{"id":"https://openalex.org/W7221465013","doi":"https://doi.org/10.64898/2026.10.03.756420","title":"The Mitochondria-Modulating Small Molecule TEM1657 Suppresses NFKBIZ Pathway and Resolves Th17-Driven Psoriatic Inflammation","display_name":"The Mitochondria-Modulating Small Molecule TEM1657 Suppresses NFKBIZ Pathway and Resolves Th17-Driven Psoriatic Inflammation","publication_year":2026,"publication_date":"2026-10-10","ids":{"openalex":"https://openalex.org/W7221465013","doi":"https://doi.org/10.64898/2026.10.03.756420"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.03.756420","doi":"https://doi.org/10.64898/2026.10.03.756420","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.756420","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756420.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756420.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002913687","display_name":"Preeti Gautam","orcid":"https://orcid.org/0000-0002-2040-5000","observed_orcids":["https://orcid.org/0000-0002-2040-5000"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Preeti Gautam","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048044317","display_name":"Aleksander Salwi\u0144ski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksander Salwinski","raw_affiliation_strings":["Plant Advanced Technologies, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Advanced Technologies, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158418674","display_name":"Ahmed B Abdelwahab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed B. Abdelwahab","raw_affiliation_strings":["Temisis Therapeutics, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temisis Therapeutics, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058557103","display_name":"Ga\u00ebl Jalce","orcid":"https://orcid.org/0000-0002-2786-5763","observed_orcids":["https://orcid.org/0000-0002-2786-5763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ga\u00ebl Jalce","raw_affiliation_strings":["Temisis Therapeutics, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temisis Therapeutics, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053794569","display_name":"Laura Boulang\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laura Boulang\u00e9","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120080836","display_name":"Jessica Bettinger","orcid":"https://orcid.org/0009-0003-1129-2408","observed_orcids":["https://orcid.org/0009-0003-1129-2408"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jessica Bettinger","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090921424","display_name":"Jordan Brouard","orcid":"https://orcid.org/0000-0002-6847-5278","observed_orcids":["https://orcid.org/0000-0002-6847-5278"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jordan Brouard","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":"https://orcid.org/0000-0002-6847-5278","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114822380","display_name":"Aliz\u00e9e Etlicher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aliz\u00e9e Etlicher","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085538296","display_name":"Romain Perouf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romain Perouf","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114021509","display_name":"Julia Halper","orcid":"https://orcid.org/0000-0003-3967-6633","observed_orcids":["https://orcid.org/0000-0003-3967-6633"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julia Halper","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002592164","display_name":"Marie Millard","orcid":"https://orcid.org/0009-0009-0101-3210","observed_orcids":["https://orcid.org/0009-0009-0101-3210"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie Millard","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014547000","display_name":"N. de Isla","orcid":"https://orcid.org/0000-0002-6701-3485","observed_orcids":["https://orcid.org/0000-0002-6701-3485"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Natalia de Isla","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080080787","display_name":"Paul Hannewald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Hannewald","raw_affiliation_strings":["Plant Advanced Technologies, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Advanced Technologies, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158358610","display_name":"Jean-Francois GINGLINGER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Francois Ginglinger","raw_affiliation_strings":["Plant Advanced Technologies, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Advanced Technologies, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158302582","display_name":"Marie-Therese RUBIO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Th\u00e9r\u00e8se Rubio","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158372009","display_name":"Jean-Yves JOUZEAU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Yves Jouzeau","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087017796","display_name":"Fr\u00e9d\u00e9ric Bourgaud","orcid":"https://orcid.org/0000-0002-9898-2625","observed_orcids":["https://orcid.org/0000-0002-9898-2625"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086158","display_name":"Laboratoire R\u00e9actions et G\u00e9nie des Proc\u00e9d\u00e9s","ror":"https://ror.org/00p6sn362","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210086158","https://openalex.org/I4210095849","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Bourgaud","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, LRGP, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, LRGP, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086158","https://openalex.org/I90183372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039109659","display_name":"David