{"id":"https://openalex.org/W7221185338","doi":"https://doi.org/10.1038/s41598-026-75258-w","title":"Multi-omics techniques reveal the molecular mechanisms of perfluoroalkyl substances in regulating preeclampsia","display_name":"Multi-omics techniques reveal the molecular mechanisms of perfluoroalkyl substances in regulating preeclampsia","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221185338","doi":"https://doi.org/10.1038/s41598-026-75258-w"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-75258-w","doi":"https://doi.org/10.1038/s41598-026-75258-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75258-w","pdf_url":"https://www.nature.com/articles/s41598-026-75258-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-75258-w_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158125140","display_name":"Yue Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158180113","display_name":"Yiqing Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqing Fu","raw_affiliation_strings":["The First Clinical Medical College, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158007853","display_name":"Junchi He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junchi He","raw_affiliation_strings":["School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138784435","display_name":"Weijiong Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijiong Guan","raw_affiliation_strings":["Dalian Medical University, No. 9, West Section of Lushun South Road, Lushunkou District, Dalian, 116044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalian Medical University, No. 9, West Section of Lushun South Road, Lushunkou District, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158094004","display_name":"Yunjin Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjin Shi","raw_affiliation_strings":["School Of Nursing, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School Of Nursing, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158227132","display_name":"Sitong Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sitong Fang","raw_affiliation_strings":["The First Clinical Medical College, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158103833","display_name":"Shujia Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujia Xiang","raw_affiliation_strings":["School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046464516","display_name":"Mingyue Ma","orcid":"https://orcid.org/0009-0005-1860-7542","observed_orcids":["https://orcid.org/0009-0005-1860-7542"]},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingyue Ma","raw_affiliation_strings":["Liaoning Key Laboratory of Environmental Pollution and Microecology, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaoning Key Laboratory of Environmental Pollution and Microecology, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]},{"raw_affiliation_string":"School of Public Health, Shenyang Medical College, No. 146 Huanghe North Street, Shenyang, 110034, China","institution_ids":["https://openalex.org/I1099802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046464516"],"corresponding_institution_ids":["https://openalex.org/I1099802"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63367961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/per-and-polyfluoroalkyl-substances","display_name":"per- and polyfluoroalkyl substances","score":0.9459999799728394},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/perfluorooctane-sulfonate","display_name":"PFOS","score":0.734000027179718},{"id":"https://openalex.org/keywords/perfluorooctanoic-acid","display_name":"perfluorooctanoic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pfna","display_name":"PFNA","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pfhxs","display_name":"PFHxS","score":0.9990000128746033},{"id":"https://openalex.org/keywords/placental-function","display_name":"placental function","score":0.671999990940094},{"id":"https://openalex.org/keywords/ppar-signaling-pathway","display_name":"PPAR signaling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.8429999947547913},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8450000286102295},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6340000033378601},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.5600000023841858},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.5839999914169312},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.6432999968528748},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6071000099182129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4043999910354614},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37560001015663147},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3019999861717224},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29580000042915344},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26100000739097595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-75258-w","doi":"https://doi.org/10.1038/s41598-026-75258-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75258-w","pdf_url":"https://www.nature.com/articles/s41598-026-75258-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-75258-w","doi":"https://doi.org/10.1038/s41598-026-75258-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75258-w","pdf_url":"https://www.nature.com/articles/s41598-026-75258-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328881","display_name":"Key