{"id":"https://openalex.org/W7221130171","doi":"https://doi.org/10.26434/chemrxiv.15010149/v1","title":"Structure-Activity Relationship Studies of the Complement Regulator-Recruiting Peptide 5C6","display_name":"Structure-Activity Relationship Studies of the Complement Regulator-Recruiting Peptide 5C6","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221130171","doi":"https://doi.org/10.26434/chemrxiv.15010149/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15010149/v1","doi":"https://doi.org/10.26434/chemrxiv.15010149/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15010149/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.26434/chemrxiv.15010149/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029290157","display_name":"Cl\u00e9ment Bechtler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Cl\u00e9ment Bechtler","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092696625","display_name":"Jannes Felsch","orcid":"https://orcid.org/0009-0009-7106-1939","observed_orcids":["https://orcid.org/0009-0009-7106-1939"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jannes Felsch","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024012071","display_name":"Ekaterina S. Umnyakova","orcid":"https://orcid.org/0000-0002-0311-3305","observed_orcids":["https://orcid.org/0000-0002-0311-3305"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ekaterina Umnyakova","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102774964","display_name":"Lukas Kaufmann","orcid":"https://orcid.org/0000-0001-8218-7486","observed_orcids":["https://orcid.org/0000-0001-8218-7486"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Kaufmann","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053162481","display_name":"Christina Lamers","orcid":"https://orcid.org/0000-0003-0962-8171","observed_orcids":["https://orcid.org/0000-0003-0962-8171"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Christina Lamers","raw_affiliation_strings":["Department of Pharmaceutical Sciences","Institute for Drug Discovery, Faculty of Medicine","Leipzig University","University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"Institute for Drug Discovery, Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Leipzig University","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074301183","display_name":"John D. Lambris","orcid":"https://orcid.org/0000-0002-9370-5776","observed_orcids":["https://orcid.org/0000-0002-9370-5776"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Lambris","raw_affiliation_strings":["Perelman School of Medicine","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056886927","display_name":"Daniel Ricklin","orcid":"https://orcid.org/0000-0001-6140-0233","observed_orcids":["https://orcid.org/0000-0001-6140-0233"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Ricklin","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Basel"],"raw_orcid":"https://orcid.org/0000-0001-6140-0233","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-factor-h","display_name":"complement factor H","score":0.7580000162124634},{"id":"https://openalex.org/keywords/complement-regulation","display_name":"complement regulation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8669999837875366},{"id":"https://openalex.org/keywords/macrocyclic-peptides","display_name":"macrocyclic peptides","score":0.7940000295639038},{"id":"https://openalex.org/keywords/biomaterial-coatings","display_name":"biomaterial coatings","score":0.6420000195503235},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.5770000219345093},{"id":"https://openalex.org/keywords/peptide-analogs","display_name":"peptide analogues","score":0.5189999938011169},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.7660999894142151},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6606000065803528},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6287999749183655},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5967000126838684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5766000151634216},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.5242999792098999},{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.5041000247001648},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43389999866485596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4262000024318695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41130000352859497},{"id":"https://openalex.org/C138873322","wikidata":"https://www.wikidata.org/wiki/Q83130456","display_name":"Complement control protein","level":5,"score":0.37720000743865967},{"id":"https://openalex.org/C3017707949","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Negative regulator","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.3009999990463257},{"id":"https://openalex.org/C179369057","wikidata":"https://www.wikidata.org/wiki/Q20970075","display_name":"Complement factor I","level":4,"score":0.28529998660087585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27649998664855957},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2648000121116638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15010149/v1","doi":"https://doi.org/10.26434/chemrxiv.15010149/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15010149/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15010149/v1","doi":"https://doi.org/10.26434/chemrxiv.15010149/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15010149/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4307742628","https://openalex.org/W7065310365","https://openalex.org/W1784299432","https://openalex.org/W7097853674","https://openalex.org/W4413236576","https://openalex.org/W2044318362","https://openalex.org/W2001730579","https://openalex.org/W4414019589","https://openalex.org/W7211953225","https://openalex.org/W2063558507"],"abstract_inverted_index":{"Active":[0],"recruitment":[1],"of":[2,74,82,97,147],"host":[3],"complement":[4,36,49],"regulators":[5],"to":[6,14,19,43,92,107,114],"biomedical":[7],"surfaces":[8,47],"emerges":[9],"as":[10],"a":[11,80,116,141],"therapeutic":[12],"strategy":[13],"prevent":[15],"adverse":[16],"immuno-inflammatory":[17],"reactions":[18],"biomaterials":[20],"and":[21,32,110,125],"organ":[22],"transplants.":[23],"Coating":[24],"with":[25,88,120],"the":[26,34,58,72,144],"macrocyclic":[27],"peptide":[28],"5C6,":[29],"which":[30],"binds":[31],"recruits":[33],"central":[35],"regulator":[37],"factor":[38],"H":[39],"(FH),":[40],"was":[41],"shown":[42],"protect":[44],"clinically":[45],"relevant":[46],"from":[48],"attack.":[50],"While":[51],"we":[52,78],"previously":[53],"identified":[54,100],"general":[55],"determinants":[56],"for":[57,143],"5C6-FH":[59],"interaction,":[60],"more":[61],"granular":[62],"structure-activity":[63],"relationship":[64],"(SAR)":[65],"studies":[66,91],"have":[67],"hitherto":[68],"been":[69],"missing.":[70],"In":[71],"absence":[73],"published":[75],"target":[76,122],"structures,":[77],"employed":[79],"panel":[81],"focused":[83],"amino":[84],"acid":[85],"substitutions":[86],"combined":[87,111],"biomolecular":[89],"interaction":[90],"achieve":[93],"an":[94],"SAR":[95],"profile":[96],"5C6.":[98],"We":[99],"three":[101],"positions":[102],"that":[103,131],"are":[104],"particularly":[105],"amenable":[106],"affinity":[108],"optimization":[109],"several":[112],"changes":[113],"produce":[115],"next-generation":[117],"5C6":[118],"analog":[119],"enhanced":[121],"residence":[123],"time":[124],"serum":[126],"stability.":[127],"Biomaterial-related":[128],"assays":[129],"suggest":[130],"such":[132],"analogs":[133],"may":[134],"confer":[135],"benefits":[136],"under":[137],"stress":[138],"conditions,":[139],"providing":[140],"path":[142],"further":[145],"development":[146],"5C6-based":[148],"coatings.":[149]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-10T00:00:00"}