{"id":"https://openalex.org/W7221104977","doi":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","title":"Early Characterization of Hypoxic-Ischemic Encephalopathy: Contribution of Biochemical, Imaging, and Electrophysiological Markers to Patient Profiling in the Ancillary Cohort LyTONEPAL","display_name":"Early Characterization of Hypoxic-Ischemic Encephalopathy: Contribution of Biochemical, Imaging, and Electrophysiological Markers to Patient Profiling in the Ancillary Cohort LyTONEPAL","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221104977","doi":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/42962306"},"language":"en","primary_location":{"id":"doi:10.1016/j.pediatrneurol.2026.10.001","doi":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","pdf_url":"https://www.pedneur.com/article/S0887-8994(26)00318-8/pdf","source":{"id":"https://openalex.org/S165686931","display_name":"Pediatric Neurology","issn_l":"0887-8994","issn":["0887-8994","1873-5150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pedneur.com/article/S0887-8994(26)00318-8/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138037790","display_name":"Alexandra Givernaud","orcid":"https://orcid.org/0009-0009-7482-0283","observed_orcids":["https://orcid.org/0009-0009-7482-0283"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alexandra Givernaud","raw_affiliation_strings":["Department of Neonatology and Pediatric Intensive Care, Reims University Hospital, Reims, France. Electronic address: agivernaud@chu-reims.fr"],"raw_orcid":"https://orcid.org/0009-0009-7482-0283","affiliations":[{"raw_affiliation_string":"Department of Neonatology and Pediatric Intensive Care, Reims University Hospital, Reims, France. Electronic address: agivernaud@chu-reims.fr","institution_ids":["https://openalex.org/I4210105796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027384562","display_name":"Margaux Alloux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Margaux Alloux","raw_affiliation_strings":["Department of Research and Public Health, Reims University Hospital, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Public Health, Reims University Hospital, Reims, France","institution_ids":["https://openalex.org/I4210105796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002131847","display_name":"Jonathan Beck","orcid":"https://orcid.org/0000-0001-9456-2984","observed_orcids":["https://orcid.org/0000-0001-9456-2984"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jonathan Beck","raw_affiliation_strings":["Department of Neonatology and Pediatric Intensive Care, Reims University Hospital, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology and Pediatric Intensive Care, Reims University Hospital, Reims, France","institution_ids":["https://openalex.org/I4210105796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014415460","display_name":"Philippe Vo Van","orcid":"https://orcid.org/0000-0003-0654-2874","observed_orcids":["https://orcid.org/0000-0003-0654-2874"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Vo Van","raw_affiliation_strings":["Department of Neonatology, Lyon University Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Lyon University Hospital, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053614610","display_name":"Nathalie Bednarek","orcid":"https://orcid.org/0000-0002-1908-4617","observed_orcids":["https://orcid.org/0000-0002-1908-4617"]},"institutions":[{"id":"https://openalex.org/I4210100943","display_name":"Centre de Recherche en Sciences et Technologies de l'Information et de la Communication","ror":"https://ror.org/016wdna72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210100943","https://openalex.org/I4210141980","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Bednarek","raw_affiliation_strings":["University of Reims Champagne-Ardenne, CReSTIC EA 3804, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Reims Champagne-Ardenne, CReSTIC EA 3804, Reims, France","institution_ids":["https://openalex.org/I4210100943","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022132629","display_name":"Thierry Debillon","orcid":"https://orcid.org/0000-0001-9947-270X","observed_orcids":["https://orcid.org/0000-0001-9947-270X"]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]},{"id":"https://openalex.org/I4210136308","display_name":"Translational Innovation in Medicine and Complexity","ror":"https://ror.org/03985kf35","country_code":"FR","type":"facility","lineage":["https://openalex.org/I106785703","https://openalex.org/I1294671590","https://openalex.org/I4210095849","https://openalex.org/I4210104684","https://openalex.org/I4210136308","https://openalex.org/I4210159245","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Debillon","raw_affiliation_strings":["TIMC-IMAG Research Department, University Grenoble Alpes, Grenoble, France; Department of Neonatal Intensive Care, Grenoble Alpes University Hospital, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMC-IMAG Research Department, University Grenoble Alpes, Grenoble, France; Department of Neonatal Intensive Care, Grenoble Alpes University