{"id":"https://openalex.org/W7221111652","doi":"https://doi.org/10.1039/d6pm00190d","title":"Potential to modulate corneal epithelial repair via nitric oxide-releasing glycosaminoglycans","display_name":"Potential to modulate corneal epithelial repair via nitric oxide-releasing glycosaminoglycans","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7221111652","doi":"https://doi.org/10.1039/d6pm00190d","pmid":"https://pubmed.ncbi.nlm.nih.gov/42899131","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678718"},"language":"en","primary_location":{"id":"doi:10.1039/d6pm00190d","doi":"https://doi.org/10.1039/d6pm00190d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6pm00190d","pdf_url":"https://pubs.rsc.org/pm/article-pdf/doi/10.1039/D6PM00190D/14863971/d6pm00190d.pdf","source":{"id":"https://openalex.org/S4387292600","display_name":"RSC Pharmaceutics","issn_l":"2976-8713","issn":["2976-8713"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.rsc.org/pm/article-pdf/doi/10.1039/D6PM00190D/14863971/d6pm00190d.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098992284","display_name":"Margery E. Purvis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margery E. Purvis","raw_affiliation_strings":["Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111294809","display_name":"Madelyn P. Bucci","orcid":"https://orcid.org/0000-0002-7423-2029","observed_orcids":["https://orcid.org/0000-0002-7423-2029"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madelyn P. Bucci","raw_affiliation_strings":["Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA","Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119688555","display_name":"Tsian D. Ramrattan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsian D. Ramrattan","raw_affiliation_strings":["Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032493640","display_name":"Shannon Margaret Wallet","orcid":"https://orcid.org/0000-0003-4650-651X","observed_orcids":["https://orcid.org/0000-0003-4650-651X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon M. Wallet","raw_affiliation_strings":["Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA","Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028486659","display_name":"Mark H. Schoenfisch","orcid":"https://orcid.org/0000-0002-2212-0658","observed_orcids":["https://orcid.org/0000-0002-2212-0658"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark H. Schoenfisch","raw_affiliation_strings":["Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"],"raw_orcid":"https://orcid.org/0000-0002-2212-0658","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028486659"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72695344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.11879999935626984,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-epithelial-wound-healing","display_name":"corneal epithelial wound healing","score":0.777999997138977},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7379999756813049},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8389999866485596},{"id":"https://openalex.org/keywords/carboxymethyl-cellulose","display_name":"carboxymethyl cellulose","score":0.859000027179718},{"id":"https://openalex.org/keywords/epithelial-cell-migration","display_name":"epithelial cell migration","score":0.8830000162124634},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bioactive-wound-dressings","display_name":"bioactive wound dressings","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.864799976348877},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8309999704360962},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6654999852180481},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5371999740600586},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3472999930381775},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6pm00190d","doi":"https://doi.org/10.1039/d6pm00190d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6pm00190d","pdf_url":"https://pubs.rsc.org/pm/article-pdf/doi/10.1039/D6PM00190D/14863971/d6pm00190d.pdf","source":{"id":"https://openalex.org/S4387292600","display_name":"RSC Pharmaceutics","issn_l":"2976-8713","issn":["2976-8713"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:42899131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42899131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678718","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678718/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Pharm","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1039/d6pm00190d","doi":"https://doi.org/10.1039/d6pm00190d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6pm00190d","pdf_url":"https://pubs.rsc.org/pm/article-pdf/doi/10.1039/D6PM00190D/14863971/d6pm00190d.pdf","source":{"id":"https://openalex.org/S4387292600","display_name":"RSC Pharmaceutics","issn_l":"2976-8713","issn":["2976-8713"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000896850","display_name":"Nitric oxide-releasing glycosaminoglycans for treating complex wounds","funder_award_id":"R01DK132778","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221111652.pdf","grobid_xml":"https://content.openalex.org/works/W7221111652.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2744657202","https://openalex.org/W7108076208","https://openalex.org/W2340139225","https://openalex.org/W2083256342","https://openalex.org/W3160426122","https://openalex.org/W4393970933","https://openalex.org/W1124425351","https://openalex.org/W1821983418","https://openalex.org/W3185171619","https://openalex.org/W4312080563"],"abstract_inverted_index":{"barrier":[0],"restoration.":[1,68],"A":[2,41],"derivative":[3,29,49],"consisting":[4],"of":[5,37,79],"CS":[6],"with":[7,16,59,84,89],"prolonged":[8],"NO":[9],"release":[10],"and":[11,63],"low":[12,94],"molecular":[13,95],"weight":[14,96],"HA":[15,28,48,66,97],"intermediate":[17],"NO-release":[18],"kinetics":[19],"were":[20],"identified":[21],"as":[22,71],"the":[23,38,47,61],"most":[24],"promising":[25,105],"materials.":[26],"The":[27],"enhanced":[30,67],"epithelial":[31],"migration":[32,39],"even":[33],"during":[34],"later":[35],"timepoints":[36],"assays.":[40],"carboxymethylcellulose":[42],"(CMC)":[43],"gel":[44,101],"formulation":[45,102],"containing":[46],"further":[50],"promoted":[51],"cell":[52],"migration.":[53],"In":[54],"corneal":[55,110],"tissue":[56,80],"models,":[57],"treatment":[58],"both":[60],"free":[62],"CMC-formulated":[64],"NO-releasing":[65],"Barrier":[69],"recovery,":[70],"measured":[72],"by":[73],"transepithelial":[74],"electrical":[75],"resistance,":[76],"confirmed":[77],"restoration":[78],"integrity":[81],"post-wounding,":[82],"concomitant":[83],"a":[85,99,104],"cytokine":[86],"milieu":[87],"associated":[88],"pro-wound":[90],"healing.":[91],"Overall,":[92],"NO-releasing,":[93],"in":[98],"CMC":[100],"represents":[103],"bioactive":[106],"strategy":[107],"for":[108],"promoting":[109],"wound":[111],"repair.":[112]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-10T00:00:00"}
