{"id":"https://openalex.org/W7221096243","doi":"https://doi.org/10.64898/2026.10.08.757680","title":"Cancer-associated mutations reconfigure dynamical responses in EGFR kinase","display_name":"Cancer-associated mutations reconfigure dynamical responses in EGFR kinase","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221096243","doi":"https://doi.org/10.64898/2026.10.08.757680"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.08.757680","doi":"https://doi.org/10.64898/2026.10.08.757680","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.08.757680","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757680.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757680.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116270309","display_name":"Lorenzo Tulli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lorenzo Tulli","raw_affiliation_strings":["Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","School of Chemistry, University of Bristol, Bristol BS8 1TS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042341429","display_name":"Alessio Lodola","orcid":"https://orcid.org/0000-0002-8675-1002","observed_orcids":["https://orcid.org/0000-0002-8675-1002"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Lodola","raw_affiliation_strings":["Dipartimento Farmaceutico, Universit\u00e0 degli Studi di Parma, viale G.P. Usberti 27/A Campus Universitario, I-43100 Parma, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8675-1002","affiliations":[{"raw_affiliation_string":"Dipartimento Farmaceutico, Universit\u00e0 degli Studi di Parma, viale G.P. Usberti 27/A Campus Universitario, I-43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048108","display_name":"Adrian John Mulholland","orcid":"https://orcid.org/0000-0003-1015-4567","observed_orcids":["https://orcid.org/0000-0003-1015-4567"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adrian J. Mulholland","raw_affiliation_strings":["Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","School of Chemistry, University of Bristol, Bristol BS8 1TS, UK"],"raw_orcid":"https://orcid.org/0000-0003-1015-4567","affiliations":[{"raw_affiliation_string":"Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040445576","display_name":"A. Sofia F. Oliveira","orcid":"https://orcid.org/0000-0001-8753-4950","observed_orcids":["https://orcid.org/0000-0001-8753-4950"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"A. Sofia F. Oliveira","raw_affiliation_strings":["Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","School of Chemistry, University of Bristol, Bristol BS8 1TS, UK"],"raw_orcid":"https://orcid.org/0000-0001-8753-4950","affiliations":[{"raw_affiliation_string":"Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"School of Chemistry, University of Bristol, Bristol BS8 1TS, UK","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040445576"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.1168999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-kinase-domain","display_name":"EGFR kinase domain","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cancer-associated-mutations","display_name":"cancer-associated mutations","score":0.9639999866485596},{"id":"https://openalex.org/keywords/allosteric-communication","display_name":"allosteric communication","score":0.753000020980835},{"id":"https://openalex.org/keywords/l858r","display_name":"L858R","score":0.7710000276565552},{"id":"https://openalex.org/keywords/t790m","display_name":"T790M","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/atp-binding-site","display_name":"ATP binding site","score":0.7979999780654907},{"id":"https://openalex.org/keywords/signal-propagation","display_name":"signal propagation","score":0.550000011920929},{"id":"https://openalex.org/keywords/allosteric-networks","display_name":"allosteric networks","score":0.5149999856948853},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.414000004529953},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.42800000309944153},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8471999764442444},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.8179000020027161},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6241000294685364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5825999975204468},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.5397999882698059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5169000029563904},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4763999879360199},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4717999994754791},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4537000060081482},{"id":"https://openalex.org/C2911166042","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor Protein-Tyrosine Kinases","level":4,"score":0.4404999911785126},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4226999878883362},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3944999873638153},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.361299991607666},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.3393999934196472},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.28060001134872437},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2694000005722046},{"id":"https://openalex.org/C79186569","wikidata":"https://www.wikidata.org/wiki/Q14897880","display_name":"Tropomyosin receptor kinase C","level":5,"score":0.26930001378059387},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.2612999975681305}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.08.757680","doi":"https://doi.org/10.64898/2026.10.08.757680","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.08.757680","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757680.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.08.757680","doi":"https://doi.org/10.64898/2026.10.08.757680","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.08.757680","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.08.757680.