{"id":"https://openalex.org/W7221473887","doi":"https://doi.org/10.21203/rs.3.rs-10942986/v1","title":"Radiation-Induced High-Grade Glioma in a Long-Term Survivor of Medulloblastoma: A Case Report","display_name":"Radiation-Induced High-Grade Glioma in a Long-Term Survivor of Medulloblastoma: A Case Report","publication_year":2026,"publication_date":"2026-10-11","ids":{"openalex":"https://openalex.org/W7221473887","doi":"https://doi.org/10.21203/rs.3.rs-10942986/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10942986/v1","doi":"https://doi.org/10.21203/rs.3.rs-10942986/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10942986/v1","pdf_url":"https://www.researchsquare.com/article/rs-10942986/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10942986/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158357355","display_name":"Uzma Magsi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Uzma Magsi","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030502756","display_name":"Farrah Bashir","orcid":"https://orcid.org/0009-0000-2460-9388","observed_orcids":["https://orcid.org/0009-0000-2460-9388"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Farrah Bashir","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154824272","display_name":"Khurram Minhas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Khurram Minhas","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110716171","display_name":"Mazhar Qureshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Bilal Mazhar Qureshi","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108977575","display_name":"Sartaj Uddin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sartaj Uddin","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155472546","display_name":"Shayan Sirat Maheen Anwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shayan Sirat Maheen Anwar","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102744065","display_name":"Muhammad Shahzad Shamim","orcid":"https://orcid.org/0000-0001-8305-8854","observed_orcids":["https://orcid.org/0000-0001-8305-8854"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Shahzad Shamim","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048228345","display_name":"Naureen Mushtaq","orcid":"https://orcid.org/0000-0002-5461-3350","observed_orcids":["https://orcid.org/0000-0002-5461-3350"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Naureen Mushtaq","raw_affiliation_strings":["Aga Khan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University","institution_ids":["https://openalex.org/I118185606"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118185606"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.7279999852180481},{"id":"https://openalex.org/keywords/radiation-induced-glioma","display_name":"radiation-induced glioma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.7200000286102295},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.765999972820282},{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/craniospinal-irradiation","display_name":"craniospinal irradiation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/long-term-survivors","display_name":"long-term survivors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/focal-seizures","display_name":"focal seizures","score":0.6159999966621399},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6309999823570251},{"id":"https://openalex.org/keywords/atrx","display_name":"ATRX","score":0.7080000042915344},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.5109999775886536},{"id":"https://openalex.org/keywords/h3k27m-mutation","display_name":"H3K27M mutation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8179000020027161},{"id":"https://openalex.org/C2780966972","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Headaches","level":2,"score":0.5760999917984009},{"id":"https://openalex.org/C2778681053","wikidata":"https://www.wikidata.org/wiki/Q5569541","display_name":"Glial tumor","level":3,"score":0.508899986743927},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.487199991941452},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.4634999930858612},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.43810001015663147},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4372999966144562},{"id":"https://openalex.org/C17624336","wikidata":"https://www.wikidata.org/wiki/Q461644","display_name":"Glasgow