{"id":"https://openalex.org/W7221365296","doi":"https://doi.org/10.1186/s13567-026-01851-6","title":"An efficient and versatile reverse genetics system for bovine coronavirus facilitates antiviral evaluation","display_name":"An efficient and versatile reverse genetics system for bovine coronavirus facilitates antiviral evaluation","publication_year":2026,"publication_date":"2026-10-10","ids":{"openalex":"https://openalex.org/W7221365296","doi":"https://doi.org/10.1186/s13567-026-01851-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42859170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13654213"},"language":"en","primary_location":{"id":"doi:10.1186/s13567-026-01851-6","doi":"https://doi.org/10.1186/s13567-026-01851-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-026-01851-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01851-6.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01851-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113316104","display_name":"Yiran Zeng","orcid":"https://orcid.org/0009-0001-3542-6955","observed_orcids":["https://orcid.org/0009-0001-3542-6955","https://orcid.org/0009-0009-5618-4279"]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Zeng","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158270241","display_name":"Hanqiong Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanqiong Gao","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082754243","display_name":"Yuanlu Lu","orcid":"https://orcid.org/0000-0002-1868-2439","observed_orcids":["https://orcid.org/0000-0002-1868-2439"]},"institutions":[{"id":"https://openalex.org/I4405263417","display_name":"Shangqiu Polytechnic","ror":"https://ror.org/00pnmg910","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263417"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanlu Lu","raw_affiliation_strings":["College of Veterinary Medicine, Shangqiu Polytechnic, Shangqiu, 476000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Shangqiu Polytechnic, Shangqiu, 476000, China","institution_ids":["https://openalex.org/I4405263417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033833621","display_name":"Menglu Fan","orcid":"https://orcid.org/0000-0001-8191-600X","observed_orcids":["https://orcid.org/0000-0001-8191-600X"]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menglu Fan","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158273850","display_name":"Zhiyuan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyuan Liu","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158275439","display_name":"Yue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]},{"id":"https://openalex.org/I4210135208","display_name":"Xinjiang Academy of Animal Science","ror":"https://ror.org/02tcape08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210135208"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","Xinjiang Academy of Animal Sciences Institute of Veterinary Medicine, Key Laboratory for Prevention and Control of Herbivorous Animal Diseases of the Ministry of Agriculture and Rural Affairs and Xinjiang Animal Disease Research Key Laboratory, Urumchi, 830000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","institution_ids":["https://openalex.org/I119454577"]},{"raw_affiliation_string":"Xinjiang Academy of Animal Sciences Institute of Veterinary Medicine, Key Laboratory for Prevention and Control of Herbivorous Animal Diseases of the Ministry of Agriculture and Rural Affairs and Xinjiang Animal Disease Research Key Laboratory, Urumchi, 830000, China","institution_ids":["https://openalex.org/I4210135208","https://openalex.org/I4210151987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158272771","display_name":"Linjuan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linjuan Wu","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158266145","display_name":"Jun Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135208","display_name":"Xinjiang Academy of Animal Science","ror":"https://ror.org/02tcape08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210135208"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Xia","raw_affiliation_strings":["Xinjiang Academy of Animal Sciences Institute of Veterinary Medicine, Key Laboratory for Prevention and Control of Herbivorous Animal Diseases of the Ministry of Agriculture and Rural Affairs and Xinjiang Animal Disease Research Key Laboratory, Urumchi, 830000, China. 1065291747@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinjiang Academy of Animal Sciences Institute of Veterinary Medicine, Key Laboratory for Prevention and Control of Herbivorous Animal Diseases of the Ministry of Agriculture and Rural Affairs and Xinjiang Animal Disease Research Key Laboratory, Urumchi, 830000, China. 1065291747@qq.com","institution_ids":["https://openalex.org/I4210135208","https://openalex.org/I4210151987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025127620","display_name":"Jihui Ping","orcid":"https://orcid.org/0000-0003-4583-2575","observed_orcids":["https://orcid.org/0000-0003-4583-2575"]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jihui Ping","raw_affiliation_strings":["Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. jihui.ping@njau.