{"id":"https://openalex.org/W7221121237","doi":"https://doi.org/10.5649/jjphcs.52.679","title":"Risk Factors for Peripheral Intravenous Infusion\u2013Related Local Adverse Events Associated With Fosaprepitant: A Retrospective Study","display_name":"Risk Factors for Peripheral Intravenous Infusion\u2013Related Local Adverse Events Associated With Fosaprepitant: A Retrospective Study","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221121237","doi":"https://doi.org/10.5649/jjphcs.52.679"},"language":"en","primary_location":{"id":"doi:10.5649/jjphcs.52.679","doi":"https://doi.org/10.5649/jjphcs.52.679","is_oa":true,"landing_page_url":"https://doi.org/10.5649/jjphcs.52.679","pdf_url":"https://www.jstage.jst.go.jp/article/jjphcs/52/10/52_679/_pdf","source":{"id":"https://openalex.org/S2764699316","display_name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","issn_l":"1346-342X","issn":["1346-342X","1882-1499"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327904648","host_organization_name":"Japanese Society of Pharmaceutical Health Care and Sciences","host_organization_lineage":["https://openalex.org/P4327904648"],"host_organization_lineage_names":["Japanese Society of Pharmaceutical Health Care and Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7221121237"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jjphcs/52/10/52_679/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023594502","display_name":"Kayo Motomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109301","display_name":"Yodogawa Christian Hospital","ror":"https://ror.org/01ybxrm80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109301"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayo Motomura","raw_affiliation_strings":["Department of Pharmacy, Yodogawa Christian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Yodogawa Christian Hospital","institution_ids":["https://openalex.org/I4210109301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021931393","display_name":"Keisuke Kongo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109301","display_name":"Yodogawa Christian Hospital","ror":"https://ror.org/01ybxrm80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109301"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Kongo","raw_affiliation_strings":["Department of Pharmacy, Yodogawa Christian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Yodogawa Christian Hospital","institution_ids":["https://openalex.org/I4210109301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073073859","display_name":"Katsuya Makihara","orcid":"https://orcid.org/0000-0003-4153-8555","observed_orcids":["https://orcid.org/0000-0003-4153-8555"]},"institutions":[{"id":"https://openalex.org/I4210109301","display_name":"Yodogawa Christian Hospital","ror":"https://ror.org/01ybxrm80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109301"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya Makihara","raw_affiliation_strings":["Department of Pharmacy, Yodogawa Christian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Yodogawa Christian Hospital","institution_ids":["https://openalex.org/I4210109301"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054181443","display_name":"Tomokazu Matsumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109301","display_name":"Yodogawa Christian Hospital","ror":"https://ror.org/01ybxrm80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109301"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokazu Matsumura","raw_affiliation_strings":["Department of Pharmacy, Yodogawa Christian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Yodogawa Christian Hospital","institution_ids":["https://openalex.org/I4210109301"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210109301"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"10","first_page":"679","last_page":"686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.5849999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.5849999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.1517000049352646,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fosaprepitant","display_name":"fosaprepitant","score":1.0},{"id":"https://openalex.org/keywords/nk1-receptor-antagonists","display_name":"NK1 receptor antagonists","score":0.8880000114440918},{"id":"https://openalex.org/keywords/peripheral-intravenous-infusion","display_name":"peripheral intravenous infusion","score":0.8930000066757202},{"id":"https://openalex.org/keywords/local-adverse-events","display_name":"local adverse events","score":0.8999999761581421},{"id":"https://openalex.org/keywords/phlebitis","display_name":"phlebitis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/vascular-pain","display_name":"vascular pain","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea-and-vomiting","display_name":"chemotherapy-induced nausea and vomiting","score":0.8489999771118164},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7139999866485596},{"id":"https://openalex.org/keywords/number-of-chemotherapy-cycles","display_name":"chemotherapy cycles","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8235999941825867},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.699400007724762},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6258999705314636},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.3725999891757965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3666999936103821},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3296999931335449},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3215999901294708},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.31850001215934753},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5649/jjphcs.52.679","doi":"https://doi.org/10.5649/jjphcs.52.679","is_oa":true,"landing_page_url":"https://doi.org/10.5649/jjphcs.52.679","pdf_url":"https://www.jstage.jst.go.jp/article/jjphcs/52/10/52_679/_pdf","source":{"id":"https://openalex.org/S2764699316","display_name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","issn_l":"1346-342X","issn":["1346-342X","1882-1499"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327904648","host_organization_name":"Japanese Society of Pharmaceutical Health Care and Sciences","host_organization_lineage":["https://openalex.org/P4327904648"],"host_organization_lineage_names":["Japanese Society of Pharmaceutical Health Care and Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5649/jjphcs.52.679","doi":"https://doi.org/10.5649/jjphcs.52.679","is_oa":true,"landing_page_url":"https://doi.org/10.5649/jjphcs.52.679","pdf_url":"https://www.jstage.jst.go.jp/article/jjphcs/52/10/52_679/_pdf","source":{"id":"https://openalex.org/S2764699316","display_name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","issn_l":"1346-342X","issn":["1346-342X","1882-1499"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327904648","host_organization_name":"Japanese Society of Pharmaceutical Health Care and Sciences","host_organization_lineage":["https://openalex.org/P4327904648"],"host_organization_lineage_names":["Japanese Society of Pharmaceutical Health Care and Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221121237.pdf","grobid_xml":"https://content.openalex.org/works/W7221121237.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1528154222","https://openalex.org/W2048838970","https://openalex.org/W2097027935","https://openalex.org/W2121960517","https://openalex.org/W2165395427","https://openalex.org/W2798041563","https://openalex.org/W2890337393","https://openalex.org/W2940679990","https://openalex.org/W3103447250","https://openalex.org/W4390776701"],"related_works":["https://openalex.org/W2897648375","https://openalex.org/W3012529425","https://openalex.org/W2964193378","https://openalex.org/W2061903802","https://openalex.org/W2097027935","https://openalex.org/W2005073977","https://openalex.org/W2767291627","https://openalex.org/W2462891655","https://openalex.org/W4405948670","https://openalex.org/W2937587772"],"abstract_inverted_index":{"Objective:":[0],"Fosaprepitant,":[1],"an":[2],"intravenous":[3],"neurokinin-1":[4],"(NK1)":[5],"receptor":[6],"antagonist":[7],"used":[8],"to":[9,17],"prevent":[10],"chemotherapy-induced":[11],"nausea":[12],"and":[13,29,34,52],"vomiting,":[14],"is":[15],"known":[16],"cause":[18],"local":[19,53],"adverse":[20,54],"events":[21,55],"at":[22],"peripheral":[23],"infusion":[24],"sites,":[25],"including":[26],"vascular":[27],"pain":[28],"phlebitis.":[30],"Although":[31],"female":[32],"sex":[33],"the":[35,46],"number":[36],"of":[37],"chemotherapy":[38],"cycles":[39],"have":[40],"been":[41,58],"reported":[42],"as":[43],"risk":[44],"factors,":[45],"association":[47],"between":[48],"concomitant":[49],"antineoplastic":[50],"agents":[51],"has":[56],"not":[57],"comprehensively":[59],"investigated.":[60]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-10T00:00:00"}
