{"id":"https://openalex.org/W7221083403","doi":"https://doi.org/10.64898/2026.10.07.756687","title":"Repurposing dopamine D 3 receptor fluorescent ligands for D 2 receptor","display_name":"Repurposing dopamine D 3 receptor fluorescent ligands for D 2 receptor","publication_year":2026,"publication_date":"2026-10-09","ids":{"openalex":"https://openalex.org/W7221083403","doi":"https://doi.org/10.64898/2026.10.07.756687"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.07.756687","doi":"https://doi.org/10.64898/2026.10.07.756687","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.756687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.07.756687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.07.756687.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158050136","display_name":"K\u00e4tlin Ots","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"K\u00e4tlin Ots","raw_affiliation_strings":["Institute of Chemistry, University of Tartu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054097958","display_name":"T\u00f5nis Laasfeld","orcid":"https://orcid.org/0000-0002-4730-3047","observed_orcids":["https://orcid.org/0000-0002-4730-3047"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"T\u00f5nis Laasfeld","raw_affiliation_strings":["Institute of Chemistry, University of Tartu"],"raw_orcid":"https://orcid.org/0000-0002-4730-3047","affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018342161","display_name":"Kaspar Hollo","orcid":"https://orcid.org/0000-0002-1379-2268","observed_orcids":["https://orcid.org/0000-0002-1379-2268"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kaspar Hollo","raw_affiliation_strings":["Institute of Chemistry, University of Tartu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026689310","display_name":"Mihkel Ilisson","orcid":"https://orcid.org/0000-0002-2228-9701","observed_orcids":["https://orcid.org/0000-0002-2228-9701"]},"institutions":[{"id":"https://openalex.org/I2802241215","display_name":"Tartu University Hospital","ror":"https://ror.org/01dm91j21","country_code":"EE","type":"healthcare","lineage":["https://openalex.org/I2802241215"]},{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Mihkel Ilisson","raw_affiliation_strings":["Institute of Clinical Medicine, Faculty of Medicine, University of Tartu","Tartu University Hospital"],"raw_orcid":"https://orcid.org/0000-0002-2228-9701","affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, Faculty of Medicine, University of Tartu","institution_ids":["https://openalex.org/I56085075"]},{"raw_affiliation_string":"Tartu University Hospital","institution_ids":["https://openalex.org/I2802241215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092029316","display_name":"Sandra Ortigueira","orcid":"https://orcid.org/0000-0001-9544-2394","observed_orcids":["https://orcid.org/0000-0001-9544-2394"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra Ortigueira Noya","raw_affiliation_strings":["Faculty of Pharmacy, University of Santiago de Compostela"],"raw_orcid":"https://orcid.org/0000-0001-9544-2394","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, University of Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081073251","display_name":"Fabian Gra\u00dfl","orcid":"https://orcid.org/0000-0002-3265-5613","observed_orcids":["https://orcid.org/0000-0002-3265-5613"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Grassl","raw_affiliation_strings":["Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137916365","display_name":"Dimitra Tousi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dimitra Tousi","raw_affiliation_strings":["Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128991709","display_name":"Hanna-Riia Allas","orcid":"https://orcid.org/0009-0001-2320-6525","observed_orcids":["https://orcid.org/0009-0001-2320-6525"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Hanna-Riia Allas","raw_affiliation_strings":["Institute of Chemistry, University of Tartu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016374765","display_name":"Mar\u00eda Majellaro","orcid":"https://orcid.org/0000-0003-3490-7703","observed_orcids":["https://orcid.org/0000-0003-3490-7703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Majellaro","raw_affiliation_strings":["Celtarys Research S.L"],"raw_orcid":"https://orcid.org/0000-0003-3490-7703","affiliations":[{"raw_affiliation_string":"Celtarys Research S.L","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014750512","display_name":"Erki Enkvist","orcid":"https://orcid.org/0000-0001-7375-3765","observed_orcids":["https://orcid.org/0000-0001-7375-3765"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Erki Enkvist","raw_affiliation_strings":["Institute of Chemistry, University of