{"id":"https://openalex.org/W7221016299","doi":"https://doi.org/10.1002/ctd2.70220","title":"Longitudinal liquid biopsy alongside positron emission tomography\u2010computed tomography surveillance in p16\u2010positive oropharyngeal squamous cell carcinoma: A translational case study","display_name":"Longitudinal liquid biopsy alongside positron emission tomography\u2010computed tomography surveillance in p16\u2010positive oropharyngeal squamous cell carcinoma: A translational case study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7221016299","doi":"https://doi.org/10.1002/ctd2.70220"},"language":"en","primary_location":{"id":"doi:10.1002/ctd2.70220","doi":"https://doi.org/10.1002/ctd2.70220","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.70220","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70220","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70220","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132897216","display_name":"Sreedevi Damodaran","orcid":"https://orcid.org/0009-0007-2331-9064","observed_orcids":["https://orcid.org/0009-0007-2331-9064"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sreedevi Damodaran","raw_affiliation_strings":["Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia"],"raw_orcid":"https://orcid.org/0009-0007-2331-9064","affiliations":[{"raw_affiliation_string":"Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","institution_ids":["https://openalex.org/I11701301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053009810","display_name":"Chameera Ekanayake Weeramange","orcid":"https://orcid.org/0000-0001-7384-5512","observed_orcids":["https://orcid.org/0000-0001-7384-5512"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chameera Ekanayake Weeramange","raw_affiliation_strings":["Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","institution_ids":["https://openalex.org/I11701301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046513838","display_name":"Liz Kenny","orcid":"https://orcid.org/0000-0002-7556-0542","observed_orcids":["https://orcid.org/0000-0002-7556-0542"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405256125","display_name":"GenesisCare","ror":"https://ror.org/03sxgeg61","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4405256125"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lizbeth Kenny","raw_affiliation_strings":["GenesisCare Australia, GenesisCare  Brisbane Australia","School of Medicine The University of Queensland  Brisbane Australia"],"raw_orcid":"https://orcid.org/0000-0002-7556-0542","affiliations":[{"raw_affiliation_string":"GenesisCare Australia, GenesisCare  Brisbane Australia","institution_ids":["https://openalex.org/I4405256125"]},{"raw_affiliation_string":"School of Medicine The University of Queensland  Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076806944","display_name":"Sarju S. Vasani","orcid":"https://orcid.org/0000-0003-1471-9692","observed_orcids":["https://orcid.org/0000-0003-1471-9692"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarju Vasani","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery Royal Brisbane and Women's Hospital  Brisbane Australia","Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","School of Medicine The University of Queensland  Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery Royal Brisbane and Women's Hospital  Brisbane Australia","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","institution_ids":["https://openalex.org/I11701301"]},{"raw_affiliation_string":"School of Medicine The University of Queensland  Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057122690","display_name":"Omar Breik","orcid":"https://orcid.org/0000-0001-7996-9268","observed_orcids":["https://orcid.org/0000-0001-7996-9268"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Omar Breik","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery Royal Brisbane and Women's Hospital  Brisbane Australia","Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","School of Medicine The University of Queensland  Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery Royal Brisbane and Women's Hospital  Brisbane Australia","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","institution_ids":["https://openalex.org/I11701301"]},{"raw_affiliation_string":"School of Medicine The University of Queensland  Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058556002","display_name":"Touraj Taheri","orcid":"https://orcid.org/0000-0003-4771-9998","observed_orcids":["https://orcid.org/0000-0003-4771-9998"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Touraj Taheri","raw_affiliation_strings":["Department of Anatomical Pathology Royal Brisbane and Women's Hospital  Brisbane Australia","School of Medicine The University of Queensland  Brisbane Australia"],"raw_orcid":"https://orcid.org/0000-0003-4771-9998","affiliations":[{"raw_affiliation_string":"Department of Anatomical Pathology Royal Brisbane and Women's Hospital  Brisbane Australia","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"School of Medicine The University of Queensland  Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032806596","display_name":"Paul Leo","orcid":"https://orcid.org/0000-0001-8325-4134","observed_orcids":["https://orcid.org/0000-0001-8325-4134"]},"institutions":[{"id":"https://openalex.org/I1308309334","display_name":"Translational Research Institute","ror":"https://ror.org/00v807439","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1308309334"]},{"id":"https://openalex.org/I4210154382","display_name":"AGRF Ltd","ror":"https://ror.org/053v53919","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154382"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul