{"id":"https://openalex.org/W7221449293","doi":"https://doi.org/10.64898/2026.10.03.756294","title":"Spatiotemporal Heterogeneity of HPV Integration Architectures Drive Oncogenic Features of Oropharyngeal Cancer","display_name":"Spatiotemporal Heterogeneity of HPV Integration Architectures Drive Oncogenic Features of Oropharyngeal Cancer","publication_year":2026,"publication_date":"2026-10-10","ids":{"openalex":"https://openalex.org/W7221449293","doi":"https://doi.org/10.64898/2026.10.03.756294","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13692024"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.03.756294","doi":"https://doi.org/10.64898/2026.10.03.756294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.756294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756294.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084990332","display_name":"Wenjin Gu","orcid":"https://orcid.org/0000-0002-0028-1645","observed_orcids":["https://orcid.org/0000-0002-0028-1645"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjin Gu","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158328712","display_name":"Apurva Dhanesh Bhangale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apurva Dhanesh Bhangale","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101182256","display_name":"Xiaomeng Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaomeng Du","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609330","display_name":"Xinyi Deng","orcid":"https://orcid.org/0000-0001-9241-5382","observed_orcids":["https://orcid.org/0000-0001-9241-5382","https://orcid.org/0009-0003-4241-9598"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyi Deng","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158405579","display_name":"Elizabeth U Gensterblum-Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth U. Gensterblum-Miller","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017846002","display_name":"Jordan Currie","orcid":"https://orcid.org/0000-0003-1840-6765","observed_orcids":["https://orcid.org/0000-0003-1840-6765"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Currie","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009530339","display_name":"Collin V. Brummel","orcid":"https://orcid.org/0000-0001-7198-8560","observed_orcids":["https://orcid.org/0000-0001-7198-8560"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Collin V. Brummel","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106605261","display_name":"Vital Nyabashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vital Nyabashi","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158322846","display_name":"Marisa Buchakjian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisa Buchakjian","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037249246","display_name":"Keith A. Casper","orcid":"https://orcid.org/0000-0003-2878-3863","observed_orcids":["https://orcid.org/0000-0003-2878-3863"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith A Casper","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158281326","display_name":"Steven E Chinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Chinn","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135380695","display_name":"David Forner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Forner","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037580244","display_name":"Kelly Michele Malloy","orcid":"https://orcid.org/0000-0002-0337-9293","observed_orcids":["https://orcid.org/0000-0002-0337-9293"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly M Malloy","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133856321","display_name":"Michelle L. Mierzwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L Mierzwa","raw_affiliation_strings":["Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158327555","display_name":"Mark E Prince","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E Prince","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083322184","display_name":"Jennifer Lobo Shah","orcid":"https://orcid.org/0000-0002-3847-8865","observed_orcids":["https://orcid.org/0000-0002-3847-8865"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Shah","raw_affiliation_strings":["Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063061362","display_name":"Andrew G. Shuman","orcid":"https://orcid.org/0000-0002-9305-7860","observed_orcids":["https://orcid.org/0000-0002-9305-7860"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew G Shuman","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012790496","display_name":"Chaz L. Stucken","orcid":"https://orcid.org/0000-0003-1448-3376","observed_orcids":["https://orcid.org/0000-0003-1448-3376"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaz L Stucken","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158406001","display_name":"Paul L Swiecicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul L Swiecicki","raw_affiliation_strings":["Department of Internal Medicine, Hematology/Oncology Division, University of Michigan Cancer Center, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hematology/Oncology Division, University of Michigan Cancer Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158321339","display_name":"Francis P Worden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis P Worden","raw_affiliation_strings":["Department of Internal Medicine, Hematology/Oncology Division, University of Michigan Cancer