Tartu"],"raw_orcid":"https://orcid.org/0000-0001-7375-3765","affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038297867","display_name":"Markus R. Heinrich","orcid":"https://orcid.org/0000-0001-7113-2025","observed_orcids":["https://orcid.org/0000-0001-7113-2025"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Heinrich","raw_affiliation_strings":["Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":"https://orcid.org/0000-0001-7113-2025","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075652944","display_name":"Eddy Sotelo","orcid":"https://orcid.org/0000-0001-5571-2812","observed_orcids":["https://orcid.org/0000-0001-5571-2812"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eddy Sotelo","raw_affiliation_strings":["Faculty of Pharmacy, University of Santiago de Compostela"],"raw_orcid":"https://orcid.org/0000-0001-5571-2812","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, University of Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056670099","display_name":"Anni Allikalt","orcid":"https://orcid.org/0000-0002-3056-3088","observed_orcids":["https://orcid.org/0000-0002-3056-3088"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":true,"raw_author_name":"Anni Allikalt","raw_affiliation_strings":["Institute of Chemistry, University of Tartu"],"raw_orcid":"https://orcid.org/0000-0002-3056-3088","affiliations":[{"raw_affiliation_string":"Institute of Chemistry, University of Tartu","institution_ids":["https://openalex.org/I56085075"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056670099"],"corresponding_institution_ids":["https://openalex.org/I56085075"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.7820000052452087},{"id":"https://openalex.org/keywords/fluorescent-ligands","display_name":"fluorescent ligands","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.6259999871253967},{"id":"https://openalex.org/keywords/live-cell-fluorescence-microscopy","display_name":"live-cell fluorescence microscopy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.5649999976158142},{"id":"https://openalex.org/keywords/saturable-binding","display_name":"saturable binding","score":0.6740000247955322},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.7440000176429749},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.800000011920929},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antiparkinsonian-drugs","display_name":"antiparkinsonian drugs","score":0.6690000295639038},{"id":"https://openalex.org/keywords/machine-learning-screening","display_name":"machine learning screening","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.8707000017166138},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6740000247955322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6276000142097473},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.5927000045776367},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5667999982833862},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4747999906539917},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4675999879837036},{"id":"https://openalex.org/C2909005528","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand Assay","level":3,"score":0.426800012588501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4187999963760376},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.3540000021457672},{"id":"https://openalex.org/C85196483","wikidata":"https://www.wikidata.org/wiki/Q6545857","display_name":"Ligand binding assay","level":3,"score":0.34950000047683716},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3312000036239624},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C152900378","wikidata":"https://www.wikidata.org/wiki/Q7302366","display_name":"Receptor\u2013ligand kinetics","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.29600000381469727},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.25600001215934753},{"id":"https://openalex.org/C103133801","wikidata":"https://www.wikidata.org/wiki/Q408572","display_name":"Sigma-1 receptor","level":4,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.07.756687","doi":"https://doi.org/10.64898/2026.10.07.756687","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.756687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.07.756687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.07.756687","doi":"https://doi.org/10.64898/2026.10.07.756687","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.756687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.10.07.756687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.4083999991416931,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G537861404","display_name":"Exploring Genetic Mutations in G Protein-Coupled Receptors and their Impact on Drug Response","funder_award_id":"PSG912","funder_id":"https://openalex.org/F4320321090","funder_display_name":"Eesti Teadusagentuur"}],"funders":[{"id":"https://openalex.org/F4320321090","display_name":"Eesti Teadusagentuur","ror":"https://ror.org/00jjeja18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221083403.pdf","grobid_xml":"https://content.openalex.org/works/W7221083403.