Leo","raw_affiliation_strings":["Australian Genomic Research Facility  Brisbane Australia","Translational Research Institute  Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Genomic Research Facility  Brisbane Australia","institution_ids":["https://openalex.org/I4210154382"]},{"raw_affiliation_string":"Translational Research Institute  Brisbane Australia","institution_ids":["https://openalex.org/I1308309334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051086683","display_name":"Brett G.M. Hughes","orcid":"https://orcid.org/0000-0002-1811-0537","observed_orcids":["https://orcid.org/0000-0002-1811-0537"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brett G. M. Hughes","raw_affiliation_strings":["Cancer Care Services Royal Brisbane and Women's Hospital  Brisbane Australia","School of Medicine The University of Queensland  Brisbane Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Care Services Royal Brisbane and Women's Hospital  Brisbane Australia","institution_ids":["https://openalex.org/I2799393793"]},{"raw_affiliation_string":"School of Medicine The University of Queensland  Brisbane Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035406666","display_name":"Chamindie Punyadeera","orcid":"https://orcid.org/0000-0001-9039-8259","observed_orcids":["https://orcid.org/0000-0001-9039-8259","https://orcid.org/0000-0002-9424-9661"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]},{"id":"https://openalex.org/I1308309334","display_name":"Translational Research Institute","ror":"https://ror.org/00v807439","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1308309334"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Chamindie Punyadeera","raw_affiliation_strings":["Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","Translational Research Institute  Brisbane Australia"],"raw_orcid":"https://orcid.org/0000-0001-9039-8259","affiliations":[{"raw_affiliation_string":"Saliva and Liquid Biopsy Translational Laboratory Institute for Biomedicine and Glycomics Griffith University  Brisbane Australia","institution_ids":["https://openalex.org/I11701301"]},{"raw_affiliation_string":"Translational Research Institute  Brisbane Australia","institution_ids":["https://openalex.org/I1308309334"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035406666"],"corresponding_institution_ids":["https://openalex.org/I11701301","https://openalex.org/I1308309334"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79031458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9440000057220459},{"id":"https://openalex.org/keywords/post-treatment-surveillance","display_name":"post-treatment surveillance","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/metastasis-detection","display_name":"metastasis detection","score":0.6899999976158142},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.699999988079071},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.77920001745224},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6496000289916992},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.59170001745224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5177000164985657},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.47380000352859497},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.45019999146461487},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.44830000400543213},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.43939998745918274},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C2779079599","wikidata":"https://www.wikidata.org/wiki/Q3774464","display_name":"Iliac crest","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.4081000089645386},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.40779998898506165},{"id":"https://openalex.org/C2775924586","wikidata":"https://www.wikidata.org/wiki/Q7581955","display_name":"Squamous intraepithelial lesion","level":5,"score":0.39910000562667847},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C127077266","wikidata":"https://www.wikidata.org/wiki/Q3488638","display_name":"PET-CT","level":3,"score":0.3644999861717224},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.3628999888896942},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34209999442100525},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.3257000148296356},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.3188999891281128},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2700999975204468},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C2777415128","wikidata":"https://www.wikidata.org/wiki/Q419849","display_name":"Fluorodeoxyglucose","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.2547000050544739}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ctd2.70220","doi":"https://doi.org/10.1002/ctd2.70220","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.70220","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70220","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8c607927e5cf4faca56f62f8342a2031","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8c607927e5cf4faca56f62f8342a2031","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Discovery, Vol 6, Iss 5, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ctd2.70220","doi":"https://doi.org/10.1002/ctd2.70220","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.70220","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.70220","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G3315018960","display_name":"ARC Research Hub for Molecular Biosensors at Point-of-Use (MOBIUS)","funder_award_id":"IH240100013","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G7320242883","display_name":"Capturing