Alexa Mousley","orcid":"https://orcid.org/0000-0002-9222-5076","observed_orcids":["https://orcid.org/0000-0002-9222-5076"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexa Mousley","raw_affiliation_strings":["University of Cambridge;"],"raw_orcid":"https://orcid.org/0000-0002-9222-5076","affiliations":[{"raw_affiliation_string":"University of Cambridge;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051309276","display_name":"Francisco P\u00e1scoa dos Santos","orcid":"https://orcid.org/0000-0002-3199-4365","observed_orcids":["https://orcid.org/0000-0002-3199-4365"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Francisco Pascoa dos Santos","raw_affiliation_strings":["University of Amsterdam"],"raw_orcid":"https://orcid.org/0000-0002-3199-4365","affiliations":[{"raw_affiliation_string":"University of Amsterdam","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037927272","display_name":"Duncan Edward Astle","orcid":"https://orcid.org/0000-0002-7042-5392","observed_orcids":["https://orcid.org/0000-0002-7042-5392"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Duncan Astle","raw_affiliation_strings":["University of Cambridge;"],"raw_orcid":"https://orcid.org/0000-0002-7042-5392","affiliations":[{"raw_affiliation_string":"University of Cambridge;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005391007","display_name":"Kayson Fakhar","orcid":"https://orcid.org/0000-0003-0615-1777","observed_orcids":["https://orcid.org/0000-0003-0615-1777"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kayson Fakhar","raw_affiliation_strings":["University of Cambridge;"],"raw_orcid":"https://orcid.org/0000-0003-0615-1777","affiliations":[{"raw_affiliation_string":"University of Cambridge;","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091979246"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.2345999926328659,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.10970000177621841,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-network-architecture","display_name":"brain network architecture","score":0.9729999899864197},{"id":"https://openalex.org/keywords/network-topology","display_name":"network topology","score":0.3799999952316284},{"id":"https://openalex.org/keywords/metabolic-efficiency","display_name":"metabolic efficiency","score":0.7509999871253967},{"id":"https://openalex.org/keywords/computing-power","display_name":"computational power","score":0.8479999899864197},{"id":"https://openalex.org/keywords/resource-trade-offs","display_name":"resource allocation trade-offs","score":0.5809999704360962},{"id":"https://openalex.org/keywords/human-brain-development","display_name":"human brain development","score":0.6819999814033508},{"id":"https://openalex.org/keywords/brain-evolution","display_name":"brain evolution","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mammalian-brain","display_name":"mammalian brain","score":0.5839999914169312},{"id":"https://openalex.org/keywords/brain-maturation","display_name":"brain maturation","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.808899998664856},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5716000199317932},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.5009999871253967},{"id":"https://openalex.org/C3020766347","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Mammalian brain","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.41519999504089355},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.39559999108314514},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.3896999955177307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3758000135421753},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.37549999356269836},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36169999837875366},{"id":"https://openalex.org/C193415008","wikidata":"https://www.wikidata.org/wiki/Q639681","display_name":"Network architecture","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33239999413490295},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.29660001397132874},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29420000314712524},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C2988562018","wikidata":"https://www.wikidata.org/wiki/Q1063","display_name":"Biological evolution","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C123138037","wikidata":"https://www.wikidata.org/wiki/Q5570871","display_name":"Global network","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.25780001282691956},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.25209999084472656},{"id":"https://openalex.org/C189950617","wikidata":"https://www.wikidata.org/wiki/Q937228","display_name":"Property (philosophy)","level":2,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.07.757032","doi":"https://doi.org/10.64898/2026.10.07.757032","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.757032","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.07.757032","doi":"https://doi.org/10.64898/2026.10.07.757032","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.757032","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3153605442","https://openalex.org/W4309146552","https://openalex.org/W2117208984","https://openalex.org/W1983485726","https://openalex.org/W2057245137","https://openalex.org/W6997334314","https://openalex.org/W1673584506","https://openalex.org/W7214361580","https://openalex.org/W4404512225","https://openalex.org/W2118132736"],"abstract_inverted_index":{"A":[0],"brain's":[1],"wiring":[2,48],"must":[3],"satisfy":[4],"conflicting":[5],"pressures,":[6,70],"from":[7,14,194],"the":[8,15,65,155,172,183],"outside":[9],"world":[10],"(be":[11],"capable)":[12],"and":[13,39,62,77,91,107,116,126,147,150,164,180,182],"inside":[16],"(stay":[17],"within":[18],"finite":[19],"resources).":[20],"These":[21],"pressures":[22,35,45],"often":[23],"have":[24],"opposing":[25],"requirements.":[26],"Prior":[27],"work":[28],"studies":[29],"these":[30],"trade-offs":[31,59],"mostly":[32],"between":[33,175],"2-3":[34],"at":[36,60,123],"a":[37,195],"time,":[38],"thus":[40],"cannot":[41],"say":[42],"how":[43],"many":[44],"shape":[46],"brain":[47,75,97],"or":[49],"for":[50,167],"which":[51],"trade-off":[52,174,190],"brains":[53,128,153,186],"decide.":[54],"To":[55],"see":[56],"all":[57,124],"possible":[58],"once":[61],"to":[63,114,143],"uncover":[64],"set":[66],"of":[67,134],"most":[68],"important":[69],"we":[71],"generate":[72],"25,000":[73],"synthetic":[74],"networks":[76,98],"describe":[78],"each":[79],"by":[80],"29":[81],"network":[82,120],"properties.":[83],"We":[84],"then":[85],"place":[86],"635":[87],"human":[88,159],"(ages":[89],"6-22)":[90],"224":[92],"mammalian":[93],"(12":[94],"taxonomic":[95],"orders)":[96],"in":[99,130,154,188],"this":[100,135,189],"property":[101],"space.":[102],"The":[103],"space":[104],"is":[105,121],"triangular,":[106],"follows":[108],"three":[109],"pressures:":[110],"computational":[111,178],"capability,":[112,163],"robustness":[113,146],"damage,":[115],"metabolic":[117,141,176],"efficiency.":[118,168],"No":[119],"optimal":[122],"three,":[125],"biological":[127],"cluster":[129],"one":[131],"small":[132],"niche":[133],"triangle.":[136],"There,":[137],"they":[138],"accept":[139],"higher":[140],"cost":[142],"gain":[144],"both":[145],"capability.":[148],"Development":[149],"evolution":[151],"move":[152],"same":[156],"direction;":[157],"additionally,":[158],"maturation":[160],"first":[161],"raises":[162],"later":[165],"optimizes":[166],"This":[169],"study":[170],"underscores":[171],"triangular":[173],"efficiency,":[177],"capacity":[179],"robustness,":[181],"narrow":[184],"region":[185],"occupy":[187],"triangle,":[191],"visible":[192],"only":[193],"multi-property,":[196],"cross-species":[197],"perspective.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-12T00:00:00"}