{"id":"https://openalex.org/W7221157701","doi":"https://doi.org/10.3389/fmicb.2026.1965937","title":"Berberine-fluconazole synergy against drug-resistant Candida albicans: association with disruption of the Ire1-mediated UPR pathway","display_name":"Berberine-fluconazole synergy against drug-resistant Candida albicans: association with disruption of the Ire1-mediated UPR pathway","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221157701","doi":"https://doi.org/10.3389/fmicb.2026.1965937","pmid":"https://pubmed.ncbi.nlm.nih.gov/42920692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13690794"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1965937","doi":"https://doi.org/10.3389/fmicb.2026.1965937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1965937","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1965937/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1965937/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158227367","display_name":"Daifan Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daifan Yue","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130810899","display_name":"Dongming Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongming Zheng","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709131","display_name":"Zhen Song","orcid":"https://orcid.org/0000-0003-2322-9484","observed_orcids":["https://orcid.org/0000-0003-2322-9484"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Song","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138946686","display_name":"Dongmei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongmei Li","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158222855","display_name":"Yan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7777723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1965937","last_page":"1965937"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9950000047683716},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antifungal-synergy","display_name":"antifungal synergy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.7599999904632568},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9300000071525574},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ire1","display_name":"IRE1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atg1","display_name":"Atg1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/invasive-candidiasis","display_name":"invasive candidiasis","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8072999715805054},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7627999782562256},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7257000207901001},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.54830002784729},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.5480999946594238},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.534500002861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5289999842643738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4708000123500824},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.46790000796318054},{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.45179998874664307},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.435699999332428},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.4205999970436096},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.415800005197525},{"id":"https://openalex.org/C2910135453","wikidata":"https://www.wikidata.org/wiki/Q3122802","display_name":"Fungal protein","level":4,"score":0.40130001306533813},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3880999982357025},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.36820000410079956},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.35089999437332153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3199999928474426},{"id":"https://openalex.org/C2781331208","wikidata":"https://www.wikidata.org/wiki/Q18032378","display_name":"XBP1","level":5,"score":0.3059000074863434},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.2962000072002411},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C2775839086","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Pathogenic fungus","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fmicb.2026.1965937","doi":"https://doi.org/10.3389/fmicb.2026.1965937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1965937","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1965937/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-9995839/v1","doi":"https://doi.org/10.21203/rs.3.rs-9995839/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9995839/v1","pdf_url":"https://www.researchsquare.com/article/rs-9995839/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13690794","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13690794/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13690794/pdf/fmicb-17-1965937.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:42920692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42920692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ba062f0a42b54b19bfcea2f5c9566bcc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ba062f0a42b54b19bfcea2f5c9566bcc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1965937","doi":"https://doi.org/10.3389/fmicb.2026.1965937","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1965937","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1965937/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3606181777","display_name":null,"funder_award_id":"2024MS553","funder_id":"https://openalex.org/F4320329536","funder_display_name":"Sichuan Provincial Administration of Traditional Chinese Medicine"}],"funders":[{"id":"https://openalex.org/F4320329536","display_name":"Sichuan Provincial Administration of Traditional Chinese Medicine","ror":"https://ror.org/03x55t826"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221157701.pdf","grobid_xml":"https://content.openalex.org/works/W7221157701.