elusive bionanoparticles via oscillating field induced convection","funder_award_id":"DP250101156","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G851803900","display_name":"Biosensor based clinical-decision support for patients with heart failure","funder_award_id":"2002576","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8699421738","display_name":"Multi-analyte liquid biopsy-based biomarkers for oropharyngeal cancer","funder_award_id":"2012560","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320466","display_name":"Gallipoli Medical Research Foundation","ror":"https://ror.org/02p32hv70"},{"id":"https://openalex.org/F4320320485","display_name":"Royal Brisbane and Women's Hospital Foundation","ror":"https://ror.org/01ftvnv05"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7221016299.pdf","grobid_xml":"https://content.openalex.org/works/W7221016299.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2292031635","https://openalex.org/W2313665888","https://openalex.org/W2504219691","https://openalex.org/W2904056720","https://openalex.org/W2906178571","https://openalex.org/W2921748131","https://openalex.org/W2927420473","https://openalex.org/W2951317368","https://openalex.org/W3003505060","https://openalex.org/W3045269735","https://openalex.org/W3095237376","https://openalex.org/W3186958396","https://openalex.org/W4283315868","https://openalex.org/W4309606878","https://openalex.org/W4311648984","https://openalex.org/W4391531970","https://openalex.org/W4398241879","https://openalex.org/W4402144870","https://openalex.org/W4416992153"],"related_works":["https://openalex.org/W2944448645","https://openalex.org/W4395035512","https://openalex.org/W4384925117","https://openalex.org/W4412653078","https://openalex.org/W7148923497","https://openalex.org/W4387811376","https://openalex.org/W2900537863","https://openalex.org/W4415439461","https://openalex.org/W4382182055","https://openalex.org/W3209803959"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Post\u2010treatment":[2],"surveillance":[3,257],"of":[4,78,252],"p16\u2010positive":[5,55,188],"oropharyngeal":[6],"squamous":[7,189],"cell":[8,190],"carcinoma":[9],"(OPSCC)":[10],"relies":[11],"on":[12],"clinical":[13],"assessment":[14],"and":[15,44,68,80,99,115,126,138,155,207,210,221,255,269],"fluorodeoxyglucose":[16],"positron":[17],"emission":[18],"tomographycomputed":[19],"tomography":[20],"(FDG":[21],"PET\u2010CT).":[22],"Longitudinal":[23],"liquid":[24],"biopsy":[25],"may":[26],"provide":[27],"complementary":[28,253],"biological":[29],"information,":[30],"but":[31,176,258],"the":[32],"relationship":[33],"between":[34,267],"oral\u2010rinse":[35,69],"human":[36],"papillomavirus":[37],"(HPV)":[38],"DNA,":[39],"circulating":[40],"tumour":[41,125],"cells":[42,209],"(CTCs),":[43],"imaging":[45,254],"findings":[46],"remains":[47],"incompletely":[48],"defined.":[49],"Methods":[50],"A":[51],"77\u2010year\u2010old":[52],"man":[53],"with":[54,146,161,234,242],"OPSCC":[56],"underwent":[57],"serial":[58],"liquid\u2010biopsy":[59,256],"sampling":[60],"within":[61],"an":[62],"ongoing":[63],"prospective":[64,250],"cohort.":[65],"Peripheral":[66],"blood":[67,94],"specimens":[70],"were":[71,88,140],"collected":[72],"before":[73],"treatment,":[74],"at":[75,142,158,202],"week":[76],"4":[77,203],"chemoradiotherapy,":[79,150],"approximately":[81,223],"13":[82],"weeks":[83],"after":[84,226],"treatment":[85],"completion.":[86],"CTCs":[87,139,156,200,240],"enriched":[89],"from":[90],"15":[91],"mL":[92],"peripheral":[93],"using":[95],"marker\u2010independent":[96],"spiral":[97],"microfluidics":[98],"characterised":[100],"by":[101,109],"immunofluorescence.":[102],"Oral\u2010rinse":[103,133,192,229],"high\u2010risk":[104],"HPV":[105],"DNA":[106,135,152,194,231],"was":[107,136,195],"assessed":[108],"multiplex":[110],"quantitative":[111],"polymerase":[112],"chain":[113],"reaction":[114],"reported":[116],"qualitatively.":[117],"Results":[118],"Baseline":[119],"PET\u2010CT":[120,170],"demonstrated":[121],"a":[122,162,178,211],"base\u2010of\u2010tongue":[123],"primary":[124],"cervical":[127],"nodal":[128],"disease":[129],"without":[130],"distant":[131,244,270],"metastases.":[132],"HPV16":[134,151,193,230],"detected,":[137,198],"identified":[141,177],"3":[143],"CTCs/mL,":[144,204],"predominantly":[145],"cytokeratin\u2010positive":[147],"phenotypes.":[148,166],"During":[149],"remained":[153],"detectable":[154],"persisted":[157,201],"1":[159],"CTC/mL,":[160],"shift":[163],"towards":[164],"cell\u2010surface\u2010vimentin\u2010positive":[165,206],"At":[167],"post\u2010treatment":[168],"assessment,":[169],"showed":[171],"complete":[172],"locoregional":[173,235,268],"metabolic":[174,236],"response":[175],"new":[179],"right":[180],"iliac":[181],"crest":[182],"lesion":[183],"subsequently":[184,216],"confirmed":[185],"as":[186],"metastatic":[187,263],"carcinoma.":[191],"no":[196],"longer":[197],"whereas":[199,238],"including":[205],"CD44\u2010positive":[208],"CTC\u2010white\u2010blood\u2010cell":[212],"cluster.":[213],"The":[214],"patient":[215],"developed":[217],"widespread":[218],"osseous":[219],"progression":[220],"died":[222],"eight":[224],"months":[225],"chemoradiotherapy.":[227],"Conclusions":[228],"clearance":[232],"coincided":[233,241],"response,":[237],"persistent":[239],"biopsy\u2010confirmed":[243],"metastasis.":[245],"This":[246],"hypothesis\u2010generating":[247],"observation":[248],"supports":[249],"evaluation":[251],"does":[259],"not":[260],"establish":[261],"earlier":[262],"detection":[264],"or":[265],"discrimination":[266],"recurrence.":[271]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-09T00:00:00"}