{"id":"https://openalex.org/W7221284033","doi":null,"title":"Secundaire nucleatie geherdefinieerd: De ongrijpbare aard van door schuifkrachten in vloeistoffen ge\u00efnduceerde secundaire nucleatie en de verstrekkende gevolgen daarvan","display_name":"Secundaire nucleatie geherdefinieerd: De ongrijpbare aard van door schuifkrachten in vloeistoffen ge\u00efnduceerde secundaire nucleatie en de verstrekkende gevolgen daarvan","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7221284033"},"language":"en","primary_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/795376","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/795376","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117937305","display_name":"Lorijn De Vrieze","orcid":"https://orcid.org/0000-0003-0914-8784","observed_orcids":["https://orcid.org/0000-0003-0914-8784"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"De Vrieze, Lorijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5117937305"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14479","display_name":"Freezing and Crystallization Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11087","display_name":"Solidification and crystal growth phenomena","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-nucleation","display_name":"secondary nucleation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/solute-clustering","display_name":"solute clustering","score":0.9200000166893005},{"id":"https://openalex.org/keywords/supersaturated-solutions","display_name":"supersaturated solutions","score":0.6150000095367432},{"id":"https://openalex.org/keywords/seed-crystals","display_name":"seed crystals","score":0.46000000834465027},{"id":"https://openalex.org/keywords/primary-nucleation","display_name":"primary nucleation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/crystal-breakage","display_name":"crystal breakage","score":0.8069999814033508},{"id":"https://openalex.org/keywords/crystal-growth","display_name":"crystal growth","score":0.41499999165534973},{"id":"https://openalex.org/keywords/micro-raman-spectroscopy","display_name":"micro-Raman spectroscopy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/synchrotron-small-angle-x-ray-scattering","display_name":"synchrotron small-angle X-ray scattering","score":0.9520000219345093},{"id":"https://openalex.org/keywords/crystal-size-distribution","display_name":"crystal size distribution","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.8751000165939331},{"id":"https://openalex.org/C200447597","wikidata":"https://www.wikidata.org/wiki/Q334104","display_name":"Supersaturation","level":2,"score":0.791100025177002},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.7179999947547913},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.6661999821662903},{"id":"https://openalex.org/C2779015675","wikidata":"https://www.wikidata.org/wiki/Q92796261","display_name":"Breakage","level":2,"score":0.5475000143051147},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.461899995803833},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41119998693466187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39959999918937683},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3822000026702881},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.3662000000476837},{"id":"https://openalex.org/C104169306","wikidata":"https://www.wikidata.org/wiki/Q899429","display_name":"Seed crystal","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C26456737","wikidata":"https://www.wikidata.org/wiki/Q185154","display_name":"Crystal growth","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C2780393986","wikidata":"https://www.wikidata.org/wiki/Q19892223","display_name":"Classical nucleation theory","level":3,"score":0.3285999894142151},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.32820001244544983},{"id":"https://openalex.org/C47908070","wikidata":"https://www.wikidata.org/wiki/Q900515","display_name":"Grain boundary","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C89464430","wikidata":"https://www.wikidata.org/wiki/Q849516","display_name":"Metastability","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C111603439","wikidata":"https://www.wikidata.org/wiki/Q752193","display_name":"Boundary layer","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/795376","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/795376","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7163067239","https://openalex.org/W6890222681","https://openalex.org/W4399477812","https://openalex.org/W4411157365","https://openalex.org/W4404026046","https://openalex.org/W2943354394","https://openalex.org/W4254311805","https://openalex.org/W2892399201","https://openalex.org/W183570563","https://openalex.org/W2901912943"],"abstract_inverted_index":{"It":[0,270,439],"is":[1,33,100,111,140,151,180,191,245,440,466,483,559],"well-known":[2],"in":[3,24,43,197,202,289,305,369,418,510,552],"crystallization":[4,138],"research":[5,124],"that":[6,19,76,162,192,274,318,375,470,484,562],"adding":[7],"seed":[8,85,212],"crystals":[9,78,228],"of":[10,27,50,106,118,176,184,239,258,321,357,381,386,396,435,447,487,501,509,526,541,578],"a":[11,15,40,354,527,542,574],"chemical":[12],"substance":[13],"to":[14,69,103,142,158,170,308,314,392,442,468],"solution":[16,199,209],"supersaturated":[17,198],"for":[18,130,299,522],"substance,":[20],"will":[21],"quickly":[22],"result":[23],"the":[25,48,61,84,90,95,98,104,109,116