Moulin","orcid":"https://orcid.org/0000-0001-6619-5769","observed_orcids":["https://orcid.org/0000-0001-6619-5769"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I4210152866","display_name":"Ing\u00e9nierie Mol\u00e9culaire, Cellulaire et Physiopathologie","ror":"https://ror.org/04yc2e502","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"David Moulin","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CHRU-Nancy, Inserm, IHU INFINY, F-54000, Nancy, France","Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CHRU-Nancy, Inserm, IHU INFINY, F-54000, Nancy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210100260","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210152866","https://openalex.org/I90183372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5039109659"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210100260","https://openalex.org/I4210152866","https://openalex.org/I90183372"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/3-5-dicaffeoylquinic-acid","display_name":"3,5-dicaffeoylquinic acid","score":0.9559999704360962},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nfkbiz","display_name":"NFKBIZ","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/opa1","display_name":"OPA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uptake","display_name":"mitochondrial calcium uptake","score":0.9160000085830688},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/imiquimod-induced-psoriasis","display_name":"imiquimod-induced psoriasis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cellular-bioenergetics","display_name":"cellular bioenergetics","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.9088000059127808},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.6263999938964844},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5924000144004822},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5080999732017517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4975999891757965},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.47870001196861267},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4555000066757202},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4212999939918518},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41429999470710754},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.40639999508857727},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4050000011920929},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3253999948501587},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.3206999897956848},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31690001487731934},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3050999939441681},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28839999437332153},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27379998564720154},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.03.756420","doi":"https://doi.org/10.64898/2026.10.03.756420","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.756420","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756420.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.03.756420","doi":"https://doi.org/10.64898/2026.10.03.756420","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.756420","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756420.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310925","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97"},{"id":"https://openalex.org/F4320338388","display_name":"Eurostars","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221465013.pdf","grobid_xml":"https://content.openalex.org/works/W7221465013.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223364973","https://openalex.org/W3135166417","https://openalex.org/W7136887616","https://openalex.org/W3190879361","https://openalex.org/W7208210913","https://openalex.org/W7202161485","https://openalex.org/W7148774250","https://openalex.org/W2971918104","https://openalex.org/W4403743193","https://openalex.org/W4416586505"],"abstract_inverted_index":{"Abstract":[0],"Psoriasis":[1],"is":[2,82],"a":[3,56,122],"chronic":[4],"skin":[5],"disease":[6,29,46],"characterized":[7],"by":[8,14],"red,":[9],"scaly":[10],"plaques":[11],"mainly":[12],"driven":[13],"dysregulated":[15],"T":[16],"cells":[17],"that":[18,97,124],"induce":[19],"keratinocytes":[20],"(KCs)":[21],"proliferation":[22],"and":[23,33,42,102,114,131],"inflammation.":[24],"Despite":[25],"significant":[26],"advancements":[27],"in":[28,68,76,129],"management":[30],"through":[31,84],"biologics":[32],"topical":[34],"therapies,":[35],"these":[36],"treatments":[37],"offer":[38],"only":[39],"temporary":[40],"relief":[41],"fail":[43],"to":[44],"prevent":[45],"recurrence.":[47],"Considering":[48],"the":[49],"current":[50],"therapeutic":[51],"needs,":[52],"we":[53],"described":[54],"herein":[55],"novel":[57],"small":[58],"molecule":[59],"TEM1657,":[60],"derived":[61],"from":[62],"3,5-dicaffeoylquinic":[63],"acid":[64],"with":[65],"anti-inflammatory":[66],"potency":[67],"imiquimod-induced":[69],"psoriasis":[70,130],"mouse":[71],"model":[72],"as":[73,75],"well":[74],"Th17-stimulated":[77],"KCs.":[78],"Mechanistically,":[79],"its":[80],"action":[81],"mediated":[83],"modulation":[85],"of":[86,112],"mitochondrial":[87,94,99],"dynamics,":[88],"specifically":[89],"via":[90],"OPA1,":[91],"an":[92,126],"inner":[93],"membrane":[95],"protein":[96],"alters":[98],"calcium":[100],"influx,":[101],"further":[103],"impacts":[104],"cellular":[105],"bioenergetics.":[106],"Moreover,":[107],"TEM1657":[108],"rapidly":[109],"suppresses":[110],"transcription":[111],"NFKBIZ":[113],"various":[115],"other":[116,132],"psoriasis-associated":[117],"genes.":[118],"These":[119],"observations":[120],"highlighted":[121],"pathway":[123],"represents":[125],"innovative":[127],"target":[128],"NFKBIZ-related":[133],"disorders.":[134]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-12T00:00:00"}