Hospital, Grenoble, France","institution_ids":["https://openalex.org/I2800555055","https://openalex.org/I4210136308","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001327791","display_name":"Lukshe Kanagaratnam","orcid":"https://orcid.org/0000-0003-3685-8407","observed_orcids":["https://orcid.org/0000-0003-3685-8407"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]},{"id":"https://openalex.org/I4405253620","display_name":"Vieillissement, Fragilit\u00e9","ror":"https://ror.org/00wppxb27","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253620","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lukshe Kanagaratnam","raw_affiliation_strings":["Department of Research and Public Health, University of Reims Champagne-Ardenne, UR 3797 VieFra, Reims University Hospital, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Public Health, University of Reims Champagne-Ardenne, UR 3797 VieFra, Reims University Hospital, Reims, France","institution_ids":["https://openalex.org/I4210105796","https://openalex.org/I4405253620","https://openalex.org/I96226040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045799159","display_name":"Gauthier Loron","orcid":"https://orcid.org/0000-0001-9536-9510","observed_orcids":["https://orcid.org/0000-0001-9536-9510"]},"institutions":[{"id":"https://openalex.org/I4210100943","display_name":"Centre de Recherche en Sciences et Technologies de l'Information et de la Communication","ror":"https://ror.org/016wdna72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210100943","https://openalex.org/I4210141980","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gauthier Loron","raw_affiliation_strings":["Department of Neonatology and Pediatric Intensive Care, Reims University Hospital, Reims, France; CReSTIC EA 3804, University of Reims Champagne-Ardenne, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology and Pediatric Intensive Care, Reims University Hospital, Reims, France; CReSTIC EA 3804, University of Reims Champagne-Ardenne, Reims, France","institution_ids":["https://openalex.org/I4210100943","https://openalex.org/I4210105796","https://openalex.org/I96226040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5138037790"],"corresponding_institution_ids":["https://openalex.org/I4210105796"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":{"value":3520,"currency":"USD","value_usd":3520},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7934619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":null,"first_page":"8","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxic-ischemic-encephalopathy","display_name":"hypoxic-ischemic encephalopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/neonatal-brain-injury","display_name":"neonatal brain injury","score":0.8799999952316284},{"id":"https://openalex.org/keywords/patient-characterization","display_name":"patient characterization","score":0.6909999847412109},{"id":"https://openalex.org/keywords/biochemical-markers","display_name":"biochemical markers","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.902999997138977},{"id":"https://openalex.org/keywords/electrophysiological-markers","display_name":"electrophysiological markers","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neonatal-hypoxia","display_name":"neonatal hypoxia","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7109000086784363},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.640999972820282},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.6014000177383423},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5024999976158142},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36719998717308044},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3440999984741211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34130001068115234},{"id":"https://openalex.org/C523008124","wikidata":"https://www.wikidata.org/wiki/Q5357996","display_name":"Electrodiagnosis","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2535000145435333},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25110000371932983},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25099998712539673}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.pediatrneurol.2026.10.001","doi":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","pdf_url":"https://www.pedneur.com/article/S0887-8994(26)00318-8/pdf","source":{"id":"https://openalex.org/S165686931","display_name":"Pediatric Neurology","issn_l":"0887-8994","issn":["0887-8994","1873-5150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Neurology","raw_type":"journal-article"},{"id":"pmid:42962306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42962306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric neurology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05804114v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05804114","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric Neurology, 2026, 186, pp.8-15. &#x27E8;10.1016/j.pediatrneurol.2026.10.001&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.pediatrneurol.2026.10.001","doi":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pediatrneurol.2026.10.001","pdf_url":"https://www.pedneur.com/article/S0887-8994(26)00318-8/pdf","source":{"id":"https://openalex.org/S165686931","display_name":"Pediatric Neurology","issn_l":"0887-8994","issn":["0887-8994","1873-5150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9001168373","display_name":null,"funder_award_id":"PHRC-N-13-0327","funder_id":"https://openalex.org/F4320323561","funder_display_name":"Minist\u00e8re du Travail, de l\u2019Emploi, de la Formation Professionnelle et du Dialogue Social"}],"funders":[{"id":"https://openalex.org/F4320323561","display_name":"Minist\u00e8re du Travail, de l\u2019Emploi, de la Formation Professionnelle et du Dialogue Social","ror":"https://ror.org/00dfd1509"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221104977.pdf","grobid_xml":"https://content.openalex.org/works/W7221104977.