,131,146,155,159,174,182,203,211,221,255,275,285,290,293,315,319,358,394,397,423,428,445,498,507,523,538,553],"formation":[26,117],"many":[28],"new":[29,77,576],"crystals.":[30],"This":[31,312],"process":[32],"called":[34],"secondary":[35,65,163,187,235,243,265,324,504,543,563,579],"nucleation":[36,66,123,164,244,266,304,325,342,505,544,564],"and":[37,54,114,200,229,302,409,506],"it":[38,465,558],"plays":[39],"central":[41],"role":[42],"numerous":[44,249],"industrial":[45,59],"applications,":[46],"including":[47],"production":[49],"pharmaceuticals,":[51],"food":[52],"ingredients,":[53],"specialty":[55],"chemicals.":[56],"Despite":[57],"its":[58],"importance,":[60],"fundamental":[62],"mechanisms":[63,570],"governing":[64],"remain":[67],"unknown":[68],"this":[70,177,240],"day.":[71],"The":[72,189,237,296,414],"current":[73],"consensus":[74],"concludes":[75],"must":[79],"originate":[80],"from":[81,416],"either":[82,443],"(i)":[83],"crystal":[86,107,128,213,572],"itself,":[87],"or":[88,340,451],"(ii)":[89],"small":[91,404],"liquid":[92],"layer":[93,150,179,361,550],"surrounding":[94],"seed.":[96],"While":[97],"former":[99],"obvious":[101],"due":[102],"occurrence":[105],"breakage,":[108],"latter":[110],"more":[112,172,282,364],"intricate":[113],"involves":[115],"so-called":[119],"solute":[120,193,370,448,488],"aggregates.":[121],"Secondary":[122],"primarily":[125],"focused":[126],"on":[127,350,547],"breakage":[129],"last":[132],"decades,":[133],"but":[134],"predictive":[135],"control":[136,278,297],"over":[137,210],"outcomes":[139],"yet":[141],"be":[143,218,232,268,309,431,475,492],"established.":[144],"Therefore,":[145],"complex":[147,528],"crystal-solution":[148,204,359,398,529],"boundary":[149,178,205,360,399,530,549],"currently":[152],"seen":[153],"as":[154,234,334],"missing":[156],"piece":[157],"veritable":[160],"puzzle":[161],"presents.":[165],"An":[166],"excellent":[167],"first":[168],"approach":[169],"learn":[171],"about":[173],"nature":[175,395],"through":[181],"phenomenon":[183,320],"fluid":[185,241,263,322,502],"shear-induced":[186,242,264,323,503],"nucleation.":[188,236,580],"concept":[190],"aggregates":[194,216],"spontaneously":[195],"form":[196],"accumulate":[201],"layer.":[206,531],"By":[207],"flowing":[208],"surface,":[214],"these":[215,259,387,417,533],"can":[217,230,565],"swept":[219],"into":[220,227],"bulk":[222],"solution,":[223],"where":[224],"they":[225,453],"grow":[226],"hence":[231],"detected":[233],"existence":[238,446,540],"experimentally":[246],"confirmed":[247],"by":[248,433,569],"literature":[250,260,330],"works.":[251],"However,":[252],"when":[253],"reproducing":[254],"most":[256],"representative":[257],"experiments,":[261],"no":[262,471],"could":[267,332,430],"observed.":[269],"was":[271],"slowly":[272],"realized":[273],"herein":[276,560],"developed":[277],"experiments":[279,298],"were":[280],"much":[281],"rigorous":[283],"than":[284,348],"ones":[286],"conventionally":[287],"applied":[288],"literature,":[291],"explaining":[292],"different":[294],"observations.":[295],"initial":[300,338],"breeding":[301,339],"primary":[303,341],"particular":[306],"appeared":[307],"largely":[310],"inadequate.":[311],"led":[313],"surprising":[316],"conclusion":[317,473],"might":[326,362],"not":[327,455],"even":[328],"exist:":[329],"reports":[331],"just":[333],"easily":[335],"have":[336,373,513],"described":[337],"instead.":[343],"In":[344],"any":[345],"case,":[346],"rather":[347],"relying":[349,546],"indirect":[351],"experimental":[352],"approaches,":[353],"direct":[355],"analysis":[356],"provide":[363],"clarity.":[365],"Moreover,":[366],"recent":[367],"advancements":[368],"clustering":[371,489],"detection":[372],"revealed":[374],"various":[376],"measurement":[377],"techniques":[378,388],"are":[379,389,461,519],"capable":[380],"observing":[382],"clusters/aggregates.":[383],"A":[384],"selection":[385],"used":[390],"here":[391],"investigate":[393],"layer:":[400],"micro-Raman":[401],"spectroscopy,":[402],"synchrotron":[403],"angle":[405],"X-ray":[406],"scattering":[407,412],"(SAXS),":[408],"dynamic":[410],"light":[411],"(DLS).":[413],"results":[415],"situ":[419,511],"analyses":[420],"leave":[421],"quite":[422],"confusion":[424],"though.":[425],"Interestingly,":[426],"all":[427,485],"observations":[429],"interpreted":[432],"one":[434,479],"two":[436,534],"conflicting":[437],"views.":[438],"possible":[441,499],"hypothesize":[444],"clusters":[449],"throughout,":[450],"assume":[452],"do":[454],"exist":[456],"at":[457],"all.":[458],"Both":[459,518],"explanations":[460],"equally":[462],"plausible,":[463],"so":[464],"important":[467],"realize":[469],"definite":[472],"should":[474,491],"drawn":[476],"here.":[477],"Nonetheless,":[478],"clear":[480],"takeaway":[481],"message":[482],"interpretation":[486],"measurements":[490,512],"handled":[493],"with":[494],"extreme":[495],"caution.":[496],"Together,":[497],"nonexistence":[500],"inconclusiveness":[508],"some":[514],"unrecognized,":[515],"far-reaching":[516],"consequences.":[517],"essential":[520],"evidence":[521],"assumed":[524],"presence":[525],"With":[532],"now":[535],"falling":[536],"away,":[537],"overall":[539],"mechanism":[545],"such":[548],"hangs":[551],"balance.":[554],"Adopting":[555],"Occam's":[556],"razor,":[557],"argued":[561],"take":[566],"place":[567],"exclusively":[568],"involving":[571],"breakage:":[573],"bold":[575],"definition":[577]},"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2026-10-10T00:00:00"}