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1970375581","https://openalex.org/W1980942517","https://openalex.org/W2004367369","https://openalex.org/W2009741382","https://openalex.org/W2010250072","https://openalex.org/W2016562927","https://openalex.org/W2019263782","https://openalex.org/W2046100250","https://openalex.org/W2117875646","https://openalex.org/W2137755719","https://openalex.org/W2315324126","https://openalex.org/W2568995659","https://openalex.org/W2578499796","https://openalex.org/W2724837845","https://openalex.org/W2727065253","https://openalex.org/W2903881543","https://openalex.org/W2960568844","https://openalex.org/W2999058235","https://openalex.org/W3000246374","https://openalex.org/W3010212863","https://openalex.org/W3018410811","https://openalex.org/W3022527720","https://openalex.org/W3030834164","https://openalex.org/W3036802965","https://openalex.org/W3091863200","https://openalex.org/W3094517998","https://openalex.org/W3097770690","https://openalex.org/W3116201711","https://openalex.org/W3119669174","https://openalex.org/W3123450858","https://openalex.org/W3138647824","https://openalex.org/W3168509787","https://openalex.org/W3210694891","https://openalex.org/W4224216792","https://openalex.org/W4281957633","https://openalex.org/W4296327439","https://openalex.org/W4307897939","https://openalex.org/W4313892981","https://openalex.org/W4319166170","https://openalex.org/W4322494067","https://openalex.org/W4362682776","https://openalex.org/W4376121347","https://openalex.org/W4387373415","https://openalex.org/W4390919957","https://openalex.org/W4392004363","https://openalex.org/W4400074216","https://openalex.org/W4400582752","https://openalex.org/W4401479886","https://openalex.org/W4402552053","https://openalex.org/W4403837331","https://openalex.org/W4404058074","https://openalex.org/W4408238613","https://openalex.org/W4408395759","https://openalex.org/W4408669792","https://openalex.org/W4412631925","https://openalex.org/W4413037999","https://openalex.org/W4413939458"],"related_works":["https://openalex.org/W7165111986","https://openalex.org/W4399440382","https://openalex.org/W7100347674","https://openalex.org/W3040607836","https://openalex.org/W2770964395","https://openalex.org/W305477801","https://openalex.org/W1980106726","https://openalex.org/W7140992498","https://openalex.org/W2144444421","https://openalex.org/W2169108066"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Candida":[2],"albicans":[3,43,214,230],"-mediated":[4],"invasive":[5],"candidiasis":[6],"has":[7],"high":[8],"mortality.":[9],"Novel":[10],"strategies":[11],"against":[12,40,227],"azole":[13],"resistance":[14],"and":[15,30,45,63,82,110,118,149,154,167,186,198,212,224],"biofilm-associated":[16],"infections":[17],"are":[18],"clinically":[19],"urgently":[20],"needed.":[21],"This":[22,232],"study":[23],"aimed":[24],"to":[25,46,90,129,244],"explore":[26],"the":[27,48,133,155,176,239],"synergistic":[28,54,165],"antifungal":[29],"antibiofilm":[31,225],"effects":[32,226],"of":[33,120,132,151,175],"berberine":[34],"(BBH)":[35],"combined":[36,160],"with":[37,161],"fluconazole":[38],"(FCZ)":[39],"drug-resistant":[41,228],"C.":[42,213,229],",":[44],"elucidate":[47],"underlying":[49],"molecular":[50],"mechanisms.":[51],"Methods":[52],"The":[53,218],"effect":[55],"was":[56,69,76,88,99,138],"assessed":[57],"using":[58],"fractional":[59],"inhibitory":[60],"concentration":[61],"index":[62],"time-kill":[64],"curve":[65],"assays.":[66],"BBH":[67,159],"cytotoxicity":[68],"evaluated":[70,100],"via":[71],"CCK-8":[72],"assay.":[73],"Biofilm":[74],"formation":[75],"observed":[77],"through":[78],"crystal":[79],"violet":[80],"staining":[81],"Spider":[83],"plate":[84],"culture.":[85],"Transcriptome":[86],"sequencing":[87],"performed":[89],"screen":[91],"potential":[92],"drug":[93],"targets.":[94],"Endoplasmic":[95],"reticulum":[96],"(ER)":[97],"homeostasis":[98],"by":[101,140,192],"assessing":[102],"stress":[103,241],"sensitivity,":[104],"observing":[105],"ultrastructure,":[106],"quantifying":[107],"misfolded":[108,195],"proteins,":[109],"measuring":[111],"secreted":[112,200],"protease":[113,201],"activity.":[114,202],"HAC1":[115],"splicing":[116],"analysis":[117],"detection":[119,150],"unfolded":[121],"protein":[122,196],"response":[123],"(UPR)-related":[124],"gene":[125],"expression":[126],"were":[127],"applied":[128],"verify":[130],"perturbation":[131],"UPR":[134,179,184],"pathway.":[135,180],"Autophagy":[136],"activation":[137,185],"determined":[139],"transmission":[141],"electron":[142],"microscopy,":[143],"vacuole":[144],"staining,":[145],"autophagy":[146],"inhibitor":[147],"intervention,":[148],"autophagy-related":[152],"genes":[153],"Atg1":[156],"protein.":[157],"Results":[158],"FCZ":[162],"exerted":[163],"significant":[164],"activity":[166],"biofilm":[168],"inhibition.":[169],"Such":[170],"synergism":[171,223],"depended":[172],"on":[173],"dysfunction":[174],"ER":[177,188,193,240],"stress-regulating":[178],"Combined":[181],"treatment":[182],"inhibited":[183],"disrupted":[187],"homeostasis,":[189],"as":[190],"manifested":[191],"dilation,":[194],"accumulation":[197],"reduced":[199],"High-dose":[203],"combination":[204,220],"induced":[205],"excessive":[206],"autophagy,":[207],"thereby":[208],"triggering":[209],"vacuolar":[210],"rupture":[211],"cell":[215],"death.":[216],"Conclusion":[217],"BBH-FCZ":[219],"produced":[221],"prominent":[222],".":[231],"work":[233],"provided":[234],"new":[235],"insights":[236],"into":[237],"targeting":[238],"regulatory":[242],"pathway":[243],"manage":[245],"azole-resistant":[246],"fungal":[247],"infections.":[248]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-10T00:00:00"}