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-4583-2575","affiliations":[{"raw_affiliation_string":"Jiangsu Engineering Center of Animal Immunology and MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. jihui.ping@njau.edu.cn","institution_ids":["https://openalex.org/I119454577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025127620","https://openalex.org/A5158266145"],"corresponding_institution_ids":["https://openalex.org/I119454577","https://openalex.org/I4210135208","https://openalex.org/I4210151987"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75980365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"1","first_page":"180","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-coronavirus","display_name":"bovine coronavirus","score":1.0},{"id":"https://openalex.org/keywords/reverse-genetics","display_name":"reverse genetics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/recombinant-virus-rescue","display_name":"recombinant virus rescue","score":0.9290000200271606},{"id":"https://openalex.org/keywords/antiviral-drug-screening","display_name":"antiviral drug screening","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nelfinavir","display_name":"nelfinavir","score":0.9330000281333923},{"id":"https://openalex.org/keywords/niclosamide","display_name":"niclosamide","score":0.8870000243186951},{"id":"https://openalex.org/keywords/camostat","display_name":"camostat","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nafamostat","display_name":"nafamostat","score":1.0},{"id":"https://openalex.org/keywords/virus-internalization","display_name":"viral internalization","score":0.7200000286102295},{"id":"https://openalex.org/keywords/calf-diarrhea","display_name":"calf diarrhea","score":0.9210000038146973},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8234000205993652},{"id":"https://openalex.org/C2776810377","wikidata":"https://www.wikidata.org/wiki/Q4950554","display_name":"Bovine coronavirus","level":5,"score":0.8100000023841858},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.7986999750137329},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5945000052452087},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5041000247001648},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.4341000020503998},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4133000075817108},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4090999960899353},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39570000767707825},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.37689998745918274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35690000653266907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32499998807907104},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C39060996","wikidata":"https://www.wikidata.org/wiki/Q7302706","display_name":"Recombinant virus","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.28519999980926514},{"id":"https://openalex.org/C204315192","wikidata":"https://www.wikidata.org/wiki/Q210506","display_name":"Molecular genetics","level":3,"score":0.2709999978542328},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26930001378059387},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017938","descriptor_name":"Coronavirus, Bovine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017938","descriptor_name":"Coronavirus, Bovine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017938","descriptor_name":"Coronavirus, Bovine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D059386","descriptor_name":"Reverse Genetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059386","descriptor_name":"Reverse Genetics","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13567-026-01851-6","doi":"https://doi.org/10.1186/s13567-026-01851-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-026-01851-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01851-6.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13654213","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13654213/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13654213/pdf/13567_2026_Article_1851.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet Res","raw_type":"Text"},{"id":"pmid:42859170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42859170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05793445v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05793445","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, 2026, 57 (1), pp.180. &#x27E8;10.1186/s13567-026-01851-6&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.6084/m9.figshare.c.8765607","doi":"https://doi.org/10.6084/m9.figshare.c.8765607","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8765607","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.6084/m9.figshare.c.8765607.v1","doi":"https://doi.org/10.6084/m9.figshare.c.8765607.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8765607.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"}],"best_oa_location":{"id":"doi:10.1186/s13567-026-01851-6","doi":"https://doi.org/10.1186/s13567-026-01851-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-026-01851-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13567-026-01851-6.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6179733847","display_name":null,"funder_award_id":"2023A02007","funder_id":"https://openalex.org/F4320325211","funder_display_name":"Nanjing Agricultural University"}],"funders":[{"id":"https://openalex.org/F4320325211","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221365296.pdf","grobid_xml":"https://content.openalex.org/works/W7221365296.