{"id":"https://openalex.org/W7221190404","doi":"https://doi.org/10.64898/2026.10.02.756061","title":"Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer","display_name":"Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer","publication_year":2026,"publication_date":"2026-10-08","ids":{"openalex":"https://openalex.org/W7221190404","doi":"https://doi.org/10.64898/2026.10.02.756061"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.756061","doi":"https://doi.org/10.64898/2026.10.02.756061","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756061","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756061.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756061.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015242323","display_name":"Hemant Gujar","orcid":"https://orcid.org/0000-0001-5896-7562","observed_orcids":["https://orcid.org/0000-0001-5896-7562"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hemant Gujar","raw_affiliation_strings":["Columbia University Medical Center, Columbia University","Department of Leukemia, The University of Texas, MD Anderson Cancer Center"],"raw_orcid":"https://orcid.org/0000-0001-5896-7562","affiliations":[{"raw_affiliation_string":"Columbia University Medical Center, Columbia University","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Leukemia, The University of Texas, MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071123166","display_name":"Sarah Hanache","orcid":"https://orcid.org/0000-0003-0166-3757","observed_orcids":["https://orcid.org/0000-0003-0166-3757"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Hanache","raw_affiliation_strings":["Department of Leukemia, The University of Texas, MD Anderson Cancer Center"],"raw_orcid":"https://orcid.org/0000-0003-0166-3757","affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas, MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103001675","display_name":"Sadhna Aggarwal","orcid":"https://orcid.org/0000-0002-4646-9352","observed_orcids":["https://orcid.org/0000-0002-4646-9352"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadhna Aggarwal","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-4646-9352","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015242323"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I2799503643"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7649999856948853},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7329999804496765},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.75},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cxcl3","display_name":"CXCL3","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tnfsf10","display_name":"TNFSF10","score":0.9890000224113464},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.6534000039100647},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.590499997138977},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5278000235557556},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.527400016784668},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5044000148773193},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4934999942779541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48590001463890076},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.45489999651908875},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4212999939918518},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3903999924659729},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3815999925136566},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.3707999885082245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36320000886917114},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.36000001430511475},{"id":"https://openalex.org/C179661763","wikidata":"https://www.wikidata.org/wiki/Q21113119","display_name":"CXCL2","level":5,"score":0.3562000095844269},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3506999909877777},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3440000116825104},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C140944930","wikidata":"https://www.wikidata.org/wiki/Q18026345","display_name":"CCR10","level":5,"score":0.25609999895095825},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.02.756061","doi":"https://doi.org/10.64898/2026.10.02.756061","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756061","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756061.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.756061","doi":"https://doi.org/10.64898/2026.10.02.756061","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756061","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/08/2026.10.02.756061.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221190404.pdf","grobid_xml":"https://content.openalex.org/works/W7221190404.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405821380","https://openalex.org/W4399788892","https://openalex.org/W3136066277","https://openalex.org/W4389339556","https://openalex.org/W4303613913","https://openalex.org/W4412328705","https://openalex.org/W4416999477","https://openalex.org/W4402561309","https://openalex.org/W2903629076","https://openalex.org/W2560872734"],"abstract_inverted_index":{"Abstract":[0],"Aging":[1],"and":[2,10,35,47,68,84,87,99,101,153,165,173,189,197],"tobacco":[3,174],"exposure":[4,175],"are":[5],"major":[6],"determinants":[7],"of":[8,55],"risk":[9],"outcome":[11],"in":[12,139,205],"HPV-negative":[13,44],"oral":[14],"cavity":[15],"squamous":[16],"cell":[17],"carcinoma":[18],"(OSCC),":[19],"yet":[20],"the":[21,103,144,148,186,194],"cellular":[22],"programs":[23,86],"linking":[24],"host":[25],"factors":[26],"to":[27,129,177],"tumor":[28,70,166],"immunity":[29],"remain":[30],"poorly":[31],"defined.":[32],"We":[33],"reprocessed":[34],"reanalyzed":[36],"previously":[37],"published":[38],"single-cell":[39],"RNA-seq":[40],"data":[41],"from":[42],"19":[43],"OSCC":[45],"tumors":[46],"we":[48],"identified":[49],"a":[50,63,66,76,108,136],"robust":[51],"age-and":[52],"smoking-associated":[53],"expansion":[54],"SPP1":[56,72,117,151,180],"high":[57,73,118,181],"tumor-associated":[58],"macrophages":[59],"(TAMs),":[60],"accompanied":[61],"by":[62],"shift":[64],"toward":[65],"myeloid-dominant":[67],"lymphocyte-reduced":[69],"microenvironment.":[71],"TAMs":[74,119],"exhibit":[75],"distinct":[77],"transcriptional":[78],"state":[79],"enriched":[80],"for":[81,163],"extracellular-matrix":[82],"remodeling":[83],"metabolic":[85],"reduced":[88],"antigen-presentation":[89],"pathways.":[90],"They":[91],"also":[92],"express":[93],"inflammatory":[94],"chemokines":[95],"such":[96],"as":[97,121,201],"CXCL2":[98],"CXCL3":[100],"down-regulate":[102],"cytotoxic":[104],"mediator":[105],"TNFSF10,":[106],"suggesting":[107],"broadly":[109],"protumor":[110],"TAM":[111,182],"phenotype.":[112],"Ligand-receptor":[113],"modeling":[114],"suggests":[115],"that":[116,171,184],"act":[120],"key":[122],"communication":[123],"hubs,":[124],"with":[125],"dominant":[126],"SPP1-CD44":[127,195],"signaling":[128],"T-cell":[130],"subsets.":[131],"Transcription-factor":[132],"analysis":[133],"further":[134],"implicates":[135],"POU2F1/POU2F2/SP1":[137],"module":[138],"maintaining":[140],"this":[141],"state.":[142],"In":[143],"TCGA":[145],"HNSCC":[146],"cohort,":[147],"association":[149],"between":[150],"expression":[152],"overall":[154],"survival":[155],"did":[156],"not":[157],"reach":[158],"statistical":[159],"significance":[160],"after":[161],"adjustment":[162],"age":[164],"purity.":[167],"These":[168],"findings":[169],"demonstrate":[170],"aging":[172],"converge":[176],"expand":[178],"an":[179],"population":[183],"remodels":[185],"extracellular":[187],"matrix":[188],"suppresses":[190],"antitumor":[191],"immunity,":[192],"highlighting":[193],"axis":[196],"its":[198],"upstream":[199],"regulators":[200],"potential":[202],"therapeutic":[203],"targets":[204],"high-risk":[206],"OSCC.":[207]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-10T00:00:00"}