Coma Scale","level":2,"score":0.4156000018119812},{"id":"https://openalex.org/C2776689207","wikidata":"https://www.wikidata.org/wiki/Q17835753","display_name":"ATRX","level":4,"score":0.40630000829696655},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.39329999685287476},{"id":"https://openalex.org/C2778256017","wikidata":"https://www.wikidata.org/wiki/Q3640183","display_name":"Stereotactic biopsy","level":3,"score":0.39010000228881836},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C2910938049","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferation index","level":3,"score":0.3546000123023987},{"id":"https://openalex.org/C2776882386","wikidata":"https://www.wikidata.org/wiki/Q2291130","display_name":"Hemiparesis","level":3,"score":0.35249999165534973},{"id":"https://openalex.org/C2780168130","wikidata":"https://www.wikidata.org/wiki/Q2916167","display_name":"Neurological examination","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.33980000019073486},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C2776085573","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferative index","level":3,"score":0.334199994802475},{"id":"https://openalex.org/C2780103909","wikidata":"https://www.wikidata.org/wiki/Q3875054","display_name":"Neurooncology","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.29919999837875366},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29809999465942383},{"id":"https://openalex.org/C2777318445","wikidata":"https://www.wikidata.org/wiki/Q6842571","display_name":"Midline shift","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C2778871575","wikidata":"https://www.wikidata.org/wiki/Q514921","display_name":"Craniotomy","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C2776429142","wikidata":"https://www.wikidata.org/wiki/Q1620189","display_name":"Brain biopsy","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C100136789","wikidata":"https://www.wikidata.org/wiki/Q1772448","display_name":"Coma (optics)","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2781100745","wikidata":"https://www.wikidata.org/wiki/Q1977435","display_name":"Debulking","level":4,"score":0.25529998540878296},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10942986/v1","doi":"https://doi.org/10.21203/rs.3.rs-10942986/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10942986/v1","pdf_url":"https://www.researchsquare.com/article/rs-10942986/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10942986/v1","doi":"https://doi.org/10.21203/rs.3.rs-10942986/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10942986/v1","pdf_url":"https://www.researchsquare.com/article/rs-10942986/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221473887.pdf","grobid_xml":"https://content.openalex.org/works/W7221473887.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W3174246647","https://openalex.org/W3200173100","https://openalex.org/W3201553964"],"related_works":["https://openalex.org/W7169590899","https://openalex.org/W1995750690","https://openalex.org/W2898971159","https://openalex.org/W2414209053","https://openalex.org/W2107007319","https://openalex.org/W7222484384","https://openalex.org/W1989547110","https://openalex.org/W4413856513","https://openalex.org/W7220450022","https://openalex.org/W3154514175"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Advances":[2],"in":[3,10,103,349,369],"multimodal":[4],"therapy":[5],"have":[6],"significantly":[7],"improved":[8],"survival":[9],"medulloblastoma,":[11,354],"but":[12],"long-term":[13,351],"survivors":[14,370],"remain":[15],"at":[16],"risk":[17],"of":[18,26,35,54,108,125,145,196,232,245,269,294,299,305,315,344,353,366,371,378],"secondary":[19,176,346,379],"malignancies.":[20],"We":[21],"describe":[22],"a":[23,32,52,105,122,140,175,190,203,217,241,267,345,350,358],"rare":[24],"case":[25,340],"radiation-induced":[27,316,359],"high-grade":[28,218,270,317,347],"glioma":[29,348],"developing":[30],"after":[31,64,90,98,336],"disease-free":[33],"interval":[34],"approximately":[36],"seven":[37],"years,":[38],"and":[39,71,87,111,129,147,168,209,240,253,