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1492380293","https://openalex.org/W1733847523","https://openalex.org/W1901129140","https://openalex.org/W1925492557","https://openalex.org/W1972244086","https://openalex.org/W1979466068","https://openalex.org/W1980740634","https://openalex.org/W2002156919","https://openalex.org/W2009122815","https://openalex.org/W2040867705","https://openalex.org/W2049169901","https://openalex.org/W2061359205","https://openalex.org/W2068057735","https://openalex.org/W2073724103","https://openalex.org/W2074831881","https://openalex.org/W2075872837","https://openalex.org/W2094309508","https://openalex.org/W2097744565","https://openalex.org/W2104961861","https://openalex.org/W2111889757","https://openalex.org/W2145487150","https://openalex.org/W2308013795","https://openalex.org/W2416672087","https://openalex.org/W2520449272","https://openalex.org/W2592502957","https://openalex.org/W2745925584","https://openalex.org/W2750747039","https://openalex.org/W2765340404","https://openalex.org/W2766376821","https://openalex.org/W2771606508","https://openalex.org/W2780155716","https://openalex.org/W2785023044","https://openalex.org/W2890983656","https://openalex.org/W2916278679","https://openalex.org/W2923923573","https://openalex.org/W2949744039","https://openalex.org/W2964121744","https://openalex.org/W2991118449","https://openalex.org/W3008209007","https://openalex.org/W3048556335","https://openalex.org/W3113058943","https://openalex.org/W3113202667","https://openalex.org/W3118940079","https://openalex.org/W3160759420","https://openalex.org/W3168270315","https://openalex.org/W3211922046","https://openalex.org/W4205294473","https://openalex.org/W4282933264","https://openalex.org/W4324044851","https://openalex.org/W4327605261","https://openalex.org/W4353069359","https://openalex.org/W4388526586","https://openalex.org/W4393001753","https://openalex.org/W4394984679","https://openalex.org/W4400590456","https://openalex.org/W4402484429","https://openalex.org/W4409358433","https://openalex.org/W7164155293"],"related_works":["https://openalex.org/W3113202667","https://openalex.org/W1974600573","https://openalex.org/W2091915133","https://openalex.org/W2042437346","https://openalex.org/W3168270315","https://openalex.org/W7055399193","https://openalex.org/W4387057773","https://openalex.org/W4388526586","https://openalex.org/W1821702779","https://openalex.org/W4327605261"],"abstract_inverted_index":{"Abstract":[0,159],"The":[1],"dopamine":[2,126],"D":[3,21,31,43,54,79,143],"2":[4,22,55,80,144],"receptor":[5,23,56,81,145],"is":[6],"a":[7,59,153],"principal":[8],"target":[9],"of":[10,120,141],"antipsychotic":[11],"and":[12,70,114,127,148],"antiparkinsonian":[13],"drugs,":[14],"yet":[15],"well-characterized":[16],"fluorescent":[17,38,68,146,156],"ligands":[18,39,73,86],"for":[19,41,51,155],"the":[20,30,42,53,78,95,99,118,139],"remain":[24],"scarce":[25],"compared":[26],"with":[27,125,133],"its":[28],"relative,":[29],"3":[32,44],"receptor.":[33],"Here":[34],"we":[35,65],"show":[36],"that":[37,74],"developed":[40],"subtype":[45],"can":[46],"be":[47],"repurposed":[48],"as":[49,152],"tools":[50],"studying":[52],"pharmacology.":[57],"Using":[58],"machine-learning-assisted,":[60],"live-cell":[61],"fluorescence":[62],"microscopy":[63],"assay,":[64],"screened":[66],"twelve":[67],"probes":[69,101,147],"identified":[71],"eight":[72],"bound":[75],"specifically":[76],"to":[77],"at":[82],"10":[83],"nM.":[84],"Four":[85],"exhibited":[87],"classical":[88],"saturable":[89],"binding,":[90],"yielding":[91],"K":[92],"d":[93],"in":[94,112],"nanomolar":[96],"range,":[97],"whereas":[98],"remaining":[100],"displayed":[102],"unsaturated,":[103],"time-dependent":[104],"binding":[105,124],"profiles.":[106],"Kinetic":[107],"analyses":[108],"revealed":[109],"substantial":[110],"differences":[111],"association":[113],"dissociation":[115],"behavior,":[116],"highlighting":[117],"importance":[119],"time-resolved":[121],"measurements.":[122],"Competition":[123],"haloperidol":[128],"yielded":[129],"affinity":[130],"estimates":[131],"consistent":[132],"literature":[134],"values.":[135],"These":[136],"results":[137],"expand":[138],"toolkit":[140],"validated":[142],"support":[149],"cross-receptor":[150],"repurposing":[151],"strategy":[154],"ligand":[157],"development.":[158],"Figure":[160]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-10T00:00:00"}