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2109111079","display_name":null,"funder_award_id":"BB/X009831/1","funder_id":"https://openalex.org/F4320320360","funder_display_name":"University of Bristol"},{"id":"https://openalex.org/G2272451908","display_name":null,"funder_award_id":"101021207","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5746981171","display_name":"Creating and comprehending the circuitry of life: precise biomolecular design of multi-centre redox enzymes for a synthetic metabolism","funder_award_id":"BB/W003449/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7548555450","display_name":"Dynamical-nonequilibrium simulations: an emerging approach to study time-dependent structural changes in proteins","funder_award_id":"BB/X009831/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307285","display_name":"Impact Fund","ror":"https://ror.org/00jb20j87"},{"id":"https://openalex.org/F4320312803","display_name":"American Society of Forensic Odontology","ror":"https://ror.org/03pf0rw82"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221096243.pdf","grobid_xml":"https://content.openalex.org/works/W7221096243.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1964217341","https://openalex.org/W1968324646","https://openalex.org/W2003984225","https://openalex.org/W2007649418","https://openalex.org/W2036785342","https://openalex.org/W2043696829","https://openalex.org/W2044514683","https://openalex.org/W2059715478","https://openalex.org/W2088540000","https://openalex.org/W2100794900","https://openalex.org/W2111109297","https://openalex.org/W2122706875","https://openalex.org/W2123185010","https://openalex.org/W2136343696","https://openalex.org/W2142544064","https://openalex.org/W2150213614","https://openalex.org/W2154149901","https://openalex.org/W2159013299","https://openalex.org/W2161821474","https://openalex.org/W2161879730","https://openalex.org/W2518262267","https://openalex.org/W2560717039","https://openalex.org/W2770828094","https://openalex.org/W2785841326","https://openalex.org/W2804692670","https://openalex.org/W2823592088","https://openalex.org/W2935113325","https://openalex.org/W2976516489","https://openalex.org/W2990041408","https://openalex.org/W3010387843","https://openalex.org/W3012576274","https://openalex.org/W3138090372","https://openalex.org/W3186969823","https://openalex.org/W3199928453","https://openalex.org/W4285590771","https://openalex.org/W4300166936","https://openalex.org/W4309245020","https://openalex.org/W4319815296","https://openalex.org/W4393280372","https://openalex.org/W4396903852","https://openalex.org/W4400553299","https://openalex.org/W4403000742","https://openalex.org/W4411022988","https://openalex.org/W4413354786","https://openalex.org/W4415191455","https://openalex.org/W4416940843","https://openalex.org/W7116983706","https://openalex.org/W7169613376"],"related_works":["https://openalex.org/W3027977667","https://openalex.org/W4408176568","https://openalex.org/W3179272524","https://openalex.org/W4411897900","https://openalex.org/W4291190042","https://openalex.org/W1968324646","https://openalex.org/W2038682861","https://openalex.org/W4301418031","https://openalex.org/W4389023312","https://openalex.org/W2973617310"],"abstract_inverted_index":{"SUMMARY":[0],"The":[1],"epidermal":[2],"growth":[3],"factor":[4],"receptor":[5,11,46],"(EGFR)":[6],"is":[7,35,75],"a":[8,14,36,62],"tyrosine":[9],"kinase":[10,25,97],"that":[12,30,180,199],"plays":[13],"fundamental":[15],"role":[16],"in":[17,106,111,193,209,228],"regulating":[18],"cellular":[19],"proliferation,":[20],"survival,":[21],"and":[22,34,50,58,70,110,124,148,189],"differentiation.":[23],"EGFR\u2019s":[24,204],"domain":[26],"catalyses":[27],"the":[28,90,96,101,107,114,133,141,151,167,200,214,223],"autophosphorylation":[29],"drives":[31],"downstream":[32],"signalling":[33],"known":[37],"hotspot":[38],"for":[39,56],"cancer-associated":[40],"mutations.":[41],"Such":[42],"substitutions":[43],"often":[44],"enhance":[45],"activation,":[47],"driving":[48],"oncogenesis":[49],"therapeutic":[51],"resistance,":[52],"with":[53],"major":[54],"implications":[55],"prognosis":[57],"treatment":[59],"choice;":[60],"consequently,":[61],"detailed":[63],"understanding":[64],"of":[65,103,113,216,222,239],"this":[66,156],"domain\u2019s":[67],"functional":[68,138],"dynamics,":[69],"how":[71,87],"mutations":[72],"reshape":[73],"them,":[74],"essential.":[76],"Here,":[77],"we":[78],"apply":[79],"dynamical-nonequilibrium":[80],"molecular":[81],"dynamics":[82],"(D-NEMD)":[83],"simulations":[84,182,196],"to":[85,136,175,219,230],"probe":[86],"changes":[88,218],"at":[89],"ATP-binding":[91],"site":[92],"are":[93],"transmitted":[94],"throughout":[95],"domain,":[98],"ultimately":[99],"shaping":[100],"behaviour":[102,235],"distal":[104,220],"regions":[105,221],"wild-type":[108],"protein":[109],"two":[112,201],"most":[115],"clinically":[116],"observed":[117],"non-small":[118],"cell":[119],"lung":[120],"cancer":[121],"variants,":[122],"L858R":[123,212,231],"L858R+T790M.":[125],"D-NEMD":[126,181],"reveals":[127],"previously":[128],"uncharacterised":[129],"communication":[130,177],"networks":[131],"linking":[132],"ATP":[134,168],"pocket":[135],"key":[137],"motifs,":[139],"including":[140],"P-loop,":[142],"\u03b1C-helix,":[143],"hinge":[144],"region,":[145],"activation":[146],"loop,":[147],"\u03b1F-helix,":[149],"showing":[150],"intricate":[152],"allosteric":[153,187],"connectivity":[154],"within":[155],"domain.":[157],"Notably,":[158],"numerous":[159],"cancer-related":[160],"mutation":[161,191],"sites,":[162],"despite":[163],"being":[164],"distant":[165],"from":[166],"site,":[169],"map":[170],"onto":[171],"or":[172],"lie":[173],"close":[174],"these":[176],"pathways,":[178],"indicating":[179],"can":[183],"identify":[184],"functionally":[185],"relevant":[186],"positions":[188],"potential":[190],"sites":[192],"EGFR.":[194],"Our":[195],"further":[197],"reveal":[198],"variants":[202],"rewire":[203],"internal":[205],"signal":[206],"propagation":[207],"network":[208],"distinct":[210],"ways:":[211],"diminishes":[213],"transmission":[215],"structural":[217],"C-lobe,":[224],"whereas":[225],"introducing":[226],"T790M":[227],"addition":[229],"partially":[232],"restores":[233],"wild-type-like":[234],"through":[236],"compensatory":[237],"rerouting":[238],"early-stage":[240],"dynamical":[241],"pathways.":[242]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-10T00:00:00"}