Center, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hematology/Oncology Division, University of Michigan Cancer Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048709134","display_name":"Pratyusha Yalamanchi","orcid":"https://orcid.org/0000-0003-0776-3759","observed_orcids":["https://orcid.org/0000-0003-0776-3759"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratyusha Yalamanchi","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051202793","display_name":"Jonathan Brad McHugh","orcid":"https://orcid.org/0000-0002-6138-8833","observed_orcids":["https://orcid.org/0000-0002-6138-8833"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan B. McHugh","raw_affiliation_strings":["Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, United States","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102960681","display_name":"Krystle A. Lang Kuhs","orcid":"https://orcid.org/0000-0002-7643-9330","observed_orcids":["https://orcid.org/0000-0002-7643-9330"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystle A. Lang Kuhs","raw_affiliation_strings":["Department of Epidemiology and Environmental Health, University of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Environmental Health, University of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018760379","display_name":"Alan P. Boyle","orcid":"https://orcid.org/0000-0002-2081-1105","observed_orcids":["https://orcid.org/0000-0002-2081-1105"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan P. Boyle","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779276","display_name":"Hui Jiang","orcid":"https://orcid.org/0000-0003-2718-9811","observed_orcids":["https://orcid.org/0000-0003-2718-9811","https://orcid.org/0000-0003-2183-9430"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Jiang","raw_affiliation_strings":["Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158342038","display_name":"Molly E Neal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly E. Heft Neal","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067694439","display_name":"Matthew E. Spector","orcid":"https://orcid.org/0000-0001-7646-6075","observed_orcids":["https://orcid.org/0000-0001-7646-6075"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E Spector","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158331619","display_name":"Ryan E Mills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan E. Mills","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086902130","display_name":"John Chad Brenner","orcid":"https://orcid.org/0000-0003-3238-1111","observed_orcids":["https://orcid.org/0000-0003-3238-1111"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Chad Brenner","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":"https://orcid.org/0000-0003-3238-1111","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.16979999840259552,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-integration","display_name":"HPV integration","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oropharyngeal-squamous-cell-carcinoma","display_name":"oropharyngeal squamous cell carcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8659999966621399},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.6309999823570251},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/traf2","display_name":"TRAF2","score":0.953000009059906},{"id":"https://openalex.org/keywords/kmt2c","display_name":"KMT2C","score":0.996999979019165},{"id":"https://openalex.org/keywords/oncogene-expression","display_name":"oncogene expression","score":0.7360000014305115},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9449999928474426},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/clonal-selection","display_name":"clonal selection","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6057000160217285},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.5871999859809875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5828999876976013},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5012999773025513},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.48969998955726624},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4230000078678131},{"id":"https://openalex.org/C2910786375","wikidata":"https://www.wikidata.org/wiki/Q604261","display_name":"Viral Oncogene","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C2909762590","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene Proteins","level":4,"score":0.3634999990463257},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.34700000286102295},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.3312999904155731},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C206592519","wikidata":"https://www.wikidata.org/wiki/Q1437419","display_name":"L1","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.289900004863739},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.28679999709129333},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.03.756294","doi":"https://doi.org/10.64898/2026.10.03.756294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.756294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42926491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13692024","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13692024/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.03.756294","doi":"https://doi.org/10.64898/2026.10.03.756294","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.03.756294","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/10/2026.10.03.756294.