264,289,303,328,406],"nearly":[40],"nine":[41,62,295],"years":[42,63,97,296],"following":[43],"initial":[44,66],"treatment.":[45],"Case":[46],"Presentation":[47],"A":[48,179],"19-year-old":[49],"male":[50],"with":[51,68,78,104,139,152,164,216],"history":[53,107,124],"classical":[55],"medulloblastoma":[56,302],"(CNS":[57],"WHO":[58,276],"grade":[59,277,308],"4)":[60],"presented":[61],"his":[65],"diagnosis":[67,268],"worsening":[69],"headaches":[70],"fatigue.":[72,112],"His":[73],"primary":[74,301],"tumor":[75,199],"was":[76,137,184,258,279,312],"treated":[77],"multiple":[79,160],"surgical":[80],"resections":[81],"followed":[82,120],"by":[83,121],"high-dose":[84],"craniospinal":[85,287],"irradiation":[86],"adjuvant":[88],"chemotherapy,":[89],"which":[91],"he":[92,101,117,136,329],"remained":[93],"under":[94],"surveillance.":[95],"Seven":[96],"completing":[99],"treatment,":[100],"came":[102],"four-week":[106],"weight":[109],"loss":[110],"One":[113],"week":[114],"before":[115],"admission,":[116],"developed":[118],"drowsiness,":[119],"10-day":[123],"right":[126],"focal":[127],"seizures":[128],"increasing":[130],"right-sided":[131,149],"weakness.":[132],"On":[133],"neurological":[134],"examination,":[135],"obtunded":[138],"Glasgow":[141],"Coma":[142],"Scale":[143],"score":[144],"9/15":[146],"showed":[148,223],"spastic":[150],"hemiparesis":[151],"impaired":[153],"verbal":[154],"responsiveness.":[155],"Magnetic":[156],"resonance":[157],"imaging":[158],"revealed":[159],"supratentorial":[161],"lesions":[162],"associated":[163],"extensive":[165],"vasogenic":[166],"edema":[167],"mild":[169],"midline":[170],"shift,":[171],"raising":[172],"concern":[173],"for":[174,251,394],"malignant":[177],"neoplasm.":[178],"left":[180],"frontal":[181],"burr-hole":[182],"biopsy":[183],"subsequently":[185],"performed.":[186],"Histopathological":[187],"examination":[188],"demonstrated":[189],"highly":[191,313],"cellular":[192],"glial":[193,225],"neoplasm":[194],"composed":[195],"pleomorphic,":[197],"hyperchromatic":[198],"cells":[200,248],"embedded":[201],"within":[202],"fibrillary":[204,226],"background.":[205],"Prominent":[206],"microvascular":[207],"proliferation":[208,243],"frequent":[210],"mitotic":[211],"activity":[212],"were":[213,249],"identified,":[214],"consistent":[215],"infiltrating":[219],"glioma.":[220,318],"Immunohistochemical":[221],"analysis":[222],"diffuse":[224],"acidic":[227],"protein":[228,256],"(GFAP)":[229],"positivity,":[230],"absence":[231],"IDH1":[233],"R132H":[234],"expression,":[235],"retained":[236],"ATRX":[237],"nuclear":[238],"staining,":[239],"Ki-67":[242],"index":[244],"15\u201320%.":[246],"Tumor":[247],"negative":[250],"H3K27M,":[252],"mismatch":[254],"repair":[255],"expression":[257],"preserved.":[259],"Based":[260],"on":[261],"the":[262,282,290,300,306,310,322,332,342,363,389],"histopathological":[263],"immunophenotypic":[265],"findings,":[266],"glioma,":[271,309],"favoring":[272],"astrocytoma,":[273],"NOS,":[274],"CNS":[275],"4,":[278],"established.":[280],"Given":[281],"patient's":[283,323],"previous":[284],"exposure":[285],"to":[286,331,402],"radiotherapy":[288],"prolonged":[291],"latency":[292],"period":[293],"between":[297],"treatment":[298],"development":[304,343],"high":[307],"lesion":[311],"suggestive":[314],"Despite":[319,388],"supportive":[320],"management,":[321],"clinical":[324],"condition":[325],"deteriorated":[326],"rapidly,":[327],"succumbed":[330],"disease":[333],"one":[334],"month":[335],"diagnosis.":[337],"Conclusion":[338],"This":[339],"illustrates":[341],"survivor":[352],"most":[355],"likely":[356],"representing":[357],"malignancy.":[360],"It":[361],"highlights":[362],"critical":[364],"importance":[365],"lifelong":[367],"surveillance":[368],"pediatric":[372],"brain":[373],"tumors,":[374,397],"as":[375],"early":[376],"detection":[377],"central":[380],"nervous":[381],"system":[382],"neoplasms":[383],"may":[384],"allow":[385],"timely":[386],"intervention.":[387],"limited":[390],"therapeutic":[391],"options":[392],"available":[393],"these":[395],"aggressive":[396],"prompt":[398],"recognition":[399],"remains":[400],"essential":[401],"optimize":[403],"patient":[404],"management":[405],"outcomes.":[407]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-12T00:00:00"}