Research Project of Liaoning","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221185338.pdf","grobid_xml":"https://content.openalex.org/works/W7221185338.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W2625304812","https://openalex.org/W3163361401","https://openalex.org/W4200416240","https://openalex.org/W4385648911","https://openalex.org/W4390616882","https://openalex.org/W4405808153","https://openalex.org/W4410132746","https://openalex.org/W4413427625","https://openalex.org/W7128975091"],"related_works":["https://openalex.org/W4390542743","https://openalex.org/W7164133064","https://openalex.org/W4308035788","https://openalex.org/W4405801821","https://openalex.org/W4408410714","https://openalex.org/W2951375064","https://openalex.org/W2952943059","https://openalex.org/W3034382509","https://openalex.org/W2981738984","https://openalex.org/W3206454742"],"abstract_inverted_index":{"This":[0],"study":[1,203],"employed":[2],"an":[3,173],"integrated":[4],"in":[5,197],"silico":[6],"strategy":[7],"combining":[8],"network":[9],"toxicology,":[10],"molecular":[11,13,29],"docking,":[12],"dynamics":[14],"(MD)":[15],"simulations,":[16],"machine":[17],"learning,":[18],"and":[19,34,55,66,94,104,124,130,191,218,231],"single\u2011cell":[20],"RNA":[21],"sequencing":[22],"(scRNA\u2011seq)":[23],"analysis":[24,47,179],"to":[25,39,145],"systematically":[26],"investigate":[27],"the":[28,40,97,105,139,181,226],"mechanisms":[30],"through":[31,211],"which":[32],"per\u2011":[33],"polyfluoroalkyl":[35],"substances":[36],"(PFAS)":[37],"contribute":[38],"pathogenesis":[41],"of":[42,53,168,175,184,214,229],"preeclampsia":[43,230],"(PE).":[44],"Network":[45],"toxicology":[46],"identified":[48,157],"135":[49],"potential":[50,149,233],"common":[51],"targets":[52,126],"PFAS":[54,78,118,206],"PE,":[56],"with":[57,83,172],"ALB":[58],",":[59,61,63,65],"IL6":[60],"TNF":[62,129],"IL1B":[64],"PPARG":[67],"emerging":[68],"as":[69,128],"central":[70],"hub":[71],"genes.":[72],"Functional":[73],"enrichment":[74],"analyses":[75],"revealed":[76,192],"that":[77,136],"exposure":[79],"is":[80],"significantly":[81],"associated":[82],"pathways":[84],"involving":[85],"nuclear":[86],"receptor":[87],"activity,":[88],"monocarboxylic":[89],"acid":[90,102],"transport,":[91],"inflammatory":[92],"response,":[93],"lipid":[95,216],"metabolism\u2014particularly":[96],"PPAR":[98],"signaling":[99,107],"pathway,":[100],"fatty":[101],"degradation,":[103],"IL\u201117":[106],"pathway.":[108],"Molecular":[109],"docking":[110],"demonstrated":[111],"strong":[112],"binding":[113],"affinities":[114],"between":[115],"four":[116],"representative":[117],"compounds":[119],"(PFOS,":[120],"PFOA,":[121],"PFNA,":[122],"PFHxS)":[123],"key":[125],"such":[127],"ALB.":[131],"MD":[132],"simulations":[133],"further":[134],"indicated":[135],"PFHxS":[137],"exhibited":[138],"highest":[140],"conformational":[141],"stability":[142],"when":[143],"bound":[144],"TNF,":[146],"suggesting":[147],"its":[148],"for":[150,235],"prolonged":[151],"biological":[152],"impact.":[153],"Machine":[154],"learning":[155],"modeling":[156],"a":[158],"predictive":[159],"gene":[160],"signature":[161],"(TRPM1,":[162],"PALM,":[163],"HIST1H4D,":[164],"ANK1,":[165],"RPP14)":[166],"capable":[167],"distinguishing":[169],"PE":[170],"samples":[171],"AUC":[174],"0.789.":[176],"Single\u2011cell":[177],"transcriptomic":[178],"validated":[180],"heterogeneous":[182],"expression":[183],"these":[185],"biomarkers":[186,234],"across":[187],"placental":[188,209],"cell":[189],"types":[190],"altered":[193],"intercellular":[194],"communication":[195],"networks":[196],"PE.":[198],"Collectively,":[199],"this":[200],"multi\u2011scale":[201],"computational":[202],"elucidates":[204],"how":[205],"may":[207],"disrupt":[208],"function":[210],"synergistic":[212],"modulation":[213],"inflammatory,":[215],"metabolic,":[217],"vascular":[219],"regulatory":[220],"pathways,":[221],"providing":[222],"novel":[223],"insights":[224],"into":[225],"environmental":[227],"etiology":[228],"highlighting":[232],"risk":[236],"stratification.":[237]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-10T00:00:00"}