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1454706746","https://openalex.org/W1986557899","https://openalex.org/W1988501897","https://openalex.org/W1992659712","https://openalex.org/W2002465455","https://openalex.org/W2012473334","https://openalex.org/W2016619395","https://openalex.org/W2017439846","https://openalex.org/W2025213175","https://openalex.org/W2028890224","https://openalex.org/W2158252821","https://openalex.org/W2284616577","https://openalex.org/W2471596101","https://openalex.org/W2546163324","https://openalex.org/W2755598992","https://openalex.org/W2887186833","https://openalex.org/W2890203734","https://openalex.org/W2891398221","https://openalex.org/W2937913111","https://openalex.org/W2961720002","https://openalex.org/W3008788541","https://openalex.org/W3133906224","https://openalex.org/W3185376736","https://openalex.org/W4210424482","https://openalex.org/W4220657261","https://openalex.org/W4221088002","https://openalex.org/W4224096535","https://openalex.org/W4224211875","https://openalex.org/W4283075012","https://openalex.org/W4321483500","https://openalex.org/W4353084899","https://openalex.org/W4382197639","https://openalex.org/W4387001876","https://openalex.org/W4387003916","https://openalex.org/W4399084172","https://openalex.org/W4404120886","https://openalex.org/W4405105954"],"related_works":["https://openalex.org/W3121079446","https://openalex.org/W7149449575","https://openalex.org/W3032540961","https://openalex.org/W2595054643","https://openalex.org/W7171848104","https://openalex.org/W2182239397","https://openalex.org/W3163228202","https://openalex.org/W4410299163","https://openalex.org/W3040409069","https://openalex.org/W2374724503"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"identify":[2],"and":[3,18,56,66,81,137,156,179,190,208,220,231],"characterize":[4],"different":[5],"profiles":[6],"of":[7,31,38,78,88,95,101,202,205,224,228],"newborns":[8,47],"with":[9,41,48,170,214],"hypoxic-ischemic":[10],"encephalopathy":[11],"(HIE)":[12],"according":[13],"to":[14,50,69,110,116,235],"clinical,":[15,63],"biochemical,":[16,64,80,206],"electrophysiological,":[17,65,79,207],"brain":[19,131,181,209],"imaging":[20,67,82,210],"data.":[21],"METHODS:":[22],"An":[23],"analysis":[24,55],"was":[25,165],"conducted":[26],"on":[27],"the":[28,36,73,85,89,96,197,203,225,229,236],"Long-Term":[29],"Outcome":[30],"Neonatal":[32],"hypoxic":[33],"EncePhALopathy":[34],"in":[35,140,188,212,245],"era":[37],"neuroprotective":[39],"treatment":[40],"hypothermia":[42],"ancillary":[43,90],"cohort,":[44,91],"including":[45],"204":[46],"mild":[49,171],"severe":[51,118,124],"HIE.":[52],"Multiple":[53],"factor":[54],"hierarchical":[57],"ascendant":[58],"classification":[59],"were":[60,103,113,184],"performed":[61],"using":[62,105],"data":[68,83,211],"establish":[70],"clusters":[71,100],"representing":[72],"cohort.":[74],"RESULTS:":[75],"The":[76],"combination":[77],"provided":[84],"best":[86],"representation":[87],"accounting":[92],"for":[93],"36.5%":[94],"explained":[97],"variance.":[98],"Two":[99],"patients":[102],"identified":[104],"these":[106],"factors.":[107],"Patients":[108],"allocated":[109],"cluster":[111,163],"2":[112],"more":[114,221],"likely":[115],"present":[117],"HIE":[119,172,215,226],"(70.8%;":[120],"P":[121,128,134,145,153],"<":[122,129,135,146,154,159],"0.001),":[123,130,155],"electroencephalograph":[125,175],"patterns":[126],"(65.2%;":[127],"injuries":[132],"(66.3%;":[133],"0.001)":[136],"biochemical":[138,177],"abnormalities":[139],"pH":[141],"(6.91":[142],"\u00b1":[143,151],"0.18;":[144],"0.05),":[147],"lactate":[148],"levels":[149],"(14.7":[150],"5.5;":[152],"glycemia":[157],"(P":[158],"0.05).":[160],"By":[161],"contrast,":[162],"1":[164],"predominantly":[166],"represented":[167],"by":[168],"neonates":[169,213],"symptoms,":[173],"better":[174,219],"patterns,":[176],"markers,":[178],"no":[180,185],"lesions.":[182],"There":[183],"significant":[186],"differences":[187],"maternal":[189],"obstetrical":[191],"data,":[192],"particularly":[193],"sentinel":[194],"events,":[195],"between":[196],"clusters.":[198],"CONCLUSIONS:":[199],"Early":[200],"consideration":[201],"association":[204],"would":[216],"allow":[217],"a":[218],"precise":[222],"characterization":[223],"profile":[227],"newborn":[230],"its":[232],"severity,":[233],"compared":[234],"sole":[237],"clinical":[238],"evaluation":[239],"through":[240],"Sarnat":[241],"or":[242],"Thompson":[243],"score":[244],"this":[246],"population.":[247]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-10T00:00:00"}