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1537814268","https://openalex.org/W1984494056","https://openalex.org/W1995296637","https://openalex.org/W1998450447","https://openalex.org/W2022183964","https://openalex.org/W2035167734","https://openalex.org/W2058658401","https://openalex.org/W2058915320","https://openalex.org/W2068824485","https://openalex.org/W2076193144","https://openalex.org/W2100496875","https://openalex.org/W2123334163","https://openalex.org/W2137888434","https://openalex.org/W2140790746","https://openalex.org/W2144030492","https://openalex.org/W2160121356","https://openalex.org/W2616161033","https://openalex.org/W2623680296","https://openalex.org/W2725497285","https://openalex.org/W2792460430","https://openalex.org/W2923409035","https://openalex.org/W2926591465","https://openalex.org/W3007969569","https://openalex.org/W3009912996","https://openalex.org/W3021391231","https://openalex.org/W3022734398","https://openalex.org/W3037487072","https://openalex.org/W3088885706","https://openalex.org/W3108240937","https://openalex.org/W3119203274","https://openalex.org/W3137029088","https://openalex.org/W3142564745","https://openalex.org/W3171505118","https://openalex.org/W3182008660","https://openalex.org/W4200051875","https://openalex.org/W4200486608","https://openalex.org/W4200557305","https://openalex.org/W4225293112","https://openalex.org/W4281729250","https://openalex.org/W4312160674","https://openalex.org/W4320497972","https://openalex.org/W4323037282","https://openalex.org/W4367835165","https://openalex.org/W4376642484","https://openalex.org/W4392397203","https://openalex.org/W4394942452","https://openalex.org/W4399385882","https://openalex.org/W4400408215","https://openalex.org/W4404865502","https://openalex.org/W4405720499","https://openalex.org/W4408036936","https://openalex.org/W4410589573","https://openalex.org/W4411224220","https://openalex.org/W4413101879","https://openalex.org/W4414537872","https://openalex.org/W4415845391","https://openalex.org/W4417369030"],"related_works":["https://openalex.org/W7221472178","https://openalex.org/W7221462429","https://openalex.org/W7221434348","https://openalex.org/W7221450441","https://openalex.org/W4403001385","https://openalex.org/W7154591001","https://openalex.org/W2371991538","https://openalex.org/W3095422451","https://openalex.org/W4394875894","https://openalex.org/W2031681208"],"abstract_inverted_index":{"Bovine":[0],"coronavirus":[1],"(BCoV),":[2],"a":[3,43,112,129,181],"primary":[4],"etiological":[5],"agent":[6],"of":[7,33,148,192],"calf":[8],"diarrhea,":[9],"exhibits":[10],"dual":[11],"tropism":[12],"for":[13,48,103,116,136,184],"the":[14,31,92,96,108,132,162],"respiratory":[15],"and":[16,25,35,69,85,146,159,168,189,195,205],"enteric":[17],"tracts.":[18],"However,":[19],"research":[20,188],"on":[21,51],"BCoV":[22,49,64,72,151,163,172,186],"gene":[23,119],"function":[24],"pathogenesis":[26,187],"has":[27],"been":[28],"limited":[29],"by":[30],"lack":[32],"convenient":[34],"flexible":[36],"reverse":[37,45,177],"genetics":[38,46,178],"tools.":[39],"Herein,":[40],"we":[41],"report":[42],"robust":[44],"system":[47,179],"based":[50],"an":[52],"optimized":[53],"circular":[54],"polymerase":[55],"extension":[56],"reaction":[57],"(CPER)":[58],"methodology.":[59],"We":[60],"successfully":[61,140],"rescued":[62],"recombinant":[63,71],"(rBCoV)":[65],"in":[66],"HRT-18G":[67],"cells":[68],"engineered":[70],"expressing":[73],"ZsGreen":[74],"fluorescent":[75],"protein":[76],"(rBCoV/Zs-T2A-ns2).":[77],"Phenotypic":[78],"analysis":[79],"demonstrated":[80,99],"that":[81,157],"both":[82],"unmodified":[83],"rBCoV":[84],"rBCoV/Zs-T2A-ns2":[86,133],"maintained":[87],"growth":[88],"kinetics":[89],"comparable":[90],"to":[91,201],"wild-type":[93],"BCoV.":[94],"Importantly,":[95],"reporter":[97],"virus":[98],"remarkable":[100],"genetic":[101],"stability":[102],"over":[104],"ten":[105],"passages,":[106],"identifying":[107,141],"ns2":[109],"locus":[110],"as":[111],"suitable":[113],"insertion":[114],"site":[115],"stable":[117],"foreign":[118],"expression":[120],"without":[121],"compromising":[122],"viral":[123],"fitness":[124],"or":[125],"sequence":[126],"integrity.":[127],"As":[128],"proof-of-concept":[130],"application,":[131],"was":[134],"employed":[135],"antiviral":[137,197],"compound":[138],"evaluation,":[139],"four":[142],"compounds-camostat,":[143],"nafamostat,":[144],"niclosamide,":[145],"nelfinavir-capable":[147],"effectively":[149],"inhibiting":[150],"replication.":[152],"Further":[153],"time-of-addition":[154],"assays":[155],"revealed":[156],"nelfinavir":[158],"niclosamide":[160],"targeted":[161],"replication":[164],"stage,":[165],"while":[166],"camostat":[167],"nafamostat":[169],"interfered":[170],"with":[171],"internalization.":[173],"This":[174],"versatile":[175],"CPER-based":[176],"provides":[180],"critical":[182],"platform":[183],"advanced":[185],"accelerated":[190],"development":[191],"novel":[193],"vaccines":[194],"effective":[196],"therapeutics,":[198],"ultimately":[199],"contributing":[200],"enhanced":[202],"bovine":[203],"health":[204],"sustainable":[206],"livestock":[207],"production.":[208]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-11T00:00:00"}