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000189254","display_name":null,"funder_award_id":"HG000040","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000864114","display_name":"University of Michigan Training Program in Genomic Science","funder_award_id":"T32HG000040","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000913281","display_name":"Cellular and Molecular Biology at Michigan","funder_award_id":"T32GM145470","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221449293.pdf","grobid_xml":"https://content.openalex.org/works/W7221449293.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1484463029","https://openalex.org/W1773758992","https://openalex.org/W1975804993","https://openalex.org/W1981646010","https://openalex.org/W1986241711","https://openalex.org/W1990956554","https://openalex.org/W1999574084","https://openalex.org/W2017474562","https://openalex.org/W2046912879","https://openalex.org/W2081116295","https://openalex.org/W2092987969","https://openalex.org/W2098158789","https://openalex.org/W2120388677","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2146512944","https://openalex.org/W2169456326","https://openalex.org/W2461958904","https://openalex.org/W2523093670","https://openalex.org/W2528456062","https://openalex.org/W2589237364","https://openalex.org/W2591753393","https://openalex.org/W2605196547","https://openalex.org/W2611586225","https://openalex.org/W2755262202","https://openalex.org/W2755864984","https://openalex.org/W2771219703","https://openalex.org/W2779615732","https://openalex.org/W2789624890","https://openalex.org/W2789682519","https://openalex.org/W2789843538","https://openalex.org/W2790404504","https://openalex.org/W2807039433","https://openalex.org/W2883544453","https://openalex.org/W2883647223","https://openalex.org/W2904750215","https://openalex.org/W2904887959","https://openalex.org/W2947951430","https://openalex.org/W2950197585","https://openalex.org/W2950238757","https://openalex.org/W2956115108","https://openalex.org/W2969930435","https://openalex.org/W2971761467","https://openalex.org/W2992976869","https://openalex.org/W3093429790","https://openalex.org/W3094198354","https://openalex.org/W3118238647","https://openalex.org/W3173325681","https://openalex.org/W3202418805","https://openalex.org/W3211020881","https://openalex.org/W3215267689","https://openalex.org/W4223610787","https://openalex.org/W4225708271","https://openalex.org/W4225883226","https://openalex.org/W4229445329","https://openalex.org/W4281636503","https://openalex.org/W4315710113","https://openalex.org/W4318482936","https://openalex.org/W4318825258","https://openalex.org/W4362523774","https://openalex.org/W4381995972","https://openalex.org/W4387799207","https://openalex.org/W4391432072","https://openalex.org/W4392879316","https://openalex.org/W4403282516","https://openalex.org/W4408244458","https://openalex.org/W4408853909","https://openalex.org/W4410317685","https://openalex.org/W7212986348"],"related_works":["https://openalex.org/W4365511931","https://openalex.org/W4386784391","https://openalex.org/W4411578516","https://openalex.org/W2027692271","https://openalex.org/W4391278300","https://openalex.org/W3190333921","https://openalex.org/W6921327674","https://openalex.org/W4296251980","https://openalex.org/W2941618015","https://openalex.org/W1663252269"],"abstract_inverted_index":{"Summary":[0],"Viral":[1],"integration":[2,53,65,135],"is":[3],"common":[4],"in":[5,67],"human":[6,91],"papillomavirus-positive":[7],"oropharyngeal":[8],"squamous":[9],"cell":[10],"carcinoma":[11],"(HPV+":[12],"OPSCC),":[13],"but":[14],"its":[15],"structural":[16],"and":[17,38,79,95,108,115,120,126,144],"clinical":[18],"significance":[19],"remains":[20],"unclear.":[21],"We":[22,44],"integrated":[23],"targeted":[24],"capture":[25],"sequencing":[26,34],"of":[27,35,69,110,129,141],"197":[28],"HPV+":[29],"OPSCCs":[30],"with":[31,71],"long-read":[32],"nanopore":[33],"17":[36],"tumors":[37,102],"models":[39],"to":[40],"characterize":[41],"HPV\u2013host":[42,97],"rearrangements.":[43],"developed":[45],"a":[46,138],"novel":[47],"quantitative":[48],"informatics":[49],"framework":[50],"that":[51],"classifies":[52],"structures":[54],"as":[55,137],"Type1":[56],"(simple,":[57],"single/low-copy)":[58],"or":[59],"Type2":[60,82,101,130],"(clustered,":[61],"high-copy,":[62],"rearranged).":[63],"HPV":[64,87,105],"occurred":[66],"83%":[68],"tumors,":[70],"recurrent":[72],"hotspots":[73],"including":[74],"TP63,":[75],"MYC,":[76,111],"CD274,":[77],"TRAF2,":[78],"KMT2C":[80],".":[81],"events":[83],"were":[84],"enriched":[85],"for":[86],"E2":[88],"disruption,":[89],"focal":[90],"amplifications,":[92],"preferential":[93],"transcription,":[94],"noncanonical":[96],"RNA":[98],"fusion":[99],"isoforms.":[100],"showed":[103],"increased":[104],"oncogene":[106],"expression":[107],"activation":[109],"NF-\u03baB/TNF\u03b1,":[112],"PI3K\u2013AKT\u2013mTOR,":[113],"Hippo/YAP\u2013TAZ,":[114],"epithelial":[116],"stemness":[117],"programs.":[118],"Multi-region":[119],"longitudinal":[121],"analyses":[122],"revealed":[123],"intratumoral":[124],"heterogeneity":[125],"clonal":[127],"selection":[128],"architectures":[131],"during":[132],"progression,":[133],"supporting":[134],"structure":[136],"potential":[139],"marker":[140],"aggressive":[142],"behavior":[143],"risk":[145],"stratification.":[146]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-12T00:00:00"}
